Cartilaginous tissue regeneration by non-viral gene therapy; taking the hurdles towards efficient delivery

Informazioni relative al progetto

CARTHAGO

ID dell’accordo di sovvenzione: 955335

DOI

10.3030/955335

Progetto chiuso

Data della firma CE 2 Settembre 2020

Data di avvio 1 Settembre 2020

Data di completamento 31 Agosto 2024

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 3 744 185,53

Contributo UE

€ 3 744 185,53

Coordinato da

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (5)

Reviews
Press Release about the Kick-off meeting
Website
CARTHAGO Movie

CARTHAGO Movie (prepared by the ESRs)

Information for lay people, including patients, included in website

Documents, reports (4)

Overall recruitment

Overall recruitment (advertising vacancies, etc.)

Good Practices Report
Draft framework for incorporation of ethics research in biotechnology research

ESR15: Draft framework for incorporation of ethics research in biotechnology research, including 3 manuscripts for submission on ethics of CARTHAGO technologies as example

Updated Network-training programme

Updated Networktraining programme

Pubblicazioni

Peer reviewed articles (18)

Exploring Microemulsion Systems for the Incorporation of Glucocorticoids into Bacterial Cellulose: A Novel Approach for Anti-Inflammatory Wound Dressings

Autori: Paul Zahel, Vera Bruggink, Juliana Hülsmann, Frank Steiniger, Robert K. Hofstetter, Thorsten Heinzel, Uwe Beekmann, Oliver Werz, Dana Kralisch
Pubblicato in: Pharmaceutics, Numero 16, 2024, Pagina/e 504, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics16040504

Unveiling extracellular matrix assembly : Insights and approaches through bioorthogonal chemistry

Autori: Tavakoli, Shima; Evans, Austin; Oommen, Oommen P.; Creemers, Laura; Nandi, Jharna Barman; Hilborn, Jöns; Varghese, Oommen P.
Pubblicato in: Materials Today Bio, Numero 22, 2023, Pagina/e 100768, ISSN 2590-0064
Editore: Elsevier
DOI: 10.1016/j.mtbio.2023.100768

A Modular Albumin-Oligonucleotide Biomolecular Assembly for Delivery of Antisense Therapeutics

Autori: Marwa Elkhashab, Yeter Dilek, Morten Foss, Laura B. Creemers, and Kenneth A. Howard
Pubblicato in: Mol Pharmaceutics, Numero 21, 2024, Pagina/e 491-500, ISSN 1543-8384
Editore: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.3c00561

The Added Value of the “Co” in Co-Culture Systems in Research on Osteoarthritis Pathology and Treatment Development

Autori: Katrin Agnes Muenzebrock, Valerie Kersten, Jacqueline Alblas, Joao Pedro Garcia and Laura B. Creemers
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 03, 2022, ISSN 2296-4185
Editore: Frontiers Media
DOI: 10.3389/fbioe.2022.843056

Polymeric Nanoparticles for Drug Delivery in Osteoarthritis.

Autori: Adriano P. Pontes; Tim J. M. Welting; Jaap Rip; Laura B. Creemers.
Pubblicato in: Pharmaceutics, Numero 14 (12), 2022, Pagina/e 2639, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14122639

A quality by design approach to optimise disulfide-linked hyaluronic acid hydrogels.

Autori: Saketh Reddy Ranamalla, Shima Tavakoli, Alina Silvia Porfire, Lucia Ruxandra Tefas, Manuela Banciu, Ioan Tomuța, Oommen P Varghese.
Pubblicato in: Carbohydrate Polymers, Numero 339, 2024, Pagina/e 1122251, ISSN 0144-8617
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.carbpol.2024.122251

An Albumin-Holliday Junction Biomolecular Modular Design for Programmable Multifunctionality and Prolonged Circulation

Autori: Anders Dinesen, Veronica L. Andersen, Marwa Elkhashab, Diego Pilati, Pernille Bech, Elisabeth Fuchs, Torbjørn R. Samuelsen, Alexander Winther, Yunpeng Cai, Anders Märcher, Archie Wall, Marjan Omer, Jesper S. Nielsen, Vijay Chudasama, James R. Baker, Kurt V. Gothelf, Jesper Wengel, Jørgen Kjems, Kenneth A. Howard
Pubblicato in: Bioconjugate Chemistry, Numero 35, 2024, Pagina/e 214-222, ISSN 1043-1802
Editore: American Chemical Society
DOI: 10.1021/acs.bioconjchem.3c00491

Cell uptake and intracellular trafficking of bioreducible poly(amidoamine) nanoparticles for efficient mRNA translation in chondrocytes

