A game change in continuous biosensing: Molecularly engineered affinity-based nanoswitches for personal monitoring

Informazioni relative al progetto

CONSENSE

ID dell’accordo di sovvenzione: 955623

DOI

10.3030/955623

Progetto chiuso

Data della firma CE 17 Agosto 2020

Data di avvio 1 Marzo 2021

Data di completamento 31 Agosto 2025

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 4 029 293,82

Contributo UE

€ 4 029 293,82

Coordinato da

TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands

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Risultati finali

Other (1)

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Documents, reports (1)

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Websites, patent fillings, videos etc. (1)

Website

Pubblicazioni

Peer reviewed articles (17)

High-Throughput Single-Molecule Sensors: How Can the Signals Be Analyzed in Real Time for Achieving Real-Time Continuous Biosensing?

Autori: Max H. Bergkamp, Sebastian Cajigas, Leo J. van IJzendoorn, Menno W.J. Prins
Pubblicato in: ACS Sensors, Numero 8, 2023, Pagina/e 2271-2281, ISSN 2379-3694
Editore: American Chemical Society (ACS)
DOI: 10.1021/acssensors.3c00245

Real-time continuous monitoring of dynamic concentration profiles studied with biosensing by particle motion

Autori: Max H. Bergkamp, Sebastian Cajigas, Leo J. van IJzendoorn, Menno W. J. Prins
Pubblicato in: Lab on a Chip, Numero 23, 2024, Pagina/e 4600-4609, ISSN 1473-0197
Editore: Royal Society of Chemistry
DOI: 10.1039/d3lc00410d

Paving the way towards continuous biosensing by implementing affinity-based nanoswitches on state-dependent readout platforms.

Autori: Jeroen Lammertyn; Annelies Dillen
Pubblicato in: Analyst, 2022, ISSN 0003-2654
Editore: Royal Society of Chemistry
DOI: 10.1039/d1an02308j

Design and Implementation of a Dual-Region Self-Referencing Fiber-Optic Surface Plasmon Resonance Biosensor

Autori: Valentina Bello; Wouter Vandezande; Devin Daems; Jeroen Lammertyn
Pubblicato in: ACS Sensors, 2022, ISSN 2379-3694
Editore: American Chemical Society
DOI: 10.1021/acssensors.2c01362

Exploiting Covalent Chemical Labeling with Self-Labeling Proteins

Autori: Nicola Porzberg, Klara Gries, Kai Johnsson
Pubblicato in: Annual Review of Biochemistry, Numero 94, 2025, Pagina/e 29-58, ISSN 0066-4154
Editore: Annual Reviews, Inc.
DOI: 10.1146/annurev-biochem-030222-121016

Folding Double‐Stranded DNA into Designed Shapes with Triplex‐Forming Oligonucleotides

Autori: Cindy Ng, Anirban Samanta, Ole Aalund Mandrup, Emily Tsang, Sarah Youssef, Lasse Hyldgaard Klausen, Mingdong Dong, Minke A. D. Nijenhuis, Kurt V. Gothelf
Pubblicato in: Advanced Materials, Numero 35, 2025, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202302497

Recording physiological history of cells with chemical labeling

Autori: Magnus-Carsten Huppertz, Jonas Wilhelm, Vincent Grenier, Martin W. Schneider, Tjalda Falt, Nicola Porzberg, David Hausmann, Dirk C. Hoffmann, Ling Hai, Miroslaw Tarnawski, Gabriela Pino, Krasimir Slanchev, Ilya Kolb, Claudio Acuna, Lisa M. Fenk, Herwig Baier, Julien Hiblot, Kai Johnsson
Pubblicato in: Science, Numero 383, 2024, Pagina/e 890-897, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.adg0812

Continuous Biosensing to Monitor Acute Systemic Inflammation, a Diagnostic Need for Therapeutic Guidance

Autori: Guilherme Gouveia, Abtin Saateh, Anna Swietlikowska, Claudia Scarpellini, Emily Tsang, Hatice Altug, Maarten Merkx, Annelies Dillen, Karen Leirs, Dragana Spasic, Jeroen Lammertyn, Kurt V. Gothelf, Estelle Bonedeau, Nicola Porzberg, Ruben L. Smeets, Hans J. P. M. Koenen, Menno W. J. Prins, Marien I. de Jonge
Pubblicato in: ACS Sensors, Numero 10, 2025, Pagina/e 4-14, ISSN 2379-3694
Editore: American Chemical Society (ACS)
DOI: 10.1021/acssensors.4c02569

