Twinning towards excellence in alternative methods for toxicity assessment

Informazioni relative al progetto

TWINALT

ID dell’accordo di sovvenzione: 952404

DOI

10.3030/952404

Progetto chiuso

Data della firma CE 26 Giugno 2020

Data di avvio 1 Novembre 2020

Data di completamento 31 Ottobre 2023

Finanziato da

• Twinning of research institutions

Costo totale

€ 899 892,50

Contributo UE

€ 899 892,50

Coordinato da

INSTYTUT MEDYCYNY PRACY IMIENIA PROF. DRA MED. JERZEGO NOFERA W LODZI
Poland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (10)

Report on Open day at NIOM
Five (joint) publications in high-impact journals submitted

Five joint publications in highimpact journals submitted

Report on 2 stakeholder events
Report on TWINALT flagship conference
Report on public lectures at universities
Report on 1 stakeholder event
Report on 1 matchmaking event during the flagship conference
Report on public lecture at universities

Reports on public lectures at universities

One joint publication in research coordination journal submitted
Report on workshop at junior high schools

Open Research Data Pilot (1)

Data Management Plan

Preparation of Data Management Plan

Websites, patent fillings, videos etc. (2)

Website setup, bi-annual newsletter setup, report on social media channels established

Website setup biannual newsletter setup report on social media channels established

Press releases

Pubblicazioni

Peer reviewed articles (30)

Gene-occupation interactions: a review of the literature on bladder and prostate cancer

Autori: Wieczorek E., Wolniakowska A., Roszak J., Rodrigues R.M., Vanhaecke T. and Reszka E.
Pubblicato in: Medycyna Pracy, Numero 74 (2), 2023, 2023, Pagina/e 127–144, ISSN 0465-5893
Editore: Instytut Medycyny Pracy im. Jerzego Nofera/Nofer Institute of Occupational Medicine
DOI: 10.13075/mp.5893.01361

Human hepatic in vitro models reveal distinct anti-NASH potencies of PPAR agonists

Autori: Boeckmans J., Natale A., Rombaut M., Buyl K., Cami B., Vandenberghen E., De Boe V., Heymans A., Rogiers V., De Kock J., Vanhaecke T.*, Rodrigues R.M.* (*shared last authors)
Pubblicato in: Cell Biology and Toxicology, Numero 37, 2021, 2021, Pagina/e 293–311, ISSN 0742-2091
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10565-020-09544-2

Development of an Adverse Outcome Pathway Network for Breast Cancer: A Comprehensive Representation of the Pathogenesis, Complexity and Diversity of the Disease

Autori: Del'haye G.G.*, Nulmans I.*, Bouteille S., Sermon K., Wellekens B., Rombaut M., Vanhaecke T., Vander Heyden Y. and De Kock J.
Pubblicato in: Archives of Toxicology, Numero 96, 2022, 2022, Pagina/e 2881–2897, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-022-03351-w

Hazard identification of nanomaterials: In silico unraveling of descriptors for cytotoxicity and genotoxicity

Autori: El Yamani N, Mariussen E, Gromelski M, Wyrzykowska E, Grabarek D, Puzyn T, Tanasescu S, Dusinska M, Rundén-Pran E
Pubblicato in: Nano Today, Numero 46, 2022, 2022, Pagina/e 101581, ISSN 1748-0132
Editore: Elsevier BV
DOI: 10.1016/j.nantod.2022.101581

Toxicity assessment of flavour chemicals used in e-cigarettes: current state and future challenges

Autori: Barhdadi S., Rogiers V., Deconinck E.*, Vanhaecke T.* (*shared last authors)
Pubblicato in: Archives of Toxicology, Numero 95 (8), 2021, 2021, Pagina/e 2879-2881, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-021-03080-6

Effects of Bisphenols on RACK1 Expression and Their Immunological Implications in THP-1 Cells.

