From pathobioLogy to synoviA on chip: driving rheuMatoId arthritis to the precisioN medicine GOal

Información del proyecto

FLAMIN-GO

Identificador del acuerdo de subvención: 953121

DOI

10.3030/953121

Proyecto cerrado

Fecha de la firma de la CE 6 Noviembre 2020

Fecha de inicio 1 Enero 2021

Fecha de finalización 31 Diciembre 2025

Financiado con arreglo a

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies

Coste total

Sin datos

Aportación de la UE

€ 5 821 613,75

Coordinado por

UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO
Italy

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (3)

Communication plan and dissemination plan

It will describe the project dissemination and communication strategies including the logo and graphical layout guidelines

Dissemination and communication package

It will contain all dissemination products prepared during the first reporting period RP1 1 all promotional materials developed and their distribution 2 snapshots describing the main sections of the project website 3 reference regarding all the social media used and any radio and TV broadcasts or press interviews 4 text of all the press releases published and the press conferences organized and related press review 5 the agenda of the attended events external to the project and the presentations given 6 the agenda presentations and customer satisfaction questionnaires regarding project events organized in P1 7 references to all publications produced in the reporting period 8 information on clustering activities

Dissemination and communication package - RP2

It will contain all dissemination products prepared during the second reporting period (RP2): 1) all promotional materials developed and their distribution; 2) snapshots describing the main sections of the project website; 3) reference regarding all the social media used, and any radio and TV broadcasts or press interviews; 4) text of all the press releases published and the press conferences organized and related press review; 5) the agenda of the attended events external to the project and the presentations given; 6) the agenda, presentations, and customer satisfaction questionnaires regarding project events organized in P1; 7) references to all publications produced in the reporting period; 8) information on clustering activities.

Publicaciones

Peer reviewed articles (40)

Endothelial calcium firing mediates the extravasation of metastatic tumor cells

Autores: Marina Peralta, Amandine Dupas, Annabel Larnicol, Olivier Lefebvre, Ruchi Goswami, Tristan Stemmelen, Anne Molitor, Raphael Carapito, Salvatore Girardo, Naël Osmani, Jacky G. Goetz
Publicado en: iScience, Edición 28, 2025, Página(s) 111690, ISSN 2589-0042
Editor: Elsevier BV
DOI: 10.1016/j.isci.2024.111690

Ph-Sensing Hydrogels for Non-Invasive Metabolism Monitoring in Tumor Spheroids

Autores: Riccardo Rizzo, Valentina Onesto, Giulia Morello, Helena Iuele, Francesca Scalera, Stefania Forciniti, Giuseppe Gigli, Alessandro Polini, Francesca Gervaso, Loretta L. del Mercato
Publicado en: Materials Today Bio, Edición Volume 20, June 2023, 100655, 2023, ISSN 2590-0064
Editor: Elsevier
DOI: 10.2139/ssrn.4364505

Omics approaches open new horizons in major depressive disorder: from biomarkers to precision medicine

Autores: Fabiola Stolfi, Hugo Abreu, Riccardo Sinella, Sara Nembrini, Sara Centonze, Virginia Landra, Claudio Brasso, Giuseppe Cappellano, Paola Rocca, Annalisa Chiocchetti
Publicado en: Frontiers in Psychiatry, Edición 15, 2024, ISSN 1664-0640
Editor: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2024.1422939

Design and Validation of MEDOC, a Tool to Assess the Combined Adherence to Mediterranean and Western Dietary Patterns

Autores: Camilla Barbero Mazzucca, Lorenza Scotti, Davide Raineri, Giuseppe Cappellano, Annalisa Chiocchetti
Publicado en: Nutrients, Edición 16, 2025, Página(s) 1745, ISSN 2072-6643
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu16111745

VAT photopolymerization 3D printing optimization of high aspect ratio structures for additive manufacturing of chips towards biomedical applications

Autores: Alessio Bucciarelli, Xenia Paolelli, Eleonora De Vitis, Nora Selicato, Francesca Gervaso, Giuseppe Gigli, Lorenzo Moroni, Alessandro Polini
Publicado en: Additive Manufacturing, Edición Volume 60, Part A, December 2022, 103200, 2022, ISSN 2214-8604
Editor: Elsevier BV
DOI: 10.1016/j.addma.2022.103200

Preparation and characterization of salt-mediated injectable thermosensitive chitosan/pectin hydrogels for cell embedding and culturing

