Cartilaginous tissue regeneration by non-viral gene therapy; taking the hurdles towards efficient delivery

Información del proyecto

CARTHAGO

Identificador del acuerdo de subvención: 955335

DOI

10.3030/955335

Proyecto cerrado

Fecha de la firma de la CE 2 Septiembre 2020

Fecha de inicio 1 Septiembre 2020

Fecha de finalización 31 Agosto 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 3 744 185,53

Aportación de la UE

€ 3 744 185,53

Coordinado por

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (5)

Reviews
Press Release about the Kick-off meeting
Website
CARTHAGO Movie

CARTHAGO Movie (prepared by the ESRs)

Information for lay people, including patients, included in website

Documents, reports (4)

Overall recruitment

Overall recruitment (advertising vacancies, etc.)

Good Practices Report
Draft framework for incorporation of ethics research in biotechnology research

ESR15: Draft framework for incorporation of ethics research in biotechnology research, including 3 manuscripts for submission on ethics of CARTHAGO technologies as example

Updated Network-training programme

Updated Networktraining programme

Publicaciones

Peer reviewed articles (18)

Exploring Microemulsion Systems for the Incorporation of Glucocorticoids into Bacterial Cellulose: A Novel Approach for Anti-Inflammatory Wound Dressings

Autores: Paul Zahel, Vera Bruggink, Juliana Hülsmann, Frank Steiniger, Robert K. Hofstetter, Thorsten Heinzel, Uwe Beekmann, Oliver Werz, Dana Kralisch
Publicado en: Pharmaceutics, Edición 16, 2024, Página(s) 504, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics16040504

Unveiling extracellular matrix assembly : Insights and approaches through bioorthogonal chemistry

Autores: Tavakoli, Shima; Evans, Austin; Oommen, Oommen P.; Creemers, Laura; Nandi, Jharna Barman; Hilborn, Jöns; Varghese, Oommen P.
Publicado en: Materials Today Bio, Edición 22, 2023, Página(s) 100768, ISSN 2590-0064
Editor: Elsevier
DOI: 10.1016/j.mtbio.2023.100768

A Modular Albumin-Oligonucleotide Biomolecular Assembly for Delivery of Antisense Therapeutics

Autores: Marwa Elkhashab, Yeter Dilek, Morten Foss, Laura B. Creemers, and Kenneth A. Howard
Publicado en: Mol Pharmaceutics, Edición 21, 2024, Página(s) 491-500, ISSN 1543-8384
Editor: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.3c00561

The Added Value of the “Co” in Co-Culture Systems in Research on Osteoarthritis Pathology and Treatment Development

Autores: Katrin Agnes Muenzebrock, Valerie Kersten, Jacqueline Alblas, Joao Pedro Garcia and Laura B. Creemers
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 03, 2022, ISSN 2296-4185
Editor: Frontiers Media
DOI: 10.3389/fbioe.2022.843056

Polymeric Nanoparticles for Drug Delivery in Osteoarthritis.

Autores: Adriano P. Pontes; Tim J. M. Welting; Jaap Rip; Laura B. Creemers.
Publicado en: Pharmaceutics, Edición 14 (12), 2022, Página(s) 2639, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14122639

A quality by design approach to optimise disulfide-linked hyaluronic acid hydrogels.

Autores: Saketh Reddy Ranamalla, Shima Tavakoli, Alina Silvia Porfire, Lucia Ruxandra Tefas, Manuela Banciu, Ioan Tomuța, Oommen P Varghese.
Publicado en: Carbohydrate Polymers, Edición 339, 2024, Página(s) 1122251, ISSN 0144-8617
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.carbpol.2024.122251

An Albumin-Holliday Junction Biomolecular Modular Design for Programmable Multifunctionality and Prolonged Circulation

Autores: Anders Dinesen, Veronica L. Andersen, Marwa Elkhashab, Diego Pilati, Pernille Bech, Elisabeth Fuchs, Torbjørn R. Samuelsen, Alexander Winther, Yunpeng Cai, Anders Märcher, Archie Wall, Marjan Omer, Jesper S. Nielsen, Vijay Chudasama, James R. Baker, Kurt V. Gothelf, Jesper Wengel, Jørgen Kjems, Kenneth A. Howard
Publicado en: Bioconjugate Chemistry, Edición 35, 2024, Página(s) 214-222, ISSN 1043-1802
Editor: American Chemical Society
DOI: 10.1021/acs.bioconjchem.3c00491

Cell uptake and intracellular trafficking of bioreducible poly(amidoamine) nanoparticles for efficient mRNA translation in chondrocytes

