Training European Experts in Inflammation: from the molecular players to animal models and the bedside

Informazioni relative al progetto

INFLANET

ID dell’accordo di sovvenzione: 955576

DOI

10.3030/955576

Progetto chiuso

Data della firma CE 28 Agosto 2020

Data di avvio 1 Marzo 2021

Data di completamento 31 Maggio 2025

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 3 977 117,28

Contributo UE

€ 3 977 117,28

Coordinato da

UNIVERSITE DE MONTPELLIER
France

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (26)

Final Report on Congress Presentations

Final Report on Congress Presentations due Month 48

Danger signal gradients

Report on the methods to integrate danger signal gradients in optic flow analysis

Inflammatory models

Cross validation of inflammatory models

Congress Presentations

Second report on Congress Presentations by ESRs di to the PO at Month 36

INFLANET brochure, website and advertising of vacancies

Documents to be provided to the PO including INFLANET brochure, website and advertising of vacancies

Screens to look for novel anti-inflammatory drugs

New screens to look for novel anti-inflammatory drugs

Inflammation & autophagy

Manipulation of inflammation & autophagy to fight tuberculosis

First Report on Scientific Publications

First Report on Scientific Publications due at Month

Image processing methods

Image processing methods for 3Dtime segmentation and tracking

New protocols for Genomic and transcriptomic analysis

New protocols for Genomic and transcriptomic analysis for the naalysis of the gentic basis of hereditary inflammatory diseases

3D+T trajectories and cell shapes during inflammatory episodes

Model 3D+T trajectories and cell shapes during inflammatory episodes

ASC specks and proteases in inflammation

Report on the role of ASC specks and proteases in the spreading of inflammation

Draft of the plan for the use and dissemination of knowledge
Structures and inhibitors

Report on Structures of macromolecules and inhibitors of inflammation

Reporters and labels

New reporters and labels for in vivo imaging

Consortium agreement and Supervisory Board of the network

Report to the PO Consortium agreement and Supervisory Board of the network

New reporters, sensors and mutants

New reporters, sensors and mutants to study inflammation

Single cells & specific cellular population purifications

Single cells & specific cellular population purifications for RNAseq

First Report on Congress Presentations

First Report on Congress Presentations by ESRs due at Months 20

Contributions to outreach activities

Record of all participants contributions to outreach activities targeted at schools and the general public

Medical image analysis

Software tools for medical images from patients with inflammatory diseases

Final Report on Scientific Publications

Final Report on Scientific Publications due Month 48

Transduction pathways

Report on transduction pathways stimulated during inflammation

Second report on Scientific Publications

Second report on Scientific Publications at Months 36

Large data sets

Report on the new tools to analyse and handle large sets of imaging data

Toxicology tests and screens

Results of toxicology tests and screen using the output of D2.5

Demonstrators, pilots, prototypes (2)

New multimodal and multispectral microscope setups
Imaging windows

New imaging windows for murine intravital microscopy

Websites, patent fillings, videos etc. (3)

Wikipedia articles and YouTube Channel
Video series

Video series for outreach activities

MOOC and Serious Game

Open Research Data Pilot (2)

Data Management Plan (DMP)

Data Management Plan DMP to be send to the PO

Final version of the Data Management Plan (DMP)

Pubblicazioni

Other (4)

Teleost-specific ictacalcins exhibit similar structural organization, cation-dependent activation and transcriptional regulation as human S100 proteins

Autori: Liz Hernández, Théo Paris, Maria Demou, Catherine Birck, Christina Begon-Pescia, Juan Francisco Rodríguez-Vidal, Sylwia D. Tyrkalska, Charlotte Bureau, Catherine Gonzalez, Juliette Gracia, Etienne Lelièvre, Victoriano Mulero, Mai Nguyen-Chi, Laure Yatime
Pubblicato in: bioRxiv, 2025
Editore: bioRxiv
DOI: 10.1101/2025.06.10.658860

Macrophage Inflammasome Activation Drives Anti-inflammatory Responses via Neutrophil-Derived ASC Speck Transfer and Gasdermin-Dependent Caspase-1 Inhibition

Autori: Annamaria Pedoto, Juan M. Lozano-Gil, Mai E. Nguyen-Chi, Georges Lutfalla, Diana García-Moreno, Victoriano Mulero, Sylwia D. Tyrkalska
Pubblicato in: Macrophage Inflammasome Activation Drives Anti-inflammatory Responses via Neutrophil-Derived ASC Speck Transfer and Gasdermin-Dependent Caspase-1 Inhibition, 2025
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.01.22.634381

Mathematical and numerical methods for understanding immune cell motion during wound healing

