Descripción del proyecto
Una nueva era en las pruebas de toxicidad para Polonia
El proyecto TWINALT, financiado con fondos europeos, permitirá al Instituto Nofer de Medicina Ocupacional (NIOM, por sus siglas en inglés) estimular la excelencia científica y mejorar la capacidad de innovación en los métodos de ensayo de toxicidad «in vitro». El NIOM establecerá vínculos con instituciones de investigación de renombre de Noruega, Bélgica e Italia, y se centrará en cinco áreas: métodos modernos de evaluación de la citotoxicidad (como el cribado de citotoxicidad de alto contenido), métodos alternativos estándar o modernos para la evaluación de la genotoxicidad y carcinogénesis; nuevos modelos celulares (como el cocultivo y los modelos 3D); métodos de caracterización «in vitro» de interacciones entre células y nanomateriales; y métodos de evaluación de la seguridad «in silico».
Objetivo
The objections to animal experiments which have accumulated on both ethical and scientific grounds drive the development of new alternative approaches which do not use animals. Despite the plethora of available alternative methods in different fields of safety assessment, there are still either no validated animal-free replacement methods for some toxicity endpoints or they need a thorough improvement/development. NIOM, as an institute from the Widening Country, aims to increase its capacity (portfolio) towards available in vitro methods for toxicity testing. TWINALT project aims to: i) significantly strengthen the research position of NIOM in the field of alternative methods to toxicity assessment by linking it with 3 prominent scientific partners in this field from Belgium (VUB), Norway (NILU), and Italy (UMIL); ii) enhance the S&T capacity of the 4 linked institutions with a principal focus on the NIOM; iii) commercialize and integrate the TWINALT research with the needs of society at the local, regional, national, European and global level.
Five research areas have been identified to be focused on in TWINALT: i) modern methods for cytotoxicity assessment (High Throughput/Content Screening); ii) new cell models in alternative methods (co-cultures, 3D models); iii) standard/modern alternative methods for genotoxicity and carcinogenicity assessment; iv) characterization of cell-nanomaterial interactions under in vitro conditions; v) in silico methods in safety assessment.
The work will be organized into 4 packages: i) elaboration of a common RTD and innovation strategy on alternative methods; ii) exchange of know-how with partners through training mobilities; iii) communication, exploitation and dissemination activities (web-site, regional and international events, joint publications, press releases, education, contacts with industrial sector); iv) management.
Palabras clave
Programa(s)
- H2020-EU.4.b. - Twinning of research institutions Main Programme
Tema(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-WIDESPREAD-2020-5
Régimen de financiación
CSA - Coordination and support actionCoordinador
91 348 Lodz
Polonia