Autores: Morello, Giulia; Polini, Alessandro; Scalera, Francesca; Rizzo, Riccardo; Gigli, Giuseppe; Gervaso, Francesca
Publicado en: Polymers, Edición 13(16), 2021, Página(s) 2674, ISSN 2073-4360
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/polym13162674

Nano-Microparticle Platforms in Developing Next-Generation Vaccines

Autores: Giuseppe Cappellano; Hugo Abreu; Chiara Casale; Umberto Dianzani; Annalisa Chiocchetti
Publicado en: Vaccines, Edición 9(6), 2021, Página(s) 606, ISSN 2076-393X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9060606

Nutrition and Rheumatoid Arthritis Onset: A Prospective Analysis Using the UK Biobank

Autores: Camilla Barbero Mazzucca; Lorenza Scotti; Giuseppe Cappellano; Francesco Barone-Adesi 3; Annalisa Chiocchetti
Publicado en: Nutrients, Edición 14(8), 2022, Página(s) 1554, ISSN 2072-6643
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu14081554

My cells, my model: immune-competent autologous organ-on-chip systems as a new paradigm in precision medicine

Autores: Francesco Bisconti, Hugo Abreu, Thuy Duong Nguyen, Fabiola Stolfi, Noemi Corbezzolo, Giuseppe Gigli, Davide Raineri, Giuseppe Cappellano, Alessandro Polini, Francesca Gervaso, Annalisa Chiocchetti, nu
Publicado en: Frontiers in Immunology, Edición 16, 2025, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/fimmu.2025.1712796

Calcium signaling dysregulation in rheumatoid arthritis: a comparative perspective with osteoarthritis

Autores: Thuy Duong Nguyen, Hugo Abreu, Nicoletta Tommasi, Luigi Azzarone, Rita Maria Concetta Di Martino, Beatrice Riva, Davide Raineri, Tracey Pirali, Annalisa Chiocchetti, Giuseppe Cappellano
Publicado en: Autoimmunity Reviews, Edición 24, 2025, Página(s) 103923, ISSN 1568-9972
Editor: Elsevier BV
DOI: 10.1016/j.autrev.2025.103923

The Role of Diet in Multiple Sclerosis Onset: A Prospective Study Using UK Biobank

Autores: Camilla Barbero Mazzucca, Lorenza Scotti, Cristoforo Comi, Domizia Vecchio, Annalisa Chiocchetti, Giuseppe Cappellano
Publicado en: Nutrients, Edición 16, 2025, Página(s) 1746, ISSN 2072-6643
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu16111746

An Assist for Arthritis Studies: A 3D Cell Culture of Human Fibroblast‐Like Synoviocytes by Encapsulation in a Chitosan‐Based Hydrogel

Autores: Francesco Bisconti, Beatrice Vilardo, Gaia Corallo, Francesca Scalera, Giuseppe Gigli, Annalisa Chiocchetti, Alessandro Polini, Francesca Gervaso
Publicado en: Advanced Therapeutics, Edición 7, 2025, ISSN 2366-3987
Editor: Wiley
DOI: 10.1002/adtp.202400166

Highly sensitive ratiometric fluorescent fiber matrices for oxygen sensing with micrometer spatial resolution

Autores: Giuliana Grasso, Valentina Onesto, Stefania Forciniti, Eliana D’Amone, Francesco Colella, Lara Pierantoni, Valeria Famà, Giuseppe Gigli, Rui L. Reis, J. Miguel Oliveira, Loretta L. del Mercato
Publicado en: Bio-Design and Manufacturing, Edición 7, 2024, Página(s) 292-306, ISSN 2096-5524
Editor: Springer Science and Business Media LLC
DOI: 10.1007/s42242-024-00277-3

Fluorescent nano- and microparticles for sensing cellular microenvironment: past, present and future applications

Autores: Grasso, Giuliana, Colella Francesco, Forciniti Stefania, Onesto Valentina, Iuele Helena, Siciliano Anna Chiara, Carnevali Federica, Chandra Anil, Gigli Giuseppe, del Mercato Loretta L.
Publicado en: Nanoscale Advances, Edición 5, 2023, Página(s) 4311-4336, ISSN 2516-0230
Editor: RSC Publishing
DOI: 10.1039/d3na00218g

