Twinning towards excellence in alternative methods for toxicity assessment

Project Information

TWINALT

Grant agreement ID: 952404

DOI

10.3030/952404

Project closed

EC signature date 26 June 2020

Start date 1 November 2020

End date 31 October 2023

Funded under

• Twinning of research institutions

Total cost

€ 899 892,50

EU contribution

€ 899 892,50

Coordinated by

INSTYTUT MEDYCYNY PRACY IMIENIA PROF. DRA MED. JERZEGO NOFERA W LODZI
Poland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (10)

Report on Open day at NIOM
Five (joint) publications in high-impact journals submitted

Five joint publications in highimpact journals submitted

Report on 2 stakeholder events
Report on TWINALT flagship conference
Report on public lectures at universities
Report on 1 stakeholder event
Report on 1 matchmaking event during the flagship conference
Report on public lecture at universities

Reports on public lectures at universities

One joint publication in research coordination journal submitted
Report on workshop at junior high schools

Open Research Data Pilot (1)

Data Management Plan

Preparation of Data Management Plan

Websites, patent fillings, videos etc. (2)

Website setup, bi-annual newsletter setup, report on social media channels established

Website setup biannual newsletter setup report on social media channels established

Press releases

Publications

Peer reviewed articles (30)

Gene-occupation interactions: a review of the literature on bladder and prostate cancer

Author(s): Wieczorek E., Wolniakowska A., Roszak J., Rodrigues R.M., Vanhaecke T. and Reszka E.
Published in: Medycyna Pracy, Issue 74 (2), 2023, 2023, Page(s) 127–144, ISSN 0465-5893
Publisher: Instytut Medycyny Pracy im. Jerzego Nofera/Nofer Institute of Occupational Medicine
DOI: 10.13075/mp.5893.01361

Human hepatic in vitro models reveal distinct anti-NASH potencies of PPAR agonists

Author(s): Boeckmans J., Natale A., Rombaut M., Buyl K., Cami B., Vandenberghen E., De Boe V., Heymans A., Rogiers V., De Kock J., Vanhaecke T.*, Rodrigues R.M.* (*shared last authors)
Published in: Cell Biology and Toxicology, Issue 37, 2021, 2021, Page(s) 293–311, ISSN 0742-2091
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10565-020-09544-2

Development of an Adverse Outcome Pathway Network for Breast Cancer: A Comprehensive Representation of the Pathogenesis, Complexity and Diversity of the Disease

Author(s): Del'haye G.G.*, Nulmans I.*, Bouteille S., Sermon K., Wellekens B., Rombaut M., Vanhaecke T., Vander Heyden Y. and De Kock J.
Published in: Archives of Toxicology, Issue 96, 2022, 2022, Page(s) 2881–2897, ISSN 0340-5761
Publisher: Springer Verlag
DOI: 10.1007/s00204-022-03351-w

Hazard identification of nanomaterials: In silico unraveling of descriptors for cytotoxicity and genotoxicity

Author(s): El Yamani N, Mariussen E, Gromelski M, Wyrzykowska E, Grabarek D, Puzyn T, Tanasescu S, Dusinska M, Rundén-Pran E
Published in: Nano Today, Issue 46, 2022, 2022, Page(s) 101581, ISSN 1748-0132
Publisher: Elsevier BV
DOI: 10.1016/j.nantod.2022.101581

Toxicity assessment of flavour chemicals used in e-cigarettes: current state and future challenges

Author(s): Barhdadi S., Rogiers V., Deconinck E.*, Vanhaecke T.* (*shared last authors)
Published in: Archives of Toxicology, Issue 95 (8), 2021, 2021, Page(s) 2879-2881, ISSN 0340-5761
Publisher: Springer Verlag
DOI: 10.1007/s00204-021-03080-6

Effects of Bisphenols on RACK1 Expression and Their Immunological Implications in THP-1 Cells.

