Training Network for Optimizing Adoptive T cell Therapy of Cancer

Project Information

T-OP

Grant agreement ID: 955575

DOI

10.3030/955575

Project closed

EC signature date 27 August 2020

Start date 1 March 2021

End date 30 September 2025

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 4 075 694,34

EU contribution

€ 4 075 694,34

Coordinated by

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

Reports on conferences and workshops on the website

Reports on conferences and workshops on the website this deliverable will be updated at months 12 18 23 29 34 39 45

Publications

Peer reviewed articles (17)

CAR T cell–mediated bone marrow inflammation causes hematotoxicity and favors clonal hematopoiesis

Author(s): Myriam Ben Khelil, Ahmadreza Arbab, Janesa Srikanthan, Laura Marcos Kovandzic, Véronique Vergé, Arnaud Pagès, Jessica Rengassamy, Roula Amine-Hneineh, Marine Aglave, Rémy Jelin, Vincent Ribrag, Wassila Rahali, Paul-Auguste Goutebroze, Stéphane de Botton, Laurie Menger, Ileana Antony-Debré, Jean-Baptiste Micol, Christophe Marzac, Cristina Castilla Llorente, Camille Bigenwald
Published in: Science Translational Medicine, Issue 17, 2025, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.adu9790

STING-driven activation of T cells: relevance for the adoptive cell therapy of cancer

Author(s): Fabian Richter, Christophe Paget, Lionel Apetoh
Published in: Cell Stress, Issue 7, 2023, Page(s) 95-104, ISSN 2523-0204
Publisher: Shared Science Publishers OG
DOI: 10.15698/cst2023.11.291

A-164 B cells are associated with aggressive Cases of Cutaneous T cell Lymphoma and a distinct spatio-temporal composition of the tumor microenviroenment

Author(s): S. Oganesian, M. Rudelius, G. Piontek, C. Posch, O. Weigert, M. Heide, S. Krebs, H. Blum, J. Klughammer, S. Mages, J. Watter, M. Kirmaier, A. Hadzic, M. Funk, J. Tu, A. Carboniero, L. Vona, M. von Bergwelt-Baildon, S. Theurich
Published in: European Journal of Cancer, Issue 211, 2024, Page(s) 114340, ISSN 0959-8049
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2024.114340

Role and Potential of Different T Helper Cell Subsets in Adoptive Cell Therapy

Author(s): David Andreu-Sanz, Sebastian Kobold
Published in: Cancers, Issue 15, 2025, Page(s) 1650, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15061650

Gut Microbiota Modulation through <i>Akkermansia</i> spp<i>.</i> Supplementation Increases CAR T-cell Potency

Author(s): Laura Marcos-Kovandzic, Michele Avagliano, Myriam Ben Khelil, Janesa Srikanthan, Rim Abdallah, Valentina Petrocelli, Jessica Rengassamy, Alexia Alfaro, Mathilde Bied, Marine Fidelle, Gladys Ferrere, Romain Daillère, Ahmadreza Arbab, Roula Amine-Hneineh, Arnaud Pages, Peggy Dartigues, Pierre Ly, Sylvain Simon, Sylvère Durand, Adrian Gottschlich, Florent Ginhoux, Camille Blériot, Peng Liu, Liwei
Published in: Cancer Discovery, Issue 15, 2025, Page(s) 1905-1926, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-24-1230

Enhanced conversion of T cells into CAR T cells by modulation of the MAPK/ERK pathway

Author(s): Elham Adabi, Filippos T. Charitidis, Frederic B. Thalheimer, Mar Guaza-Lasheras, Colin Clarke, Christian J. Buchholz
Published in: Cell Reports Medicine, Issue 6, 2025, Page(s) 101970, ISSN 2666-3791
Publisher: Elsevier BV
DOI: 10.1016/j.xcrm.2025.101970

