Projektbeschreibung
Neue Ära der Toxizitätsprüfungen für Polen
Das EU-finanzierte Projekt TWINALT wird es dem Nofer Institute of Occupational Medicine (NIOM) ermöglichen, wissenschaftliche Spitzenleistungen zu fördern und die Innovationsfähigkeit bei In-vitro-Toxizitätstestmethoden zu verbessern. Das NIOM wird Verbindungen zu international führenden Forschungseinrichtungen aus Norwegen, Belgien und Italien herstellen. Der Schwerpunkt wird auf fünf Forschungsbereichen liegen: moderne Methoden zur Bewertung der Zytotoxizität (z. B. Screening auf Zytotoxizität mit hohem Gehalt); standardmäßige/moderne alternative Methoden zur Bewertung der Genotoxizität und Karzinogenität; neue Zellmodelle (z. B. Co-Kultivierungs- und 3D-Modelle); In-vitro-Charakterisierungsmethoden für Zell-Nanomaterial-Wechselwirkungen; und In-silico-Sicherheitsbewertungsmethoden.
Ziel
The objections to animal experiments which have accumulated on both ethical and scientific grounds drive the development of new alternative approaches which do not use animals. Despite the plethora of available alternative methods in different fields of safety assessment, there are still either no validated animal-free replacement methods for some toxicity endpoints or they need a thorough improvement/development. NIOM, as an institute from the Widening Country, aims to increase its capacity (portfolio) towards available in vitro methods for toxicity testing. TWINALT project aims to: i) significantly strengthen the research position of NIOM in the field of alternative methods to toxicity assessment by linking it with 3 prominent scientific partners in this field from Belgium (VUB), Norway (NILU), and Italy (UMIL); ii) enhance the S&T capacity of the 4 linked institutions with a principal focus on the NIOM; iii) commercialize and integrate the TWINALT research with the needs of society at the local, regional, national, European and global level.
Five research areas have been identified to be focused on in TWINALT: i) modern methods for cytotoxicity assessment (High Throughput/Content Screening); ii) new cell models in alternative methods (co-cultures, 3D models); iii) standard/modern alternative methods for genotoxicity and carcinogenicity assessment; iv) characterization of cell-nanomaterial interactions under in vitro conditions; v) in silico methods in safety assessment.
The work will be organized into 4 packages: i) elaboration of a common RTD and innovation strategy on alternative methods; ii) exchange of know-how with partners through training mobilities; iii) communication, exploitation and dissemination activities (web-site, regional and international events, joint publications, press releases, education, contacts with industrial sector); iv) management.
Schlüsselbegriffe
Programm/Programme
- H2020-EU.4.b. - Twinning of research institutions Main Programme
Thema/Themen
Aufforderung zur Vorschlagseinreichung
Andere Projekte für diesen Aufruf anzeigenUnterauftrag
H2020-WIDESPREAD-2020-5
Finanzierungsplan
CSA - Coordination and support actionKoordinator
91 348 Lodz
Polen