Training Network for Optimizing Adoptive T cell Therapy of Cancer

Información del proyecto

T-OP

Identificador del acuerdo de subvención: 955575

DOI

10.3030/955575

Proyecto cerrado

Fecha de la firma de la CE 27 Agosto 2020

Fecha de inicio 1 Marzo 2021

Fecha de finalización 30 Septiembre 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 4 075 694,34

Aportación de la UE

€ 4 075 694,34

Coordinado por

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (1)

Reports on conferences and workshops on the website

Reports on conferences and workshops on the website this deliverable will be updated at months 12 18 23 29 34 39 45

Publicaciones

Peer reviewed articles (17)

CAR T cell–mediated bone marrow inflammation causes hematotoxicity and favors clonal hematopoiesis

Autores: Myriam Ben Khelil, Ahmadreza Arbab, Janesa Srikanthan, Laura Marcos Kovandzic, Véronique Vergé, Arnaud Pagès, Jessica Rengassamy, Roula Amine-Hneineh, Marine Aglave, Rémy Jelin, Vincent Ribrag, Wassila Rahali, Paul-Auguste Goutebroze, Stéphane de Botton, Laurie Menger, Ileana Antony-Debré, Jean-Baptiste Micol, Christophe Marzac, Cristina Castilla Llorente, Camille Bigenwald
Publicado en: Science Translational Medicine, Edición 17, 2025, ISSN 1946-6234
Editor: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.adu9790

STING-driven activation of T cells: relevance for the adoptive cell therapy of cancer

Autores: Fabian Richter, Christophe Paget, Lionel Apetoh
Publicado en: Cell Stress, Edición 7, 2023, Página(s) 95-104, ISSN 2523-0204
Editor: Shared Science Publishers OG
DOI: 10.15698/cst2023.11.291

A-164 B cells are associated with aggressive Cases of Cutaneous T cell Lymphoma and a distinct spatio-temporal composition of the tumor microenviroenment

Autores: S. Oganesian, M. Rudelius, G. Piontek, C. Posch, O. Weigert, M. Heide, S. Krebs, H. Blum, J. Klughammer, S. Mages, J. Watter, M. Kirmaier, A. Hadzic, M. Funk, J. Tu, A. Carboniero, L. Vona, M. von Bergwelt-Baildon, S. Theurich
Publicado en: European Journal of Cancer, Edición 211, 2024, Página(s) 114340, ISSN 0959-8049
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2024.114340

Role and Potential of Different T Helper Cell Subsets in Adoptive Cell Therapy

Autores: David Andreu-Sanz, Sebastian Kobold
Publicado en: Cancers, Edición 15, 2025, Página(s) 1650, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15061650

Gut Microbiota Modulation through <i>Akkermansia</i> spp<i>.</i> Supplementation Increases CAR T-cell Potency

Autores: Laura Marcos-Kovandzic, Michele Avagliano, Myriam Ben Khelil, Janesa Srikanthan, Rim Abdallah, Valentina Petrocelli, Jessica Rengassamy, Alexia Alfaro, Mathilde Bied, Marine Fidelle, Gladys Ferrere, Romain Daillère, Ahmadreza Arbab, Roula Amine-Hneineh, Arnaud Pages, Peggy Dartigues, Pierre Ly, Sylvain Simon, Sylvère Durand, Adrian Gottschlich, Florent Ginhoux, Camille Blériot, Peng Liu, Liwei
Publicado en: Cancer Discovery, Edición 15, 2025, Página(s) 1905-1926, ISSN 2159-8274
Editor: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-24-1230

Enhanced conversion of T cells into CAR T cells by modulation of the MAPK/ERK pathway

Autores: Elham Adabi, Filippos T. Charitidis, Frederic B. Thalheimer, Mar Guaza-Lasheras, Colin Clarke, Christian J. Buchholz
Publicado en: Cell Reports Medicine, Edición 6, 2025, Página(s) 101970, ISSN 2666-3791
Editor: Elsevier BV
DOI: 10.1016/j.xcrm.2025.101970

