From pathobioLogy to synoviA on chip: driving rheuMatoId arthritis to the precisioN medicine GOal

Project Information

FLAMIN-GO

Grant agreement ID: 953121

DOI

10.3030/953121

Project closed

EC signature date 6 November 2020

Start date 1 January 2021

End date 31 December 2025

Funded under

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies

Total cost

No data

EU contribution

€ 5 821 613,75

Coordinated by

UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (3)

Communication plan and dissemination plan

It will describe the project dissemination and communication strategies including the logo and graphical layout guidelines

Dissemination and communication package

It will contain all dissemination products prepared during the first reporting period RP1 1 all promotional materials developed and their distribution 2 snapshots describing the main sections of the project website 3 reference regarding all the social media used and any radio and TV broadcasts or press interviews 4 text of all the press releases published and the press conferences organized and related press review 5 the agenda of the attended events external to the project and the presentations given 6 the agenda presentations and customer satisfaction questionnaires regarding project events organized in P1 7 references to all publications produced in the reporting period 8 information on clustering activities

Dissemination and communication package - RP2

It will contain all dissemination products prepared during the second reporting period (RP2): 1) all promotional materials developed and their distribution; 2) snapshots describing the main sections of the project website; 3) reference regarding all the social media used, and any radio and TV broadcasts or press interviews; 4) text of all the press releases published and the press conferences organized and related press review; 5) the agenda of the attended events external to the project and the presentations given; 6) the agenda, presentations, and customer satisfaction questionnaires regarding project events organized in P1; 7) references to all publications produced in the reporting period; 8) information on clustering activities.

Publications

Peer reviewed articles (40)

Endothelial calcium firing mediates the extravasation of metastatic tumor cells

Author(s): Marina Peralta, Amandine Dupas, Annabel Larnicol, Olivier Lefebvre, Ruchi Goswami, Tristan Stemmelen, Anne Molitor, Raphael Carapito, Salvatore Girardo, Naël Osmani, Jacky G. Goetz
Published in: iScience, Issue 28, 2025, Page(s) 111690, ISSN 2589-0042
Publisher: Elsevier BV
DOI: 10.1016/j.isci.2024.111690

Ph-Sensing Hydrogels for Non-Invasive Metabolism Monitoring in Tumor Spheroids

Author(s): Riccardo Rizzo, Valentina Onesto, Giulia Morello, Helena Iuele, Francesca Scalera, Stefania Forciniti, Giuseppe Gigli, Alessandro Polini, Francesca Gervaso, Loretta L. del Mercato
Published in: Materials Today Bio, Issue Volume 20, June 2023, 100655, 2023, ISSN 2590-0064
Publisher: Elsevier
DOI: 10.2139/ssrn.4364505

Omics approaches open new horizons in major depressive disorder: from biomarkers to precision medicine

Author(s): Fabiola Stolfi, Hugo Abreu, Riccardo Sinella, Sara Nembrini, Sara Centonze, Virginia Landra, Claudio Brasso, Giuseppe Cappellano, Paola Rocca, Annalisa Chiocchetti
Published in: Frontiers in Psychiatry, Issue 15, 2024, ISSN 1664-0640
Publisher: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2024.1422939

Design and Validation of MEDOC, a Tool to Assess the Combined Adherence to Mediterranean and Western Dietary Patterns

Author(s): Camilla Barbero Mazzucca, Lorenza Scotti, Davide Raineri, Giuseppe Cappellano, Annalisa Chiocchetti
Published in: Nutrients, Issue 16, 2025, Page(s) 1745, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu16111745

VAT photopolymerization 3D printing optimization of high aspect ratio structures for additive manufacturing of chips towards biomedical applications

Author(s): Alessio Bucciarelli, Xenia Paolelli, Eleonora De Vitis, Nora Selicato, Francesca Gervaso, Giuseppe Gigli, Lorenzo Moroni, Alessandro Polini
Published in: Additive Manufacturing, Issue Volume 60, Part A, December 2022, 103200, 2022, ISSN 2214-8604
Publisher: Elsevier BV
DOI: 10.1016/j.addma.2022.103200

Preparation and characterization of salt-mediated injectable thermosensitive chitosan/pectin hydrogels for cell embedding and culturing