Author(s): Buoso E, Kenda M, Masi M, Linciano P, Galbiati V, Racchi M, Dolenc MS, Corsini E.
Published in: Front Pharmacol., Issue 12, 2021, 2021, Page(s) 743991, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2021.743991

Lack of in vivo genotoxic effect of dried whole Aloe ferox juice

Author(s): Galli CL, Cinelli S, Ciliutti P, Melzi G, Marinovich M.
Published in: Toxicology Reports, Issue 8, 2021, 2021, Page(s) 1471-1474, ISSN 2214-7500
Publisher: Elsevier Scientific Publishers Ireland
DOI: 10.1016/j.toxrep.2021.07.023

From NAFLD to MAFLD: Aligning translational in vitro research to clinical insights

Author(s): Gatzios A., Rombaut M., Buyl K., De Kock J., Rodrigues R.M., Rogiers V., Vanhaecke T.*, Boeckmans J.* (*shared last authors)
Published in: Biomedicines, Issue 10 (1), 2022, 2022, Page(s) 161, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines10010161

Metabolic signature of HepaRG cells exposed to ethanol and tumor necrosis factor alpha to study alcoholic steatohepatitis by LC-MS-based untargeted metabolomics

Author(s): Iturrospe E., Robeyns R., Manuela da Silva K., van de Lavoir M., Boeckmans J., Vanhaecke T., van Nuijs A.L.N., Covaci A.
Published in: Archives of Toxicology, Issue 97, 2023, 2023, Page(s) 1335–1353, ISSN 0340-5761
Publisher: Springer Verlag
DOI: 10.1007/s00204-023-03470-y

Safer chemicals using less animals: kick-off of the European ONTOX project

Author(s): Vinken M., Benfenati E., Busquet F., Castell J., Clevert D.-A., de Kok T., Dirven H., Fritsche E., Geris L., Gozalbes R., Hartung T., Jennen D., Jover R., Kandarova H., Kramer N., Krul C., Luechtefeld T., Masereeuw R., Roggen E., Schaller S., Vanhaecke T., Yang C., Piersma A.H.
Published in: Toxicology, Issue 458, 2021, 2021, Page(s) 152846, ISSN 0300-483X
Publisher: Elsevier BV
DOI: 10.1016/j.tox.2021.152846

Do cytotoxicity and cell death cause false positive results in the in vitro comet assay?

Author(s): Amaya Azqueta, Helga Stopper, Bojana Zegura, Maria Dusinska, Peter Møller
Published in: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Issue 881, 2022, 2022, Page(s) 503520, ISSN 1383-5718
Publisher: Elsevier BV
DOI: 10.1016/j.mrgentox.2022.503520

Transcriptomics Reveals Discordant Lipid Metabolism Effectsbetween In Vitro Models Exposed to Elafibranor and LiverSamples of NAFLD Patients after Bariatric Surgery

Author(s): Boeckmans J., Gatzios A., Heymans A., Rombaut M., Rogiers V., De Kock J., Vanhaecke T., Rodrigues R.M.
Published in: Cells, Issue 11(5), 2022, 2022, Page(s) 893, ISSN 2073-4409
Publisher: Basel: MDPI AG
DOI: 10.3390/cells11050893

PNPLA3 I148M and response to treatment for hepatic steatosis: A systematic review

Author(s): Boeckmans J., Gatzios A., Schattenberg J.M., Koek G.H., Rodrigues R.M. and Vanhaecke T.
Published in: Liver International, Issue 43, 2023, 2023, Page(s) 975–988, ISSN 1478-3223
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/liv.15533

Lack of mutagenicity of TiO2 nanoparticles in vitro despite cellular and nuclear uptake

Author(s): El Yamani N, García-Rodríguez A, Rubio L, Kažimírová A, Rundén-Pran E, Barančoková M, Marcos R, Dusinska M
Published in: Mutation Research - Genetic Toxicology and Environmental Mutagenesis, Issue 882, 2022, 2022, Page(s) 503545, ISSN 1383-5718
Publisher: Elsevier BV
DOI: 10.1016/j.mrgentox.2022.503545

New approach methods to improve human health risk assessment of thyroid hormone system disruption–a PARC project

Author(s): Ramhøj L., Axelstad M., Baert Y., Cañas-Portilla A.I., Chalmel C., Dahmen L., De La Vieja A., Evrard B., Haigis A.-C., Hamers T., Heikamp K., Holbech H., Iglesias-Hernandez P., Knapen D., Marchandise L., Morthorst J.E., Georgiev Nikolov N., Nissen A.C.V.E., Oelgeschlaeger M., Renko K., Rogiers V., Schüürmann G., Stinckens E., Stub M.H., Torres-Ruiz M., Van Duursen M., Vanhaecke T., Vergauwen L
Published in: Frontiers in Toxicology, Issue 5, 2023, 2023, Page(s) 1189303, ISSN 2673-3080
Publisher: Lausanne: Frontiers Media S.A.
DOI: 10.3389/ftox.2023.1189303

