BoneFix: A Paradigm Shift in Fracture Fixations via On-Site Fabrication of Bone Restoration Patches

Project Information

BoneFix

Grant agreement ID: 952150

DOI

10.3030/952150

Project closed

EC signature date 24 June 2020

Start date 1 October 2020

End date 30 June 2025

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost

€ 3 983 468,13

EU contribution

€ 3 983 468,13

Coordinated by

KUNGLIGA TEKNISKA HOEGSKOLAN
Sweden

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (2)

Training media

Videos aimed at surgeons describing the application and advantages of BoneFix

Project website

BMB will establish and update the project website in conjunction with the project coordinator The website will be continuously updated with publishable reports and other information relevant to stakeholders and the broader public

Documents, reports (2)

Publication of in vivo pain study results

Scientific publication describing pain-related behaviours in mice with BoneFix fixed fractures compared to the implantation of metal screws.

Scientific articles

The dissemination of the results will follow the dissemination plan and will be the responsibility of the project coordinator (KTH) and the consortium partners that conducted the research.

Publications

Peer reviewed articles (15)

Cyclic testing reliability analysis on a novel light-curable bone fixation technique

Author(s): Paula M. N. Cameron, Daniel J. Hutchinson, Micheal Malkoch, Peter Varga, Peter Schwarzenberg
Published in: Frontiers in Bioengineering and Biotechnology, Issue 13, 2025, ISSN 2296-4185
Publisher: Frontiers Media SA
DOI: 10.3389/fbioe.2025.1515319

Biomechanical Performance of a Novel-Curable Bone Fixation Technique

Author(s): Schwarzenberg, Peter; Colding-Rasmussen, Thomas; Hutchinson, Daniel J; Mischler, Dominic; Horstmann, Peter; Petersen, Michael Meork; Jacobsen, Stine; Pastor, Tatjana; Malkock, Michael; Wong, Christian; Varga, Peter
Published in: Scientific Reports, Issue 13, 2023, Page(s) 9339, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-35706-3

Determination of the internal loads experienced by proximal phalanx fracture fixations during rehabilitation exercises

Author(s): Peter Schwarzenberg, Thomas Colding-Rasmussen, Daniel J. Hutchinson, Jorge San Jacinto Garcia, Viktor Granskog, Michael Mørk Petersen, Tatjana Pastor, Tine Weis, Michael Malkoch, Christian Nai En Tierp-Wong, Peter Varga
Published in: Frontiers in Bioengineering and Biotechnology, Issue 12, 2024, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2024.1388399

Photo‐Curable Triazinetrione Composites With Tunable Degradation for Fracture Stabilization and Flexible Thin‐Film Applications

Author(s): Jorge San Jacinto Garcia, Natalia Sanz del Olmo, Daniel J. Hutchinson, Michael Malkoch
Published in: Journal of Applied Polymer Science, 2025, ISSN 0021-8995
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/app.57068

Biomechanical Variability and Usability of a Novel Customizable Fracture Fixation Technique

Author(s): Colding-Rasmussen, Thomas; Schwarzenberg, Peter; Horstmann, Peter Frederik; Ottesen, Casper Bent Smedegaard; Garcia, Jorge San Jacinto; Hutchinson, Daniel John; Malkoch, Michael; Petersen, Michael Mørk; Varga, Peter; Tierp-Wong, Christian Nai En
Published in: Bioengineering, Issue 10, 2023, Page(s) 1146, ISSN 2306-5354
Publisher: MDPI
DOI: 10.3390/bioengineering10101146

Injectable Dendritic Hydrogels Curable by High-Energy Visible Light for Cell Delivery in Bone Regeneration

Author(s): Noemi Molina, Francesco Torelli, Samih Mohamed-Ahmed, Daniel J. Hutchinson, Cecilie Gjerde, Ahmad Rashad, Kamal Mustafa, Michael Malkoch
Published in: Chemistry of Materials, 2025, ISSN 0897-4756
Publisher: American Chemical Society
DOI: 10.1021/acs.chemmater.5c00063

Soft Hydroxyapatite Composites Based on Triazine–Trione Systems as Potential Biomedical Engineering Frameworks

