Mechanistic Integration of vascular aND endocrine pathways for Subtyping Hypertension: an Innovative network approach for Future generation research Training

Project Information

MINDSHIFT

Grant agreement ID: 954798

DOI

10.3030/954798

Project closed

EC signature date 18 August 2020

Start date 1 January 2021

End date 31 March 2025

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 4 124 385,00

EU contribution

€ 4 124 385,00

Coordinated by

UNIVERSITEIT MAASTRICHT
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Other (4)

Media exposure of the MINDSHIFT Action as initiative for European School for Hypertension Research
ESR outreach activities

ESR outreach activities at e.g. secondary schools to create awareness for vascular health issues and research

Recruitment procedure installed

Recruitment procedure installed at all beneficiaries

Bioscientifica journal Special Issue

Publication of outcome/highlights of MINDSHIFT in Bioscientifica journal Special Issue

Websites, patent fillings, videos etc. (2)

Social media

MINDSHIFT social media pages installed by the ESR Committee

MINDSHIFT website

MINDSHIFT website including public course programme updates scheduled around general meetings Development website in M1 update until after the end of the programme M48

Publications

Book chapters (2)

Chronic Kidney Disease and the Exposome of Ageing

Author(s): Paul Shiels, Ngoc Tran, Jen McCavitt, Ognian Neytchev, Peter Stenvinkel
Published in: Subcellular Biochemistry, Biochemistry and Cell Biology of Ageing: Part IV, Clinical Science, 2023, Page(s) 79-94
Publisher: Springer International Publishing
DOI: 10.1007/978-3-031-26576-1_5

MicroRNAs in aldosterone production and action

Author(s): Scott M. MacKenzie, Lara A. Birch, Stelios Lamprou, Parisa Rezvanisanijouybari, May Fayad, Maria-Christina Zennaro, Eleanor Davies
Published in: Vitamins and Hormones, Adrenal Gland, 2024, Page(s) 137-163, ISBN 9780443194009
Publisher: Elsevier
DOI: 10.1016/bs.vh.2023.07.001

Peer reviewed articles (29)

Endothelin antagonists and the quest for a new therapeutic option in resistant hypertension

Author(s): Ralf Dechend; Christian Delles
Published in: The Lancet, 2022, ISSN 0140-6736
Publisher: The Lancet Publishing Group
DOI: 10.1016/s0140-6736(22)02181-x

Effect of rapid cooling, frozen storage, and thawing on the passive viscoelastic properties and structure of the rat aorta

Author(s): Koen W.F. van der Laan, Koen D. Reesink, Sara Lambrichts, Nicole J.J.E. Bitsch, Laura van der Taelen, Sébastien Foulquier, Tammo Delhaas, Bart Spronck, Alessandro Giudici
Published in: Journal of Biomechanics, Issue 171, 2024, Page(s) 112190, ISSN 0021-9290
Publisher: Elsevier BV
DOI: 10.1016/j.jbiomech.2024.112190

The Ultrasound Window Into Vascular Ageing: A Technology Review by the <scp>VascAgeNet COST</scp> Action

Author(s): Elisabetta Bianchini, Andrea Guala, Spyretta Golemati, Jordi Alastruey, Rachel E. Climie, Kalliopi Dalakleidi, Martina Francesconi, Dieter Fuchs, Yvonne Hartman, Afrah E.F. Malik, Monika Makūnaitė, Konstantina S. Nikita, Chloe Park, Christopher J. A. Pugh, Agnė Šatrauskienė, Dimitrios Terentes‐Printizios, Alexandra Teynor, Dick Thijssen, Arno Schmidt‐Trucksäss, Jūratė Zupkauskienė, Pi
Published in: Journal of Ultrasound in Medicine, Issue 42, 2023, Page(s) 2183-2213, ISSN 0278-4297
Publisher: American Institute for Ultrasound in Medicine
DOI: 10.1002/jum.16243

Ageing – Oxidative stress, PTMs and disease

Author(s): Ebert T, Tran N, Schurgers L, Stenvinkel P, Shiels PG
Published in: Molecular Aspects of Medicine, 2022, ISSN 0098-2997
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.mam.2022.101099

Blood pressure measurement technique in clinical practice in the NHS Greater Glasgow and Clyde

Author(s): Dellaneira Setjiadi, Colin Geddes, Christian Delles
Published in: Journal of Human Hypertension, 2024, ISSN 1476-5527
Publisher: Springer Nature
DOI: 10.1038/s41371-024-00984-5