Author(s): Morello, Giulia; Polini, Alessandro; Scalera, Francesca; Rizzo, Riccardo; Gigli, Giuseppe; Gervaso, Francesca
Published in: Polymers, Issue 13(16), 2021, Page(s) 2674, ISSN 2073-4360
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/polym13162674

Nano-Microparticle Platforms in Developing Next-Generation Vaccines

Author(s): Giuseppe Cappellano; Hugo Abreu; Chiara Casale; Umberto Dianzani; Annalisa Chiocchetti
Published in: Vaccines, Issue 9(6), 2021, Page(s) 606, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9060606

Nutrition and Rheumatoid Arthritis Onset: A Prospective Analysis Using the UK Biobank

Author(s): Camilla Barbero Mazzucca; Lorenza Scotti; Giuseppe Cappellano; Francesco Barone-Adesi 3; Annalisa Chiocchetti
Published in: Nutrients, Issue 14(8), 2022, Page(s) 1554, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu14081554

My cells, my model: immune-competent autologous organ-on-chip systems as a new paradigm in precision medicine

Author(s): Francesco Bisconti, Hugo Abreu, Thuy Duong Nguyen, Fabiola Stolfi, Noemi Corbezzolo, Giuseppe Gigli, Davide Raineri, Giuseppe Cappellano, Alessandro Polini, Francesca Gervaso, Annalisa Chiocchetti, nu
Published in: Frontiers in Immunology, Issue 16, 2025, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2025.1712796

Calcium signaling dysregulation in rheumatoid arthritis: a comparative perspective with osteoarthritis

Author(s): Thuy Duong Nguyen, Hugo Abreu, Nicoletta Tommasi, Luigi Azzarone, Rita Maria Concetta Di Martino, Beatrice Riva, Davide Raineri, Tracey Pirali, Annalisa Chiocchetti, Giuseppe Cappellano
Published in: Autoimmunity Reviews, Issue 24, 2025, Page(s) 103923, ISSN 1568-9972
Publisher: Elsevier BV
DOI: 10.1016/j.autrev.2025.103923

The Role of Diet in Multiple Sclerosis Onset: A Prospective Study Using UK Biobank

Author(s): Camilla Barbero Mazzucca, Lorenza Scotti, Cristoforo Comi, Domizia Vecchio, Annalisa Chiocchetti, Giuseppe Cappellano
Published in: Nutrients, Issue 16, 2025, Page(s) 1746, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu16111746

An Assist for Arthritis Studies: A 3D Cell Culture of Human Fibroblast‐Like Synoviocytes by Encapsulation in a Chitosan‐Based Hydrogel

Author(s): Francesco Bisconti, Beatrice Vilardo, Gaia Corallo, Francesca Scalera, Giuseppe Gigli, Annalisa Chiocchetti, Alessandro Polini, Francesca Gervaso
Published in: Advanced Therapeutics, Issue 7, 2025, ISSN 2366-3987
Publisher: Wiley
DOI: 10.1002/adtp.202400166

Highly sensitive ratiometric fluorescent fiber matrices for oxygen sensing with micrometer spatial resolution

Author(s): Giuliana Grasso, Valentina Onesto, Stefania Forciniti, Eliana D’Amone, Francesco Colella, Lara Pierantoni, Valeria Famà, Giuseppe Gigli, Rui L. Reis, J. Miguel Oliveira, Loretta L. del Mercato
Published in: Bio-Design and Manufacturing, Issue 7, 2024, Page(s) 292-306, ISSN 2096-5524
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s42242-024-00277-3

Fluorescent nano- and microparticles for sensing cellular microenvironment: past, present and future applications

Author(s): Grasso, Giuliana, Colella Francesco, Forciniti Stefania, Onesto Valentina, Iuele Helena, Siciliano Anna Chiara, Carnevali Federica, Chandra Anil, Gigli Giuseppe, del Mercato Loretta L.
Published in: Nanoscale Advances, Issue 5, 2023, Page(s) 4311-4336, ISSN 2516-0230
Publisher: RSC Publishing
DOI: 10.1039/d3na00218g

Chitosan and Pectin Hydrogels for Tissue Engineering and In Vitro Modeling

Author(s): Morello Giulia, De Iaco Gianvito, Gigli Giuseppe, Polini Alessandro, Gervaso Francesca
Published in: Gels, Issue 9(2), 2023, Page(s) 132, ISSN 2310-2861
Publisher: MDPI
DOI: 10.3390/gels9020132

