Twinning towards excellence in alternative methods for toxicity assessment

Informacje na temat projektu

TWINALT

Identyfikator umowy o grant: 952404

DOI

10.3030/952404

Projekt został zamknięty

Data podpisania przez KE 26 Czerwca 2020

Data rozpoczęcia 1 Listopada 2020

Data zakończenia 31 Października 2023

Finansowanie w ramach

• Twinning of research institutions

Koszt całkowity

€ 899 892,50

Wkład UE

€ 899 892,50

Koordynowany przez

INSTYTUT MEDYCYNY PRACY IMIENIA PROF. DRA MED. JERZEGO NOFERA W LODZI
Poland

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Documents, reports (10)

Report on Open day at NIOM
Five (joint) publications in high-impact journals submitted

Five joint publications in highimpact journals submitted

Report on 2 stakeholder events
Report on TWINALT flagship conference
Report on public lectures at universities
Report on 1 stakeholder event
Report on 1 matchmaking event during the flagship conference
Report on public lecture at universities

Reports on public lectures at universities

One joint publication in research coordination journal submitted
Report on workshop at junior high schools

Open Research Data Pilot (1)

Data Management Plan

Preparation of Data Management Plan

Websites, patent fillings, videos etc. (2)

Website setup, bi-annual newsletter setup, report on social media channels established

Website setup biannual newsletter setup report on social media channels established

Press releases

Publikacje

Peer reviewed articles (30)

Gene-occupation interactions: a review of the literature on bladder and prostate cancer

Autorzy: Wieczorek E., Wolniakowska A., Roszak J., Rodrigues R.M., Vanhaecke T. and Reszka E.
Opublikowane w: Medycyna Pracy, Numer 74 (2), 2023, 2023, Strona(/y) 127–144, ISSN 0465-5893
Wydawca: Instytut Medycyny Pracy im. Jerzego Nofera/Nofer Institute of Occupational Medicine
DOI: 10.13075/mp.5893.01361

Human hepatic in vitro models reveal distinct anti-NASH potencies of PPAR agonists

Autorzy: Boeckmans J., Natale A., Rombaut M., Buyl K., Cami B., Vandenberghen E., De Boe V., Heymans A., Rogiers V., De Kock J., Vanhaecke T.*, Rodrigues R.M.* (*shared last authors)
Opublikowane w: Cell Biology and Toxicology, Numer 37, 2021, 2021, Strona(/y) 293–311, ISSN 0742-2091
Wydawca: Kluwer Academic Publishers
DOI: 10.1007/s10565-020-09544-2

Development of an Adverse Outcome Pathway Network for Breast Cancer: A Comprehensive Representation of the Pathogenesis, Complexity and Diversity of the Disease

Autorzy: Del'haye G.G.*, Nulmans I.*, Bouteille S., Sermon K., Wellekens B., Rombaut M., Vanhaecke T., Vander Heyden Y. and De Kock J.
Opublikowane w: Archives of Toxicology, Numer 96, 2022, 2022, Strona(/y) 2881–2897, ISSN 0340-5761
Wydawca: Springer Verlag
DOI: 10.1007/s00204-022-03351-w

Hazard identification of nanomaterials: In silico unraveling of descriptors for cytotoxicity and genotoxicity

Autorzy: El Yamani N, Mariussen E, Gromelski M, Wyrzykowska E, Grabarek D, Puzyn T, Tanasescu S, Dusinska M, Rundén-Pran E
Opublikowane w: Nano Today, Numer 46, 2022, 2022, Strona(/y) 101581, ISSN 1748-0132
Wydawca: Elsevier BV
DOI: 10.1016/j.nantod.2022.101581

Toxicity assessment of flavour chemicals used in e-cigarettes: current state and future challenges

Autorzy: Barhdadi S., Rogiers V., Deconinck E.*, Vanhaecke T.* (*shared last authors)
Opublikowane w: Archives of Toxicology, Numer 95 (8), 2021, 2021, Strona(/y) 2879-2881, ISSN 0340-5761
Wydawca: Springer Verlag
DOI: 10.1007/s00204-021-03080-6

Effects of Bisphenols on RACK1 Expression and Their Immunological Implications in THP-1 Cells.