Radiomics Feature Extraction from Ultrasound B-Mode Images and Radio-Frequency Signals of the Carotid Arterial Wall: A Feasibility Study

Author(s): Maryam Jadoon, Federica Poli, Pierre Boutouyrie, Hakim Khettab, Elisabetta Bianchini, Francesco Faita, Xavier Jouven, Jean Philippe Empana, Rosa Maria Bruno
Published in: Artery Research, Issue 31, 2025, ISSN 1876-4401
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s44200-025-00076-w

Elevated blood pressure accelerates white matter brain aging among late middle-aged women: a Mendelian Randomization study in the UK Biobank

Author(s): Li Feng, Zhenyao Ye, Chen Mo, Jingtao Wang, Song Liu, Si Gao, Hongjie Ke, Travis A. Canida, Yezhi Pan, Marleen M.J. van Greevenbroek, Alfons J.H.M. Houben, Kai Wang, Kathryn S. Hatch, Yizhou Ma, David K.Y. Lei, Chixiang Chen, Braxton D. Mitchell, L. Elliot Hong, Peter Kochunov, Shuo Chen, Tianzhou Ma
Published in: Journal of Hypertension, Issue 41, 2024, Page(s) 1811-1820, ISSN 0263-6352
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/hjh.0000000000003553

Central and local arterial stiffness in White Europeans compared to age-, sex-, and BMI-matched South Asians

Author(s): Koen M. van der Sluijs, Jos Thannhauser, Iris M. Visser, P. M. Nabeel, Kiran V. Raj, Afrah E. F. Malik, Koen D. Reesink, Thijs M. H. Eijsvogels, Esmée A. Bakker, Prabhdeep Kaur, Jayaraj Joseph, Dick H. J. Thijssen
Published in: PLOS ONE, Issue 18, 2023, Page(s) e0290118, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0290118

Modulation of Calcium Signaling on Demand to Decipher the Molecular Mechanisms of Primary Aldosteronism

Author(s): Bakhta Fedlaoui, Teresa Cosentino, Zeina R. Al Sayed, Rita Alexandre Coelho, Isabelle Giscos-Douriez, Nicolo Faedda, May Fayad, Jean-Sebastien Hulot, Chris Magnus, Scott M. Sternson, Simon Travers-Allard, Stephanie Baron, David Penton, Fabio L. Fernandes-Rosa, Maria-Christina Zennaro, Sheerazed Boulkroun
Published in: Hypertension, 2025, ISSN 0194-911X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.124.23295

Type II Muscle Fiber Capillarization Is an Important Determinant of Post-Exercise Microvascular Perfusion in Older Adults

Author(s): Milan W. Betz, Floris K. Hendriks, Alfons J.H.M. Houben, Mathias D.G. van den Eynde, Lex B. Verdijk, Luc J.C. van Loon, Tim Snijders
Published in: Gerontology, Issue 70, 2024, Page(s) 290-301, ISSN 0304-324X
Publisher: S. Karger AG
DOI: 10.1159/000535831

Complement factors D and C3 cross-sectionally associate with arterial stiffness, but not independently of metabolic risk factors: The Maastricht Study

Author(s): Shunxin Jin, Koen D. Reesink, Abraham A. Kroon, Bastiaan de Galan, Carla J.H. van der Kallen, Anke Wesselius, Casper G. Schalkwijk, Coen D.A. Stehouwer, Marleen M.J. van Greevenbroek
Published in: Journal of Hypertension, Issue 40, 2024, Page(s) 2161-2170, ISSN 0263-6352
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/hjh.0000000000003237

Pickering Syndrome: An Overlooked Renovascular Cause of Recurrent Heart Failure

Author(s): Viola Sanga, Eleonora Bertoli, Filippo Crimì, Giulio Barbiero, Michele Battistel, Teresa Maria Seccia, Gian Paolo Rossi
Published in: Journal of the American Heart Association, Issue 12, 2024, ISSN 2047-9980
Publisher: Wiley-Blackwell
DOI: 10.1161/jaha.123.030474

Finerenone protects against progression of kidney and cardiovascular damage in a model of type 1 diabetes through modulation of proinflammatory and osteogenic factors.

