From pathobioLogy to synoviA on chip: driving rheuMatoId arthritis to the precisioN medicine GOal

Informations projet

FLAMIN-GO

N° de convention de subvention: 953121

DOI

10.3030/953121

Projet clôturé

Date de signature de la CE 6 Novembre 2020

Date de début 1 Janvier 2021

Date de fin 31 Decembre 2025

Financé au titre de

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies

Coût total

Aucune donnée

Contribution de l’UE

€ 5 821 613,75

Coordonné par

UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO
Italy

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Websites, patent fillings, videos etc. (3)

Communication plan and dissemination plan

It will describe the project dissemination and communication strategies including the logo and graphical layout guidelines

Dissemination and communication package

It will contain all dissemination products prepared during the first reporting period RP1 1 all promotional materials developed and their distribution 2 snapshots describing the main sections of the project website 3 reference regarding all the social media used and any radio and TV broadcasts or press interviews 4 text of all the press releases published and the press conferences organized and related press review 5 the agenda of the attended events external to the project and the presentations given 6 the agenda presentations and customer satisfaction questionnaires regarding project events organized in P1 7 references to all publications produced in the reporting period 8 information on clustering activities

Dissemination and communication package - RP2

It will contain all dissemination products prepared during the second reporting period (RP2): 1) all promotional materials developed and their distribution; 2) snapshots describing the main sections of the project website; 3) reference regarding all the social media used, and any radio and TV broadcasts or press interviews; 4) text of all the press releases published and the press conferences organized and related press review; 5) the agenda of the attended events external to the project and the presentations given; 6) the agenda, presentations, and customer satisfaction questionnaires regarding project events organized in P1; 7) references to all publications produced in the reporting period; 8) information on clustering activities.

Publications

Peer reviewed articles (40)

Endothelial calcium firing mediates the extravasation of metastatic tumor cells

Auteurs: Marina Peralta, Amandine Dupas, Annabel Larnicol, Olivier Lefebvre, Ruchi Goswami, Tristan Stemmelen, Anne Molitor, Raphael Carapito, Salvatore Girardo, Naël Osmani, Jacky G. Goetz
Publié dans: iScience, Numéro 28, 2025, Page(s) 111690, ISSN 2589-0042
Éditeur: Elsevier BV
DOI: 10.1016/j.isci.2024.111690

Ph-Sensing Hydrogels for Non-Invasive Metabolism Monitoring in Tumor Spheroids

Auteurs: Riccardo Rizzo, Valentina Onesto, Giulia Morello, Helena Iuele, Francesca Scalera, Stefania Forciniti, Giuseppe Gigli, Alessandro Polini, Francesca Gervaso, Loretta L. del Mercato
Publié dans: Materials Today Bio, Numéro Volume 20, June 2023, 100655, 2023, ISSN 2590-0064
Éditeur: Elsevier
DOI: 10.2139/ssrn.4364505

Omics approaches open new horizons in major depressive disorder: from biomarkers to precision medicine

Auteurs: Fabiola Stolfi, Hugo Abreu, Riccardo Sinella, Sara Nembrini, Sara Centonze, Virginia Landra, Claudio Brasso, Giuseppe Cappellano, Paola Rocca, Annalisa Chiocchetti
Publié dans: Frontiers in Psychiatry, Numéro 15, 2024, ISSN 1664-0640
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2024.1422939

Design and Validation of MEDOC, a Tool to Assess the Combined Adherence to Mediterranean and Western Dietary Patterns

Auteurs: Camilla Barbero Mazzucca, Lorenza Scotti, Davide Raineri, Giuseppe Cappellano, Annalisa Chiocchetti
Publié dans: Nutrients, Numéro 16, 2025, Page(s) 1745, ISSN 2072-6643
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu16111745

VAT photopolymerization 3D printing optimization of high aspect ratio structures for additive manufacturing of chips towards biomedical applications

Auteurs: Alessio Bucciarelli, Xenia Paolelli, Eleonora De Vitis, Nora Selicato, Francesca Gervaso, Giuseppe Gigli, Lorenzo Moroni, Alessandro Polini
Publié dans: Additive Manufacturing, Numéro Volume 60, Part A, December 2022, 103200, 2022, ISSN 2214-8604
Éditeur: Elsevier BV
DOI: 10.1016/j.addma.2022.103200

Preparation and characterization of salt-mediated injectable thermosensitive chitosan/pectin hydrogels for cell embedding and culturing