Micropathological Chip Modeling the Neurovascular Unit Response to Inflammatory Bone Condition

Author(s): Estrela Neto; Ana C Monteiro; Catarina L Pereira; Miguel Simões; João P Conde; Virginia Chu; Bruno Sarmento; Meriem Lamghari
Published in: Advanced Healthcare Materials, Issue 11(11), 2022, Page(s) 2102305, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202102305

Modelling methacrylated chitosan hydrogel properties through an experimental design approach: from composition to material properties

Author(s): Alessio Bucciarelli, Nora Selicato, Chiara Coricciati, Alberto Rainer, Agostina Lina Capodilupo, Giuseppe Gigli, Lorenzo Moroni, Alessandro Polini, Francesca Gervaso
Published in: Journal of Materials Chemistry B, Issue 12, 2024, Page(s) 10221-10240, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4tb00670d

Shotgun Proteomics Links Proteoglycan-4+ Extracellular Vesicles to Cognitive Protection in Amyotrophic Lateral Sclerosis

Author(s): Beatrice Vilardo, Fabiola De Marchi, Davide Raineri, Marcello Manfredi, Veronica De Giorgis, Alen Bebeti, Lorenza Scotti, Natasa Kustrimovic, Giuseppe Cappellano, Letizia Mazzini, Annalisa Chiocchetti
Published in: Biomolecules, Issue 14, 2025, Page(s) 727, ISSN 2218-273X
Publisher: MDPI AG
DOI: 10.3390/biom14060727

The Evolution of Technology‐Driven In Vitro Models for Neurodegenerative Diseases

Author(s): Eleonora De Vitis, Antonella Stanzione, Alessandro Romano, Angelo Quattrini, Giuseppe Gigli, Lorenzo Moroni, Francesca Gervaso, Alessandro Polini
Published in: Advanced Science, Issue 11, 2025, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202304989

Deep Flow Cytometry Unveils Distinct Immune Cell Subsets in Inducible T Cell Co-Stimulator Ligand (ICOSL)- and ICOS-Knockout Mice during Experimental Autoimmune Encephalomyelitis

Author(s): Davide Raineri, Hugo Abreu, Beatrice Vilardo, Natasa Kustrimovic, Chiara Venegoni, Giuseppe Cappellano, Annalisa Chiocchetti
Published in: International Journal of Molecular Sciences, Issue 25, 2025, Page(s) 2509, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25052509

Inducible T-Cell Costimulator Ligand Plays a Dual Role in Melanoma Metastasis upon Binding to Osteopontin or Inducible T-Cell Costimulator

Author(s): Davide Raineri; Giuseppe Cappellano; Beatrice Vilardo; Federica Maione; Nausicaa Clemente; Elena Canciani; Elena Boggio; Casimiro Luca Gigliotti; Chiara Monge; Chiara Dianzani; Renzo Boldorini; Umberto Dianzani; Annalisa Chiocchetti
Published in: Biomedicines, Issue 10(1), 2021, Page(s) 51, ISSN 2227-9059
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biomedicines10010051

How to Tackle the Relationship between Autoimmune Diseases and Diet: Well Begun Is Half-Done

Author(s): Camilla Barbero Mazzucca; Davide Raineri; Giuseppe Cappellano; Annalisa Chiocchetti
Published in: Nutrients, Issue 13(11), 2021, Page(s) 3956, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13113956

A fluorescent ratiometric potassium sensor based on IPG4-silica microparticles for selective detection and fluorescence imaging of potassium cations

Author(s): Francesco Colella, Stefania Forciniti, Valentina Onesto, Giuliana Grasso, Helena Iuele, Giuseppe Gigli, Loretta L. del Mercato
Published in: Journal of Materials Chemistry B, Issue 12, 2024, Page(s) 10573-10583, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4tb01047g

High-throughput viscoelastic characterization of cells in hyperbolic microchannels

Author(s): Felix Reichel, Ruchi Goswami, Salvatore Girardo, Jochen Guck
Published in: Lab on a Chip, Issue 24, 2024, Page(s) 2440-2453, ISSN 1473-0197
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3lc01061a