Lack of genotoxicity of rhubarb (rhizome) in the Ames and micronucleus in vitro tests

Author(s): Gloria Melzi, Corrado L.Galli, Paola Ciliutti, Cristina Marabottini, Marina Marinovich
Published in: Toxicology Reports, Issue 9, 2022, 2022, Page(s) 1574-1579, ISSN 2214-7500
Publisher: Elsevier Scientific Publishers Ireland
DOI: 10.1016/j.toxrep.2022.07.017

The colony forming efficiency assay for toxicity testing of nanomaterials—Modifications for higher-throughput

Author(s): Rundèn-Pran, Elise; Mariussen, Espen; El Yamani, Naouale; Elje, Elisabeth; Longhin, Eleonora Marta; Dusinska, Maria
Published in: Frontiers Toxicology, Nanotoxicology protocols SI, Issue 4, 2022, 2022, Page(s) 983316, ISSN 2673-3080
Publisher: Lausanne: Frontiers Media S.A.
DOI: 10.3389/ftox.2022.983316

Direct reprogramming of somatic cells into induced hepatocytes: cracking the Enigma code

Author(s): Rombaut M., Boeckmans J., Rodrigues R.M., van Grunsven L.A., Vanhaecke T., De Kock J.
Published in: Journal of Hepatology, Issue 75, 2021, 2021, Page(s) 690–705, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2021.04.048

The miniaturized enzyme-modified comet assay for genotoxicity testing of nanomaterials

Author(s): El Yamani N, Rundèn-Pran E, Collins AR, Longhin EM, Elje E, Hoet P, Vinković Vrček I, Doak S, Fessard V, Dusinska M
Published in: Frontiers in Toxicology (Sec. Nanotoxicology), Issue 4, 2022, 2022, Page(s) 986318, ISSN 2673-3080
Publisher: Lausanne: Frontiers Media S.A.
DOI: 10.3389/ftox.2022.986318

Development and application of a novel method to assess exposure levels of sensitizing and irritating substances leaching from menstrual hygiene products

Author(s): Marcelis Q., Gatzios A., Deconinck E., Rogiers V., Vanhaecke T.* and Desmedt B.*(*shared last authors)
Published in: Emerging Contaminants, Issue 7, 2021, 2021, Page(s) 116-123, ISSN 2405-6650
Publisher: KeAi Communications Co. Ltd. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.
DOI: 10.1016/j.emcon.2021.02.004

Light-triggered nanobombs: a nanoscale biolistic tool for efficien intracellular delivery of functional macromolecules in mammalian cells

Author(s): Fraire J.C., Shaabani E., Sharifiaghdam M., Rombaut M., Hinnekens C., Hua D., Ramon J., Raes L., Bolea-Fernandez E., Brans T., Vanhaecke F., Borghgraef P., Huang C., Sauvage F., Vanhaecke T., De Kock J., Xiong R., De Smedt S., Braeckmans K.
Published in: Nature Communications, Issue 13, 2022, 2022, Page(s) 1996, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-29713-7

Pharmacogenetics in early drug development for non-alcoholic steatohepatitis: missed chances and future opportunities

Author(s): Boeckmans J., Gatzios A., Schattenberg J.M., Rodrigues R.M., Rogiers V. and Vanhaecke T
Published in: Archives of Toxicology, Issue 97, 2023, 2023, Page(s) 1825–1827, ISSN 0340-5761
Publisher: Springer Verlag
DOI: 10.1007/s00204-023-03498-0

Applicability of the DPRA on mixture testing: Challenges and opportunities

Author(s): Marcelis Q., Deconinck E., Rogiers V., Desmedt B.*, Vanhaecke T.* (shared last authors)
Published in: Archives of Toxicology, Issue 97, 2023, 2023, Page(s) 2453–2461, ISSN 0340-5761
Publisher: Springer Verlag
DOI: 10.1007/s00204-023-03551-y