Author(s): Sanz-Gómez M, Manzano-Lista FJ, Vega-Martín E, González-Moreno D, Alcalá M, Gil-Ortega M, Somoza B, Pizzamiglio C, Ruilope LM, Aránguez I, Kolkhof P, Kreutz R, Fernández-Alfonso MS
Published in: Biomedicine&Pharmacotherapy, Issue 168, 2023, ISSN 0753-3322
Publisher: Elsevier Masson
DOI: 10.1016/j.biopha.2023.115661

Upregulation in Inflammation and Collagen Expression in Perirenal but Not in Mesenteric Adipose Tissue from Diabetic Munich Wistar Frömter Rats

Author(s): Vega-Martín E, González-Moreno D, Sanz-Gómez M, Guzmán-Aguayo AK, Manzano-Lista FJ, Schulz A, Aránguez I, Kreutz R, Fernández-Alfonso MS
Published in: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242317008

Subclassification of obesity for precision prediction of cardiometabolic diseases

Author(s): Daniel E. Coral, Femke Smit, Ali Farzaneh, Alexander Gieswinkel, Juan Fernandez Tajes, Thomas Sparsø, Carl Delfin, Pierre Bauvin, Kan Wang, Marinella Temprosa, Diederik De Cock, Jordi Blanch, José Manuel Fernández-Real, Rafael Ramos, M. Kamran Ikram, Maria F. Gomez, Maryam Kavousi, Marina Panova-Noeva, Philipp S. Wild, Carla van der Kallen, Michiel Adriaens, Marleen van Greevenbroek, Ilja Arts,
Published in: Nature Medicine, Issue 31, 2025, Page(s) 534-543, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-024-03299-7

Role of Inflammatory and Proresolving Mediators in Endothelial Dysfunction

Author(s): Ana M. Briones, Raquel Hernanz, Ana B. García‐Redondo, Cristina Rodríguez, Luis M. Blanco‐Colio, Almudena Val‐Blasco, María J. Alonso, Mercedes Salaices
Published in: Basic &amp; Clinical Pharmacology &amp; Toxicology, Issue 136, 2025, ISSN 1742-7835
Publisher: Nordic Pharmacological Society
DOI: 10.1111/bcpt.70026

Nanobody-thioesterase chimeras to specifically target protein palmitoylation

Author(s): Chien-Wen Kuo, Caglar Gök, Hannah Fulton, Eleanor Dickson-Murray, Samuel Adu, Emily K. Gallen, Sheon Mary, Alan D. Robertson, Fiona Jordan, Emma Dunning, William Mullen, Godfrey L. Smith, William Fuller
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-56716-x

Specialized Pro-Resolving Lipid Mediators: New Therapeutic Approaches for Vascular Remodeling

Author(s): Díaz Del Campo LS, Rodrigues-Díez R, Salaices M, Briones AM, García-Redondo AB
Published in: Int J Mol Sci, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23073592

Intracellular Calcium Dynamics in Primary Human Adrenocortical Cells Deciphered with a Novel Pipeline

Author(s): Hala Ajjour, Giorgia Pallafacchina, Livia Lenzini, Brasilina Caroccia, Gian Paolo Rossi
Published in: High Blood Pressure &amp; Cardiovascular Prevention, Issue 31, 2024, Page(s) 299-308, ISSN 1179-1985
Publisher: Springer
DOI: 10.1007/s40292-024-00641-5

Resolvin D2 Attenuates Cardiovascular Damage in Angiotensin II-Induced Hypertension

Author(s): Lucia S. Díaz del Campo, Ana B. García-Redondo, Cristina Rodríguez, Carlos Zaragoza, Santiago Duro-Sánchez, Francesco Palmas, Angela de Benito-Bueno, Paula G. Socuéllamos, Diego A. Peraza, Raquel Rodrigues-Díez, Carmen Valenzuela, Jesmond Dalli, Mercedes Salaices, Ana M. Briones
Published in: Hypertension, Issue 80, 2024, Page(s) 84-96, ISSN 0194-911X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.122.19448

The MAASWERP Study: An International, Comparative Case Study on Measuring Biomechanics of the Aged Murine Aorta

Author(s): Cédric H.G. Neutel, Koen W.F. van der Laan, Callan D. Wesley, Dustin N. Krüger, Margarita G. Pencheva, Casper G. Schalkwijk, Guido R.Y. De Meyer, Wim Martinet, Tammo Delhaas, Koen D. Reesink, Alessandro Giudici, Pieter-Jan Guns, Bart Spronck
Published in: Pulse, Issue 13, 2025, Page(s) 1-10, ISSN 2235-8676
Publisher: S. Karger AG
DOI: 10.1159/000542694