Engineering strategies to optimise adoptive cell therapy in ovarian cancer

Autores: Catarina Guerra, Milena Kalaitsidou, Gray Kueberuwa, Robert Hawkins, Richard Edmondson
Publicado en: Cancer Treatment Reviews, Edición 121, 2025, Página(s) 102632, ISSN 0305-7372
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.ctrv.2023.102632

Exercise Duration Modulates Cortisol Release and Chronic Cortisol Exposure Jeopardises T Cell Effector Functions

Autores: Thy Viet Luu, Line Fleischer Hach, Tina Seremet, Katharina Leuchte, Per thor Straten, Gitte Holmen Olofsson
Publicado en: Immunology, 2025, ISSN 0019-2805
Editor: Blackwell Publishing Inc.
DOI: 10.1111/imm.70028

Predictive value of preclinical models for CAR-T cell therapy clinical trials: a systematic review and meta-analysis

Autores: David Andreu-Sanz, Lisa Gregor, Emanuele Carlini, Daniele Scarcella, Carsten Marr, Sebastian Kobold
Publicado en: Journal for ImmunoTherapy of Cancer, Edición 13, 2025, Página(s) e011698, ISSN 2051-1426
Editor: BMJ
DOI: 10.1136/jitc-2025-011698

Dextran-based T-cell expansion nanoparticles for manufacturing CAR T cells with augmented efficacy

Autores: Tao Zheng, Keerthana Ramanathan, Maria Ormhøj, Mikkel Rasmus Hansen, Hólmfridur Rósa Halldórsdóttir, Hanxi Li, Kamilla Kjærgaard Munk, Carlos Rodriguez-Pardo, Rasmus Ulslev Wegener Friis, Seder Fayyad Islam, Peter M. H. Heegaard, Klaus Qvortrup, Hinrich Abken, Yi Sun, Sine Reker Hardup
Publicado en: Biorxiv, 2025, ISSN 2692-8205
Editor: bioRxiv
DOI: 10.1101/2025.04.10.648181

Programmable multispecific DNA-origami-based T-cell engagers

Autores: Klaus F. Wagenbauer, Nhi Pham, Adrian Gottschlich, Benjamin Kick, Viktorija Kozina, Christopher Frank, Daniela Trninic, Pierre Stömmer, Ruth Grünmeier, Emanuele Carlini, Christina Angeliki Tsiverioti, Sebastian Kobold, Jonas J. Funke, Hendrik Dietz
Publicado en: Nature Nanotechnology, Edición 18, 2023, Página(s) 1319-1326, ISSN 1748-3387
Editor: Nature Publishing Group
DOI: 10.1038/s41565-023-01471-7

Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia

Autores: Gottschlich A, Thomas M, Grünmeier R, Lesch S, Rohrbacher L, Igl V, Briukhovetska D, Benmebarek MR, Vick B, Dede S, Müller K, Xu T, Dhoqina D, Märkl F, Robinson S, Sendelhofert A, Schulz H, Umut Ö, Kavaka V, Tsiverioti CA, Carlini E, Nandi S, Strzalkowski T, Lorenzini T, Stock S, Müller PJ, Dörr J, Seifert M, Cadilha BL, Brabenec R, Röder N, Rataj F, Nüesch M, Modemann F, Wellbrock J, Fied
Publicado en: Nat Biotechnol., 2023, ISSN 1546-1696
Editor: Springer
DOI: 10.1038/s41587-023-01684-0

ProS1-MerTK signaling in CD4 T cells: implications for TIL expansion and functionality

Autores: Annina Kurzay, Sara Fresnillo Saló, Anne Rahbech, Tina Seremet, Cecilie Oelvang Madsen, Christopher Aled Chamberlain, Emilie Bülow Jensen, Viet Thy Luu, Özcan Met, Marlies J W Peeters, Per thor Straten
Publicado en: OncoImmunology, Edición 14, 2025, ISSN 2162-402X
Editor: Informa UK Limited
DOI: 10.1080/2162402x.2025.2532662