Autori: Adriano P. Pontes; Steffen van der Wal; Saketh R. Ranamalla; Karin Roelofs; Ioan Tomuta; Laura B. Creemers; Jaap Rip
Pubblicato in: Front. Bioeng. Biotechnol, Numero 11, 2023, ISSN 2296-4185
Editore: Frontiers Media S.A.
DOI: 10.3389/fbioe.2023.1290871

Physically and Chemically Crosslinked Hyaluronic Acid-Based Hydrogels Differentially Promote Axonal Outgrowth from Neural Tissue Cultures

Autori: Andrej Bajic, Brittmarie Andersson, Alexander Ossinger, Shima Tavakoli, Oommen P. Varghese, Nikos Schizas
Pubblicato in: Biomimetics, Numero 9, 2024, Pagina/e 140, ISSN 2313-7673
Editore: MDPI
DOI: 10.3390/biomimetics9030140

How to embed ethics into laboratory research

Autori: Buedo P, Odziemczyk I, Perek-Białas J, Waligora M
Pubblicato in: Accountability in Research, 2023, Pagina/e 1-19, ISSN 0898-9621
Editore: Taylor & Francis
DOI: 10.1080/08989621.2023.2165916

Dynamic covalent crosslinked hyaluronic acid hydrogels and nanomaterials for biomedical applications

Autori: Shujiang Wang, Shima Tavakoli, Rohith Pavan Parvathaneni, Ganesh N. Nawale, Oommen P. Oommen, Jöns Hilborna and Oommen P. Varghese
Pubblicato in: Biomaterials Science, 2022, ISSN 1473-7604
Editore: Royal Society of Chemistry
DOI: 10.1039/d2bm01154a

Noggin inhibits TGF-β1 OR TGF-β3 induced chondrogenesis of mesenchymal stromal cells

Autori: L Wen, AR Armiento, AG Guex, S Grad, L Creemers, MJ Stoddart
Pubblicato in: European Cells & Materials, Numero 47, 2024, Pagina/e 142-151, ISSN 1473-2262
Editore: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v047a10

A poly(amidoamine)-based polymeric nanoparticle platform for efficient in vivo delivery of mRNA.

Autori: Adriano P. Pontes, Steffen van der Wal, Karin Roelofs, Anne Grobbink, Laura B. Creemers, Johan F.J. Engbersen, Jaap Rip
Pubblicato in: Biomaterials Advances, Numero Volume 156, January 2024, 2024, Pagina/e 213713, ISSN 2772-9508
Editore: Elsevier B.V.
DOI: 10.1016/j.bioadv.2023.213713

Bioethics of somatic gene therapy: what do we know so far?

Autori: Buedo P, Bianchini A, Klas K, Waligora M.
Pubblicato in: Curr Med Res Opin, Numero Sep 29, 2023, Pagina/e 1-17, ISSN 0300-7995
Editore: Librapharm Ltd.
DOI: 10.1080/03007995.2023.2257600

More ethics in the laboratory, please! Scientists’ perspectives on ethics in the preclinical phase

Autori: Buedo P, Prieto E, Perek-Białas J, Odziemczyk-Stawarz I, Waligora M
Pubblicato in: Accountability in Research, 2024, Pagina/e 1-16, ISSN 0898-9621
Editore: Taylor & Francis
DOI: 10.1080/08989621.2023.2294996

Polymeric Nanoparticles Enable mRNA Transfection and Its Translation in Intervertebral Disc and Human Joint Cells, Except for M1 Macrophages

Autori: Katrin Agnes Muenzebrock, Fiona Y. W. Ho, Adriano P. Pontes, Carla Jorquera-Cordero, Lizette Utomo, Joao Pedro Garcia, Paul C. Willems, Tim J. M. Welting, Jaap Rip, Laura B. Creemers
Pubblicato in: Pharmaceutics, Numero 16, 2024, Pagina/e 438, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics16040438

An Overview of the Supramolecular Systems for Gene and Drug Delivery in Tissue Regeneration

Autori: Saketh Reddy Ranamalla, Alina Silvia Porfire, Ioan Tomuță, Manuela Banciu
Pubblicato in: Pharmaceutics, Numero 14 (8), 2022, Pagina/e 1733, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14081733

Fine-tuning Dynamic Cross–linking for Enhanced 3D Bioprinting of Hyaluronic Acid Hydrogels

Autori: Shima Tavakoli, Nithiyanandan Krishnan, Hamidreza Mokhtari, Oommen P. Oommen, Oommen P. Varghese
Pubblicato in: Advanced Functional Materials, Numero 34,4, 2024, Pagina/e 2307040-2307059, ISSN 1616-301X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202307040