Chitosan and Pectin Hydrogels for Tissue Engineering and In Vitro Modeling

Autores: Morello Giulia, De Iaco Gianvito, Gigli Giuseppe, Polini Alessandro, Gervaso Francesca
Publicado en: Gels, Edición 9(2), 2023, Página(s) 132, ISSN 2310-2861
Editor: MDPI
DOI: 10.3390/gels9020132

Micropathological Chip Modeling the Neurovascular Unit Response to Inflammatory Bone Condition

Autores: Estrela Neto; Ana C Monteiro; Catarina L Pereira; Miguel Simões; João P Conde; Virginia Chu; Bruno Sarmento; Meriem Lamghari
Publicado en: Advanced Healthcare Materials, Edición 11(11), 2022, Página(s) 2102305, ISSN 2192-2640
Editor: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202102305

Modelling methacrylated chitosan hydrogel properties through an experimental design approach: from composition to material properties

Autores: Alessio Bucciarelli, Nora Selicato, Chiara Coricciati, Alberto Rainer, Agostina Lina Capodilupo, Giuseppe Gigli, Lorenzo Moroni, Alessandro Polini, Francesca Gervaso
Publicado en: Journal of Materials Chemistry B, Edición 12, 2024, Página(s) 10221-10240, ISSN 2050-7518
Editor: Royal Society of Chemistry
DOI: 10.1039/d4tb00670d

Shotgun Proteomics Links Proteoglycan-4+ Extracellular Vesicles to Cognitive Protection in Amyotrophic Lateral Sclerosis

Autores: Beatrice Vilardo, Fabiola De Marchi, Davide Raineri, Marcello Manfredi, Veronica De Giorgis, Alen Bebeti, Lorenza Scotti, Natasa Kustrimovic, Giuseppe Cappellano, Letizia Mazzini, Annalisa Chiocchetti
Publicado en: Biomolecules, Edición 14, 2025, Página(s) 727, ISSN 2218-273X
Editor: MDPI AG
DOI: 10.3390/biom14060727

The Evolution of Technology‐Driven In Vitro Models for Neurodegenerative Diseases

Autores: Eleonora De Vitis, Antonella Stanzione, Alessandro Romano, Angelo Quattrini, Giuseppe Gigli, Lorenzo Moroni, Francesca Gervaso, Alessandro Polini
Publicado en: Advanced Science, Edición 11, 2025, ISSN 2198-3844
Editor: Wiley
DOI: 10.1002/advs.202304989

Deep Flow Cytometry Unveils Distinct Immune Cell Subsets in Inducible T Cell Co-Stimulator Ligand (ICOSL)- and ICOS-Knockout Mice during Experimental Autoimmune Encephalomyelitis

Autores: Davide Raineri, Hugo Abreu, Beatrice Vilardo, Natasa Kustrimovic, Chiara Venegoni, Giuseppe Cappellano, Annalisa Chiocchetti
Publicado en: International Journal of Molecular Sciences, Edición 25, 2025, Página(s) 2509, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25052509

Inducible T-Cell Costimulator Ligand Plays a Dual Role in Melanoma Metastasis upon Binding to Osteopontin or Inducible T-Cell Costimulator

Autores: Davide Raineri; Giuseppe Cappellano; Beatrice Vilardo; Federica Maione; Nausicaa Clemente; Elena Canciani; Elena Boggio; Casimiro Luca Gigliotti; Chiara Monge; Chiara Dianzani; Renzo Boldorini; Umberto Dianzani; Annalisa Chiocchetti
Publicado en: Biomedicines, Edición 10(1), 2021, Página(s) 51, ISSN 2227-9059
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biomedicines10010051

How to Tackle the Relationship between Autoimmune Diseases and Diet: Well Begun Is Half-Done

Autores: Camilla Barbero Mazzucca; Davide Raineri; Giuseppe Cappellano; Annalisa Chiocchetti
Publicado en: Nutrients, Edición 13(11), 2021, Página(s) 3956, ISSN 2072-6643
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13113956

A fluorescent ratiometric potassium sensor based on IPG4-silica microparticles for selective detection and fluorescence imaging of potassium cations

Autores: Francesco Colella, Stefania Forciniti, Valentina Onesto, Giuliana Grasso, Helena Iuele, Giuseppe Gigli, Loretta L. del Mercato
Publicado en: Journal of Materials Chemistry B, Edición 12, 2024, Página(s) 10573-10583, ISSN 2050-7518
Editor: Royal Society of Chemistry
DOI: 10.1039/d4tb01047g

High-throughput viscoelastic characterization of cells in hyperbolic microchannels

