Safe and sUstainable by desigN Strategies for HIgh performance multi-component NanomatErials

Leistungen

5 QSAR models to predict (eco)toxicity with a focus on mixture effects

Report describing QSAR models for prediction of (mixture) toxicity.

Machine learning modelling to support MCNMs grouping and read-across

Report describing the machine learning models to support grouping of MCNMs and read-across of information for S&SbD and risk assessment purposes (WP4).

Tool for read-across of information

Extension of the open source CEFIC LRI AMBIT read-across tool for MCNMs based on a previous development for NMs in the GRACIOUS project.

1 Atomistic and coarse-grained models of MCNMs

Report describing molecular models of carbonbased nanocomposites CNRS metal and metal oxides UNIGE as well as continuum models characterising properties of different materials NTUA

Unique properties and interactions of MCNMs

The report will include an inventory of the unique properties and interactions of MCNMs that may lead to eg mixture effects and the MCNMspecific information requirements for grouping and readacross Task 41

Background analysis of how MCNMs are covered in legislation

Report reviewing how MCNMs are addressed/covered by regulations and Guidance documents and whether there are gaps with regard to MCNMs that SUNSHINE can address.

Grouping hypotheses for MCNMs and corresponding IATA

The deliverable will include the grouping hypotheses (Task 4.3), including also the hypotheses based on the Mode of Action (Sub-Task 4.3.2), and the corresponding IATA (Sub-Task 4.3.3).

Progress reports on the implementation of international collaboration

These reports (internal Month 24) will describe the actions taken to facilitate international collaboration, especially with the USA, and the obtained results.

Project Website

A project website will be developed published by M3 of the project and constantly updated

Veröffentlichungen

Using Integrated Approaches to Testing and Assessment to streamline Grouping and Read-Across of solid nanomaterials

Autoren: V Stone, A Oomen, H Johnston, D Hristozov, O Schmidt, T Stoeger, S Aparicio, U Vogel, W Wohlleben, F Murphy
Veröffentlicht in: Toxicology Letters, Ausgabe Volume 384, Supplement 1, September 2023, 2023, Seite(n) Pages S.13 - S.14, ISSN 1879-3169
Herausgeber: Elsevier

Predicting environmental concentrations of nanomaterials for exposure assessment - a review

Autoren: Arturo A. Keller; Yuanfang Zheng; Antonia Praetorius; Joris T.K. Quik; Bernd Nowack
Veröffentlicht in: NanoImpact, Ausgabe Volume 33, January 2024, 100496, 2024, ISSN 2452-0748
Herausgeber: Elsevier
DOI: 10.1016/j.impact.2024.100496

A structure–activity approach towards the toxicity assessment of multicomponent metal oxide nanomaterials

Autoren: G. P. Gakis, I. G. Aviziotis, C. A. Charitidis
Veröffentlicht in: Nanoscale, 2023, ISSN 2040-3372
Herausgeber: RSC
DOI: 10.1039/d3nr03174h

Screening level approach to support companies in making safe and sustainable by design decisions at the early stages of innovation

Autoren: Lisa Pizzol; Arianna Livieri; Beatrice Salieri; Lucian Farcal; Lya G. Soeteman-Hernández; Hubert Rauscher; Alex Zabeo; Magda Blosi; Anna Luisa Costa; Willie Peijnenburg; Stella Stoycheva; Neil Hunt; Maria José López-Tendero; Cástor Salgado; Julian J. Reinosa; Jose F. Fernández; Danail Hristozov
Veröffentlicht in: Crossref, Ausgabe 1, 2023, ISSN 2666-7894
Herausgeber: Elsevier
DOI: 10.1016/j.cesys.2023.100132

In Vitro Cytokinesis Block Micronucleus (CBMN) Assay to Evaluate the Genotoxicity of Multicomponent Nanomaterials – a Tiered Testing Approach

Autoren: Angela Saccardo, Stephen J Evans, Mariajose Lopez Tendero, José Balbuena, José M L Cormano, Gareth J S Jenkins, Martin J D Clift, Shareen H Doak
Veröffentlicht in: Annals of work exposures and health, Ausgabe Volume 67, Ausgabe Supplement_1 May 2023, 2023, ISSN 2398-7316
Herausgeber: Oxford Academic
DOI: 10.1093/annweh/wxac087.146

Review and Prospects on the Ecotoxicity of Mixtures of Nanoparticles and Hybrid Nanomaterials

Autoren: Fan Zhang; Zhuang Wang; Willie J. G. M. Peijnenburg; Martina G. Vijver
Veröffentlicht in: Environmental Science and Technology, Ausgabe 56(22), 2022, Seite(n) 15238 - 15250, ISSN 1520-5851
Herausgeber: ACS
DOI: 10.1021/acs.est.2c03333

