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Biosafety assays for the diagnosis and prediction of drug-related complement pathology

Project description

Minimising allergic reactions to intravenous immunotherapies with new biosafety testing

Drug development proceeds along a regulated pathway from innovation and research to preclinical and clinical trials to review by national authorities. Many drugs do not make it through clinical trials due to unpredicted adverse side effects in people. Others make it through, despite the side effects, when these are deemed of low enough risk or incidence. For many therapies administered intravenously, infusion reactions (IRs) are common, particularly among immunotherapeutics. Even though these can be severe and even life-threatening, assaying for allergic IRs before a drug gets to clinical phases is challenging because relevant biomarkers or animal models are scarce. EU funding of the Biosafety project is building capacity at Hungary's Semmelweis University with the goal of addressing this problem to enhance the safety of immunotherapeutics for patients who need them.

Call for proposal

H2020-WIDESPREAD-2020-5
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Coordinator

SEMMELWEIS EGYETEM
Address
Ulloi Utca 26
1085 Budapest
Hungary
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 325 000

Participants (5)

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 75 000
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
TECODEVELOPMENT GMBH
Germany
EU contribution
€ 100 000
Address
Marie-curie-str. 1
53359 Rheinbach
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIERAU SCHMEISER KATJA
Italy
EU contribution
€ 100 000
Address
Via Colle San Francesco 7
00049 Velletri
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PERCUROS BV
Netherlands
EU contribution
€ 200 000
Address
Eerbeeklaan 42
2573 HT 'S-gravenhage
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TECOBIOSCIENCES GMBH
Germany
EU contribution
€ 100 000
Address
Bussardstrasse 35
84036 Landshut
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)