Autorzy: Buoso E, Kenda M, Masi M, Linciano P, Galbiati V, Racchi M, Dolenc MS, Corsini E.
Opublikowane w: Front Pharmacol., Numer 12, 2021, 2021, Strona(/y) 743991, ISSN 1663-9812
Wydawca: Frontiers Media S.A.
DOI: 10.3389/fphar.2021.743991

Lack of in vivo genotoxic effect of dried whole Aloe ferox juice

Autorzy: Galli CL, Cinelli S, Ciliutti P, Melzi G, Marinovich M.
Opublikowane w: Toxicology Reports, Numer 8, 2021, 2021, Strona(/y) 1471-1474, ISSN 2214-7500
Wydawca: Elsevier Scientific Publishers Ireland
DOI: 10.1016/j.toxrep.2021.07.023

From NAFLD to MAFLD: Aligning translational in vitro research to clinical insights

Autorzy: Gatzios A., Rombaut M., Buyl K., De Kock J., Rodrigues R.M., Rogiers V., Vanhaecke T.*, Boeckmans J.* (*shared last authors)
Opublikowane w: Biomedicines, Numer 10 (1), 2022, 2022, Strona(/y) 161, ISSN 2227-9059
Wydawca: MDPI
DOI: 10.3390/biomedicines10010161

Metabolic signature of HepaRG cells exposed to ethanol and tumor necrosis factor alpha to study alcoholic steatohepatitis by LC-MS-based untargeted metabolomics

Autorzy: Iturrospe E., Robeyns R., Manuela da Silva K., van de Lavoir M., Boeckmans J., Vanhaecke T., van Nuijs A.L.N., Covaci A.
Opublikowane w: Archives of Toxicology, Numer 97, 2023, 2023, Strona(/y) 1335–1353, ISSN 0340-5761
Wydawca: Springer Verlag
DOI: 10.1007/s00204-023-03470-y

Safer chemicals using less animals: kick-off of the European ONTOX project

Autorzy: Vinken M., Benfenati E., Busquet F., Castell J., Clevert D.-A., de Kok T., Dirven H., Fritsche E., Geris L., Gozalbes R., Hartung T., Jennen D., Jover R., Kandarova H., Kramer N., Krul C., Luechtefeld T., Masereeuw R., Roggen E., Schaller S., Vanhaecke T., Yang C., Piersma A.H.
Opublikowane w: Toxicology, Numer 458, 2021, 2021, Strona(/y) 152846, ISSN 0300-483X
Wydawca: Elsevier BV
DOI: 10.1016/j.tox.2021.152846

Do cytotoxicity and cell death cause false positive results in the in vitro comet assay?

Autorzy: Amaya Azqueta, Helga Stopper, Bojana Zegura, Maria Dusinska, Peter Møller
Opublikowane w: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Numer 881, 2022, 2022, Strona(/y) 503520, ISSN 1383-5718
Wydawca: Elsevier BV
DOI: 10.1016/j.mrgentox.2022.503520

Transcriptomics Reveals Discordant Lipid Metabolism Effectsbetween In Vitro Models Exposed to Elafibranor and LiverSamples of NAFLD Patients after Bariatric Surgery

Autorzy: Boeckmans J., Gatzios A., Heymans A., Rombaut M., Rogiers V., De Kock J., Vanhaecke T., Rodrigues R.M.
Opublikowane w: Cells, Numer 11(5), 2022, 2022, Strona(/y) 893, ISSN 2073-4409
Wydawca: Basel: MDPI AG
DOI: 10.3390/cells11050893

PNPLA3 I148M and response to treatment for hepatic steatosis: A systematic review

Autorzy: Boeckmans J., Gatzios A., Schattenberg J.M., Koek G.H., Rodrigues R.M. and Vanhaecke T.
Opublikowane w: Liver International, Numer 43, 2023, 2023, Strona(/y) 975–988, ISSN 1478-3223
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/liv.15533

Lack of mutagenicity of TiO2 nanoparticles in vitro despite cellular and nuclear uptake

Autorzy: El Yamani N, García-Rodríguez A, Rubio L, Kažimírová A, Rundén-Pran E, Barančoková M, Marcos R, Dusinska M
Opublikowane w: Mutation Research - Genetic Toxicology and Environmental Mutagenesis, Numer 882, 2022, 2022, Strona(/y) 503545, ISSN 1383-5718
Wydawca: Elsevier BV
DOI: 10.1016/j.mrgentox.2022.503545

New approach methods to improve human health risk assessment of thyroid hormone system disruption–a PARC project

Autorzy: Ramhøj L., Axelstad M., Baert Y., Cañas-Portilla A.I., Chalmel C., Dahmen L., De La Vieja A., Evrard B., Haigis A.-C., Hamers T., Heikamp K., Holbech H., Iglesias-Hernandez P., Knapen D., Marchandise L., Morthorst J.E., Georgiev Nikolov N., Nissen A.C.V.E., Oelgeschlaeger M., Renko K., Rogiers V., Schüürmann G., Stinckens E., Stub M.H., Torres-Ruiz M., Van Duursen M., Vanhaecke T., Vergauwen L
Opublikowane w: Frontiers in Toxicology, Numer 5, 2023, 2023, Strona(/y) 1189303, ISSN 2673-3080
Wydawca: Lausanne: Frontiers Media S.A.
DOI: 10.3389/ftox.2023.1189303