Autori: Buoso E, Kenda M, Masi M, Linciano P, Galbiati V, Racchi M, Dolenc MS, Corsini E.
Pubblicato in: Front Pharmacol., Numero 12, 2021, 2021, Pagina/e 743991, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2021.743991

Lack of in vivo genotoxic effect of dried whole Aloe ferox juice

Autori: Galli CL, Cinelli S, Ciliutti P, Melzi G, Marinovich M.
Pubblicato in: Toxicology Reports, Numero 8, 2021, 2021, Pagina/e 1471-1474, ISSN 2214-7500
Editore: Elsevier Scientific Publishers Ireland
DOI: 10.1016/j.toxrep.2021.07.023

From NAFLD to MAFLD: Aligning translational in vitro research to clinical insights

Autori: Gatzios A., Rombaut M., Buyl K., De Kock J., Rodrigues R.M., Rogiers V., Vanhaecke T.*, Boeckmans J.* (*shared last authors)
Pubblicato in: Biomedicines, Numero 10 (1), 2022, 2022, Pagina/e 161, ISSN 2227-9059
Editore: MDPI
DOI: 10.3390/biomedicines10010161

Metabolic signature of HepaRG cells exposed to ethanol and tumor necrosis factor alpha to study alcoholic steatohepatitis by LC-MS-based untargeted metabolomics

Autori: Iturrospe E., Robeyns R., Manuela da Silva K., van de Lavoir M., Boeckmans J., Vanhaecke T., van Nuijs A.L.N., Covaci A.
Pubblicato in: Archives of Toxicology, Numero 97, 2023, 2023, Pagina/e 1335–1353, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-023-03470-y

Safer chemicals using less animals: kick-off of the European ONTOX project

Autori: Vinken M., Benfenati E., Busquet F., Castell J., Clevert D.-A., de Kok T., Dirven H., Fritsche E., Geris L., Gozalbes R., Hartung T., Jennen D., Jover R., Kandarova H., Kramer N., Krul C., Luechtefeld T., Masereeuw R., Roggen E., Schaller S., Vanhaecke T., Yang C., Piersma A.H.
Pubblicato in: Toxicology, Numero 458, 2021, 2021, Pagina/e 152846, ISSN 0300-483X
Editore: Elsevier BV
DOI: 10.1016/j.tox.2021.152846

Do cytotoxicity and cell death cause false positive results in the in vitro comet assay?

Autori: Amaya Azqueta, Helga Stopper, Bojana Zegura, Maria Dusinska, Peter Møller
Pubblicato in: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Numero 881, 2022, 2022, Pagina/e 503520, ISSN 1383-5718
Editore: Elsevier BV
DOI: 10.1016/j.mrgentox.2022.503520

Transcriptomics Reveals Discordant Lipid Metabolism Effectsbetween In Vitro Models Exposed to Elafibranor and LiverSamples of NAFLD Patients after Bariatric Surgery

Autori: Boeckmans J., Gatzios A., Heymans A., Rombaut M., Rogiers V., De Kock J., Vanhaecke T., Rodrigues R.M.
Pubblicato in: Cells, Numero 11(5), 2022, 2022, Pagina/e 893, ISSN 2073-4409
Editore: Basel: MDPI AG
DOI: 10.3390/cells11050893

PNPLA3 I148M and response to treatment for hepatic steatosis: A systematic review

Autori: Boeckmans J., Gatzios A., Schattenberg J.M., Koek G.H., Rodrigues R.M. and Vanhaecke T.
Pubblicato in: Liver International, Numero 43, 2023, 2023, Pagina/e 975–988, ISSN 1478-3223
Editore: Blackwell Publishing Inc.
DOI: 10.1111/liv.15533

Lack of mutagenicity of TiO2 nanoparticles in vitro despite cellular and nuclear uptake

Autori: El Yamani N, García-Rodríguez A, Rubio L, Kažimírová A, Rundén-Pran E, Barančoková M, Marcos R, Dusinska M
Pubblicato in: Mutation Research - Genetic Toxicology and Environmental Mutagenesis, Numero 882, 2022, 2022, Pagina/e 503545, ISSN 1383-5718
Editore: Elsevier BV
DOI: 10.1016/j.mrgentox.2022.503545

New approach methods to improve human health risk assessment of thyroid hormone system disruption–a PARC project

Autori: Ramhøj L., Axelstad M., Baert Y., Cañas-Portilla A.I., Chalmel C., Dahmen L., De La Vieja A., Evrard B., Haigis A.-C., Hamers T., Heikamp K., Holbech H., Iglesias-Hernandez P., Knapen D., Marchandise L., Morthorst J.E., Georgiev Nikolov N., Nissen A.C.V.E., Oelgeschlaeger M., Renko K., Rogiers V., Schüürmann G., Stinckens E., Stub M.H., Torres-Ruiz M., Van Duursen M., Vanhaecke T., Vergauwen L
Pubblicato in: Frontiers in Toxicology, Numero 5, 2023, 2023, Pagina/e 1189303, ISSN 2673-3080
Editore: Lausanne: Frontiers Media S.A.
DOI: 10.3389/ftox.2023.1189303