Autores: Adriano P. Pontes; Steffen van der Wal; Saketh R. Ranamalla; Karin Roelofs; Ioan Tomuta; Laura B. Creemers; Jaap Rip
Publicado en: Front. Bioeng. Biotechnol, Edición 11, 2023, ISSN 2296-4185
Editor: Frontiers Media S.A.
DOI: 10.3389/fbioe.2023.1290871

Physically and Chemically Crosslinked Hyaluronic Acid-Based Hydrogels Differentially Promote Axonal Outgrowth from Neural Tissue Cultures

Autores: Andrej Bajic, Brittmarie Andersson, Alexander Ossinger, Shima Tavakoli, Oommen P. Varghese, Nikos Schizas
Publicado en: Biomimetics, Edición 9, 2024, Página(s) 140, ISSN 2313-7673
Editor: MDPI
DOI: 10.3390/biomimetics9030140

How to embed ethics into laboratory research

Autores: Buedo P, Odziemczyk I, Perek-Białas J, Waligora M
Publicado en: Accountability in Research, 2023, Página(s) 1-19, ISSN 0898-9621
Editor: Taylor & Francis
DOI: 10.1080/08989621.2023.2165916

Dynamic covalent crosslinked hyaluronic acid hydrogels and nanomaterials for biomedical applications

Autores: Shujiang Wang, Shima Tavakoli, Rohith Pavan Parvathaneni, Ganesh N. Nawale, Oommen P. Oommen, Jöns Hilborna and Oommen P. Varghese
Publicado en: Biomaterials Science, 2022, ISSN 1473-7604
Editor: Royal Society of Chemistry
DOI: 10.1039/d2bm01154a

Noggin inhibits TGF-β1 OR TGF-β3 induced chondrogenesis of mesenchymal stromal cells

Autores: L Wen, AR Armiento, AG Guex, S Grad, L Creemers, MJ Stoddart
Publicado en: European Cells & Materials, Edición 47, 2024, Página(s) 142-151, ISSN 1473-2262
Editor: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v047a10

A poly(amidoamine)-based polymeric nanoparticle platform for efficient in vivo delivery of mRNA.

Autores: Adriano P. Pontes, Steffen van der Wal, Karin Roelofs, Anne Grobbink, Laura B. Creemers, Johan F.J. Engbersen, Jaap Rip
Publicado en: Biomaterials Advances, Edición Volume 156, January 2024, 2024, Página(s) 213713, ISSN 2772-9508
Editor: Elsevier B.V.
DOI: 10.1016/j.bioadv.2023.213713

Bioethics of somatic gene therapy: what do we know so far?

Autores: Buedo P, Bianchini A, Klas K, Waligora M.
Publicado en: Curr Med Res Opin, Edición Sep 29, 2023, Página(s) 1-17, ISSN 0300-7995
Editor: Librapharm Ltd.
DOI: 10.1080/03007995.2023.2257600

More ethics in the laboratory, please! Scientists’ perspectives on ethics in the preclinical phase

Autores: Buedo P, Prieto E, Perek-Białas J, Odziemczyk-Stawarz I, Waligora M
Publicado en: Accountability in Research, 2024, Página(s) 1-16, ISSN 0898-9621
Editor: Taylor & Francis
DOI: 10.1080/08989621.2023.2294996

Polymeric Nanoparticles Enable mRNA Transfection and Its Translation in Intervertebral Disc and Human Joint Cells, Except for M1 Macrophages

Autores: Katrin Agnes Muenzebrock, Fiona Y. W. Ho, Adriano P. Pontes, Carla Jorquera-Cordero, Lizette Utomo, Joao Pedro Garcia, Paul C. Willems, Tim J. M. Welting, Jaap Rip, Laura B. Creemers
Publicado en: Pharmaceutics, Edición 16, 2024, Página(s) 438, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics16040438

An Overview of the Supramolecular Systems for Gene and Drug Delivery in Tissue Regeneration

Autores: Saketh Reddy Ranamalla, Alina Silvia Porfire, Ioan Tomuță, Manuela Banciu
Publicado en: Pharmaceutics, Edición 14 (8), 2022, Página(s) 1733, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14081733

Fine-tuning Dynamic Cross–linking for Enhanced 3D Bioprinting of Hyaluronic Acid Hydrogels

Autores: Shima Tavakoli, Nithiyanandan Krishnan, Hamidreza Mokhtari, Oommen P. Oommen, Oommen P. Varghese
Publicado en: Advanced Functional Materials, Edición 34,4, 2024, Página(s) 2307040-2307059, ISSN 1616-301X
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202307040