Auteurs: Morello, Giulia; Polini, Alessandro; Scalera, Francesca; Rizzo, Riccardo; Gigli, Giuseppe; Gervaso, Francesca
Publié dans: Polymers, Numéro 13(16), 2021, Page(s) 2674, ISSN 2073-4360
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/polym13162674

Nano-Microparticle Platforms in Developing Next-Generation Vaccines

Auteurs: Giuseppe Cappellano; Hugo Abreu; Chiara Casale; Umberto Dianzani; Annalisa Chiocchetti
Publié dans: Vaccines, Numéro 9(6), 2021, Page(s) 606, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9060606

Nutrition and Rheumatoid Arthritis Onset: A Prospective Analysis Using the UK Biobank

Auteurs: Camilla Barbero Mazzucca; Lorenza Scotti; Giuseppe Cappellano; Francesco Barone-Adesi 3; Annalisa Chiocchetti
Publié dans: Nutrients, Numéro 14(8), 2022, Page(s) 1554, ISSN 2072-6643
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu14081554

My cells, my model: immune-competent autologous organ-on-chip systems as a new paradigm in precision medicine

Auteurs: Francesco Bisconti, Hugo Abreu, Thuy Duong Nguyen, Fabiola Stolfi, Noemi Corbezzolo, Giuseppe Gigli, Davide Raineri, Giuseppe Cappellano, Alessandro Polini, Francesca Gervaso, Annalisa Chiocchetti, nu
Publié dans: Frontiers in Immunology, Numéro 16, 2025, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/fimmu.2025.1712796

Calcium signaling dysregulation in rheumatoid arthritis: a comparative perspective with osteoarthritis

Auteurs: Thuy Duong Nguyen, Hugo Abreu, Nicoletta Tommasi, Luigi Azzarone, Rita Maria Concetta Di Martino, Beatrice Riva, Davide Raineri, Tracey Pirali, Annalisa Chiocchetti, Giuseppe Cappellano
Publié dans: Autoimmunity Reviews, Numéro 24, 2025, Page(s) 103923, ISSN 1568-9972
Éditeur: Elsevier BV
DOI: 10.1016/j.autrev.2025.103923

The Role of Diet in Multiple Sclerosis Onset: A Prospective Study Using UK Biobank

Auteurs: Camilla Barbero Mazzucca, Lorenza Scotti, Cristoforo Comi, Domizia Vecchio, Annalisa Chiocchetti, Giuseppe Cappellano
Publié dans: Nutrients, Numéro 16, 2025, Page(s) 1746, ISSN 2072-6643
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu16111746

An Assist for Arthritis Studies: A 3D Cell Culture of Human Fibroblast‐Like Synoviocytes by Encapsulation in a Chitosan‐Based Hydrogel

Auteurs: Francesco Bisconti, Beatrice Vilardo, Gaia Corallo, Francesca Scalera, Giuseppe Gigli, Annalisa Chiocchetti, Alessandro Polini, Francesca Gervaso
Publié dans: Advanced Therapeutics, Numéro 7, 2025, ISSN 2366-3987
Éditeur: Wiley
DOI: 10.1002/adtp.202400166

Highly sensitive ratiometric fluorescent fiber matrices for oxygen sensing with micrometer spatial resolution

Auteurs: Giuliana Grasso, Valentina Onesto, Stefania Forciniti, Eliana D’Amone, Francesco Colella, Lara Pierantoni, Valeria Famà, Giuseppe Gigli, Rui L. Reis, J. Miguel Oliveira, Loretta L. del Mercato
Publié dans: Bio-Design and Manufacturing, Numéro 7, 2024, Page(s) 292-306, ISSN 2096-5524
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/s42242-024-00277-3

Fluorescent nano- and microparticles for sensing cellular microenvironment: past, present and future applications

Auteurs: Grasso, Giuliana, Colella Francesco, Forciniti Stefania, Onesto Valentina, Iuele Helena, Siciliano Anna Chiara, Carnevali Federica, Chandra Anil, Gigli Giuseppe, del Mercato Loretta L.
Publié dans: Nanoscale Advances, Numéro 5, 2023, Page(s) 4311-4336, ISSN 2516-0230
Éditeur: RSC Publishing
DOI: 10.1039/d3na00218g

