Training Network for Optimizing Adoptive T cell Therapy of Cancer

Informazioni relative al progetto

T-OP

ID dell’accordo di sovvenzione: 955575

DOI

10.3030/955575

Progetto chiuso

Data della firma CE 27 Agosto 2020

Data di avvio 1 Marzo 2021

Data di completamento 30 Settembre 2025

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 4 075 694,34

Contributo UE

€ 4 075 694,34

Coordinato da

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (1)

Reports on conferences and workshops on the website

Reports on conferences and workshops on the website this deliverable will be updated at months 12 18 23 29 34 39 45

Pubblicazioni

Peer reviewed articles (17)

CAR T cell–mediated bone marrow inflammation causes hematotoxicity and favors clonal hematopoiesis

Autori: Myriam Ben Khelil, Ahmadreza Arbab, Janesa Srikanthan, Laura Marcos Kovandzic, Véronique Vergé, Arnaud Pagès, Jessica Rengassamy, Roula Amine-Hneineh, Marine Aglave, Rémy Jelin, Vincent Ribrag, Wassila Rahali, Paul-Auguste Goutebroze, Stéphane de Botton, Laurie Menger, Ileana Antony-Debré, Jean-Baptiste Micol, Christophe Marzac, Cristina Castilla Llorente, Camille Bigenwald
Pubblicato in: Science Translational Medicine, Numero 17, 2025, ISSN 1946-6234
Editore: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.adu9790

STING-driven activation of T cells: relevance for the adoptive cell therapy of cancer

Autori: Fabian Richter, Christophe Paget, Lionel Apetoh
Pubblicato in: Cell Stress, Numero 7, 2023, Pagina/e 95-104, ISSN 2523-0204
Editore: Shared Science Publishers OG
DOI: 10.15698/cst2023.11.291

A-164 B cells are associated with aggressive Cases of Cutaneous T cell Lymphoma and a distinct spatio-temporal composition of the tumor microenviroenment

Autori: S. Oganesian, M. Rudelius, G. Piontek, C. Posch, O. Weigert, M. Heide, S. Krebs, H. Blum, J. Klughammer, S. Mages, J. Watter, M. Kirmaier, A. Hadzic, M. Funk, J. Tu, A. Carboniero, L. Vona, M. von Bergwelt-Baildon, S. Theurich
Pubblicato in: European Journal of Cancer, Numero 211, 2024, Pagina/e 114340, ISSN 0959-8049
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2024.114340

Role and Potential of Different T Helper Cell Subsets in Adoptive Cell Therapy

Autori: David Andreu-Sanz, Sebastian Kobold
Pubblicato in: Cancers, Numero 15, 2025, Pagina/e 1650, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15061650

Gut Microbiota Modulation through <i>Akkermansia</i> spp<i>.</i> Supplementation Increases CAR T-cell Potency

Autori: Laura Marcos-Kovandzic, Michele Avagliano, Myriam Ben Khelil, Janesa Srikanthan, Rim Abdallah, Valentina Petrocelli, Jessica Rengassamy, Alexia Alfaro, Mathilde Bied, Marine Fidelle, Gladys Ferrere, Romain Daillère, Ahmadreza Arbab, Roula Amine-Hneineh, Arnaud Pages, Peggy Dartigues, Pierre Ly, Sylvain Simon, Sylvère Durand, Adrian Gottschlich, Florent Ginhoux, Camille Blériot, Peng Liu, Liwei
Pubblicato in: Cancer Discovery, Numero 15, 2025, Pagina/e 1905-1926, ISSN 2159-8274
Editore: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-24-1230

Enhanced conversion of T cells into CAR T cells by modulation of the MAPK/ERK pathway

Autori: Elham Adabi, Filippos T. Charitidis, Frederic B. Thalheimer, Mar Guaza-Lasheras, Colin Clarke, Christian J. Buchholz
Pubblicato in: Cell Reports Medicine, Numero 6, 2025, Pagina/e 101970, ISSN 2666-3791
Editore: Elsevier BV
DOI: 10.1016/j.xcrm.2025.101970

