A game change in continuous biosensing: Molecularly engineered affinity-based nanoswitches for personal monitoring

Información del proyecto

CONSENSE

Identificador del acuerdo de subvención: 955623

DOI

10.3030/955623

Proyecto cerrado

Fecha de la firma de la CE 17 Agosto 2020

Fecha de inicio 1 Marzo 2021

Fecha de finalización 31 Agosto 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 4 029 293,82

Aportación de la UE

€ 4 029 293,82

Coordinado por

TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Other (1)

Training Plan available on the website

Documents, reports (1)

Outreach Plan

Websites, patent fillings, videos etc. (1)

Website

Publicaciones

Peer reviewed articles (16)

High-Throughput Single-Molecule Sensors: How Can the Signals Be Analyzed in Real Time for Achieving Real-Time Continuous Biosensing?

Autores: Max H. Bergkamp, Sebastian Cajigas, Leo J. van IJzendoorn, Menno W.J. Prins
Publicado en: ACS Sensors, Edición 8, 2023, Página(s) 2271-2281, ISSN 2379-3694
Editor: American Chemical Society (ACS)
DOI: 10.1021/acssensors.3c00245

Real-time continuous monitoring of dynamic concentration profiles studied with biosensing by particle motion

Autores: Max H. Bergkamp, Sebastian Cajigas, Leo J. van IJzendoorn, Menno W. J. Prins
Publicado en: Lab on a Chip, Edición 23, 2024, Página(s) 4600-4609, ISSN 1473-0197
Editor: Royal Society of Chemistry
DOI: 10.1039/d3lc00410d

Paving the way towards continuous biosensing by implementing affinity-based nanoswitches on state-dependent readout platforms.

Autores: Jeroen Lammertyn; Annelies Dillen
Publicado en: Analyst, 2022, ISSN 0003-2654
Editor: Royal Society of Chemistry
DOI: 10.1039/d1an02308j

Design and Implementation of a Dual-Region Self-Referencing Fiber-Optic Surface Plasmon Resonance Biosensor

Autores: Valentina Bello; Wouter Vandezande; Devin Daems; Jeroen Lammertyn
Publicado en: ACS Sensors, 2022, ISSN 2379-3694
Editor: American Chemical Society
DOI: 10.1021/acssensors.2c01362

Exploiting Covalent Chemical Labeling with Self-Labeling Proteins

Autores: Nicola Porzberg, Klara Gries, Kai Johnsson
Publicado en: Annual Review of Biochemistry, Edición 94, 2025, Página(s) 29-58, ISSN 0066-4154
Editor: Annual Reviews, Inc.
DOI: 10.1146/annurev-biochem-030222-121016

Folding Double‐Stranded DNA into Designed Shapes with Triplex‐Forming Oligonucleotides

Autores: Cindy Ng, Anirban Samanta, Ole Aalund Mandrup, Emily Tsang, Sarah Youssef, Lasse Hyldgaard Klausen, Mingdong Dong, Minke A. D. Nijenhuis, Kurt V. Gothelf
Publicado en: Advanced Materials, Edición 35, 2025, ISSN 0935-9648
Editor: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202302497

Recording physiological history of cells with chemical labeling

Autores: Magnus-Carsten Huppertz, Jonas Wilhelm, Vincent Grenier, Martin W. Schneider, Tjalda Falt, Nicola Porzberg, David Hausmann, Dirk C. Hoffmann, Ling Hai, Miroslaw Tarnawski, Gabriela Pino, Krasimir Slanchev, Ilya Kolb, Claudio Acuna, Lisa M. Fenk, Herwig Baier, Julien Hiblot, Kai Johnsson
Publicado en: Science, Edición 383, 2024, Página(s) 890-897, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.adg0812

Continuous Biosensing to Monitor Acute Systemic Inflammation, a Diagnostic Need for Therapeutic Guidance

Autores: Guilherme Gouveia, Abtin Saateh, Anna Swietlikowska, Claudia Scarpellini, Emily Tsang, Hatice Altug, Maarten Merkx, Annelies Dillen, Karen Leirs, Dragana Spasic, Jeroen Lammertyn, Kurt V. Gothelf, Estelle Bonedeau, Nicola Porzberg, Ruben L. Smeets, Hans J. P. M. Koenen, Menno W. J. Prins, Marien I. de Jonge
Publicado en: ACS Sensors, Edición 10, 2025, Página(s) 4-14, ISSN 2379-3694
Editor: American Chemical Society (ACS)
DOI: 10.1021/acssensors.4c02569