Author(s): Lin, Jinjian; Fan, Yanmiao; Hutchinson, Daniel J.; Malkoch, Michael
Published in: ACS Appl Mater Interfaces, Issue 15, 2023, Page(s) 7329-7339, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.2c16235

Impact of Polyester Dendrimers as Branched Multifunctional Cross-Linking Additives in Triazine-Trione-Based Composites Developed via High-Energy Visible Light Thiol-ene Chemistry

Author(s): Lin, Jinjian; Sanz del Olmo, Natalia; San Jacinto Garcia, Jorge; Hutchinson, Daniel J.; Malkoch, Michael
Published in: ACS Applied Polymer Materials, Issue 5, 2023, Page(s) 10395-10403, ISSN 2637-6105
Publisher: American Chemical Society
DOI: 10.1021/acsapm.3c02246

Synthesis and Characterization of Amino-Functional Polyester Dendrimers Based On Bis-MPA with Enhanced Hydrolytic Stability and Inherent Antibacterial Properties

Author(s): Namata, Faridah; Sanz del Olmo, Natalia; Molina, Noemi; Malkoch, Michael
Published in: Biomacromolecules, Issue 24, 2023, Page(s) 858-867, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.2c01286

Antibacterial Hydrogel Adhesives Based on Bifunctional Telechelic Dendritic-Linear–Dendritic Block Copolymers

Author(s): Sanz del Olmo, Natalia; Molina, Noemi; Fan, Yanmiao; Hutchinson, Daniel J.; Malkoch, Michael
Published in: J. Am. Chem. Soc., Issue 146, 2024, Page(s) 17240-17249, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.4c03673

Biomechanical Characterization of Metacarpal Fixation: Internal Load Determination and Evaluation of a Novel Adhesive Osteosynthesis

Author(s): Peter Schwarzenberg, Gordian Banzer, Guillaume Patt‐Lafitte, Jérôme Schlatter, Daniel J. Hutchinson, Michael Malkoch, Peter Varga, Tatjana Pastor
Published in: Journal of Orthopaedic Research, 2025, ISSN 0736-0266
Publisher: Elsevier BV
DOI: 10.1002/jor.70027

Toughening and strengthening of visible light-cured hydroxyapatite thiol-ene resin composite intended as bone fixation using 2D textile

Author(s): Patt-Lafitte, Guillaume; Valfort, Oliver; Hutchinson, Daniel J.; Malkoch, Michael; Eglin, David
Published in: Journal of Materials Research and Technology, Issue 29, 2024, Page(s) 982-990, ISSN 2238-7854
Publisher: Elsevier Editora Ltda
DOI: 10.1016/j.jmrt.2024.01.127

Enhanced Degradability of Thiol–Ene Composites through the Inclusion of Isosorbide-Based Polycarbonates

Author(s): Jorge San Jacinto Garcia, Natalia Sanz del Olmo, Daniel J. Hutchinson, Michael Malkoch
Published in: ACS Applied Materials & Interfaces, Issue 16, 2024, Page(s) 40056-40068, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.4c09626

Photo‐Clickable Triazine‐Trione Thermosets as Promising 3D Scaffolds for Tissue Engineering Applications

Author(s): Åshild Johansen, Jinjian Lin, Shuntaro Yamada, Samih Mohamed‐Ahmed, Mohammed A. Yassin, Cecilie Gjerde, Daniel J. Hutchinson, Kamal Mustafa, Michael Malkoch
Published in: Advanced Healthcare Materials, Issue 16, 2024, Page(s) 40056, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202401202

Novel Customizable Fracture Fixation Technique vs. Conventional Metal Locking Plate: An Exploratory Comparative Study of Fixation Stability in an Experimental In Vivo Ovine Bilateral Phalangeal Fracture Model

Author(s): Thomas Colding-Rasmussen, Nanett Kvist Nikolaisen, Peter Frederik Horstmann, Michael Mørk Petersen, Daniel John Hutchinson, Michael Malkoch, Stine Jacobsen, Christian Nai En Tierp-Wong
Published in: Materials, Issue 18, 2025, Page(s) 3359, ISSN 1996-1944
Publisher: MDPI Open Access Publishing
DOI: 10.3390/ma18143359