Spatial Molecular Heterogeneity on Biofunctionalized Particles Quantified by Three-Dimensional Single-Molecule DNA-PAINT

Autori: Wei Shan Tan, Arthur M. de Jong, Menno W. J. Prins
Pubblicato in: Langmuir, Numero 41, 2025, Pagina/e 22181-22192, ISSN 0743-7463
Editore: American Chemical Society
DOI: 10.1021/acs.langmuir.5c02403

Understanding Fast and Slow Signal Changes in a Competitive Particle-Based Continuous Biosensor

Autori: Sebastian Cajigas, Arthur M. de Jong, Junhong Yan, Menno W. J. Prins
Pubblicato in: Analytical Chemistry, Numero 97, 2025, Pagina/e 12719-12727, ISSN 0003-2700
Editore: American Chemical Society
DOI: 10.1021/acs.analchem.5c01457

Long‐Term and Continuous Plasmonic Oligonucleotide Monitoring Enabled by Regeneration Approach

Autori: Abtin Saateh, Saeid Ansaryan, Jiarui Gao, Livio Oliveira de Miranda, Peter Zijlstra, Hatice Altug
Pubblicato in: Angewandte Chemie International Edition, Numero 63, 2025, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202410076

A Diketopinic Reagent for the Reversible Bioconjugation to Arginine Residues on Native Antibodies

Autori: Mathias B. Bertelsen, Emily Tsang, Johan Palmfeldt, Celine H. Kristoffersen, Marija Nisavic, Kurt V. Gothelf
Pubblicato in: Bioconjugate Chemistry, Numero 35, 2024, Pagina/e 1755-1761, ISSN 1043-1802
Editore: American Chemical Society
DOI: 10.1021/acs.bioconjchem.4c00317

Reversible Protection and Targeted Delivery of DNA Origami with a Disulfide‐Containing Cationic Polymer

Autori: Sarah Youssef, Emily Tsang, Anirban Samanta, Vipin Kumar, Kurt V. Gothelf
Pubblicato in: Small, Numero 20, 2024, ISSN 1613-6810
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202301058

Integrated Signal Amplification on a Fiber Optic SPR Sensor Using Duplexed Aptamers

Autori: Annelies Dillen, Claudia Scarpellini, Woud Daenen, Seppe Driesen, Peter Zijlstra & Jeroen Lammertyn
Pubblicato in: ACS Sensors, 2023, ISSN 2379-3694
Editore: American Chemical Society
DOI: 10.1021/acssensors.2c02388

Molecular Origins of Long-Term Changes in a Competitive Continuous Biosensor with Single-Molecule Resolution

Autori: Sebastian Cajigas, Arthur M. de Jong, Junhong Yan, Menno W. J. Prins
Pubblicato in: ACS Sensors, Numero 9, 2024, Pagina/e 3520-3530, ISSN 2379-3694
Editore: American Chemical Society (ACS)
DOI: 10.1021/acssensors.4c00107

Revealing Spatial Molecular Heterogeneity of High-Density Biofunctionalized Surfaces Using DNA-PAINT

Autori: Wei Shan Tan, Arthur M. de Jong, Menno W. J. Prins
Pubblicato in: ACS Applied Materials & Interfaces, Numero 16, 2025, Pagina/e 58191-58202, ISSN 1944-8244
Editore: American Chemical Society
DOI: 10.1021/acsami.4c10310

RAPPID-M: A Mix-and-Measure Bioluminescent Sandwich Immunoassay Based on Generic Antibody-Binding Protein M

Autori: Anna Swietlikowska, Eva van Aalen, Max Bossink, Laura van Weesep, Maarten Merkx
Pubblicato in: ACS Sensors, Numero 10, 2025, Pagina/e 7915-7923, ISSN 2379-3694
Editore: American Chemical Society (ACS)
DOI: 10.1021/acssensors.5c02450

Conference proceedings (1)

CONTINUOUS BIOSENSING ENABLED BY MICROFLUIDICS INTEGRATED WITH NANOSWITCH-BASED FIBER OPTIC SPR

Autori: Annelies Dillen, Claudia Scarpellini, Jalu Setiya, Jolien Breukers, Seppe Driesen, Aurélie Mohrbacher, Livio Oliveira, Peter Zijlstra, Filip Delport, Karen Leirs, Dragana Spasic, Jeroen Lammertyn
Pubblicato in: 2024 MicroTAS Book of Abstracts, 2025
Editore: Chemical and Biological Microsystems Society
DOI: 10.70477/htmf7256