Engineering strategies to optimise adoptive cell therapy in ovarian cancer

Autori: Catarina Guerra, Milena Kalaitsidou, Gray Kueberuwa, Robert Hawkins, Richard Edmondson
Pubblicato in: Cancer Treatment Reviews, Numero 121, 2025, Pagina/e 102632, ISSN 0305-7372
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.ctrv.2023.102632

Exercise Duration Modulates Cortisol Release and Chronic Cortisol Exposure Jeopardises T Cell Effector Functions

Autori: Thy Viet Luu, Line Fleischer Hach, Tina Seremet, Katharina Leuchte, Per thor Straten, Gitte Holmen Olofsson
Pubblicato in: Immunology, 2025, ISSN 0019-2805
Editore: Blackwell Publishing Inc.
DOI: 10.1111/imm.70028

Predictive value of preclinical models for CAR-T cell therapy clinical trials: a systematic review and meta-analysis

Autori: David Andreu-Sanz, Lisa Gregor, Emanuele Carlini, Daniele Scarcella, Carsten Marr, Sebastian Kobold
Pubblicato in: Journal for ImmunoTherapy of Cancer, Numero 13, 2025, Pagina/e e011698, ISSN 2051-1426
Editore: BMJ
DOI: 10.1136/jitc-2025-011698

Dextran-based T-cell expansion nanoparticles for manufacturing CAR T cells with augmented efficacy

Autori: Tao Zheng, Keerthana Ramanathan, Maria Ormhøj, Mikkel Rasmus Hansen, Hólmfridur Rósa Halldórsdóttir, Hanxi Li, Kamilla Kjærgaard Munk, Carlos Rodriguez-Pardo, Rasmus Ulslev Wegener Friis, Seder Fayyad Islam, Peter M. H. Heegaard, Klaus Qvortrup, Hinrich Abken, Yi Sun, Sine Reker Hardup
Pubblicato in: Biorxiv, 2025, ISSN 2692-8205
Editore: bioRxiv
DOI: 10.1101/2025.04.10.648181

Programmable multispecific DNA-origami-based T-cell engagers

Autori: Klaus F. Wagenbauer, Nhi Pham, Adrian Gottschlich, Benjamin Kick, Viktorija Kozina, Christopher Frank, Daniela Trninic, Pierre Stömmer, Ruth Grünmeier, Emanuele Carlini, Christina Angeliki Tsiverioti, Sebastian Kobold, Jonas J. Funke, Hendrik Dietz
Pubblicato in: Nature Nanotechnology, Numero 18, 2023, Pagina/e 1319-1326, ISSN 1748-3387
Editore: Nature Publishing Group
DOI: 10.1038/s41565-023-01471-7

Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia

Autori: Gottschlich A, Thomas M, Grünmeier R, Lesch S, Rohrbacher L, Igl V, Briukhovetska D, Benmebarek MR, Vick B, Dede S, Müller K, Xu T, Dhoqina D, Märkl F, Robinson S, Sendelhofert A, Schulz H, Umut Ö, Kavaka V, Tsiverioti CA, Carlini E, Nandi S, Strzalkowski T, Lorenzini T, Stock S, Müller PJ, Dörr J, Seifert M, Cadilha BL, Brabenec R, Röder N, Rataj F, Nüesch M, Modemann F, Wellbrock J, Fied
Pubblicato in: Nat Biotechnol., 2023, ISSN 1546-1696
Editore: Springer
DOI: 10.1038/s41587-023-01684-0

ProS1-MerTK signaling in CD4 T cells: implications for TIL expansion and functionality

Autori: Annina Kurzay, Sara Fresnillo Saló, Anne Rahbech, Tina Seremet, Cecilie Oelvang Madsen, Christopher Aled Chamberlain, Emilie Bülow Jensen, Viet Thy Luu, Özcan Met, Marlies J W Peeters, Per thor Straten
Pubblicato in: OncoImmunology, Numero 14, 2025, ISSN 2162-402X
Editore: Informa UK Limited
DOI: 10.1080/2162402x.2025.2532662