Autores: Felix Reichel, Ruchi Goswami, Salvatore Girardo, Jochen Guck
Publicado en: Lab on a Chip, Edición 24, 2024, Página(s) 2440-2453, ISSN 1473-0197
Editor: Royal Society of Chemistry
DOI: 10.1039/d3lc01061a

Circulating GLAST+ EVs are increased in amyotrophic lateral sclerosis

Autores: Davide Raineri, Fabiola De Marchi, Beatrice Vilardo, Camilla Barbero Mazzucca, Lorenza Scotti, Natasa Kustrimovic, Letizia Mazzini, Giuseppe Cappellano, Annalisa Chiocchetti
Publicado en: Frontiers in Molecular Biosciences, Edición 11, 2024, ISSN 2296-889X
Editor: Frontiers Media SA
DOI: 10.3389/fmolb.2024.1507498

Viscoelastic properties of suspended cells measured with shear flow deformation cytometry

Autores: Gerum R., Mirzahossein E., Eroles M., Elsterer J., Mainka A., Bauer A., Sonntag S., Winterl A., Bartl J., Fischer L., Abuhattum S., Goswami R., Girardo S., Guck J., Schrüfer S., Ströhlein N., Nosratlo M., Herrmann H., Schultheis D., Rico F., Müller S. J., Gekle S., Fabry B.
Publicado en: Elife, Edición 11, e78823, 2022, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.78823

High levels of circulating osteopontin in inflammatory lung disease regardless of Sars-CoV-2 infection

Autores: Giuseppe Cappellano, Hugo Abreu, Davide Raineri, Lorenza Scotti, Luigi Castello, Rosanna Vaschetto, Annalisa Chiocchetti
Publicado en: EMBO Molecular Medicine, Edición 13(5), 2021, Página(s) e14124, ISSN 1757-4684
Editor: EMBO Press
DOI: 10.15252/emmm.202114124

Worse Disease Prognosis Is Associated to an Increase of Platelet-Derived Extracellular Vesicles in Hospitalized SARS-CoV-2 Patients

Autores: Raineri Davide, Venegoni Chiara, Calella Maria Grazia, Vaschetto Rosanna, Scotti Lorenza, Manfredi Marcello, Gavello Francesco, Castello Luigi, Chiocchetti Annalisa, Cappellano Giuseppe
Publicado en: Disease Markers, Edición Volume 2022, Article ID 8074655, 2022, ISSN 0278-0240
Editor: IOS Press
DOI: 10.1155/2022/8074655

Human T-Cell Responses to Metallic Ion-Doped Bioactive Glasses

Autores: Hugo Abreu, Mari Lallukka, Marta Miola, Silvia Spriano, Enrica Vernè, Davide Raineri, Massimiliano Leigheb, Mario Ronga, Giuseppe Cappellano, Annalisa Chiocchetti
Publicado en: International Journal of Molecular Sciences, Edición 25, 2025, Página(s) 4501, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25084501

Cell-Laden 3D Printed GelMA/HAp and THA Hydrogel Bioinks: Development of Osteochondral Tissue-like Bioinks

Autores: Jahangir S., Vecstaudza J., Augurio A., Canciani E., Stipniece L., Locs J., Alini M., Serra T.
Publicado en: Materials, Edición 16(22), 2023, Página(s) 7214, ISSN 1996-1944
Editor: MDPI Open Access Publishing
DOI: 10.3390/ma16227214

Extracellular Vesicles in Musculoskeletal Regeneration: Modulating the Therapy of the Future

Autores: Abreu, Hugo; Canciani, Elena; Raineri, Davide; Cappellano, Giuseppe; Rimondini, Lia; Chiocchetti, Annalisa
Publicado en: Cells, Edición 11(1), 2021, Página(s) 43, ISSN 2073-4409
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11010043

Probiotic-derived extracellular vesicles: the next breakthrough in postbiotics for rheumatoid arthritis

Autores: Federica Dell’Atti, Hugo Abreu, Patrizia Malfa, Davide Raineri, Giuseppe Cappellano, Annalisa Chiocchetti
Publicado en: Frontiers in Immunology, Edición 16, 2025, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/fimmu.2025.1620185

Photo/thermo-sensitive chitosan and gelatin-based interpenetrating polymer network for mimicking muscle tissue extracellular matrix