Conference proceedings (9)

Dendritic-Linear-Dendritic (DLD) Based Materials and Their Potential Use inBiomedical Applications

Author(s): Molina, Noemi; Sanz del Olmo, Natalia; Hutchinson, Daniel J.; Malkoch, Michael
Published in: ARI Abstracts Periodical, Issue 3, 2023, Page(s) 177, ISSN 2960-2483
Publisher: AO Research Institute Davos

Strong photo-curable thiol-ene based composites for use in the fixation of bonefractures

Author(s): Hutchinson, Daniel J.; Granskog, Viktor; Malkoch, Michael
Published in: ARI Abstracts Periodical, Issue 3, 2023, Page(s) 153, ISSN 2960-2483
Publisher: AO Research Institute Davos

Degradable thiol-ene composites for bone repair

Author(s): San Jacinto, Jorge; Hutchinson, Daniel J.; Sanz del Olmo, Natalia; Malkoch, Michael
Published in: ARI Abstracts Periodical, Issue 3, 2023, Page(s) 303, ISSN 2960-2483
Publisher: AO Research Institute Davos

Fabrication of biodegradable high strength and shape-shifting polylactic acidmembrane for reinforcement of a photo-curable composite bone fixation patch

Author(s): Patt-Lafitte, Guillaume; Hutchinson, Daniel J.; Malkoch, Michael; Eglin, David
Published in: ARI Abstracts Periodical, Issue 3, 2023, Page(s) 462, ISSN 2960-2483
Publisher: AO Research Institute Davos

Welfare monitoring in the novel ovine thoracic limb, bilateral, single-toeostectomy model (OBST)

Author(s): Nikolaisen, Nannet Kvist.; Tierp-Wong, Christian Nai En.; Colding-Rasmussen, Thomas; Petersen, Michael Mork; Hutchinson, Daniel; Lindegaard, Casper; Jacobsen, Stine
Published in: ARI Abstracts Periodical, Issue 3, 2023, Page(s) 144, ISSN 2960-2483
Publisher: AO Research Insitute Davos

Biomechanical analysis of a novel osteosynthesis device with standard andphysiological testing

Author(s): Schwarzenberg, Peter; Colding-Rasmussen, Thomas; Hutchinson, Daniel J.; San Jacinto Garcia, Jorge; Jacobsen, Stine; Horstmann, Peter; Petersen, Michael Mork; Mischler, Dominic; Granskog, V.; Pastor, Tatjana; Weis, Tine; Malkoch, Michael; Wong, Christian; Varga, Peter
Published in: ARI Abstracts Periodical, Issue 3, 2023, Page(s) 314, ISSN 2960-2483
Publisher: AO Research Institute Davos

The effect of PET meshes on the mechanical and structural properties of a photo-curable hydroxyapatite composite intended as internal fixation in complex bonefractures

Author(s): Patt-Lafitte, Guillaume, Rasolonjatovo, Sarah; Hutchinson, Daniel J.; Malkoch, Michael; Eglin, David
Published in: ARI Abstracts Periodical, Issue 3, 2023, Page(s) 228, ISSN 2960-2483
Publisher: AO Research Institute Davos

Cytocompatibility and osteogenic differentiation of mesenchymal stem cellswithin phototunable polyester-based PEGylated dendritic hydrogels

Author(s): Torelli, Francesco; Mohamed-Ahmed, Samih; Rashad, Ahmad; Cabeza, Noemi M.; Hutchinson, Daniel J.; Malkoch, Michael; Mustafa, Kamal
Published in: ARI Abstracts Periodical, Issue 3, 2023, Page(s) 492, ISSN 2960-2483
Publisher: AO Research Institute Davos

From bench to chairside: Mesenchymal stem cells and biomedical engineering inbone regeneration

Author(s): Mustafa, Kamal E.
Published in: ARI Abstracts Periodical, Issue 3, 2023, Page(s) 312, ISSN 2960-2483
Publisher: AO Research Institute Davos