Precision-cut tumor tissue slices, a novel tool to study the tumor microenvironment interactions with chimeric antigen receptor (CAR) T cells

Autori: Valeria Durante, Alina Wittwer, Benjamin Theek, Manuel Martinez-Osuna, Emmanuel Donnadieu, Olaf Hardt, Dominik Eckardt, Andreas Bosio, Sonja Schallenberg, Christoph Herbel
Pubblicato in: PLOS One, Numero 20, 2025, Pagina/e e0327322, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0327322

T-cell specific in vivo gene delivery with DART-AAVs targeted to CD8

Autori: Muhammed Burak Demircan, Luca J. Zinser, Alexander Michels, Mar Guaza-Lasheras, Fabian John, Johanna M. Gorol, Samuel A. Theuerkauf, Dorothee M. Günther, Dirk Grimm, Florian R. Greten, Petr Chlanda, Frederic B. Thalheimer, Christian J. Buchholz
Pubblicato in: Molecular Therapy, Numero 32, 2025, Pagina/e 3470-3484, ISSN 1525-0016
Editore: Nature Publishing Group
DOI: 10.1016/j.ymthe.2024.08.002

T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis

Autori: Daria Briukhovetska, Javier Suarez-Gosalvez, Cornelia Voigt, Anamarija Markota, Anastasios D. Giannou, Maryam Schübel, Jakob Jobst, Tao Zhang, Janina Dörr, Florian Märkl, Lina Majed, Philipp Jie Müller, Peter May, Adrian Gottschlich, Nicholas Tokarew, Jöran Lücke, Arman Oner, Melanie Schwerdtfeger, David Andreu-Sanz, Ruth Grünmeier, Matthias Seifert, Stefanos Michaelides, Michael Hristov, L
Pubblicato in: Immunity, Numero 56, 2024, Pagina/e 143-161.e11, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2022.12.010

Impact of the selective A2AR and A2BR dual antagonist AB928/etrumadenant on CAR T cell function

Autori: Matthias Seifert, Mohamed-Reda Benmebarek, Daria Briukhovetska, Florian Märkl, Janina Dörr, Bruno L. Cadilha, Jakob Jobst, Sophia Stock, David Andreu-Sanz, Theo Lorenzini, Ruth Grünmeier, Arman Oner, Hannah Obeck, Lina Majed, Dario Dhoqina, Manouk Feinendegen, Adrian Gottschlich, Jin Zhang, Ulrike Schindler, Stefan Endres, Sebastian Kobold
Pubblicato in: British Journal of Cancer, Numero 127, 2022, Pagina/e 2175-2185, ISSN 0007-0920
Editore: Nature Publishing Group
DOI: 10.1038/s41416-022-02013-z

Non-peer reviewed articles (1)

L-Asparaginase treatment induces reversible immunoregulatory and immunosuppressive effects in non-malignant B cells in a model of T-cell dependent B cell activation

Autori: Amar Hadzic, María Alejandra García-Márquez, Pol Bannasch, Nina Haindl, Katharina Frey, Martin Kirmaier, Maximilian Funk, Anneli Tischmacher, Jingke Tu, Adriano Carboniero, Ludovica Vona, Sabine Oganesian, Hans Schlößer, Werner Schmitz, Michael von Bergwelt, David M. Cordas dos Santos, Sebastian Theurich
Pubblicato in: bioRxiv, 2024, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.11.27.625617

Conference proceedings (1)

1083 Functional impact of adrenergic signaling on T and NK cells: where exercise meets cancer

Autori: Thy V Luu, Agnete WP Jensen, Gitte H Olofsson, Per thor Straten
Pubblicato in: Regular and Young Investigator Award Abstracts, 2025, Pagina/e A1192-A1192
Editore: BMJ Publishing Group Ltd
DOI: 10.1136/jitc-2023-sitc2023.1083