Project description DEENESFRITPL A minimally invasive treatment option for bone fractures According to the World Health Organisation's projections, the incidence of osteoporosis fractures will have risen to 4.5 million by 2025. Current fracture fixators are rigid and thus not efficient in stabilising thin, fragile, inaccessible and shattered bones. The EU-funded BoneFix project's researchers will work on a novel class of bone adhesives and bone restoration materials, which will enable the personalised treatment of bone fractures via minimally invasive surgery under local anaesthesia. To achieve their goals, the team will develop a novel library of biocompatible, biodegradable thiol-ene based monomers, linear polycarbonates and multi-purpose dendritic materials that can bind to wet bones. The ultimate solution will be a bone restoration patch – a customisable, universal solution for fractures that upon complete healing will be fully resorbed. Show the project objective Hide the project objective Objective As Europe’s population rapidly ages so too does the socioeconomic cost of bone fractures. According to WHO, the total number of osteoporosis-related fractures in EU patients will rise to 4.5 million in 2025, which translates to 8.5 incidents per minute. Unfortunately, clinically used metal fixators are old-fashion solutions and their rigid design combined with open surgery and general anaesthesia, make them poor fixators for fractures on thin, fragile, inaccessible and shattered bone. Our solution is BoneFix, a novel class of bone adhesives that will allow for personalized surgical treatment of bone fractures via minimal invasive surgery under local anaesthesia. This will be accomplished by developing a novel library of biocompatible, biodegradable triazine monomers, linear polycarbonates and multi-purpose dendritic materials, capable of binding to wet bone, together with strong biodegradable organic/ceramic composites. Building from the bottom up, the concept involves three domains: a bone substitute void filler, topological mechanical fixation patch, and a protective anti-bacterial hydrogel layer. The components will be delivered through narrow gauge needles and solidify “on fracture site” via High Energy Visible Light Off-Stoichiometric Thiol-Ene Coupling chemistry (HEV-OSTEC). Collectively, these will form a Bone Restoration Patch (BRP) - a customizable, universal solution for fractures that upon complete healing will be fully resorbed. The BRPs will be thoroughly evaluated by stakeholders in order to assess relevant properties, both ex vivo and finally in vivo on relevant animal models. The ultimate goal is to cement a new disruptive technology and a paradigm shift in clinical interventions of bone fractures in which BoneFix heals, fixates and protects complex fractures making screws, plates and open surgery obsolete. Fields of science medical and health sciencesclinical medicinesurgeryengineering and technologymaterials engineeringcompositesmedical and health sciencesclinical medicineanaesthesiologymedical and health sciencesmedical biotechnologyimplantsartificial bone Keywords BoneFix Programme(s) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.2. - FET Proactive Topic(s) FETPROACT-EIC-05-2019 - FET Proactive: emerging paradigms and communities Call for proposal H2020-FETPROACT-2019-2020 See other projects for this call Sub call H2020-EIC-FETPROACT-2019 Funding Scheme RIA - Research and Innovation action Coordinator KUNGLIGA TEKNISKA HOEGSKOLAN Net EU contribution € 1 269 712,50 Address BRINELLVAGEN 8 100 44 Stockholm Sweden See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 269 712,50 Participants (6) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITETET I BERGEN Norway Net EU contribution € 607 002,50 Address MUSEPLASSEN 1 5020 Bergen See on map Region Norge Vestlandet Vestland Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 607 002,50 AO-FORSCHUNGSINSTITUT DAVOS Switzerland Net EU contribution € 399 820,70 Address CLAVADELERSTRASSE 8 7270 Davos Platz See on map Region Schweiz/Suisse/Svizzera Ostschweiz Graubünden / Grigioni / Grischun Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 399 820,70 REGION HOVEDSTADEN Denmark Net EU contribution € 879 586,88 Address KONGENS VAENGE 2 3400 Hillerod See on map Region Danmark Hovedstaden Nordsjælland Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 879 586,88 KAROLINSKA INSTITUTET Sweden Net EU contribution € 228 565,00 Address Nobels Vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 228 565,00 BIOMEDICAL BONDING AB Sweden Net EU contribution € 302 500,00 Address TEKNIKRINGEN 38 BV 114 28 Stockholm See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Östra Sverige Stockholm Stockholms län Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 302 500,00 INSTITUT MINES-TELECOM France Net EU contribution € 296 280,55 Address 19 PLACE MARGUERITE PEREY 91120 Palaiseau See on map Region Ile-de-France Ile-de-France Essonne Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 296 280,55