Chitosan and Pectin Hydrogels for Tissue Engineering and In Vitro Modeling

Auteurs: Morello Giulia, De Iaco Gianvito, Gigli Giuseppe, Polini Alessandro, Gervaso Francesca
Publié dans: Gels, Numéro 9(2), 2023, Page(s) 132, ISSN 2310-2861
Éditeur: MDPI
DOI: 10.3390/gels9020132

Micropathological Chip Modeling the Neurovascular Unit Response to Inflammatory Bone Condition

Auteurs: Estrela Neto; Ana C Monteiro; Catarina L Pereira; Miguel Simões; João P Conde; Virginia Chu; Bruno Sarmento; Meriem Lamghari
Publié dans: Advanced Healthcare Materials, Numéro 11(11), 2022, Page(s) 2102305, ISSN 2192-2640
Éditeur: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202102305

Modelling methacrylated chitosan hydrogel properties through an experimental design approach: from composition to material properties

Auteurs: Alessio Bucciarelli, Nora Selicato, Chiara Coricciati, Alberto Rainer, Agostina Lina Capodilupo, Giuseppe Gigli, Lorenzo Moroni, Alessandro Polini, Francesca Gervaso
Publié dans: Journal of Materials Chemistry B, Numéro 12, 2024, Page(s) 10221-10240, ISSN 2050-7518
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d4tb00670d

Shotgun Proteomics Links Proteoglycan-4+ Extracellular Vesicles to Cognitive Protection in Amyotrophic Lateral Sclerosis

Auteurs: Beatrice Vilardo, Fabiola De Marchi, Davide Raineri, Marcello Manfredi, Veronica De Giorgis, Alen Bebeti, Lorenza Scotti, Natasa Kustrimovic, Giuseppe Cappellano, Letizia Mazzini, Annalisa Chiocchetti
Publié dans: Biomolecules, Numéro 14, 2025, Page(s) 727, ISSN 2218-273X
Éditeur: MDPI AG
DOI: 10.3390/biom14060727

The Evolution of Technology‐Driven In Vitro Models for Neurodegenerative Diseases

Auteurs: Eleonora De Vitis, Antonella Stanzione, Alessandro Romano, Angelo Quattrini, Giuseppe Gigli, Lorenzo Moroni, Francesca Gervaso, Alessandro Polini
Publié dans: Advanced Science, Numéro 11, 2025, ISSN 2198-3844
Éditeur: Wiley
DOI: 10.1002/advs.202304989

Deep Flow Cytometry Unveils Distinct Immune Cell Subsets in Inducible T Cell Co-Stimulator Ligand (ICOSL)- and ICOS-Knockout Mice during Experimental Autoimmune Encephalomyelitis

Auteurs: Davide Raineri, Hugo Abreu, Beatrice Vilardo, Natasa Kustrimovic, Chiara Venegoni, Giuseppe Cappellano, Annalisa Chiocchetti
Publié dans: International Journal of Molecular Sciences, Numéro 25, 2025, Page(s) 2509, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25052509

Inducible T-Cell Costimulator Ligand Plays a Dual Role in Melanoma Metastasis upon Binding to Osteopontin or Inducible T-Cell Costimulator

Auteurs: Davide Raineri; Giuseppe Cappellano; Beatrice Vilardo; Federica Maione; Nausicaa Clemente; Elena Canciani; Elena Boggio; Casimiro Luca Gigliotti; Chiara Monge; Chiara Dianzani; Renzo Boldorini; Umberto Dianzani; Annalisa Chiocchetti
Publié dans: Biomedicines, Numéro 10(1), 2021, Page(s) 51, ISSN 2227-9059
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biomedicines10010051

How to Tackle the Relationship between Autoimmune Diseases and Diet: Well Begun Is Half-Done

Auteurs: Camilla Barbero Mazzucca; Davide Raineri; Giuseppe Cappellano; Annalisa Chiocchetti
Publié dans: Nutrients, Numéro 13(11), 2021, Page(s) 3956, ISSN 2072-6643
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13113956

A fluorescent ratiometric potassium sensor based on IPG4-silica microparticles for selective detection and fluorescence imaging of potassium cations

Auteurs: Francesco Colella, Stefania Forciniti, Valentina Onesto, Giuliana Grasso, Helena Iuele, Giuseppe Gigli, Loretta L. del Mercato
Publié dans: Journal of Materials Chemistry B, Numéro 12, 2024, Page(s) 10573-10583, ISSN 2050-7518
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d4tb01047g

High-throughput viscoelastic characterization of cells in hyperbolic microchannels