Circulating GLAST+ EVs are increased in amyotrophic lateral sclerosis

Author(s): Davide Raineri, Fabiola De Marchi, Beatrice Vilardo, Camilla Barbero Mazzucca, Lorenza Scotti, Natasa Kustrimovic, Letizia Mazzini, Giuseppe Cappellano, Annalisa Chiocchetti
Published in: Frontiers in Molecular Biosciences, Issue 11, 2024, ISSN 2296-889X
Publisher: Frontiers Media SA
DOI: 10.3389/fmolb.2024.1507498

Viscoelastic properties of suspended cells measured with shear flow deformation cytometry

Author(s): Gerum R., Mirzahossein E., Eroles M., Elsterer J., Mainka A., Bauer A., Sonntag S., Winterl A., Bartl J., Fischer L., Abuhattum S., Goswami R., Girardo S., Guck J., Schrüfer S., Ströhlein N., Nosratlo M., Herrmann H., Schultheis D., Rico F., Müller S. J., Gekle S., Fabry B.
Published in: Elife, Issue 11, e78823, 2022, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.78823

High levels of circulating osteopontin in inflammatory lung disease regardless of Sars-CoV-2 infection

Author(s): Giuseppe Cappellano, Hugo Abreu, Davide Raineri, Lorenza Scotti, Luigi Castello, Rosanna Vaschetto, Annalisa Chiocchetti
Published in: EMBO Molecular Medicine, Issue 13(5), 2021, Page(s) e14124, ISSN 1757-4684
Publisher: EMBO Press
DOI: 10.15252/emmm.202114124

Worse Disease Prognosis Is Associated to an Increase of Platelet-Derived Extracellular Vesicles in Hospitalized SARS-CoV-2 Patients

Author(s): Raineri Davide, Venegoni Chiara, Calella Maria Grazia, Vaschetto Rosanna, Scotti Lorenza, Manfredi Marcello, Gavello Francesco, Castello Luigi, Chiocchetti Annalisa, Cappellano Giuseppe
Published in: Disease Markers, Issue Volume 2022, Article ID 8074655, 2022, ISSN 0278-0240
Publisher: IOS Press
DOI: 10.1155/2022/8074655

Human T-Cell Responses to Metallic Ion-Doped Bioactive Glasses

Author(s): Hugo Abreu, Mari Lallukka, Marta Miola, Silvia Spriano, Enrica Vernè, Davide Raineri, Massimiliano Leigheb, Mario Ronga, Giuseppe Cappellano, Annalisa Chiocchetti
Published in: International Journal of Molecular Sciences, Issue 25, 2025, Page(s) 4501, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25084501

Cell-Laden 3D Printed GelMA/HAp and THA Hydrogel Bioinks: Development of Osteochondral Tissue-like Bioinks

Author(s): Jahangir S., Vecstaudza J., Augurio A., Canciani E., Stipniece L., Locs J., Alini M., Serra T.
Published in: Materials, Issue 16(22), 2023, Page(s) 7214, ISSN 1996-1944
Publisher: MDPI Open Access Publishing
DOI: 10.3390/ma16227214

Extracellular Vesicles in Musculoskeletal Regeneration: Modulating the Therapy of the Future

Author(s): Abreu, Hugo; Canciani, Elena; Raineri, Davide; Cappellano, Giuseppe; Rimondini, Lia; Chiocchetti, Annalisa
Published in: Cells, Issue 11(1), 2021, Page(s) 43, ISSN 2073-4409
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11010043

Probiotic-derived extracellular vesicles: the next breakthrough in postbiotics for rheumatoid arthritis

Author(s): Federica Dell’Atti, Hugo Abreu, Patrizia Malfa, Davide Raineri, Giuseppe Cappellano, Annalisa Chiocchetti
Published in: Frontiers in Immunology, Issue 16, 2025, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2025.1620185

Photo/thermo-sensitive chitosan and gelatin-based interpenetrating polymer network for mimicking muscle tissue extracellular matrix

Author(s): Antonella Stanzione, Alessandro Polini, Francesca Scalera, Giuseppe Gigli, Lorenzo Moroni, Francesca Gervaso
Published in: Heliyon, Issue 10, 2025, Page(s) e39820, ISSN 2405-8440
Publisher: Elsevier BV
DOI: 10.1016/j.heliyon.2024.e39820