Autores: Antonella Stanzione, Alessandro Polini, Francesca Scalera, Giuseppe Gigli, Lorenzo Moroni, Francesca Gervaso
Publicado en: Heliyon, Edición 10, 2025, Página(s) e39820, ISSN 2405-8440
Editor: Elsevier BV
DOI: 10.1016/j.heliyon.2024.e39820

Image-based cell sorting using focused travelling surface acoustic waves

Autores: Ahmad Ahsan Nawaz, Despina Soteriou, Catherine K. Xu, Ruchi Goswami, Maik Herbig, Jochen Guck and Salvatore Girardo
Publicado en: Lab on Chip, Edición Edición 2, 2023, 2023, Página(s) 372-387, ISSN 1473-0189
Editor: RSC Publishing
DOI: 10.1039/d2lc00636g

Deep immunophenotyping of circulating immune cells in major depressive disorder patients reveals immune correlates of clinical course and treatment response

Autores: Fabiola Stolfi, Claudio Brasso, Davide Raineri, Virginia Landra, Camilla Barbero Mazzucca, Ali Ghazanfar, Lorenza Scotti, Riccardo Sinella, Vincenzo Villari, Giuseppe Cappellano, Paola Rocca, Annalisa
Publicado en: Brain, Behavior, & Immunity - Health, Edición 43, 2025, Página(s) 100942, ISSN 2666-3546
Editor: Elsevier BV
DOI: 10.1016/j.bbih.2024.100942

The convergence of high-tech emerging technologies into the next stage of organ-on-a-chips

Autores: Polini, Alessandro; Moroni, Lorenzo
Publicado en: Biomaterials and Biosystems, Edición 1, 2021, Página(s) 100012, ISSN 2666-5344
Editor: Elsevier BV
DOI: 10.1016/j.bbiosy.2021.100012

Evaluation of the immune response of peripheral blood mononuclear cells cultured on Ti6Al4V-ELI polished or etched surfaces

Autores: Hugo Abreu, Mari Lallukka, Davide Raineri, Massimiliano Leigheb, Mario Ronga, Giuseppe Cappellano, Silvia Spriano, Annalisa Chiocchetti
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 12, 2024, ISSN 2296-4185
Editor: Frontiers Media SA
DOI: 10.3389/fbioe.2024.1458091

Efficient and gentle delivery of molecules into cells with different elasticity via Progressive Mechanoporation

Autores: Alena Uvizl; Ruchi Goswami; Shanil Gandhi; Martina Augsburg; Frank Buchholz; Jochen Guck; Jörg Mansfeld; Salvatore Girardo
Publicado en: Lab on a Chip, Edición 21, 2021, Página(s) 2437-2452, ISSN 1473-0197
Editor: Royal Society of Chemistry
DOI: 10.1039/d0lc01224f

Thermosensitive chitosan-based hydrogels supporting motor neuron-like NSC-34 cell differentiation

Autores: Stanzione, Antonella; Polini, Alessandro; La Pesa, Velia; Quattrini, Angelo; Gigli, Giuseppe; Moroni, Lorenzo; Gervaso, Francesca
Publicado en: Biomaterials Science, Edición 9, 2021, Página(s) 7492-7503, ISSN 2047-4830
Editor: Royal Society of Chemistry
DOI: 10.1039/d1bm01129d

A microfabricated multi‑compartment device for neuron and Schwann cell differentiation

Autores: De Vitis, Eleonora; La Pesa, Velia; Gervaso, Francesca; Romano, Alessandro; Quattrini, Angelo; Gigli, Giuseppe; Moroni, Lorenzo; Polini, Alessandro
Publicado en: Scientific reports, Edición 11, 2021, Página(s) 7019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-021-86300-4

Conference proceedings (2)

Development of bioprinted osteochondral tissue: an in-vitro model for drug discovery

Autores: Jahangir Shahrbanoo; Vecstaudža Jana; Canciani Elena; Ločs Jānis; Alini Mauro; Serra Tiziano
Publicado en: TERMIS 2022 Conference Book and Book Abstracts, 2023, Página(s) 191-192, ISSN 1937-3341
Editor: Mary Ann Liebert, Inc., publishers
DOI: 10.5281/zenodo.6587068

Amorphous calcium phosphate nanoparticles for development of 3D printing bio-inks for orthopaedic application

Autores: Vecstaudza, Jana; Locs, Janis
Publicado en: eCM Periodical, Edición 3, 2021, Página(s) 20, ISSN 2522-235X
Editor: AO Research Institute Davos
DOI: 10.5281/zenodo.6586447