Lack of genotoxicity of rhubarb (rhizome) in the Ames and micronucleus in vitro tests

Autorzy: Gloria Melzi, Corrado L.Galli, Paola Ciliutti, Cristina Marabottini, Marina Marinovich
Opublikowane w: Toxicology Reports, Numer 9, 2022, 2022, Strona(/y) 1574-1579, ISSN 2214-7500
Wydawca: Elsevier Scientific Publishers Ireland
DOI: 10.1016/j.toxrep.2022.07.017

The colony forming efficiency assay for toxicity testing of nanomaterials—Modifications for higher-throughput

Autorzy: Rundèn-Pran, Elise; Mariussen, Espen; El Yamani, Naouale; Elje, Elisabeth; Longhin, Eleonora Marta; Dusinska, Maria
Opublikowane w: Frontiers Toxicology, Nanotoxicology protocols SI, Numer 4, 2022, 2022, Strona(/y) 983316, ISSN 2673-3080
Wydawca: Lausanne: Frontiers Media S.A.
DOI: 10.3389/ftox.2022.983316

Direct reprogramming of somatic cells into induced hepatocytes: cracking the Enigma code

Autorzy: Rombaut M., Boeckmans J., Rodrigues R.M., van Grunsven L.A., Vanhaecke T., De Kock J.
Opublikowane w: Journal of Hepatology, Numer 75, 2021, 2021, Strona(/y) 690–705, ISSN 0168-8278
Wydawca: Elsevier BV
DOI: 10.1016/j.jhep.2021.04.048

The miniaturized enzyme-modified comet assay for genotoxicity testing of nanomaterials

Autorzy: El Yamani N, Rundèn-Pran E, Collins AR, Longhin EM, Elje E, Hoet P, Vinković Vrček I, Doak S, Fessard V, Dusinska M
Opublikowane w: Frontiers in Toxicology (Sec. Nanotoxicology), Numer 4, 2022, 2022, Strona(/y) 986318, ISSN 2673-3080
Wydawca: Lausanne: Frontiers Media S.A.
DOI: 10.3389/ftox.2022.986318

Development and application of a novel method to assess exposure levels of sensitizing and irritating substances leaching from menstrual hygiene products

Autorzy: Marcelis Q., Gatzios A., Deconinck E., Rogiers V., Vanhaecke T.* and Desmedt B.*(*shared last authors)
Opublikowane w: Emerging Contaminants, Numer 7, 2021, 2021, Strona(/y) 116-123, ISSN 2405-6650
Wydawca: KeAi Communications Co. Ltd. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.
DOI: 10.1016/j.emcon.2021.02.004

Light-triggered nanobombs: a nanoscale biolistic tool for efficien intracellular delivery of functional macromolecules in mammalian cells

Autorzy: Fraire J.C., Shaabani E., Sharifiaghdam M., Rombaut M., Hinnekens C., Hua D., Ramon J., Raes L., Bolea-Fernandez E., Brans T., Vanhaecke F., Borghgraef P., Huang C., Sauvage F., Vanhaecke T., De Kock J., Xiong R., De Smedt S., Braeckmans K.
Opublikowane w: Nature Communications, Numer 13, 2022, 2022, Strona(/y) 1996, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-022-29713-7

Pharmacogenetics in early drug development for non-alcoholic steatohepatitis: missed chances and future opportunities

Autorzy: Boeckmans J., Gatzios A., Schattenberg J.M., Rodrigues R.M., Rogiers V. and Vanhaecke T
Opublikowane w: Archives of Toxicology, Numer 97, 2023, 2023, Strona(/y) 1825–1827, ISSN 0340-5761
Wydawca: Springer Verlag
DOI: 10.1007/s00204-023-03498-0

Applicability of the DPRA on mixture testing: Challenges and opportunities

Autorzy: Marcelis Q., Deconinck E., Rogiers V., Desmedt B.*, Vanhaecke T.* (shared last authors)
Opublikowane w: Archives of Toxicology, Numer 97, 2023, 2023, Strona(/y) 2453–2461, ISSN 0340-5761
Wydawca: Springer Verlag
DOI: 10.1007/s00204-023-03551-y