Image-based cell sorting using focused travelling surface acoustic waves

Author(s): Ahmad Ahsan Nawaz, Despina Soteriou, Catherine K. Xu, Ruchi Goswami, Maik Herbig, Jochen Guck and Salvatore Girardo
Published in: Lab on Chip, Issue Issue 2, 2023, 2023, Page(s) 372-387, ISSN 1473-0189
Publisher: RSC Publishing
DOI: 10.1039/d2lc00636g

Deep immunophenotyping of circulating immune cells in major depressive disorder patients reveals immune correlates of clinical course and treatment response

Author(s): Fabiola Stolfi, Claudio Brasso, Davide Raineri, Virginia Landra, Camilla Barbero Mazzucca, Ali Ghazanfar, Lorenza Scotti, Riccardo Sinella, Vincenzo Villari, Giuseppe Cappellano, Paola Rocca, Annalisa
Published in: Brain, Behavior, & Immunity - Health, Issue 43, 2025, Page(s) 100942, ISSN 2666-3546
Publisher: Elsevier BV
DOI: 10.1016/j.bbih.2024.100942

The convergence of high-tech emerging technologies into the next stage of organ-on-a-chips

Author(s): Polini, Alessandro; Moroni, Lorenzo
Published in: Biomaterials and Biosystems, Issue 1, 2021, Page(s) 100012, ISSN 2666-5344
Publisher: Elsevier BV
DOI: 10.1016/j.bbiosy.2021.100012

Evaluation of the immune response of peripheral blood mononuclear cells cultured on Ti6Al4V-ELI polished or etched surfaces

Author(s): Hugo Abreu, Mari Lallukka, Davide Raineri, Massimiliano Leigheb, Mario Ronga, Giuseppe Cappellano, Silvia Spriano, Annalisa Chiocchetti
Published in: Frontiers in Bioengineering and Biotechnology, Issue 12, 2024, ISSN 2296-4185
Publisher: Frontiers Media SA
DOI: 10.3389/fbioe.2024.1458091

Efficient and gentle delivery of molecules into cells with different elasticity via Progressive Mechanoporation

Author(s): Alena Uvizl; Ruchi Goswami; Shanil Gandhi; Martina Augsburg; Frank Buchholz; Jochen Guck; Jörg Mansfeld; Salvatore Girardo
Published in: Lab on a Chip, Issue 21, 2021, Page(s) 2437-2452, ISSN 1473-0197
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0lc01224f

Thermosensitive chitosan-based hydrogels supporting motor neuron-like NSC-34 cell differentiation

Author(s): Stanzione, Antonella; Polini, Alessandro; La Pesa, Velia; Quattrini, Angelo; Gigli, Giuseppe; Moroni, Lorenzo; Gervaso, Francesca
Published in: Biomaterials Science, Issue 9, 2021, Page(s) 7492-7503, ISSN 2047-4830
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1bm01129d

A microfabricated multi‑compartment device for neuron and Schwann cell differentiation

Author(s): De Vitis, Eleonora; La Pesa, Velia; Gervaso, Francesca; Romano, Alessandro; Quattrini, Angelo; Gigli, Giuseppe; Moroni, Lorenzo; Polini, Alessandro
Published in: Scientific reports, Issue 11, 2021, Page(s) 7019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-86300-4

Conference proceedings (2)

Development of bioprinted osteochondral tissue: an in-vitro model for drug discovery

Author(s): Jahangir Shahrbanoo; Vecstaudža Jana; Canciani Elena; Ločs Jānis; Alini Mauro; Serra Tiziano
Published in: TERMIS 2022 Conference Book and Book Abstracts, 2023, Page(s) 191-192, ISSN 1937-3341
Publisher: Mary Ann Liebert, Inc., publishers
DOI: 10.5281/zenodo.6587068

Amorphous calcium phosphate nanoparticles for development of 3D printing bio-inks for orthopaedic application

Author(s): Vecstaudza, Jana; Locs, Janis
Published in: eCM Periodical, Issue 3, 2021, Page(s) 20, ISSN 2522-235X
Publisher: AO Research Institute Davos
DOI: 10.5281/zenodo.6586447