Engineering strategies to optimise adoptive cell therapy in ovarian cancer

Author(s): Catarina Guerra, Milena Kalaitsidou, Gray Kueberuwa, Robert Hawkins, Richard Edmondson
Published in: Cancer Treatment Reviews, Issue 121, 2025, Page(s) 102632, ISSN 0305-7372
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.ctrv.2023.102632

Exercise Duration Modulates Cortisol Release and Chronic Cortisol Exposure Jeopardises T Cell Effector Functions

Author(s): Thy Viet Luu, Line Fleischer Hach, Tina Seremet, Katharina Leuchte, Per thor Straten, Gitte Holmen Olofsson
Published in: Immunology, 2025, ISSN 0019-2805
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/imm.70028

Predictive value of preclinical models for CAR-T cell therapy clinical trials: a systematic review and meta-analysis

Author(s): David Andreu-Sanz, Lisa Gregor, Emanuele Carlini, Daniele Scarcella, Carsten Marr, Sebastian Kobold
Published in: Journal for ImmunoTherapy of Cancer, Issue 13, 2025, Page(s) e011698, ISSN 2051-1426
Publisher: BMJ
DOI: 10.1136/jitc-2025-011698

Dextran-based T-cell expansion nanoparticles for manufacturing CAR T cells with augmented efficacy

Author(s): Tao Zheng, Keerthana Ramanathan, Maria Ormhøj, Mikkel Rasmus Hansen, Hólmfridur Rósa Halldórsdóttir, Hanxi Li, Kamilla Kjærgaard Munk, Carlos Rodriguez-Pardo, Rasmus Ulslev Wegener Friis, Seder Fayyad Islam, Peter M. H. Heegaard, Klaus Qvortrup, Hinrich Abken, Yi Sun, Sine Reker Hardup
Published in: Biorxiv, 2025, ISSN 2692-8205
Publisher: bioRxiv
DOI: 10.1101/2025.04.10.648181

Programmable multispecific DNA-origami-based T-cell engagers

Author(s): Klaus F. Wagenbauer, Nhi Pham, Adrian Gottschlich, Benjamin Kick, Viktorija Kozina, Christopher Frank, Daniela Trninic, Pierre Stömmer, Ruth Grünmeier, Emanuele Carlini, Christina Angeliki Tsiverioti, Sebastian Kobold, Jonas J. Funke, Hendrik Dietz
Published in: Nature Nanotechnology, Issue 18, 2023, Page(s) 1319-1326, ISSN 1748-3387
Publisher: Nature Publishing Group
DOI: 10.1038/s41565-023-01471-7

Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia

Author(s): Gottschlich A, Thomas M, Grünmeier R, Lesch S, Rohrbacher L, Igl V, Briukhovetska D, Benmebarek MR, Vick B, Dede S, Müller K, Xu T, Dhoqina D, Märkl F, Robinson S, Sendelhofert A, Schulz H, Umut Ö, Kavaka V, Tsiverioti CA, Carlini E, Nandi S, Strzalkowski T, Lorenzini T, Stock S, Müller PJ, Dörr J, Seifert M, Cadilha BL, Brabenec R, Röder N, Rataj F, Nüesch M, Modemann F, Wellbrock J, Fied
Published in: Nat Biotechnol., 2023, ISSN 1546-1696
Publisher: Springer
DOI: 10.1038/s41587-023-01684-0

ProS1-MerTK signaling in CD4 T cells: implications for TIL expansion and functionality

Author(s): Annina Kurzay, Sara Fresnillo Saló, Anne Rahbech, Tina Seremet, Cecilie Oelvang Madsen, Christopher Aled Chamberlain, Emilie Bülow Jensen, Viet Thy Luu, Özcan Met, Marlies J W Peeters, Per thor Straten
Published in: OncoImmunology, Issue 14, 2025, ISSN 2162-402X
Publisher: Informa UK Limited
DOI: 10.1080/2162402x.2025.2532662