Spatial Molecular Heterogeneity on Biofunctionalized Particles Quantified by Three-Dimensional Single-Molecule DNA-PAINT

Autores: Wei Shan Tan, Arthur M. de Jong, Menno W. J. Prins
Publicado en: Langmuir, Edición 41, 2025, Página(s) 22181-22192, ISSN 0743-7463
Editor: American Chemical Society
DOI: 10.1021/acs.langmuir.5c02403

Understanding Fast and Slow Signal Changes in a Competitive Particle-Based Continuous Biosensor

Autores: Sebastian Cajigas, Arthur M. de Jong, Junhong Yan, Menno W. J. Prins
Publicado en: Analytical Chemistry, Edición 97, 2025, Página(s) 12719-12727, ISSN 0003-2700
Editor: American Chemical Society
DOI: 10.1021/acs.analchem.5c01457

Long‐Term and Continuous Plasmonic Oligonucleotide Monitoring Enabled by Regeneration Approach

Autores: Abtin Saateh, Saeid Ansaryan, Jiarui Gao, Livio Oliveira de Miranda, Peter Zijlstra, Hatice Altug
Publicado en: Angewandte Chemie International Edition, Edición 63, 2025, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202410076

A Diketopinic Reagent for the Reversible Bioconjugation to Arginine Residues on Native Antibodies

Autores: Mathias B. Bertelsen, Emily Tsang, Johan Palmfeldt, Celine H. Kristoffersen, Marija Nisavic, Kurt V. Gothelf
Publicado en: Bioconjugate Chemistry, Edición 35, 2024, Página(s) 1755-1761, ISSN 1043-1802
Editor: American Chemical Society
DOI: 10.1021/acs.bioconjchem.4c00317

Reversible Protection and Targeted Delivery of DNA Origami with a Disulfide‐Containing Cationic Polymer

Autores: Sarah Youssef, Emily Tsang, Anirban Samanta, Vipin Kumar, Kurt V. Gothelf
Publicado en: Small, Edición 20, 2024, ISSN 1613-6810
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202301058

Integrated Signal Amplification on a Fiber Optic SPR Sensor Using Duplexed Aptamers

Autores: Annelies Dillen, Claudia Scarpellini, Woud Daenen, Seppe Driesen, Peter Zijlstra & Jeroen Lammertyn
Publicado en: ACS Sensors, 2023, ISSN 2379-3694
Editor: American Chemical Society
DOI: 10.1021/acssensors.2c02388

Molecular Origins of Long-Term Changes in a Competitive Continuous Biosensor with Single-Molecule Resolution

Autores: Sebastian Cajigas, Arthur M. de Jong, Junhong Yan, Menno W. J. Prins
Publicado en: ACS Sensors, Edición 9, 2024, Página(s) 3520-3530, ISSN 2379-3694
Editor: American Chemical Society (ACS)
DOI: 10.1021/acssensors.4c00107

Revealing Spatial Molecular Heterogeneity of High-Density Biofunctionalized Surfaces Using DNA-PAINT

Autores: Wei Shan Tan, Arthur M. de Jong, Menno W. J. Prins
Publicado en: ACS Applied Materials & Interfaces, Edición 16, 2025, Página(s) 58191-58202, ISSN 1944-8244
Editor: American Chemical Society
DOI: 10.1021/acsami.4c10310

Conference proceedings (1)

CONTINUOUS BIOSENSING ENABLED BY MICROFLUIDICS INTEGRATED WITH NANOSWITCH-BASED FIBER OPTIC SPR

Autores: Annelies Dillen, Claudia Scarpellini, Jalu Setiya, Jolien Breukers, Seppe Driesen, Aurélie Mohrbacher, Livio Oliveira, Peter Zijlstra, Filip Delport, Karen Leirs, Dragana Spasic, Jeroen Lammertyn
Publicado en: 2024 MicroTAS Book of Abstracts, 2025
Editor: Chemical and Biological Microsystems Society
DOI: 10.70477/htmf7256