Unraveling the complexity of fungal drug tolerance at multiple scales of biology

Publicaciones

The natural diversity of the yeast proteome reveals chromosome-wide dosage compensation in aneuploids

Autores: Julia Muenzner, Pauline Trébulle, Federica Agostini, Christoph B. Messner, Martin Steger, Andrea Lehmann, Elodie Caudal, Anna-Sophia Egger, Fatma Amari, Natalie Barthel, Matteo De Chiara, Michael Mülleder, Vadim Demichev, Gianni Liti, Joseph Schacherer, Toni Gossmann, Judith Berman, Markus Ralser
Publicado en: 2022
Editor: Biorxiv
DOI: 10.1101/2022.04.06.487392

Inorganic sulfur fixation via a new homocysteine synthase allows yeast cells to cooperatively compensate for methionine auxotrophy

Autores: Jason S.L. Yu, Benjamin M. Heineike, Johannes Hartl, Clara Correia-Melo, Simran Kaur Aulakh, Andrea Lehmann, Oliver Lemke, Federica Agostini, Cory T. Lee, Vadim Demichev, Christoph B. Messner, Michael Mülleder, Markus Ralser
Publicado en: 2022
Editor: Biorxiv
DOI: 10.1101/2022.03.14.484209

The Proteomic Landscape of Genome-Wide Genetic Perturbations

Autores: Christoph B. Messner, Vadim Demichev, Julia Muenzner, Simran Aulakh, Annika Röhl, Lucía Herrera-Domínguez, Anna-Sophia Egger, Stephan Kamrad, Oliver Lemke, Enrica Calvani, Michael Mülleder, Kathryn S. Lilley, Georg Kustatscher, Markus Ralser
Publicado en: 2022
Editor: Biorxiv
DOI: 10.1101/2022.05.17.492318

High-throughput proteomics of nanogram-scale samples with Zeno SWATH DIA

Autores: Ziyue Wang, Michael Mülleder, Ihor Batruch, Anjali Chelur, Kathrin Textoris-Taube, Torsten Schwecke, Johannes Hartl, Jason Causon, Jose Castro-Perez, Vadim Demichev, Stephen Tate, Markus Ralser
Publicado en: 2022
Editor: Biorxiv
DOI: 10.1101/2022.04.14.488299

Increasing the throughput of sensitive proteomics by plexDIA

Autores: Jason Derks, Andrew Leduc, Georg Wallmann, R. Gray Huffman, Matthew Willetts, Saad Khan, Harrison Specht, Markus Ralser, Vadim Demichev & Nikolai Slavov
Publicado en: Nature Biotechnology, Edición 15461696, 2022, ISSN 1546-1696
Editor: Nature Biotechnology
DOI: 10.1038/s41587-022-01389-w

The importance of antimicrobial resistance in medical mycology

Autores: Neil A. R. Gow, Carolyn Johnson, Judith Berman, Alix T. Coste, Christina A. Cuomo, David S. Perlin, Tihana Bicanic, Thomas S. Harrison, Nathan Wiederhold, Mike Bromley, Tom Chiller & Keegan Edgar
Publicado en: Getting acquainted with npj Antimicrobials and Resistance, 2022, ISSN 2041-1723
Editor: Nature Publishing Group

A live-cell ergosterol reporter for visualization of the effects of fluconazole on the human fungal pathogen Candida albicans

Autores: Antonio Serrano , Miguel A Basante-Bedoya, Martine Bassilan, Robert A Arkowitz
Publicado en: mBio, Edición Nov 30;14(6), 2023, ISSN 2150-7511
Editor: American Society of Microbiology

The metabolic growth limitations of petite cells lacking the mitochondrial genome

Autores: Jakob Vowinckel, Johannes Hartl, Hans Marx, Martin Kerick, Kathrin Runggatscher, Markus A. Keller, Michael Mülleder, Jason Day, Manuela Weber, Mark Rinnerthaler, Jason S. L. Yu, Simran Kaur Aulakh, Andrea Lehmann, Diethard Mattanovich, Bernd Timmermann, Nianshu Zhang, Cory D. Dunn, James I. MacRae, Michael Breitenbach & Markus Ralser
Publicado en: Nature Metabolism, Edición 25225812, 2021, ISSN 2522-5812
Editor: Nat. Metab.
DOI: 10.1038/s42255-021-00477-6

dia-PASEF data analysis using FragPipe and DIA-NN for deep proteomics of low sample amounts

Autores: Vadim Demichev, Lukasz Szyrwiel, Fengchao Yu, Guo Ci Teo, George Rosenberger, Agathe Niewienda, Daniela Ludwig, Jens Decker, Stephanie Kaspar-Schoenefeld, Kathryn S. Lilley, Michael Mülleder, Alexey I. Nesvizhskii & Markus Ralser
Publicado en: Nature Communications, Edición 20411723, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-31492-0

Reshaping Echinocandin Antifungal Drugs To Circumvent Glucan Synthase Point-Mutation-Mediated Resistance

