Descripción del proyecto
Consorcio de investigación para el desarrollo de nanoestructuras terapéuticas y de diagnóstico
El tratamiento oncológico combinado, basado en la administración simultánea mediante nanotransportadores de varios agentes farmacológicos con distintos modos de acción, representa una estrategia terapéutica eficaz. Los materiales nanoestructurados permiten administrar el fármaco de forma eficaz y ofrecen una gran sensibilidad para el diagnóstico. El proyecto financiado con fondos europeos NANO4TARMED ayudará a establecer un consorcio de centros de investigación en la República Checa, Italia e Irlanda para la creación de una agrupación científica que promoverá la investigación y el desarrollo mediante una serie de talleres, seminarios y un amplio intercambio de investigadores noveles. El consorcio trabajará para desarrollar nanoestructuras 3D funcionales de modalidad dual para la administración dirigida de fármacos terapéuticos y la obtención de imágenes celulares.
Objetivo
Cancer is one of the leading causes of death worldwide. Great efforts are still necessary to individuate new therapeutic strategies aimed to reduce cancer recurrence and to define new potential adjuvant targets for inhibiting invasion and metastasis, two significant contributors to death among patients. The combination therapy based on the simultaneous administration of two or more pharmacologically active agents with different modes of action using nanocarriers for the delivery could represent an effective strategy for the treatment. The increase in efficacy of a therapeutic formulation is causally related to its ability to selectively target diseased tissue, overcome biological barriers, and smartly respond to the disease environment to release therapeutic agents. The increasing interest in the employment of nanostructured materials to medicine-related branches is attributable to its unique properties allowing highly efficient drug delivery, molecular sensing applicable in diagnosis, multiplex imaging, or construction of point of care therapeutic devices. This project aims at an establishment of a consortium consisted of Regional centre of advanced technologies and materials (part of Palacký University), The Institute of Science and Technology for Ceramics (part of CNR) and Maynooth University which will through a set of workshops, seminars and extensive exchange of early-stage researchers develop an efficient scientific cluster. The research of the cluster will aim the development of functional 3D dual-modality nanostructures for targeted drug delivery and cell imaging.
Ámbito científico
Palabras clave
Programa(s)
- H2020-EU.4.b. - Twinning of research institutions Main Programme
Tema(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-WIDESPREAD-2020-5
Régimen de financiación
CSA - Coordination and support actionCoordinador
771 47 Olomouc
Chequia