Cartilaginous tissue regeneration by non-viral gene therapy; taking the hurdles towards efficient delivery

Project Information

CARTHAGO

Grant agreement ID: 955335

DOI

10.3030/955335

Project closed

EC signature date 2 September 2020

Start date 1 September 2020

End date 31 August 2024

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 3 744 185,53

EU contribution

€ 3 744 185,53

Coordinated by

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (5)

Reviews
Press Release about the Kick-off meeting
Website
CARTHAGO Movie

CARTHAGO Movie (prepared by the ESRs)

Information for lay people, including patients, included in website

Documents, reports (4)

Overall recruitment

Overall recruitment (advertising vacancies, etc.)

Good Practices Report
Draft framework for incorporation of ethics research in biotechnology research

ESR15: Draft framework for incorporation of ethics research in biotechnology research, including 3 manuscripts for submission on ethics of CARTHAGO technologies as example

Updated Network-training programme

Updated Networktraining programme

Publications

Peer reviewed articles (18)

Exploring Microemulsion Systems for the Incorporation of Glucocorticoids into Bacterial Cellulose: A Novel Approach for Anti-Inflammatory Wound Dressings

Author(s): Paul Zahel, Vera Bruggink, Juliana Hülsmann, Frank Steiniger, Robert K. Hofstetter, Thorsten Heinzel, Uwe Beekmann, Oliver Werz, Dana Kralisch
Published in: Pharmaceutics, Issue 16, 2024, Page(s) 504, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics16040504

Unveiling extracellular matrix assembly : Insights and approaches through bioorthogonal chemistry

Author(s): Tavakoli, Shima; Evans, Austin; Oommen, Oommen P.; Creemers, Laura; Nandi, Jharna Barman; Hilborn, Jöns; Varghese, Oommen P.
Published in: Materials Today Bio, Issue 22, 2023, Page(s) 100768, ISSN 2590-0064
Publisher: Elsevier
DOI: 10.1016/j.mtbio.2023.100768

A Modular Albumin-Oligonucleotide Biomolecular Assembly for Delivery of Antisense Therapeutics

Author(s): Marwa Elkhashab, Yeter Dilek, Morten Foss, Laura B. Creemers, and Kenneth A. Howard
Published in: Mol Pharmaceutics, Issue 21, 2024, Page(s) 491-500, ISSN 1543-8384
Publisher: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.3c00561

The Added Value of the “Co” in Co-Culture Systems in Research on Osteoarthritis Pathology and Treatment Development

Author(s): Katrin Agnes Muenzebrock, Valerie Kersten, Jacqueline Alblas, Joao Pedro Garcia and Laura B. Creemers
Published in: Frontiers in Bioengineering and Biotechnology, Issue 03, 2022, ISSN 2296-4185
Publisher: Frontiers Media
DOI: 10.3389/fbioe.2022.843056

Polymeric Nanoparticles for Drug Delivery in Osteoarthritis.

Author(s): Adriano P. Pontes; Tim J. M. Welting; Jaap Rip; Laura B. Creemers.
Published in: Pharmaceutics, Issue 14 (12), 2022, Page(s) 2639, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14122639

A quality by design approach to optimise disulfide-linked hyaluronic acid hydrogels.

Author(s): Saketh Reddy Ranamalla, Shima Tavakoli, Alina Silvia Porfire, Lucia Ruxandra Tefas, Manuela Banciu, Ioan Tomuța, Oommen P Varghese.
Published in: Carbohydrate Polymers, Issue 339, 2024, Page(s) 1122251, ISSN 0144-8617
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.carbpol.2024.122251

An Albumin-Holliday Junction Biomolecular Modular Design for Programmable Multifunctionality and Prolonged Circulation

Author(s): Anders Dinesen, Veronica L. Andersen, Marwa Elkhashab, Diego Pilati, Pernille Bech, Elisabeth Fuchs, Torbjørn R. Samuelsen, Alexander Winther, Yunpeng Cai, Anders Märcher, Archie Wall, Marjan Omer, Jesper S. Nielsen, Vijay Chudasama, James R. Baker, Kurt V. Gothelf, Jesper Wengel, Jørgen Kjems, Kenneth A. Howard
Published in: Bioconjugate Chemistry, Issue 35, 2024, Page(s) 214-222, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.3c00491

Cell uptake and intracellular trafficking of bioreducible poly(amidoamine) nanoparticles for efficient mRNA translation in chondrocytes

