Descrizione del progetto
Una nuova era per le prove di tossicità in Polonia
Il progetto TWINALT, finanziato dall’UE, consentirà al Nofer Institute of Occupational Medicine (NIOM) di incentivare l’eccellenza scientifica e di potenziare la capacità di innovazione nei metodi di prova di tossicità in vitro. Il NIOM stabilirà stretti collegamenti con istituzioni di ricerca leader a livello internazionale provenienti dalla Norvegia, dal Belgio e dall’Italia. Il progetto si concentrerà su cinque aree di ricerca: metodi moderni per la valutazione della citotossicità (ad esempio screening di citotossicità a elevato contenuto); metodi alternativi moderni/standard per la valutazione della genotossicità e della cancerogenicità; nuovi modelli cellulari (ad esempio modelli 3D e di co-colture); metodi di caratterizzazione in vitro di interazioni tra cellula e nanomateriali; metodi di valutazione della sicurezza in silico.
Obiettivo
The objections to animal experiments which have accumulated on both ethical and scientific grounds drive the development of new alternative approaches which do not use animals. Despite the plethora of available alternative methods in different fields of safety assessment, there are still either no validated animal-free replacement methods for some toxicity endpoints or they need a thorough improvement/development. NIOM, as an institute from the Widening Country, aims to increase its capacity (portfolio) towards available in vitro methods for toxicity testing. TWINALT project aims to: i) significantly strengthen the research position of NIOM in the field of alternative methods to toxicity assessment by linking it with 3 prominent scientific partners in this field from Belgium (VUB), Norway (NILU), and Italy (UMIL); ii) enhance the S&T capacity of the 4 linked institutions with a principal focus on the NIOM; iii) commercialize and integrate the TWINALT research with the needs of society at the local, regional, national, European and global level.
Five research areas have been identified to be focused on in TWINALT: i) modern methods for cytotoxicity assessment (High Throughput/Content Screening); ii) new cell models in alternative methods (co-cultures, 3D models); iii) standard/modern alternative methods for genotoxicity and carcinogenicity assessment; iv) characterization of cell-nanomaterial interactions under in vitro conditions; v) in silico methods in safety assessment.
The work will be organized into 4 packages: i) elaboration of a common RTD and innovation strategy on alternative methods; ii) exchange of know-how with partners through training mobilities; iii) communication, exploitation and dissemination activities (web-site, regional and international events, joint publications, press releases, education, contacts with industrial sector); iv) management.
Parole chiave
Programma(i)
- H2020-EU.4.b. - Twinning of research institutions Main Programme
Argomento(i)
Invito a presentare proposte
Vedi altri progetti per questo bandoBando secondario
H2020-WIDESPREAD-2020-5
Meccanismo di finanziamento
CSA - Coordination and support actionCoordinatore
91 348 Lodz
Polonia