Periodic Reporting for period 1 - BioInspireSensing (Multidisciplinary Training of Young Researchers in Novel Implantable Bio-inspired sensors)
Periodo di rendicontazione: 2021-01-01 al 2022-12-31
Healthcare expenditure growth along recent times underlies the need for new and more reliable, low-cost and easy-to-use diagnostic tools. Novel biosensors based on implantable solutions has increased in the last decades. These sensors can provide real time information and new therapeutic strategies on demand at the point-of-care. BioInspireSensing project was founded to fabricate a non-invasive treatment based on implantable sensors to help to make diagnoses and guiding drug administration.
This technology will improve the quality of life of European citizens, by providing less invasive, more reliable and earlier diagnosis, which ultimately also has a strong positive impact in the sustainability of healthcare systems.
Several Universities, private and public companies participate in this project. The collaboration between public and private sector is considered essential in the current research training programs implemented in Europe. Within the consortium, the involvement of the private sector is very substantial in relation to the research and training programs, as well as their implementation. In this sense, the collaboration between the public and private sectors will be strengthened.
The main objectives of this project are:
• Formation of interdisciplinary PhD: The purpose of this transnational training network is to train PhD students, in investigating, building, and producing a new generation of bioinspired implantable sensors of pressure, temperature and acidity.
• Construction of a bioresorbable sensor prototype: BioInspireSensing project will apply the state-of-the-art in ion channel proteins, cell membrane transport, unilamellar vesicles, tethered planar lipid bilayer, synthetic biochemistry, and biodegradable and flexible conducting polymers to obtain the novel sensors. It will take advantage of a unique multi-sectorial and multi-field environment to further teach early stage researchers (ESR) to apply the gained knowledge in analysing and designing/engineering complex biological nanosensors of medical importance.
This technology will improve the quality of life of European citizens, by providing less invasive, more reliable and earlier diagnosis, which ultimately also has a strong positive impact in the sustainability of healthcare systems.
Several Universities, private and public companies participate in this project. The collaboration between public and private sector is considered essential in the current research training programs implemented in Europe. Within the consortium, the involvement of the private sector is very substantial in relation to the research and training programs, as well as their implementation. In this sense, the collaboration between the public and private sectors will be strengthened.
The main objectives of this project are:
• Formation of interdisciplinary PhD: The purpose of this transnational training network is to train PhD students, in investigating, building, and producing a new generation of bioinspired implantable sensors of pressure, temperature and acidity.
• Construction of a bioresorbable sensor prototype: BioInspireSensing project will apply the state-of-the-art in ion channel proteins, cell membrane transport, unilamellar vesicles, tethered planar lipid bilayer, synthetic biochemistry, and biodegradable and flexible conducting polymers to obtain the novel sensors. It will take advantage of a unique multi-sectorial and multi-field environment to further teach early stage researchers (ESR) to apply the gained knowledge in analysing and designing/engineering complex biological nanosensors of medical importance.
BioInspireSensing project is divided in individual research project that each ESRs have to develop during their PhD. The individual research projects (IRPs) of ESRs focus on different key aspects of biosensors in order to innovate in the use of natural materials as novel bioinspired sensors. In fact, the purpose of BioInspireSensing is to make ESRs aware of the challenges in the development of new implantable sensors and train them in new interdisciplinary methodology in the field of biosensors.During the project, different deliverables and milestones have been writing in order to achieve the main goal of each IRPs. Different committees (recruitment committee, training committee and supervisory committee) have been created as well, in order to control and delivered all the milestones and deliverables described in the grant agreement.Furthermore it has been established to create for each ESR a unique researcher identifier number (Researcher ID or ORCID) for the indexation of published articles. The publication will publish in Zenodo repository and open access journals.
The purpose of this trans-national training network is to train PhD students, in investigating, building, and producing a new generation of bioinspired implantable sensors of pressure, temperature and acidity. New devices will be made of complex hybrid materials, composed of natural molecules and synthetic biopolymers, with the additional properties of being fully biocompatible and bioresorbable, unlike most of existing implantable sensors; anticipating, thus, a new generation of sensors that would not require posterior surgical extraction.