Autoren: Veronica Di Battista, ORCID logo ‡ab Karla R. Sanchez-Lievanos, ORCID logo ‡ac Nina Jeliazkova, ORCID logo d Fiona Murphy,e Georgia Tsiliki,fg Alex Zabeo,h Agnieszka Gajewicz-Skretna, ORCID logo i Alicja Mikołajczyk, ORCID logo ij Danail Hristozov,k Vicki Stone,e Otmar Schmid,l Neil Hunt,m Agnes G. Oomenno and Wendel Wohlleben ORCID logo *a
Veröffentlicht in: Environmental Science: Nano, Ausgabe 1/2024, 2024, ISSN 2051-8161
Herausgeber: Royal Society of Chemistry
DOI: 10.1039/d3en00338h

Membrane Phase Drives the Assembly of Gold Nanoparticles on Biomimetic Lipid Bilayers

Autoren: Jacopo Cardellini, Lucrezia Caselli, Enrico Lavagna, Sebastian Salassi, Heinz Amenitsch, Martino Calamai, Costanza Montis, Giulia Rossi, Debora Berti
Veröffentlicht in: J. Phys. Chem., Ausgabe C 2022, 126, 9, 2021, ISSN 1932-7455
Herausgeber: American Chemical Society
DOI: 10.1021/acs.jpcc.1c08914

Identification of emerging safety and sustainability issues of advanced materials: Proposal for a systematic approach

Autoren: Willie J.G.M. Peijnenburg; Agnes G. Oomen; Lya G. Soeteman-Hernández; Monique Groenewold; Adriënne J.A.M. Sips; Cornelle W. Noorlander; J.A.B. Kettelarij; Eric A.J. Bleeker
Veröffentlicht in: NanoImpact, Ausgabe 1, 2021, ISSN 2452-0748
Herausgeber: Science Direct
DOI: 10.1016/j.impact.2021.100342

Correction: Development of a transferable coarse-grained model of polydimethylsiloxane

Autoren: Sonia Cambiaso; Fabio Rasera; Giulia Rossi; Davide Bochicchio
Veröffentlicht in: Soft Matter, Ausgabe 42, 2022, 2022, ISSN 2048-769X
Herausgeber: Royal Society of Chemistry
DOI: 10.1039/d2sm90137d

“Advanced materials” and the challenges on the horizon for testing their (eco)toxicity and assessing their hazard

Autoren: Fazel Abdolahpur Monikh; Willie Peijnenburg; Agnes G. Oomen; Eugenia Valsami-Jones; Vicki Stone; Raine Kortet; Jarkko Akkanen; Peng Zhang; Jukka Kekäläinen; Alena Sevcu; Jussi V. K. Kukkonen
Veröffentlicht in: Environmental Science: Advance, Ausgabe 2/2023, 2023, Seite(n) 162-170, ISSN 2754-7000
Herausgeber: Royal Society of Chemistry
DOI: 10.1039/d2va00128d

How to formulate hypotheses and IATAs to support grouping and read-across of nanoforms

Autoren: Fiona A. Murphy, Helinor J. Johnston, Susan Dekkers, Eric A. J. Bleeker, Agnes G. Oomen, Teresa F. Fernandes, Kirsten Rasmussen, Paula Jantunen, Hubert Rauscher, Neil Hunt, Luisana di Cristos, Hedwig M. Braakhuis, Andrea Haase, Danail Hristozov, Wendel Wohlleben, Stefania Sabella, Vicki Stone
Veröffentlicht in: ALTEX - Alternatives to Animal Experimentation, 2023, ISSN 0378-4274
Herausgeber: Elsevier BV
DOI: 10.14573/altex.2203241

Safe-and-sustainable-by-design chemicals and advanced materials: a paradigm shift towards prevention-based risk governance is needed

Autoren: Danail Hristozov; Alex Zabeo; Lya G. Soeteman-Hernández; Lisa Pizzol; Stella Stoycheva
Veröffentlicht in: Crossref, Ausgabe 4, 2023, ISSN 2666-7894
Herausgeber: RSC
DOI: 10.1039/d3su00045a

Status, implications and challenges of European safe and sustainable by design paradigms applicable to nanomaterials and advanced materials

Autoren: Irini Furxhi; Anna Costa; Socorro Vázquez-Campos; Carlos Fito-López; Danail Hristozov; Juan Antonio Tamayo Ramos; Susanne Resch; Margherita Cioffi; Steffi Friedrichs; Cris Rocca; Eugenia Valsami-Jones; Iseult Lynch; Sánchez Jiménez Araceli; Lucian Farcal
Veröffentlicht in: Crossref, Ausgabe 4, 2023, ISSN 2666-7894
Herausgeber: RSC
DOI: 10.1039/d2su00101b