2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension

Author(s): Giuseppe Mancia, Reinhold Kreutz, Mattias Brunström, Michel Burnier, Guido Grassi, Andrzej Januszewicz, Maria Lorenza Muiesan, Konstantinos Tsioufis, Enrico Agabiti-Rosei, Engi Abd Elhady Algharably, Michel Azizi, Athanase Benetos, Claudio Borghi, Jana Brguljan Hitij, Renata Cifkova, Antonio Coca, Veronique Cornelissen, J. Kennedy Cruickshank, Pedro G. Cunha, A.H. Jan Danser, Rosa Maria de Pinho,
Published in: Journal of Hypertension, Issue 41, 2024, Page(s) 1874-2071, ISSN 0263-6352
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/hjh.0000000000003480

El gen estimulado por interferón 15 (ISG15) modula el fenotipo de células musculares lisas vasculares y el remodelado vascular patológico

Author(s): Julius Soudant, Raquel González-Blázquez, Abraham Merino, Constanza Ballesteros-Martínez, Raquel Rodrigues-Diez, Rosa Moreno-Carriles, J. Francisco Nistal, Susana Guerra, Juan Miguel Redondo, Mercedes Salaices, Ana M. Briones, Ana B. García-Redondo
Published in: Clínica e Investigación en Arteriosclerosis, 2025, Page(s) 500769, ISSN 0214-9168
Publisher: Ediciones Doyma S.A.
DOI: 10.1016/j.arteri.2025.500769

Maternally inherited essential hypertension: adding further complexity to an already complex condition.

Author(s): Delles, Christian
Published in: American Journal of Hypertension, Issue 1, 2022, ISSN 0895-7061
Publisher: Oxford University Press
DOI: 10.1093/ajh/hpab133

Nailfold video-capillaroscopy in the study of cardiovascular disease: a systematic review

Author(s): Matthew W.S. Lim, Dellaneira Setjiadi, Stephen J.H. Dobbin, Ninian N. Lang, Christian Delles, Paul J. Connelly
Published in: Blood Pressure Monitoring, 2024, ISSN 1359-5237
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/mbp.0000000000000624

Resolvin D2 prevents vascular remodeling, hypercontractility and endothelial dysfunction in obese hypertensive mice through modulation of vascular and proinflammatory factors

Author(s): Raquel Rodrigues-Diez, Constanza Ballesteros-Martinez, Rosa María Moreno-Carriles, Francisco Nistal, Lucía S. Díaz del Campo, Victoria Cachofeiro, Jesmond Dalli, Ana B. García-Redondo, Juan M. Redondo, Mercedes Salaices, Ana M. Briones
Published in: Biomedicine &amp; Pharmacotherapy, Issue 174, 2024, Page(s) 116564, ISSN 0753-3322
Publisher: Elsevier Masson
DOI: 10.1016/j.biopha.2024.116564

Circulating immune cells in cerebral small vessel disease: a systematic review

Author(s): L. Van der Taelen, A. M. Briones, T. Unger, J. Staals, R. J. van Oostenbrugge, S. Foulquier
Published in: Biogerontology, Issue 26, 2025, ISSN 1389-5729
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10522-025-10250-x

Capillary rarefaction: a missing link in renal and cardiovascular disease?

Author(s): Floor M. E. G. Steegh, Anke A. Keijbeck, Patrick A. de Hoogt, Timo Rademakers, Alfons J. H. M. Houben, Koen D. Reesink, Coen D. A. Stehouwer, Mat J. A. P. Daemen, Carine J. Peutz-Kootstra
Published in: Angiogenesis, Issue 27, 2024, Page(s) 23-35, ISSN 0969-6970
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10456-023-09883-8

Double CYP11B1/CYP11B2 Immunohistochemistry and Detection of KCNJ5 Mutations in Primary Aldosteronism

Author(s): Brasilina Caroccia, Livia Lenzini, Giulio Ceolotto, Francesca Gioco, Andrea Benetti, Alessandra Giannella, Hala Ajjour, Francesca Galuppini, Gianmaria Pennelli, Teresa Maria Seccia, Celso Gomez-Sanchez, Gian Paolo Rossi
Published in: The Journal of Clinical Endocrinology &amp; Metabolism, Issue 109, 2025, Page(s) 2433-2443, ISSN 0021-972X
Publisher: The Endocrine Society
DOI: 10.1210/clinem/dgae411