Precision-cut tumor tissue slices, a novel tool to study the tumor microenvironment interactions with chimeric antigen receptor (CAR) T cells

Author(s): Valeria Durante, Alina Wittwer, Benjamin Theek, Manuel Martinez-Osuna, Emmanuel Donnadieu, Olaf Hardt, Dominik Eckardt, Andreas Bosio, Sonja Schallenberg, Christoph Herbel
Published in: PLOS One, Issue 20, 2025, Page(s) e0327322, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0327322

T-cell specific in vivo gene delivery with DART-AAVs targeted to CD8

Author(s): Muhammed Burak Demircan, Luca J. Zinser, Alexander Michels, Mar Guaza-Lasheras, Fabian John, Johanna M. Gorol, Samuel A. Theuerkauf, Dorothee M. Günther, Dirk Grimm, Florian R. Greten, Petr Chlanda, Frederic B. Thalheimer, Christian J. Buchholz
Published in: Molecular Therapy, Issue 32, 2025, Page(s) 3470-3484, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2024.08.002

T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis

Author(s): Daria Briukhovetska, Javier Suarez-Gosalvez, Cornelia Voigt, Anamarija Markota, Anastasios D. Giannou, Maryam Schübel, Jakob Jobst, Tao Zhang, Janina Dörr, Florian Märkl, Lina Majed, Philipp Jie Müller, Peter May, Adrian Gottschlich, Nicholas Tokarew, Jöran Lücke, Arman Oner, Melanie Schwerdtfeger, David Andreu-Sanz, Ruth Grünmeier, Matthias Seifert, Stefanos Michaelides, Michael Hristov, L
Published in: Immunity, Issue 56, 2024, Page(s) 143-161.e11, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2022.12.010

Impact of the selective A2AR and A2BR dual antagonist AB928/etrumadenant on CAR T cell function

Author(s): Matthias Seifert, Mohamed-Reda Benmebarek, Daria Briukhovetska, Florian Märkl, Janina Dörr, Bruno L. Cadilha, Jakob Jobst, Sophia Stock, David Andreu-Sanz, Theo Lorenzini, Ruth Grünmeier, Arman Oner, Hannah Obeck, Lina Majed, Dario Dhoqina, Manouk Feinendegen, Adrian Gottschlich, Jin Zhang, Ulrike Schindler, Stefan Endres, Sebastian Kobold
Published in: British Journal of Cancer, Issue 127, 2022, Page(s) 2175-2185, ISSN 0007-0920
Publisher: Nature Publishing Group
DOI: 10.1038/s41416-022-02013-z

Non-peer reviewed articles (1)

L-Asparaginase treatment induces reversible immunoregulatory and immunosuppressive effects in non-malignant B cells in a model of T-cell dependent B cell activation

Author(s): Amar Hadzic, María Alejandra García-Márquez, Pol Bannasch, Nina Haindl, Katharina Frey, Martin Kirmaier, Maximilian Funk, Anneli Tischmacher, Jingke Tu, Adriano Carboniero, Ludovica Vona, Sabine Oganesian, Hans Schlößer, Werner Schmitz, Michael von Bergwelt, David M. Cordas dos Santos, Sebastian Theurich
Published in: bioRxiv, 2024, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.11.27.625617

Thesis and dissertations (1)

Functional stimulation of CAR T cells with artificial antigen presenting scaffolds

Author(s): Ramanathan K
Published in: 2025
Publisher: DTU Health Technology

Conference proceedings (1)

1083 Functional impact of adrenergic signaling on T and NK cells: where exercise meets cancer

Author(s): Thy V Luu, Agnete WP Jensen, Gitte H Olofsson, Per thor Straten
Published in: Regular and Young Investigator Award Abstracts, 2025, Page(s) A1192-A1192
Publisher: BMJ Publishing Group Ltd
DOI: 10.1136/jitc-2023-sitc2023.1083