Autori: Giulia Lupi, Seol Ah Park, Martin Ambroz, Resul Ozbilgic, Mai Nguyen Chi, Georges Lutfalla, Karol Mikula
Pubblicato in: arXiv, 2025
Editore: arXiv

Beneficios y riesgos del inflamasoma, pieza clave de los procesos inflamatorios

Autori: Tyrkalska SD, Pedoto A, Lozano-Gil M, Mulero V.
Pubblicato in: 2024
Editore: The Conversation 2024

Peer reviewed articles (17)

Autoinflammatory encephalopathy due to PTPN1 haploinsufficiency: a case series

Autori: Gaofeng Zhu, Blaise Didry-Barca, Luis Seabra, Gillian I Rice, Carolina Uggenti, Moncef Touimy, Mathieu P Rodero, Rolando Hernandez Trapero, Vincent Bondet, Darragh Duffy, Philippe Gautier, Katie Livingstone, Fraser J H Sutherland, Pierre Lebon, Mélanie Parisot, Christine Bole-Feysot, Cécile Masson, Nicolas Cagnard, Patrick Nitschké, Glenn Anderson, Birgit Assmann, Magalie Barth, Odile Boespflug
Pubblicato in: The Lancet Neurology, Numero 24, 2025, Pagina/e 218-229, ISSN 1474-4422
Editore: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(24)00526-x

Curcumin-mediated NRF2 induction limits inflammatory damage in, preclinical models of cystic fibrosis

Autori: Stephen A. Leon-Icaza, Maxence Frétaud, Sarahdja Cornélie, Charlotte Bureau, Laure Yatime, R.Andres Floto, Stephen A. Renshaw, Jean-Louis Herrmann, Christelle Langevin, Céline Cougoule, Audrey Bernut
Pubblicato in: Biomedicine & Pharmacotherapy, Numero 186, 2025, Pagina/e 117957, ISSN 0753-3322
Editore: Elsevier Masson
DOI: 10.1016/j.biopha.2025.117957

Dynamical swirl structures powered by microswimmers in active nematics

Autori: Partha Sarathi Mondal, Pawan Kumar Mishra, Tamás Vicsek, Shradha Mishra
Pubblicato in: Physica A: Statistical Mechanics and its Applications, Numero 659, 2025, Pagina/e 130338, ISSN 0378-4371
Editore: Elsevier BV
DOI: 10.1016/j.physa.2024.130338

Macrophages undergo a behavioural switch during wound healing in zebrafish

Autori: Sipka T., Park S.A., Ozbilgic R., Balas L., Durand T., Mikula K., Lutfalla G., Nguyen-Chi M.
Pubblicato in: Free Radical Biology and Medicine, 2022, Pagina/e 200-212, ISSN 0891-5849
Editore: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2022.09.021

The Spike protein of SARS-CoV-2 signals via Tlr2 in zebrafish

Autori: Sylwia D. Tyrkalska, Alicia Martìnez-Lòpez, Annamaria Pedoto, Sergio Candel, Maria L. Cayuela, Victoriano Mulero
Pubblicato in: Developmental & Comparative Immunology, 2023, ISSN 0145-305X
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.dci.2022.104626

3D cell segregation geometry and dynamics are governed by tissue surface tension regulation

Autori: Elod Méhes, Enys Mones, Máté Varga, Áron Zsigmond, Beáta Biri-Kovács, László Nyitray, Vanessa Barone, Gabriel Krens, Carl-Philipp Heisenberg, Tamás Vicsek
Pubblicato in: Communications Biology, Numero 6, 2024, ISSN 2399-3642
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s42003-023-05181-7

Zebrafish models of COVID-19

Autori: Sylwia D Tyrkalska; Sergio Candel; Annamaria Pedoto; Diana García-Moreno; Francisca Alcaraz-Pérez; Álvaro Sánchez-Ferrer; María L Cayuela; Victoriano Mulero
Pubblicato in: Crossref, Numero 2, 2023, ISSN 2398-7316
Editore: Oxford Academic Press
DOI: 10.1093/femsre/fuac042

Delay-induced phase transitions in active matter

Autori: Fatemeh Pakpour, Tamás Vicsek
Pubblicato in: Physica A: Statistical Mechanics and its Applications, Numero 634, 2024, Pagina/e 129453, ISSN 0378-4371
Editore: Elsevier BV
DOI: 10.1016/j.physa.2023.129453

Using zebrafish to understand reciprocal interactions between the nervous and immune systems and the microbial world

Autori: Jean-Pierre Levraud; John F. Rawls; Anne E. Clatworthy
Pubblicato in: Journal of Neuroinflammation, Numero 3, 2022, ISSN 1742-2094
Editore: BioMed Central
DOI: 10.1186/s12974-022-02506-x