The rise of 3R centres and platforms in Europe

Author(s): Neuhaus W, Reininger-Gutmann B, Rinner B, Plasenzotti R, Wilflingseder D, De Kock J, Vanhaecke T, Rogiers V, Jírová D, Kejlová K, Knudsen LE, Nielsen RN, Kleuser B, Kral V, Thöne-Reineke C, Hartung T, Pallocca G, Leist M, Hippenstiel S, Lang A, Retter I, Krämer S, Jedlicka P, Ameli K, Fritsche E, Tigges J, Buettner M, Bleich A, Baumgart N, Baumgart J, Meinhardt MW, Spanagel R, Chourbaji S, Kr
Published in: Alternatives to Laboratory Animals, Issue 50 (2), 2022, 2022, Page(s) 90-120, ISSN 2632-3559
Publisher: SAGE Publications
DOI: 10.1177/02611929221099165

Advanced Respiratory Models for Hazard Assessment of Nanomaterials—Performance of Mono-, Co- and Tricultures

Author(s): Laura M. Camassa, Elisabeth Elje, Espen Mariussen, Eleonora M. Longhin, Maria Dusinska, Shan Zienolddiny-Narui, Elise Rundén-Pran
Published in: Nanomaterials (Special Issue Nanoparticle Analysis, Toxicity and Environmental Impact, Issue 12 (15), 2022, 2022, Page(s) 2609, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano12152609

Novel Prediction Models for Genotoxicity Based on Biomarker Genes in Human HepaRG™ Cells

Author(s): Thienpont A., Verhulst S., van Grunsven L.A., Rogiers V., Vanhaecke T.*, Mertens B.* (*shared last authors)
Published in: ALTEX - Alternatives to Animal Experimentation, Issue 40 (2), 2023, 2023, Page(s) 271–286, ISSN 1868-8551
Publisher: Springer Spektrum | Springer-Verlag GmbH
DOI: 10.14573/altex.2206201

Different Sensitivity of Advanced Bronchial and Alveolar Mono- and Coculture Models for Hazard Assessment of Nanomaterials

Author(s): Elje E, Mariussen E, McFadden E, Dusinska M, Rundén-Pran E
Published in: Nanomaterials (Basel), Issue 13 (3), 2023, 2023, Page(s) 407, ISSN 2079-4991
Publisher: Basel: MDPI AG
DOI: 10.3390/nano13030407

An integrated in silico-in vitro investigation to assess the skin sensitization potential of 4-Octylphenol

Author(s): de Souza IR, Iulini M, Galbiati V, Silva EZM, Sivek TW, Rodrigues AC, Gradia DF, Pestana CB, Leme DM, Corsini E.
Published in: Toxicology, Issue 493, 2023, 2023, Page(s) 153548, ISSN 0300-483X
Publisher: Elsevier BV
DOI: 10.1016/j.tox.2023.153548

Innovative tools and methods for toxicity testing within PARC work package 5 on hazard assessment

Author(s): de Castelbajac T., Aiello-Holden K., Garcia Arenas C., Svingen T., Ramhøj L., Zalko D., Barouki R., Vanhaecke T., Rogiers V., Audebert A., Oelgeschlaeger M., Braeuning A., Blanc E., Tal T., Ruegg J., Fritsche E., Marx-Stoelting P. and Rivière G.
Published in: Frontiers in Toxicology (Sec. In Vitro Toxicology), Issue 5, 2023, 2023, Page(s) 1216369, ISSN 2673-3080
Publisher: Lausanne: Frontiers Media S.A.
DOI: 10.3389/ftox.2023.1216369

Quantitative risk assessment of allergens leaching from menstrual hygiene products

Author(s): Marcelis Q., Gatzios A., Deconinck E., Rogiers V., Desmedt B.*, Vanhaecke T.* (shared last authors)
Published in: Regulatory Toxicology and Pharmacology, Issue 135, 2022, 2022, Page(s) 105260, ISSN 0273-2300
Publisher: Academic Press
DOI: 10.1016/j.yrtph.2022.105260

Conference proceedings (1)

Twinning towards excellence in alternative methods for toxicity assessment – TWINALT project

Author(s): Zuzanna Sobańska, Joanna Roszak, Tamara Vanhaecke, Maria Dusinska, Elise Rundén-Pran, Marina Marinovich, Edyta Reszka
Published in: ALTEX Proceedings, Issue 10 (2), 2022, 2022, Page(s) 24, ISSN 2194-0479
Publisher: Springer Spektrum | Springer-Verlag GmbH
DOI: 10.58847/ap.2202