Precision-cut tumor tissue slices, a novel tool to study the tumor microenvironment interactions with chimeric antigen receptor (CAR) T cells

Autores: Valeria Durante, Alina Wittwer, Benjamin Theek, Manuel Martinez-Osuna, Emmanuel Donnadieu, Olaf Hardt, Dominik Eckardt, Andreas Bosio, Sonja Schallenberg, Christoph Herbel
Publicado en: PLOS One, Edición 20, 2025, Página(s) e0327322, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0327322

T-cell specific in vivo gene delivery with DART-AAVs targeted to CD8

Autores: Muhammed Burak Demircan, Luca J. Zinser, Alexander Michels, Mar Guaza-Lasheras, Fabian John, Johanna M. Gorol, Samuel A. Theuerkauf, Dorothee M. Günther, Dirk Grimm, Florian R. Greten, Petr Chlanda, Frederic B. Thalheimer, Christian J. Buchholz
Publicado en: Molecular Therapy, Edición 32, 2025, Página(s) 3470-3484, ISSN 1525-0016
Editor: Nature Publishing Group
DOI: 10.1016/j.ymthe.2024.08.002

T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis

Autores: Daria Briukhovetska, Javier Suarez-Gosalvez, Cornelia Voigt, Anamarija Markota, Anastasios D. Giannou, Maryam Schübel, Jakob Jobst, Tao Zhang, Janina Dörr, Florian Märkl, Lina Majed, Philipp Jie Müller, Peter May, Adrian Gottschlich, Nicholas Tokarew, Jöran Lücke, Arman Oner, Melanie Schwerdtfeger, David Andreu-Sanz, Ruth Grünmeier, Matthias Seifert, Stefanos Michaelides, Michael Hristov, L
Publicado en: Immunity, Edición 56, 2024, Página(s) 143-161.e11, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2022.12.010

Impact of the selective A2AR and A2BR dual antagonist AB928/etrumadenant on CAR T cell function

Autores: Matthias Seifert, Mohamed-Reda Benmebarek, Daria Briukhovetska, Florian Märkl, Janina Dörr, Bruno L. Cadilha, Jakob Jobst, Sophia Stock, David Andreu-Sanz, Theo Lorenzini, Ruth Grünmeier, Arman Oner, Hannah Obeck, Lina Majed, Dario Dhoqina, Manouk Feinendegen, Adrian Gottschlich, Jin Zhang, Ulrike Schindler, Stefan Endres, Sebastian Kobold
Publicado en: British Journal of Cancer, Edición 127, 2022, Página(s) 2175-2185, ISSN 0007-0920
Editor: Nature Publishing Group
DOI: 10.1038/s41416-022-02013-z

Non-peer reviewed articles (1)

L-Asparaginase treatment induces reversible immunoregulatory and immunosuppressive effects in non-malignant B cells in a model of T-cell dependent B cell activation

Autores: Amar Hadzic, María Alejandra García-Márquez, Pol Bannasch, Nina Haindl, Katharina Frey, Martin Kirmaier, Maximilian Funk, Anneli Tischmacher, Jingke Tu, Adriano Carboniero, Ludovica Vona, Sabine Oganesian, Hans Schlößer, Werner Schmitz, Michael von Bergwelt, David M. Cordas dos Santos, Sebastian Theurich
Publicado en: bioRxiv, 2024, ISSN 2692-8205
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.11.27.625617

Conference proceedings (1)

1083 Functional impact of adrenergic signaling on T and NK cells: where exercise meets cancer

Autores: Thy V Luu, Agnete WP Jensen, Gitte H Olofsson, Per thor Straten
Publicado en: Regular and Young Investigator Award Abstracts, 2025, Página(s) A1192-A1192
Editor: BMJ Publishing Group Ltd
DOI: 10.1136/jitc-2023-sitc2023.1083