Opis projektu
Nowa technologia dla wczesnej diagnozy nieswoistego zapalenia jelit i raka jelit
Choroby układu pokarmowego dotykają 15–40 % europejskiej populacji. Rak jelita grubego jest odpowiedzialny za setki tysięcy zachorowań każdego roku i jest najczęstszym rodzajem raka u mężczyzn i drugim najczęstszym u kobiet. Coraz liczniejsze badania przesiewowe są jednak uważane za największe obciążenie dla systemu opieki zdrowotnej. Celem finansowanego przez UE projektu AUTOCAPSULE jest opracowanie technologii wczesnej diagnozy nieswoistego zapalenia jelit i raka jelit oraz monitorowanie skuteczności leczenia w miejscu opieki nad pacjentem. Technologia wykorzystuje autonomiczną kapsułę, która jest wszczepiana do układu pokarmowego na kilka tygodni i monitoruje określony obszar, po poddaniu magnetycznej manipulacji przez zewnętrzne ramię robotyczne. Kapsuła będzie zdolna do multimodalnej detekcji, w tym obrazowania mikroultrasonograficznego, obrazowania światłem białym oraz monitorowania pH i stanu zapalnego.
Cel
AUTOCAPSULE aims at demonstrating the viability of a technology for early diagnosis of Inflammatory Bowel Disease (IBD) and bowel cancer and for monitoring of treatment effectiveness at primary or secondary point of care. The technology vision is based on an untethered autonomous capsule that is both implantable in the gastro-intestinal (GI) tract for several weeks in order to monitor a specific area, and that can explore the GI tract for endoscopy in a point of care, through magnetic manipulation with an external robotic arm and limited expertise of the operator . The capsule is capable of multimodal sensing, including micro ultrasound imaging, white light imaging, ph monitoring and inflammation monitoring.
The GI system is highly complex, subject to frequent external stimulus through eating and digestion, and carries an extremely high burden of disease: 15 – 40% of the European population report functional GI conditions. However, the range of conditions encompassed is too diverse a target for immediate action and we will therefore focus on inflammatory bowel disease (IBD) and colorectal cancer. Even for those diseases alone, the affected European populations are large, with colorectal cancer being the most common cancer in men (30% of all new cancers) and second most common in women (25% of all new cancers) with a total of about 350,000 cases in the EU in 2012. Moreover, the burden on healthcare systems is rising worldwide, with increased screening cited as the primary reason.
In the course of the AUTOCAPSULE project two parallel tracks will be followed to demonstrate the technology vision, each focusing on a subset of the vision capsule features. One focuses on the development and demonstration of an untethered autonomous robotic capsule, capable of micro ultrasound imaging and white light imaging. The other focuses on the development and demonstration of an implantable capsule, capable of operating with sub-mW wireless power supply and of being parked in the GI tract for several weeks. AUTOCAPSULE will demonstrate capsules with partial complementary implementations of the technology vision and will show a path towards the fabrication and industrial development of the full vision capsule.
Dziedzina nauki
- medical and health sciencesclinical medicinegastroenterologyinflammatory bowel disease
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringroboticsautonomous robots
- medical and health sciencesclinical medicineoncologycolorectal cancer
- natural sciencesphysical sciencesacousticsultrasound
Słowa kluczowe
Program(-y)
Zaproszenie do składania wniosków
Zobacz inne projekty w ramach tego zaproszeniaSzczegółowe działanie
H2020-EIC-FETPROACT-2019
System finansowania
RIA - Research and Innovation actionKoordynator
56126 Pisa
Włochy