A game change in continuous biosensing: Molecularly engineered affinity-based nanoswitches for personal monitoring

Project Information

CONSENSE

Grant agreement ID: 955623

DOI

10.3030/955623

Project closed

EC signature date 17 August 2020

Start date 1 March 2021

End date 31 August 2025

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 4 029 293,82

EU contribution

€ 4 029 293,82

Coordinated by

TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands

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Deliverables

Other (1)

Training Plan available on the website

Documents, reports (1)

Outreach Plan

Websites, patent fillings, videos etc. (1)

Website

Publications

Peer reviewed articles (17)

High-Throughput Single-Molecule Sensors: How Can the Signals Be Analyzed in Real Time for Achieving Real-Time Continuous Biosensing?

Author(s): Max H. Bergkamp, Sebastian Cajigas, Leo J. van IJzendoorn, Menno W.J. Prins
Published in: ACS Sensors, Issue 8, 2023, Page(s) 2271-2281, ISSN 2379-3694
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acssensors.3c00245

Real-time continuous monitoring of dynamic concentration profiles studied with biosensing by particle motion

Author(s): Max H. Bergkamp, Sebastian Cajigas, Leo J. van IJzendoorn, Menno W. J. Prins
Published in: Lab on a Chip, Issue 23, 2024, Page(s) 4600-4609, ISSN 1473-0197
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3lc00410d

Paving the way towards continuous biosensing by implementing affinity-based nanoswitches on state-dependent readout platforms.

Author(s): Jeroen Lammertyn; Annelies Dillen
Published in: Analyst, 2022, ISSN 0003-2654
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1an02308j

Design and Implementation of a Dual-Region Self-Referencing Fiber-Optic Surface Plasmon Resonance Biosensor

Author(s): Valentina Bello; Wouter Vandezande; Devin Daems; Jeroen Lammertyn
Published in: ACS Sensors, 2022, ISSN 2379-3694
Publisher: American Chemical Society
DOI: 10.1021/acssensors.2c01362

Exploiting Covalent Chemical Labeling with Self-Labeling Proteins

Author(s): Nicola Porzberg, Klara Gries, Kai Johnsson
Published in: Annual Review of Biochemistry, Issue 94, 2025, Page(s) 29-58, ISSN 0066-4154
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-biochem-030222-121016

Folding Double‐Stranded DNA into Designed Shapes with Triplex‐Forming Oligonucleotides

Author(s): Cindy Ng, Anirban Samanta, Ole Aalund Mandrup, Emily Tsang, Sarah Youssef, Lasse Hyldgaard Klausen, Mingdong Dong, Minke A. D. Nijenhuis, Kurt V. Gothelf
Published in: Advanced Materials, Issue 35, 2025, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202302497

Recording physiological history of cells with chemical labeling

Author(s): Magnus-Carsten Huppertz, Jonas Wilhelm, Vincent Grenier, Martin W. Schneider, Tjalda Falt, Nicola Porzberg, David Hausmann, Dirk C. Hoffmann, Ling Hai, Miroslaw Tarnawski, Gabriela Pino, Krasimir Slanchev, Ilya Kolb, Claudio Acuna, Lisa M. Fenk, Herwig Baier, Julien Hiblot, Kai Johnsson
Published in: Science, Issue 383, 2024, Page(s) 890-897, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.adg0812

Continuous Biosensing to Monitor Acute Systemic Inflammation, a Diagnostic Need for Therapeutic Guidance

Author(s): Guilherme Gouveia, Abtin Saateh, Anna Swietlikowska, Claudia Scarpellini, Emily Tsang, Hatice Altug, Maarten Merkx, Annelies Dillen, Karen Leirs, Dragana Spasic, Jeroen Lammertyn, Kurt V. Gothelf, Estelle Bonedeau, Nicola Porzberg, Ruben L. Smeets, Hans J. P. M. Koenen, Menno W. J. Prins, Marien I. de Jonge
Published in: ACS Sensors, Issue 10, 2025, Page(s) 4-14, ISSN 2379-3694
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acssensors.4c02569