Plasticity of cancer invasion and energy metabolism

Autori: Maria Parlani, Carolina Jorgez, and Peter Friedl
Pubblicato in: Trends in Cell Biology, 2022, ISSN 1879-3088
Editore: Elsevier
DOI: 10.1016/j.tcb.2022.09.009

Type I Interferonopathy due to a Homozygous Loss-of-Inhibitory Function Mutation in STAT2

Autori: Gaofeng Zhu, Mihaly Badonyi, Lina Franklin, Luis Seabra, Gillian I. Rice, null Anne-Boland-Auge, Jean-François Deleuze, Salima El-Chehadeh, Mathieu Anheim, Anne de Saint-Martin, Sandra Pellegrini, Joseph A. Marsh, Yanick J. Crow, Marie-Therese El-Daher
Pubblicato in: Journal of Clinical Immunology, Numero 43, 2023, Pagina/e 808-818, ISSN 0271-9142
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10875-023-01445-3

Dissecting the recruitment and self-organization of αSMA-positive fibroblasts in the foreign body response

Autori: Maria Parlani, Matthew L. Bedell, Antonios G. Mikos, Peter Friedl, and Eleonora Dondossola
Pubblicato in: Science Advances, 2022, ISSN 2375-2548
Editore: American Association for the Advancement of Science
DOI: 10.1126/sciadv.add0014

Molecular Actors of Inflammation and Their Signaling Pathways: Mechanistic Insights from Zebrafish

Autori: Leiba J., Ozbilgic R., Hernandez L., Demou M., Lutfalla G., Yatime L., Nguyen-Chi M.
Pubblicato in: Biology, 2023, ISSN 2079-7737
Editore: Biology
DOI: 10.3390/biology12020153

Virtual Orientation Tools (VOTj): Fiji plugins for object centering and alignment

Autori: Satheesan, S., Gehrig, J., & Thomas, L. S. V. (2024).
Pubblicato in: microPublication Biology, 2024, ISSN 2578-9430
Editore: Caltech Library
DOI: 10.17912/micropub.biology.001221

Macrophages Trajectories Smoothing by Evolving Curves

Autori: Giulia Lupi, Karol Mikula, Seol Ah Park
Pubblicato in: Tatra Mountains Mathematical Publications, Numero 87, 2025, Pagina/e 145-170, ISSN 1338-9750
Editore: Walter de Gruyter GmbH
DOI: 10.2478/tmmp-2023-0031

Silica crystals activate toll-like receptors and inflammasomes to promote local and systemic immune responses in zebrafish

Autori: Sylwia D. Tyrkalska, Annamaria Pedoto, Alicia Martìnez-Lòpez,José A.Ros-Lucas, Pablo Mesa-del-Castillo, Sergio Candel, Victoriano Mulero
Pubblicato in: Developmental & Comparative Immunology, Volume 138, January 2023, 104523, 2023, ISSN 0145-305X
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.dci.2022.104523

Dynamics of macrophage polarization support Salmonella persistence in a whole living organism

Autori: Jade Leiba, Tamara Sipka, Christina Begon-Pescia, Matteo Bernardello, Sofiane Tairi, Lionello Bossi, Anne-Alicia Gonzalez, Xavier Mialhe, Emilio J Gualda, Pablo Loza-Alvarez, Anne Blanc-Potard, Georges Lutfalla, Mai E Nguyen-Chi
Pubblicato in: eLife, Numero 13, 2024, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.89828

Conference proceedings (3)

Automated Completion of Segmented Fragments of Macrophages using Weighted Dilation and Erosion in 2D+time microscopy videos

Autori: Seol Ah Park, Karol Mikula
Pubblicato in: Proceedings of the Conference ALGORITMY 2024, 2024, Pagina/e pp. 11 – 20
Editore: Algoritmy

Vector field reconstruction from sparse samples by triple-Laplacian

Autori: Giulia Lupi, Karol Mikula
Pubblicato in: Proceedings of the Conference Algoritmy, 2024, Pagina/e pp. 85–98
Editore: Algoritmy

Automatic Path Extraction Inside the Aorta from CT Data

Autori: Konan A. Allaly Jozef Urbán
Pubblicato in: Proceedings of the Conference Algoritmy 2024, 2024, Pagina/e 255 - 263, ISBN 978-80-89829-33-0
Editore: Jednota slovenských matematikov a fyzikov

Thesis and dissertations (1)

In the Eye of the Swarm: Unravelling Neutrophil Swarming Dynamics in Zebrafish

Autori: Olijhoek, Nils Ingmar
Pubblicato in: White Rose eTheses Online, 2025
Editore: White Rose Libraries