Descripción del proyecto
Formar a la próxima generación de investigadores traslacionales
La lumbalgia es la principal causa de morbilidad en el mundo y la degeneración de los discos intervertebrales constituye la etiología subyacente en prácticamente la mitad de los casos. El proyecto Disc4All, financiado con fondos europeos, tiene por objeto investigar la interrelación entre los factores genéticos, ambientales, celulares y psicológicos de la lumbalgia, todavía poco conocida. Los investigadores aplicarán un método colaborativo interdisciplinar para integrar esta información en un mapa de procesos degenerativos y factores de riesgo. Al mismo tiempo, ofrecerán un programa de formación experimental e «in silico» a investigadores noveles con el fin de dotarles de las habilidades necesarias para una carrera de investigación traslacional sobre trastornos con múltiples factores.
Objetivo
The European community requires early stage researchers (ESRs) who can work across the boundaries of traditional disciplines, integrating experimental and in silico approaches to understand and manage complex multifactorial disorders. This training network utilises intervertebral disc degeneration (LDD) leading to low back pain (LBP) as a relevant application for data integration and computational simulations in translational medicine. LBP is the largest cause of morbidity worldwide, yet there remains controversy as to the specific cause leading to poor treatment options and prognosis. LDD is reported to account for 50% of LBP in young adults, but the interplay of factors from genetics, environmental, cellular responses and social and psychological factors is poorly understood. Unfortunately, the integration of such data into a holistic and rational map of degenerative processes and risk factors has not been achieved, requiring creation of professional crosscompetencies, which current training programmes fail to address. Disc4All aims to tackle this issue through collaborative expertise of clinicians; computational physicists and biologists; geneticists; computer scientists; cell and molecular biologists; microbiologists; bioinformaticians; and industrial partners. It provides interdisciplinary training in data curation and integration; experimental and theoretical/computational modelling; computer algorithm development; tool generation; and model and simulation platforms to transparently integrate primary data for enhanced clinical interpretations through models and simulations. Complementary training is offered in dissemination; project management; research integrity; ethics; regulation; policy; business strategy; and public and patient engagement. The Disc4All ESRs will provide a new generation of internationally mobile professionals with unique skill sets for the development of thriving careers in translational research applied to multifactorial disorders.
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MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinador
08002 Barcelona
España