Spatial Molecular Heterogeneity on Biofunctionalized Particles Quantified by Three-Dimensional Single-Molecule DNA-PAINT

Author(s): Wei Shan Tan, Arthur M. de Jong, Menno W. J. Prins
Published in: Langmuir, Issue 41, 2025, Page(s) 22181-22192, ISSN 0743-7463
Publisher: American Chemical Society
DOI: 10.1021/acs.langmuir.5c02403

Understanding Fast and Slow Signal Changes in a Competitive Particle-Based Continuous Biosensor

Author(s): Sebastian Cajigas, Arthur M. de Jong, Junhong Yan, Menno W. J. Prins
Published in: Analytical Chemistry, Issue 97, 2025, Page(s) 12719-12727, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.5c01457

Long‐Term and Continuous Plasmonic Oligonucleotide Monitoring Enabled by Regeneration Approach

Author(s): Abtin Saateh, Saeid Ansaryan, Jiarui Gao, Livio Oliveira de Miranda, Peter Zijlstra, Hatice Altug
Published in: Angewandte Chemie International Edition, Issue 63, 2025, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202410076

A Diketopinic Reagent for the Reversible Bioconjugation to Arginine Residues on Native Antibodies

Author(s): Mathias B. Bertelsen, Emily Tsang, Johan Palmfeldt, Celine H. Kristoffersen, Marija Nisavic, Kurt V. Gothelf
Published in: Bioconjugate Chemistry, Issue 35, 2024, Page(s) 1755-1761, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.4c00317

Reversible Protection and Targeted Delivery of DNA Origami with a Disulfide‐Containing Cationic Polymer

Author(s): Sarah Youssef, Emily Tsang, Anirban Samanta, Vipin Kumar, Kurt V. Gothelf
Published in: Small, Issue 20, 2024, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202301058

Integrated Signal Amplification on a Fiber Optic SPR Sensor Using Duplexed Aptamers

Author(s): Annelies Dillen, Claudia Scarpellini, Woud Daenen, Seppe Driesen, Peter Zijlstra & Jeroen Lammertyn
Published in: ACS Sensors, 2023, ISSN 2379-3694
Publisher: American Chemical Society
DOI: 10.1021/acssensors.2c02388

Molecular Origins of Long-Term Changes in a Competitive Continuous Biosensor with Single-Molecule Resolution

Author(s): Sebastian Cajigas, Arthur M. de Jong, Junhong Yan, Menno W. J. Prins
Published in: ACS Sensors, Issue 9, 2024, Page(s) 3520-3530, ISSN 2379-3694
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acssensors.4c00107

Revealing Spatial Molecular Heterogeneity of High-Density Biofunctionalized Surfaces Using DNA-PAINT

Author(s): Wei Shan Tan, Arthur M. de Jong, Menno W. J. Prins
Published in: ACS Applied Materials & Interfaces, Issue 16, 2025, Page(s) 58191-58202, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.4c10310

RAPPID-M: A Mix-and-Measure Bioluminescent Sandwich Immunoassay Based on Generic Antibody-Binding Protein M

Author(s): Anna Swietlikowska, Eva van Aalen, Max Bossink, Laura van Weesep, Maarten Merkx
Published in: ACS Sensors, Issue 10, 2025, Page(s) 7915-7923, ISSN 2379-3694
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acssensors.5c02450

Conference proceedings (1)

CONTINUOUS BIOSENSING ENABLED BY MICROFLUIDICS INTEGRATED WITH NANOSWITCH-BASED FIBER OPTIC SPR

Author(s): Annelies Dillen, Claudia Scarpellini, Jalu Setiya, Jolien Breukers, Seppe Driesen, Aurélie Mohrbacher, Livio Oliveira, Peter Zijlstra, Filip Delport, Karen Leirs, Dragana Spasic, Jeroen Lammertyn
Published in: 2024 MicroTAS Book of Abstracts, 2025
Publisher: Chemical and Biological Microsystems Society
DOI: 10.70477/htmf7256