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Stimuli Responsive Materials for the Rapid Detection and Treatment of Healthcare Associated Infections

Objective

Healthcare Associated Infections (HAIs) are bacterial infections obtained as a result of clinical treatment e.g. following medical intervention. HAIs are a problem of tremendous proportion as more than 4 million EC citizens get infected annually. The ECDC estimates 147,000 HAI-related deaths in Europe each year, a large part stemming from wound infections. These alarming facts motivate the urgent need to develop novel medical devices, in particular wound dressings, which rapidly signal and prevent or eradicate invasive bacterial colonization following a stimulus. Current antimicrobial coatings rely on slow, passive diffusion of antimicrobials, hence the antimicrobial may not be sufficiently concentrated to eradicate the infection; such low concentration zones promote evolution of resistance. To tackle these challenges in healthcare in light of an increasingly aging population and unprecedented antibiotic resistance levels, there is an urgent need for dedicated research leaders in industry and academia. These scientists of the future still will need primary training in, e.g., chemistry or microbiology, but they will have to operate at the interface between disciplines. Future materials chemists will need to perform microbiology experiments and to appreciate the engineering required to translate a lab invention to a production prototype. They have to understand the societal, business and regulatory environment around new medical device development. The research focus of STIMULUS is on wound infections. The objectives are: 1) Diagnostic: To create materials that clearly and rapidly signal when infection is present; 2) Therapeutic: triggered release of antimicrobials to treat the infection; 3) Translational and theranostic: integration of responsive materials into prototype wound dressings. Integrated with this research, we will create a lasting and comprehensive training programme for ESRs, making them suitable for leading research on theranostic medical devices.

Field of science

  • /natural sciences/biological sciences/microbiology/bacteriology
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance/antibiotic resistance

Call for proposal

H2020-MSCA-ITN-2020
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

UNIVERSITAET FUER BODENKULTUR WIEN
Address
Gregor Mendel Strasse 33
1180 Wien
Austria
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 528 414,48

Participants (8)

UNIVERSITY OF BATH
United Kingdom
EU contribution
€ 606 345,12
Address
Claverton Down
BA2 7AY Bath
Activity type
Higher or Secondary Education Establishments
PAUL HARTMANN AG
Germany
EU contribution
€ 252 788,40
Address
Paul Hartmann Strasse 12
89522 Heidenheim An Der Brenz
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITAET SIEGEN
Germany
EU contribution
€ 505 576,80
Address
Adolf Reichwein Strasse 2A
57076 Siegen
Activity type
Higher or Secondary Education Establishments
Department of Health
United Kingdom
EU contribution
€ 303 172,56
Address
Quarry House, Quarry Hill
LS2 7UE Leeds
Activity type
Research Organisations
ATTO-TEC GMBH
Germany
EU contribution
€ 252 788,40
Address
Am Eichenhang 50
57076 Siegen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
KOC UNIVERSITY
Turkey
EU contribution
€ 470 496,24
Address
Rumeli Feneri Yolu Sariyer
34450 Istanbul
Activity type
Higher or Secondary Education Establishments
TECHNISCHE UNIVERSITAT DARMSTADT
Germany
EU contribution
€ 505 576,80
Address
Karolinenplatz 5
64289 Darmstadt
Activity type
Higher or Secondary Education Establishments
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 531 239,76
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments