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Biosafety assays for the diagnosis and prediction of drug-related complement pathology

Project description

Minimising allergic reactions to intravenous immunotherapies with new biosafety testing

Drug development proceeds along a regulated pathway from innovation and research to preclinical and clinical trials to review by national authorities. Many drugs do not make it through clinical trials due to unpredicted adverse side effects in people. Others make it through, despite the side effects, when these are deemed of low enough risk or incidence. For many therapies administered intravenously, infusion reactions (IRs) are common, particularly among immunotherapeutics. Even though these can be severe and even life-threatening, assaying for allergic IRs before a drug gets to clinical phases is challenging because relevant biomarkers or animal models are scarce. EU funding of the Biosafety project is building capacity at Hungary's Semmelweis University with the goal of addressing this problem to enhance the safety of immunotherapeutics for patients who need them.

Call for proposal

H2020-WIDESPREAD-2018-2020

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Sub call

H2020-WIDESPREAD-2020-5

Coordinator

SEMMELWEIS EGYETEM
Net EU contribution
€ 325 000,00
Address
Ulloi Utca 26
1085 Budapest
Hungary

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Region
Közép-Magyarország Budapest Budapest
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Participants (5)

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
Net EU contribution
€ 75 000,00
Address
Albinusdreef 2
2333 ZA Leiden

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Region
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
TECODEVELOPMENT GMBH
Germany
Net EU contribution
€ 100 000,00
Address
Marie-curie-str. 1
53359 Rheinbach

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nordrhein-Westfalen Köln Rhein-Sieg-Kreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
BIERAU SCHMEISER KATJA
Italy
Net EU contribution
€ 100 000,00
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
PERCUROS BV
Netherlands
Net EU contribution
€ 200 000,00
Address
Eerbeeklaan 42
2573 HT 'S-gravenhage

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
West-Nederland Zuid-Holland Agglomeratie ’s-Gravenhage
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
TECOBIOSCIENCES GMBH
Germany
Net EU contribution
€ 100 000,00
Address
Bussardstrasse 35
84036 Landshut

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Bayern Niederbayern Landshut, Landkreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00