Auteurs: Felix Reichel, Ruchi Goswami, Salvatore Girardo, Jochen Guck
Publié dans: Lab on a Chip, Numéro 24, 2024, Page(s) 2440-2453, ISSN 1473-0197
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d3lc01061a

Circulating GLAST+ EVs are increased in amyotrophic lateral sclerosis

Auteurs: Davide Raineri, Fabiola De Marchi, Beatrice Vilardo, Camilla Barbero Mazzucca, Lorenza Scotti, Natasa Kustrimovic, Letizia Mazzini, Giuseppe Cappellano, Annalisa Chiocchetti
Publié dans: Frontiers in Molecular Biosciences, Numéro 11, 2024, ISSN 2296-889X
Éditeur: Frontiers Media SA
DOI: 10.3389/fmolb.2024.1507498

Viscoelastic properties of suspended cells measured with shear flow deformation cytometry

Auteurs: Gerum R., Mirzahossein E., Eroles M., Elsterer J., Mainka A., Bauer A., Sonntag S., Winterl A., Bartl J., Fischer L., Abuhattum S., Goswami R., Girardo S., Guck J., Schrüfer S., Ströhlein N., Nosratlo M., Herrmann H., Schultheis D., Rico F., Müller S. J., Gekle S., Fabry B.
Publié dans: Elife, Numéro 11, e78823, 2022, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.78823

High levels of circulating osteopontin in inflammatory lung disease regardless of Sars-CoV-2 infection

Auteurs: Giuseppe Cappellano, Hugo Abreu, Davide Raineri, Lorenza Scotti, Luigi Castello, Rosanna Vaschetto, Annalisa Chiocchetti
Publié dans: EMBO Molecular Medicine, Numéro 13(5), 2021, Page(s) e14124, ISSN 1757-4684
Éditeur: EMBO Press
DOI: 10.15252/emmm.202114124

Worse Disease Prognosis Is Associated to an Increase of Platelet-Derived Extracellular Vesicles in Hospitalized SARS-CoV-2 Patients

Auteurs: Raineri Davide, Venegoni Chiara, Calella Maria Grazia, Vaschetto Rosanna, Scotti Lorenza, Manfredi Marcello, Gavello Francesco, Castello Luigi, Chiocchetti Annalisa, Cappellano Giuseppe
Publié dans: Disease Markers, Numéro Volume 2022, Article ID 8074655, 2022, ISSN 0278-0240
Éditeur: IOS Press
DOI: 10.1155/2022/8074655

Human T-Cell Responses to Metallic Ion-Doped Bioactive Glasses

Auteurs: Hugo Abreu, Mari Lallukka, Marta Miola, Silvia Spriano, Enrica Vernè, Davide Raineri, Massimiliano Leigheb, Mario Ronga, Giuseppe Cappellano, Annalisa Chiocchetti
Publié dans: International Journal of Molecular Sciences, Numéro 25, 2025, Page(s) 4501, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25084501

Cell-Laden 3D Printed GelMA/HAp and THA Hydrogel Bioinks: Development of Osteochondral Tissue-like Bioinks

Auteurs: Jahangir S., Vecstaudza J., Augurio A., Canciani E., Stipniece L., Locs J., Alini M., Serra T.
Publié dans: Materials, Numéro 16(22), 2023, Page(s) 7214, ISSN 1996-1944
Éditeur: MDPI Open Access Publishing
DOI: 10.3390/ma16227214

Extracellular Vesicles in Musculoskeletal Regeneration: Modulating the Therapy of the Future

Auteurs: Abreu, Hugo; Canciani, Elena; Raineri, Davide; Cappellano, Giuseppe; Rimondini, Lia; Chiocchetti, Annalisa
Publié dans: Cells, Numéro 11(1), 2021, Page(s) 43, ISSN 2073-4409
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11010043

Probiotic-derived extracellular vesicles: the next breakthrough in postbiotics for rheumatoid arthritis

Auteurs: Federica Dell’Atti, Hugo Abreu, Patrizia Malfa, Davide Raineri, Giuseppe Cappellano, Annalisa Chiocchetti
Publié dans: Frontiers in Immunology, Numéro 16, 2025, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/fimmu.2025.1620185

Photo/thermo-sensitive chitosan and gelatin-based interpenetrating polymer network for mimicking muscle tissue extracellular matrix