The rise of 3R centres and platforms in Europe

Autorzy: Neuhaus W, Reininger-Gutmann B, Rinner B, Plasenzotti R, Wilflingseder D, De Kock J, Vanhaecke T, Rogiers V, Jírová D, Kejlová K, Knudsen LE, Nielsen RN, Kleuser B, Kral V, Thöne-Reineke C, Hartung T, Pallocca G, Leist M, Hippenstiel S, Lang A, Retter I, Krämer S, Jedlicka P, Ameli K, Fritsche E, Tigges J, Buettner M, Bleich A, Baumgart N, Baumgart J, Meinhardt MW, Spanagel R, Chourbaji S, Kr
Opublikowane w: Alternatives to Laboratory Animals, Numer 50 (2), 2022, 2022, Strona(/y) 90-120, ISSN 2632-3559
Wydawca: SAGE Publications
DOI: 10.1177/02611929221099165

Advanced Respiratory Models for Hazard Assessment of Nanomaterials—Performance of Mono-, Co- and Tricultures

Autorzy: Laura M. Camassa, Elisabeth Elje, Espen Mariussen, Eleonora M. Longhin, Maria Dusinska, Shan Zienolddiny-Narui, Elise Rundén-Pran
Opublikowane w: Nanomaterials (Special Numer Nanoparticle Analysis, Toxicity and Environmental Impact, Numer 12 (15), 2022, 2022, Strona(/y) 2609, ISSN 2079-4991
Wydawca: MDPI
DOI: 10.3390/nano12152609

Novel Prediction Models for Genotoxicity Based on Biomarker Genes in Human HepaRG™ Cells

Autorzy: Thienpont A., Verhulst S., van Grunsven L.A., Rogiers V., Vanhaecke T.*, Mertens B.* (*shared last authors)
Opublikowane w: ALTEX - Alternatives to Animal Experimentation, Numer 40 (2), 2023, 2023, Strona(/y) 271–286, ISSN 1868-8551
Wydawca: Springer Spektrum | Springer-Verlag GmbH
DOI: 10.14573/altex.2206201

Different Sensitivity of Advanced Bronchial and Alveolar Mono- and Coculture Models for Hazard Assessment of Nanomaterials

Autorzy: Elje E, Mariussen E, McFadden E, Dusinska M, Rundén-Pran E
Opublikowane w: Nanomaterials (Basel), Numer 13 (3), 2023, 2023, Strona(/y) 407, ISSN 2079-4991
Wydawca: Basel: MDPI AG
DOI: 10.3390/nano13030407

An integrated in silico-in vitro investigation to assess the skin sensitization potential of 4-Octylphenol

Autorzy: de Souza IR, Iulini M, Galbiati V, Silva EZM, Sivek TW, Rodrigues AC, Gradia DF, Pestana CB, Leme DM, Corsini E.
Opublikowane w: Toxicology, Numer 493, 2023, 2023, Strona(/y) 153548, ISSN 0300-483X
Wydawca: Elsevier BV
DOI: 10.1016/j.tox.2023.153548

Innovative tools and methods for toxicity testing within PARC work package 5 on hazard assessment

Autorzy: de Castelbajac T., Aiello-Holden K., Garcia Arenas C., Svingen T., Ramhøj L., Zalko D., Barouki R., Vanhaecke T., Rogiers V., Audebert A., Oelgeschlaeger M., Braeuning A., Blanc E., Tal T., Ruegg J., Fritsche E., Marx-Stoelting P. and Rivière G.
Opublikowane w: Frontiers in Toxicology (Sec. In Vitro Toxicology), Numer 5, 2023, 2023, Strona(/y) 1216369, ISSN 2673-3080
Wydawca: Lausanne: Frontiers Media S.A.
DOI: 10.3389/ftox.2023.1216369

Quantitative risk assessment of allergens leaching from menstrual hygiene products

Autorzy: Marcelis Q., Gatzios A., Deconinck E., Rogiers V., Desmedt B.*, Vanhaecke T.* (shared last authors)
Opublikowane w: Regulatory Toxicology and Pharmacology, Numer 135, 2022, 2022, Strona(/y) 105260, ISSN 0273-2300
Wydawca: Academic Press
DOI: 10.1016/j.yrtph.2022.105260

Conference proceedings (1)

Twinning towards excellence in alternative methods for toxicity assessment – TWINALT project

Autorzy: Zuzanna Sobańska, Joanna Roszak, Tamara Vanhaecke, Maria Dusinska, Elise Rundén-Pran, Marina Marinovich, Edyta Reszka
Opublikowane w: ALTEX Proceedings, Numer 10 (2), 2022, 2022, Strona(/y) 24, ISSN 2194-0479
Wydawca: Springer Spektrum | Springer-Verlag GmbH
DOI: 10.58847/ap.2202