Author(s): Adriano P. Pontes; Steffen van der Wal; Saketh R. Ranamalla; Karin Roelofs; Ioan Tomuta; Laura B. Creemers; Jaap Rip
Published in: Front. Bioeng. Biotechnol, Issue 11, 2023, ISSN 2296-4185
Publisher: Frontiers Media S.A.
DOI: 10.3389/fbioe.2023.1290871

Physically and Chemically Crosslinked Hyaluronic Acid-Based Hydrogels Differentially Promote Axonal Outgrowth from Neural Tissue Cultures

Author(s): Andrej Bajic, Brittmarie Andersson, Alexander Ossinger, Shima Tavakoli, Oommen P. Varghese, Nikos Schizas
Published in: Biomimetics, Issue 9, 2024, Page(s) 140, ISSN 2313-7673
Publisher: MDPI
DOI: 10.3390/biomimetics9030140

How to embed ethics into laboratory research

Author(s): Buedo P, Odziemczyk I, Perek-Białas J, Waligora M
Published in: Accountability in Research, 2023, Page(s) 1-19, ISSN 0898-9621
Publisher: Taylor & Francis
DOI: 10.1080/08989621.2023.2165916

Dynamic covalent crosslinked hyaluronic acid hydrogels and nanomaterials for biomedical applications

Author(s): Shujiang Wang, Shima Tavakoli, Rohith Pavan Parvathaneni, Ganesh N. Nawale, Oommen P. Oommen, Jöns Hilborna and Oommen P. Varghese
Published in: Biomaterials Science, 2022, ISSN 1473-7604
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2bm01154a

Noggin inhibits TGF-β1 OR TGF-β3 induced chondrogenesis of mesenchymal stromal cells

Author(s): L Wen, AR Armiento, AG Guex, S Grad, L Creemers, MJ Stoddart
Published in: European Cells & Materials, Issue 47, 2024, Page(s) 142-151, ISSN 1473-2262
Publisher: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v047a10

A poly(amidoamine)-based polymeric nanoparticle platform for efficient in vivo delivery of mRNA.

Author(s): Adriano P. Pontes, Steffen van der Wal, Karin Roelofs, Anne Grobbink, Laura B. Creemers, Johan F.J. Engbersen, Jaap Rip
Published in: Biomaterials Advances, Issue Volume 156, January 2024, 2024, Page(s) 213713, ISSN 2772-9508
Publisher: Elsevier B.V.
DOI: 10.1016/j.bioadv.2023.213713

Bioethics of somatic gene therapy: what do we know so far?

Author(s): Buedo P, Bianchini A, Klas K, Waligora M.
Published in: Curr Med Res Opin, Issue Sep 29, 2023, Page(s) 1-17, ISSN 0300-7995
Publisher: Librapharm Ltd.
DOI: 10.1080/03007995.2023.2257600

More ethics in the laboratory, please! Scientists’ perspectives on ethics in the preclinical phase

Author(s): Buedo P, Prieto E, Perek-Białas J, Odziemczyk-Stawarz I, Waligora M
Published in: Accountability in Research, 2024, Page(s) 1-16, ISSN 0898-9621
Publisher: Taylor & Francis
DOI: 10.1080/08989621.2023.2294996

Polymeric Nanoparticles Enable mRNA Transfection and Its Translation in Intervertebral Disc and Human Joint Cells, Except for M1 Macrophages

Author(s): Katrin Agnes Muenzebrock, Fiona Y. W. Ho, Adriano P. Pontes, Carla Jorquera-Cordero, Lizette Utomo, Joao Pedro Garcia, Paul C. Willems, Tim J. M. Welting, Jaap Rip, Laura B. Creemers
Published in: Pharmaceutics, Issue 16, 2024, Page(s) 438, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics16040438

An Overview of the Supramolecular Systems for Gene and Drug Delivery in Tissue Regeneration

Author(s): Saketh Reddy Ranamalla, Alina Silvia Porfire, Ioan Tomuță, Manuela Banciu
Published in: Pharmaceutics, Issue 14 (8), 2022, Page(s) 1733, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14081733

Fine-tuning Dynamic Cross–linking for Enhanced 3D Bioprinting of Hyaluronic Acid Hydrogels

Author(s): Shima Tavakoli, Nithiyanandan Krishnan, Hamidreza Mokhtari, Oommen P. Oommen, Oommen P. Varghese
Published in: Advanced Functional Materials, Issue 34,4, 2024, Page(s) 2307040-2307059, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202307040