The BioInspireSensing consortium forms a strategic research alliance of carefully selected world leading partners from academia and industry. The network brings together scientists and experts with a wide range of interdisciplinary skills from computational science up to bioengineering and clinics. The selected supervisors have extensive leadership experience: as participants in other ITN and EC projects; as heads of departments, institutes and research groups, and have experience in international and intersectoral postgraduate schools, and have contributed to curriculum development.
The expected results related with ESRs are
• Novel strategies using ion channel proteins in synergy with advanced biodegradable materials to develop bioresorbable sensors.
• Novel ways to address protein membrane phenomena such as channel gating ion conductance, etc.
• Advanced methods for developing natural molecules as sensor device.
• New approaches to monitor physical and chemical variables.
• General overview on all stages of implantable sensor development.
The expected impacts that BioInspireSensing generate cover from education to new product development, thanks to the participation of selected supervisors and PhD students with an extensive experience in high quality research and leadership. This project will train the young future leading scientists in Europe and future business leaders with a strong academic background. In addition, it will create a high competitive technology, increasing Europe’s global competitiveness through the development and commercialization of new implantable sensors. The private partners get access to inter-disciplinary skilled scientists, which is of outmost importance for the development of new technologies that ensures their advantage over competitors.
●BioInspireSensing social networks
All activities and events where BIS consortium members are involved and participate are subject to be published in each available social network to increase the visibility of the BIS project.
LinkedIn
https://www.linkedin.com/company/bioinspiresensing/
Twitter
https://twitter.com/bioinspsensing
Facebook
https://www.facebook.com/bioinspiresensing
Instagram
https://www.instagram.com/bioinspiresensing/
The use of various communication channels is essential in order to promote and to demonstrate the added value of the BioInspireSensing project across the European Union. To this aim, various means and channels of communication have been implemented. and are updated regularly. Among the peers, scientific dissemination is meant to provide an opportunity for future collaboration and for a societal and economical exploitation of the scientific results. The outreach activities carried out aim to build people's trust in scientific activities as well as heighten young people’s interest in science and research careers. The emphasis is put on the visibility of the BioInspireSensing project among the scientific community as well as among the public.
The BioInspireSensing consortium forms a strategic research alliance of carefully selected world leading partners from academia and industry. The network brings together scientists and experts with a wide range of interdisciplinary skills from computational science up to bioengineering and clinics. The selected supervisors have extensive leadership experience: as participants in other ITN and EC projects; as heads of departments, institutes and research groups, and have experience in international and intersectoral postgraduate schools, and have contributed to curriculum development.
The expected results related with ESRs are
• Novel strategies using ion channel proteins in synergy with advanced biodegradable materials to develop bioresorbable sensors.
• Novel ways to address protein membrane phenomena such as channel gating ion conductance, etc.
• Advanced methods for developing natural molecules as sensor device.
• New approaches to monitor physical and chemical variables.
• General overview on all stages of implantable sensor development.
The expected impacts that BioInspireSensing generate cover from education to new product development, thanks to the participation of selected supervisors and PhD students with an extensive experience in high quality research and leadership. This project will train the young future leading scientists in Europe and future business leaders with a strong academic background. In addition, it will create a high competitive technology, increasing Europe’s global competitiveness through the development and commercialization of new implantable sensors. The private partners get access to inter-disciplinary skilled scientists, which is of outmost importance for the development of new technologies that ensures their advantage over competitors.
●BioInspireSensing social networks
All activities and events where BIS consortium members are involved and participate are subject to be published in each available social network to increase the visibility of the BIS project.
https://www.linkedin.com/company/bioinspiresensing/
https://twitter.com/bioinspsensing
https://www.facebook.com/bioinspiresensing
https://www.instagram.com/bioinspiresensing/
The use of various communication channels is essential in order to promote and to demonstrate the added value of the BioInspireSensing project across the European Union. To this aim, various means and channels of communication have been implemented. and are updated regularly. Among the peers, scientific dissemination is meant to provide an opportunity for future collaboration and for a societal and economical exploitation of the scientific results. The outreach activities carried out aim to build people's trust in scientific activities as well as heighten young people’s interest in science and research careers. The emphasis is put on the visibility of the BioInspireSensing project among the scientific community as well as among the public.