CORDIS
EU research results

CORDIS

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Autonomous multimodal implantable endoscopic capsule for the gastrointestinal tract

Project information

Grant agreement ID: 952118

Status

Grant agreement signed

  • Start date

    1 November 2020

  • End date

    31 October 2024

Funded under:

H2020-EU.1.2.2.

  • Overall budget:

    € 3 992 860

  • EU contribution

    € 3 992 860

Coordinated by:

UNIVERSITA DI PISA

Italy

Objective

AUTOCAPSULE aims at demonstrating the viability of a technology for early diagnosis of Inflammatory Bowel Disease (IBD) and bowel cancer and for monitoring of treatment effectiveness at primary or secondary point of care. The technology vision is based on an untethered autonomous capsule that is both implantable in the gastro-intestinal (GI) tract for several weeks in order to monitor a specific area, and that can explore the GI tract for endoscopy in a point of care, through magnetic manipulation with an external robotic arm and limited expertise of the operator . The capsule is capable of multimodal sensing, including micro ultrasound imaging, white light imaging, ph monitoring and inflammation monitoring.

The GI system is highly complex, subject to frequent external stimulus through eating and digestion, and carries an extremely high burden of disease: 15 – 40% of the European population report functional GI conditions. However, the range of conditions encompassed is too diverse a target for immediate action and we will therefore focus on inflammatory bowel disease (IBD) and colorectal cancer. Even for those diseases alone, the affected European populations are large, with colorectal cancer being the most common cancer in men (30% of all new cancers) and second most common in women (25% of all new cancers) with a total of about 350,000 cases in the EU in 2012. Moreover, the burden on healthcare systems is rising worldwide, with increased screening cited as the primary reason.

In the course of the AUTOCAPSULE project two parallel tracks will be followed to demonstrate the technology vision, each focusing on a subset of the vision capsule features. One focuses on the development and demonstration of an untethered autonomous robotic capsule, capable of micro ultrasound imaging and white light imaging. The other focuses on the development and demonstration of an implantable capsule, capable of operating with sub-mW wireless power supply and of being parked in the GI tract for several weeks. AUTOCAPSULE will demonstrate capsules with partial complementary implementations of the technology vision and will show a path towards the fabrication and industrial development of the full vision capsule.

Coordinator

UNIVERSITA DI PISA

Address

Lungarno Pacinotti 43/44
56126 Pisa

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 922 500

Participants (4)

UNIVERSITY OF LEEDS

United Kingdom

EU Contribution

€ 778 840

UNIVERSITY OF GLASGOW

United Kingdom

EU Contribution

€ 797 881,25

INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM

Belgium

EU Contribution

€ 771 138,75

QUANTAVIS SRL

Italy

EU Contribution

€ 722 500

Project information

Grant agreement ID: 952118

Status

Grant agreement signed

  • Start date

    1 November 2020

  • End date

    31 October 2024

Funded under:

H2020-EU.1.2.2.

  • Overall budget:

    € 3 992 860

  • EU contribution

    € 3 992 860

Coordinated by:

UNIVERSITA DI PISA

Italy