Lack of genotoxicity of rhubarb (rhizome) in the Ames and micronucleus in vitro tests

Autori: Gloria Melzi, Corrado L.Galli, Paola Ciliutti, Cristina Marabottini, Marina Marinovich
Pubblicato in: Toxicology Reports, Numero 9, 2022, 2022, Pagina/e 1574-1579, ISSN 2214-7500
Editore: Elsevier Scientific Publishers Ireland
DOI: 10.1016/j.toxrep.2022.07.017

The colony forming efficiency assay for toxicity testing of nanomaterials—Modifications for higher-throughput

Autori: Rundèn-Pran, Elise; Mariussen, Espen; El Yamani, Naouale; Elje, Elisabeth; Longhin, Eleonora Marta; Dusinska, Maria
Pubblicato in: Frontiers Toxicology, Nanotoxicology protocols SI, Numero 4, 2022, 2022, Pagina/e 983316, ISSN 2673-3080
Editore: Lausanne: Frontiers Media S.A.
DOI: 10.3389/ftox.2022.983316

Direct reprogramming of somatic cells into induced hepatocytes: cracking the Enigma code

Autori: Rombaut M., Boeckmans J., Rodrigues R.M., van Grunsven L.A., Vanhaecke T., De Kock J.
Pubblicato in: Journal of Hepatology, Numero 75, 2021, 2021, Pagina/e 690–705, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2021.04.048

The miniaturized enzyme-modified comet assay for genotoxicity testing of nanomaterials

Autori: El Yamani N, Rundèn-Pran E, Collins AR, Longhin EM, Elje E, Hoet P, Vinković Vrček I, Doak S, Fessard V, Dusinska M
Pubblicato in: Frontiers in Toxicology (Sec. Nanotoxicology), Numero 4, 2022, 2022, Pagina/e 986318, ISSN 2673-3080
Editore: Lausanne: Frontiers Media S.A.
DOI: 10.3389/ftox.2022.986318

Development and application of a novel method to assess exposure levels of sensitizing and irritating substances leaching from menstrual hygiene products

Autori: Marcelis Q., Gatzios A., Deconinck E., Rogiers V., Vanhaecke T.* and Desmedt B.*(*shared last authors)
Pubblicato in: Emerging Contaminants, Numero 7, 2021, 2021, Pagina/e 116-123, ISSN 2405-6650
Editore: KeAi Communications Co. Ltd. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.
DOI: 10.1016/j.emcon.2021.02.004

Light-triggered nanobombs: a nanoscale biolistic tool for efficien intracellular delivery of functional macromolecules in mammalian cells

Autori: Fraire J.C., Shaabani E., Sharifiaghdam M., Rombaut M., Hinnekens C., Hua D., Ramon J., Raes L., Bolea-Fernandez E., Brans T., Vanhaecke F., Borghgraef P., Huang C., Sauvage F., Vanhaecke T., De Kock J., Xiong R., De Smedt S., Braeckmans K.
Pubblicato in: Nature Communications, Numero 13, 2022, 2022, Pagina/e 1996, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-29713-7

Pharmacogenetics in early drug development for non-alcoholic steatohepatitis: missed chances and future opportunities

Autori: Boeckmans J., Gatzios A., Schattenberg J.M., Rodrigues R.M., Rogiers V. and Vanhaecke T
Pubblicato in: Archives of Toxicology, Numero 97, 2023, 2023, Pagina/e 1825–1827, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-023-03498-0

Applicability of the DPRA on mixture testing: Challenges and opportunities

Autori: Marcelis Q., Deconinck E., Rogiers V., Desmedt B.*, Vanhaecke T.* (shared last authors)
Pubblicato in: Archives of Toxicology, Numero 97, 2023, 2023, Pagina/e 2453–2461, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-023-03551-y