Auteurs: Antonella Stanzione, Alessandro Polini, Francesca Scalera, Giuseppe Gigli, Lorenzo Moroni, Francesca Gervaso
Publié dans: Heliyon, Numéro 10, 2025, Page(s) e39820, ISSN 2405-8440
Éditeur: Elsevier BV
DOI: 10.1016/j.heliyon.2024.e39820

Image-based cell sorting using focused travelling surface acoustic waves

Auteurs: Ahmad Ahsan Nawaz, Despina Soteriou, Catherine K. Xu, Ruchi Goswami, Maik Herbig, Jochen Guck and Salvatore Girardo
Publié dans: Lab on Chip, Numéro Numéro 2, 2023, 2023, Page(s) 372-387, ISSN 1473-0189
Éditeur: RSC Publishing
DOI: 10.1039/d2lc00636g

Deep immunophenotyping of circulating immune cells in major depressive disorder patients reveals immune correlates of clinical course and treatment response

Auteurs: Fabiola Stolfi, Claudio Brasso, Davide Raineri, Virginia Landra, Camilla Barbero Mazzucca, Ali Ghazanfar, Lorenza Scotti, Riccardo Sinella, Vincenzo Villari, Giuseppe Cappellano, Paola Rocca, Annalisa
Publié dans: Brain, Behavior, & Immunity - Health, Numéro 43, 2025, Page(s) 100942, ISSN 2666-3546
Éditeur: Elsevier BV
DOI: 10.1016/j.bbih.2024.100942

The convergence of high-tech emerging technologies into the next stage of organ-on-a-chips

Auteurs: Polini, Alessandro; Moroni, Lorenzo
Publié dans: Biomaterials and Biosystems, Numéro 1, 2021, Page(s) 100012, ISSN 2666-5344
Éditeur: Elsevier BV
DOI: 10.1016/j.bbiosy.2021.100012

Evaluation of the immune response of peripheral blood mononuclear cells cultured on Ti6Al4V-ELI polished or etched surfaces

Auteurs: Hugo Abreu, Mari Lallukka, Davide Raineri, Massimiliano Leigheb, Mario Ronga, Giuseppe Cappellano, Silvia Spriano, Annalisa Chiocchetti
Publié dans: Frontiers in Bioengineering and Biotechnology, Numéro 12, 2024, ISSN 2296-4185
Éditeur: Frontiers Media SA
DOI: 10.3389/fbioe.2024.1458091

Efficient and gentle delivery of molecules into cells with different elasticity via Progressive Mechanoporation

Auteurs: Alena Uvizl; Ruchi Goswami; Shanil Gandhi; Martina Augsburg; Frank Buchholz; Jochen Guck; Jörg Mansfeld; Salvatore Girardo
Publié dans: Lab on a Chip, Numéro 21, 2021, Page(s) 2437-2452, ISSN 1473-0197
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0lc01224f

Thermosensitive chitosan-based hydrogels supporting motor neuron-like NSC-34 cell differentiation

Auteurs: Stanzione, Antonella; Polini, Alessandro; La Pesa, Velia; Quattrini, Angelo; Gigli, Giuseppe; Moroni, Lorenzo; Gervaso, Francesca
Publié dans: Biomaterials Science, Numéro 9, 2021, Page(s) 7492-7503, ISSN 2047-4830
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d1bm01129d

A microfabricated multi‑compartment device for neuron and Schwann cell differentiation

Auteurs: De Vitis, Eleonora; La Pesa, Velia; Gervaso, Francesca; Romano, Alessandro; Quattrini, Angelo; Gigli, Giuseppe; Moroni, Lorenzo; Polini, Alessandro
Publié dans: Scientific reports, Numéro 11, 2021, Page(s) 7019, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-021-86300-4

Conference proceedings (2)

Development of bioprinted osteochondral tissue: an in-vitro model for drug discovery

Auteurs: Jahangir Shahrbanoo; Vecstaudža Jana; Canciani Elena; Ločs Jānis; Alini Mauro; Serra Tiziano
Publié dans: TERMIS 2022 Conference Book and Book Abstracts, 2023, Page(s) 191-192, ISSN 1937-3341
Éditeur: Mary Ann Liebert, Inc., publishers
DOI: 10.5281/zenodo.6587068

Amorphous calcium phosphate nanoparticles for development of 3D printing bio-inks for orthopaedic application

Auteurs: Vecstaudza, Jana; Locs, Janis
Publié dans: eCM Periodical, Numéro 3, 2021, Page(s) 20, ISSN 2522-235X
Éditeur: AO Research Institute Davos
DOI: 10.5281/zenodo.6586447