Development of a transferable coarse-grained model of polydimethylsiloxane

Autoren: Sonia Cambiaso; GIULIA ROSSI; Fabio Rasera Figueiredo; Davide Bochicchio
Veröffentlicht in: Soft Matter, Ausgabe 40, 2022, 2022, ISSN 2048-769X
Herausgeber: Royal Society of Chemistry
DOI: 10.1039/d2sm00939k

Identification of the safe(r) by design alternatives for nanosilver-enabled wound dressings

Autoren: V. Cazzagon; E. Giubilato; A. Bonetto; M. Blosi; I. Zanoni; A. L. Costa; C. Vineis; A. Varesano; A. Marcomini; D. Hristozov; E. Semenzin; E. Badetti
Veröffentlicht in: Frontiers in Bioengineering and Biotechnology, 2022, ISSN 2296-4185
Herausgeber: Frontiers Media SA
DOI: 10.3389/fbioe.2022.987650

A Martini Coarse Grained Model of Citrate-Capped Gold Nanoparticles Interacting with Lipid Bilayers.

Autoren: Sebastian Salassi; Lucrezia Caselli; Jacopo Cardellini; Enrico Lavagna; Costanza Montis; Debora Berti; Giulia Rossi
Veröffentlicht in: Journal of Chemical Theory and Computation, Ausgabe 1, 2021, ISSN 1549-9618
Herausgeber: American Chemical Society
DOI: 10.1021/acs.jctc.1c00627

Socio-Economic Life Cycle-Based Framework for Safe and Sustainable Design of Engineered Nanomaterials and Nano-Enabled Products

Autoren: Stella Stoycheva, Alex Zabeo, Lisa Pizzol, Danail Hristozov
Veröffentlicht in: MDPI Sustainability, 2022, ISSN 2071-1050
Herausgeber: MDPI Open Access Publishing
DOI: 10.3390/su14095734

INISS-Nano: revised concept and action plan (International Network Initiative on Safe and Sustainable Nanotechnologies)

Autoren: Falk, Andreas; Pogany, Alexander; Aungkavattana, Pavadee; Bañares, Miguel A.; Beitollahi, Ali; Bim, Vinicius; Briffa, Sophie; Bochon, Anthony; Cassee, Flemming; Doridot, Fernand; Exner, Thomas; Farias, Patricia M.A.; Favre, Georges; Franzese, Giancarlo; Friedrichs, Steffi; Hristozov, Danail; Hunt, Neil; Indaraprasirt, Ramjitti; Karim, Md. E.; Khandelwal, Neha; Malsch, Ineke; Marcoulaki, Effie; Ma
Veröffentlicht in: INISS-nano, Ausgabe 2, 2022
Herausgeber: INISS-Nano
DOI: 10.5281/zenodo.6818049

International Network Initiative on Safe and Sustainable Nanotechnologies (INISS-nano)

Autoren: Falk, Andreas
Veröffentlicht in: Open Aire, Ausgabe 1, 2021, ISSN 2452-0748
Herausgeber: Zenodo
DOI: 10.5281/zenodo.5004929

INISS-Nano: revised concept and action plan (International Network Initiative on Safe and Sustainable Nanotechnologies)

Autoren: Falk, Andreas; Pogany, Alexander; Aungkavattana, Pavadee; Bañares, Miguel A.; Beitollahi, Ali; Bim, Vinicius; Briffa, Sophie; Bochon, Anthony; Cassee, Flemming; Doridot, Fernand; Exner, Thomas; Farias, Patricia M.A.; Favre, Georges; Franzese, Giancarlo; Friedrichs, Steffi; Hristozov, Danail; Hunt, Neil; Indaraprasirt, Ramjitti; Karim, Md. E.; Khandelwal, Neha; Malsch, Ineke; Marcoulaki, Effie; Ma
Veröffentlicht in: Ausgabe 5, 2023, ISSN 2666-7894
Herausgeber: Zenodo
DOI: 10.5281/zenodo.7877359

Using Integrated Approaches to Testing and Assessment to streamline Grouping and Read-Across of solid nanomaterials

Autoren: V Stone, A Oomen, H Johnston, D Hristozov, O Schmidt, T Stoeger, S Aparicio, U Vogel, W Wohlleben, F Murphy
Veröffentlicht in: Toxicology Letters, 2023, ISSN 0378-4274
Herausgeber: Elsevier
DOI: 10.1016/s0378-4274(23)00296-5

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