The rise of 3R centres and platforms in Europe

Autori: Neuhaus W, Reininger-Gutmann B, Rinner B, Plasenzotti R, Wilflingseder D, De Kock J, Vanhaecke T, Rogiers V, Jírová D, Kejlová K, Knudsen LE, Nielsen RN, Kleuser B, Kral V, Thöne-Reineke C, Hartung T, Pallocca G, Leist M, Hippenstiel S, Lang A, Retter I, Krämer S, Jedlicka P, Ameli K, Fritsche E, Tigges J, Buettner M, Bleich A, Baumgart N, Baumgart J, Meinhardt MW, Spanagel R, Chourbaji S, Kr
Pubblicato in: Alternatives to Laboratory Animals, Numero 50 (2), 2022, 2022, Pagina/e 90-120, ISSN 2632-3559
Editore: SAGE Publications
DOI: 10.1177/02611929221099165

Advanced Respiratory Models for Hazard Assessment of Nanomaterials—Performance of Mono-, Co- and Tricultures

Autori: Laura M. Camassa, Elisabeth Elje, Espen Mariussen, Eleonora M. Longhin, Maria Dusinska, Shan Zienolddiny-Narui, Elise Rundén-Pran
Pubblicato in: Nanomaterials (Special Numero Nanoparticle Analysis, Toxicity and Environmental Impact, Numero 12 (15), 2022, 2022, Pagina/e 2609, ISSN 2079-4991
Editore: MDPI
DOI: 10.3390/nano12152609

Novel Prediction Models for Genotoxicity Based on Biomarker Genes in Human HepaRG™ Cells

Autori: Thienpont A., Verhulst S., van Grunsven L.A., Rogiers V., Vanhaecke T.*, Mertens B.* (*shared last authors)
Pubblicato in: ALTEX - Alternatives to Animal Experimentation, Numero 40 (2), 2023, 2023, Pagina/e 271–286, ISSN 1868-8551
Editore: Springer Spektrum | Springer-Verlag GmbH
DOI: 10.14573/altex.2206201

Different Sensitivity of Advanced Bronchial and Alveolar Mono- and Coculture Models for Hazard Assessment of Nanomaterials

Autori: Elje E, Mariussen E, McFadden E, Dusinska M, Rundén-Pran E
Pubblicato in: Nanomaterials (Basel), Numero 13 (3), 2023, 2023, Pagina/e 407, ISSN 2079-4991
Editore: Basel: MDPI AG
DOI: 10.3390/nano13030407

An integrated in silico-in vitro investigation to assess the skin sensitization potential of 4-Octylphenol

Autori: de Souza IR, Iulini M, Galbiati V, Silva EZM, Sivek TW, Rodrigues AC, Gradia DF, Pestana CB, Leme DM, Corsini E.
Pubblicato in: Toxicology, Numero 493, 2023, 2023, Pagina/e 153548, ISSN 0300-483X
Editore: Elsevier BV
DOI: 10.1016/j.tox.2023.153548

Innovative tools and methods for toxicity testing within PARC work package 5 on hazard assessment

Autori: de Castelbajac T., Aiello-Holden K., Garcia Arenas C., Svingen T., Ramhøj L., Zalko D., Barouki R., Vanhaecke T., Rogiers V., Audebert A., Oelgeschlaeger M., Braeuning A., Blanc E., Tal T., Ruegg J., Fritsche E., Marx-Stoelting P. and Rivière G.
Pubblicato in: Frontiers in Toxicology (Sec. In Vitro Toxicology), Numero 5, 2023, 2023, Pagina/e 1216369, ISSN 2673-3080
Editore: Lausanne: Frontiers Media S.A.
DOI: 10.3389/ftox.2023.1216369

Quantitative risk assessment of allergens leaching from menstrual hygiene products

Autori: Marcelis Q., Gatzios A., Deconinck E., Rogiers V., Desmedt B.*, Vanhaecke T.* (shared last authors)
Pubblicato in: Regulatory Toxicology and Pharmacology, Numero 135, 2022, 2022, Pagina/e 105260, ISSN 0273-2300
Editore: Academic Press
DOI: 10.1016/j.yrtph.2022.105260

Conference proceedings (1)

Twinning towards excellence in alternative methods for toxicity assessment – TWINALT project

Autori: Zuzanna Sobańska, Joanna Roszak, Tamara Vanhaecke, Maria Dusinska, Elise Rundén-Pran, Marina Marinovich, Edyta Reszka
Pubblicato in: ALTEX Proceedings, Numero 10 (2), 2022, 2022, Pagina/e 24, ISSN 2194-0479
Editore: Springer Spektrum | Springer-Verlag GmbH
DOI: 10.58847/ap.2202