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European Network Linking Informatics and Genomics of Helper T cells in Tissues

Project description

Training the next generation of immunologists in Big Data analysis

Omics technologies have revolutionised both basic and clinical science, transforming Big Data into a challenging field. As a result, there is a pressing need for researchers capable of interpreting, integrating and exploiting this vast source of information. The EU-funded ENLIGHT-TENplus project aims to generate qualified individuals who possess the immunology background combined with bioinformatics expertise to analyse omics data. The scientific focus of these early-stage researchers will be to identify factors that shape the functional properties of tissue-resident T cells. The project's findings will contribute to the exploitation of the therapeutic potential of these cells especially in various human autoimmune diseases.

Objective

ENLIGHT-TEN+ is a European Network Linking Informatics and Genomics of Helper T cells in Tissues: A crucial missing link in our current research environment is the lack of qualified individuals who possess the immunology skills to recognise and define important scientific questions amenable to -omics approaches, and also the bioinformatic expertise to interrogate and interpret the resulting Big Data appropriately. Thus, our mission is to provide cross-disciplinary training for a new generation of enthusiastic researchers who have in-depth understanding of T cell immunology and are also capable to handle large datasets. Our network of 15 beneficiaries from 10 European countries combines expertise on T cell biology with state-of-the-art technologies generating Big Data, cutting-edge bioinformatic tools including artificial intelligence, preclinical models and samples from patient cohorts. ENLIGHT-TEN+ will identify microenvironmental factors shaping the functional properties of tissue-resident T cells, which offer important therapeutic potential in various human autoimmune diseases, making them a key target for pharmaceutical companies. 15 early-stage researchers (ESRs) will be empowered to push our knowledge of tissue-resident T cells beyond the state-of-the-art which will enable the identification of novel biomarkers and support the development of advanced therapeutic concepts. The generation of Big Data is an emerging and challenging field, and there is high demand in both the academic and industrial sector for researchers to be able to analyse, integrate and exploit this rich source of information. ENLIGHT-TEN+ will combine individual strengths of innovative laboratories and enterprises from complementary disciplines to provide unique interdisciplinary training as an ideal stepping-stone for the ESRs to enter and strengthen Europe’s academia as well as pharmaceutical and bioinformatics companies, thereby placing them at the forefront of this emerging field.

Coordinator

HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
Net EU contribution
€ 252 788,40
Address
INHOFFENSTRASSE 7
38124 Braunschweig
Germany

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Region
Niedersachsen Braunschweig Braunschweig, Kreisfreie Stadt
Activity type
Research Organisations
Links
Total cost
€ 252 788,40

Participants (15)