Autores: Moriah Jospe-Kaufman, Dr. Efrat Ben-Zeev, Dr. Austin Mottola, Dr. Anna Dukhovny, Prof. Judith Berman, Prof. Shmuel Carmeli, Prof. Micha Fridman
Publicado en: NA, 2024, ISSN 1521-3773
Editor: Agwandte Chemie

Tackling the emerging threat of antifungal resistance to human health

Autores: Matthew C. Fisher, Ana Alastruey-Izquierdo, Judith Berman, Tihana Bicanic, Elaine M. Bignell, Paul Bowyer, Michael Bromley, Roger Brüggemann, Gary Garber, Oliver A. Cornely, Sarah. J. Gurr, Thomas S. Harrison, Ed Kuijper, Johanna Rhodes, Donald C. Sheppard, Adilia Warris, P. Lewis White, Jianping Xu, Bas Zwaan & Paul E. Verweij
Publicado en: Nature Reviews Microbiology, Edición 17401534, 2022, ISSN 1740-1534
Editor: Nature
DOI: 10.1038/s41579-022-00720-1

Tunicamycin Potentiates Antifungal Drug Tolerance via Aneuploidy in Candida albicans

Autores: Feng Yang, Vladimir Gritsenko, Yaniv Slor Futterman, Lu Gao, Cheng Zhen, Hui Lu, Yuan-ying Jiang jiangyy@tongji.edu.cn, Judith Berman
Publicado en: mBio, Edición 21507511, 2021, ISSN 2150-7511
Editor: ASM Journals
DOI: 10.1128/mbio.02272-21

Microbial communities form rich extracellular metabolomes that foster metabolic interactions and promote drug tolerance

Autores: Jason S. L. Yu, Clara Correia-Melo, Francisco Zorrilla, Lucia Herrera-Dominguez, Mary Y. Wu, Johannes Hartl, Kate Campbell, Sonja Blasche, Marco Kreidl, Anna-Sophia Egger, Christoph B. Messner, Vadim Demichev, Anja Freiwald, Michael Mülleder, Michael Howell, Judith Berman, Kiran R. Patil, Mohammad Tauqeer Alam & Markus Ralser
Publicado en: Nature Microbiology, Edición 20585276, 2022, ISSN 2058-5276
Editor: Nat Microbiol
DOI: 10.1038/s41564-022-01072-5

Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to antifungal compounds

Autores: Vanessa DumeauxSamira MassahiVan BettauerAustin MottolaAnna DukovnySanny Singh KhurdiaAnna Carolina Borges Pereira CostaRaha Parvizi OmranShawn SimpsonJinglin Lucy XieMalcolm WhitewayJudith BermanMichael T Hallett
Publicado en: Computational and Systems Biology, Microbiology and Infectious Disease, 2023, ISSN 2050-084X
Editor: eLife Sciences Publications

Antifungal Tolerance and Resistance Emerge at Distinct Drug Concentrations and Rely upon Different Aneuploid Chromosomes

Autores: Feng Yang https://orcid.org/0000-0003-2363-0745, Eduardo F. C. Scopel https://orcid.org/0000-0002-0064-3466, Hao Li, Liu-liu Sun, Nora Kawar, Yong-bing Cao, Yuan-Ying Jiang jiangyy@tongji.edu.cn, Judith Berman
Publicado en: ASM Journals, 2024, ISSN 2379-5077
Editor: ASM Journals

The future of fungi: threats and opportunities

Autores: Nicola T Case, Judith Berman, David S Blehert, Robert A Cramer, Christina Cuomo, Cameron R Currie, Iuliana V Ene, Matthew C Fisher, Lillian K Fritz-Laylin, Aleeza C Gerstein, N Louise Glass, Neil A R Gow, Sarah J Gurr, Chris Todd Hittinger, Tobias M Hohl, Iliyan D Iliev, Timothy Y James, Hailing Jin, Bruce S Klein, James W Kronstad, Jeffrey M Lorch, Victoria McGovern, Aaron P Mitchell, Julia A Seg
Publicado en: G3, 2022, ISSN 2160-1836
Editor: Genetics Society of America

Microbial communities form rich extracellular metabolomes that foster metabolic interactions and promote drug tolerance.

Autores: Jason S. L. Yu; Clara Correia-Melo; Francisco Zorrilla; Lucia Herrera-Dominguez; Mary Y. Wu; Johannes Hartl; Kate Campbell; Sonja Blasche; Marco Kreidl; Anna-Sophia Egger; Christoph B. Messner; Vadim Demichev; Anja Freiwald; Michael Mülleder; Michael Howell; Judith Berman; Kiran R. Patil; Mohammad Tauqeer Alam; Markus Ralser
Publicado en: Nature Microbiology, Edición 4, 2022, Página(s) pages542–555, ISSN 2058-5276
Editor: NPG
DOI: 10.17863/cam.83116

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