Training network to advance integrated computational simulations in translational medicine, applied to intervertebral disc degeneration

Información del proyecto

Disc4All

Identificador del acuerdo de subvención: 955735

DOI

10.3030/955735

Proyecto cerrado

Fecha de la firma de la CE 31 Agosto 2020

Fecha de inicio 1 Noviembre 2020

Fecha de finalización 31 Mayo 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 3 996 776,52

Aportación de la UE

€ 3 996 776,52

Coordinado por

UNIVERSIDAD POMPEU FABRA
Spain

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (6)

Potential inputs for policy feedback
Annual Winter & Summer Schools and Advanced Training Event Public Reports

These deliverable will be updated in the following months: 12, 18, 24, 39, 48

Deployable platform backend design
Final conference Public Report
Design & capacity of the agnostic platform, with integrated cloud services & remote access

Design capacity of the agnostic platform with integrated cloud services remote access

Science-based & Transferable skills Public Report

Demonstrators, pilots, prototypes (2)

AB-FE Multiscale mechanistic modelling software
Phenotype-gene biomarker-comorbidities association tool

Open Research Data Pilot (2)

Primary data interoperability & secondary data
Data governance framework

Other (2)

ESRs Recruitment published
Supervisory Board of the network

Websites, patent fillings, videos etc. (2)

Project Website with Social Media & Annual Public Progress Reports

This deliverable will be updated in the following months: 1, 12, 24, 39, 48

Dissemination & Outreach Reports

This deliverable will be upadated in the following months: 24, 55

Publicaciones

Peer reviewed articles (26)

A systematic review of intervertebral disc degeneration clinical trial protocols

Autores: Francis Chemorion, Jerome Noailly, Marc-Antonio Bisotti
Publicado en: Open Research Europe, Edición 5, 2025, Página(s) 284, ISSN 2732-5121
Editor: F1000 Research Ltd
DOI: 10.12688/openreseurope.21091.1

Immuno-Modulatory Effects of Intervertebral Disc Cells

Autores: Bermudez-Lekerika P, Crump KB, Tseranidou S, Nüesch A, Kanelis E, Alminnawi A, Baumgartner L, Muñoz-Moya E, Compte R, Gualdi F, Alexopoulos LG, Geris L, Wuertz-Kozak K, Le Maitre CL, Noailly J, Gantenbein B
Publicado en: Frontiers in Cell and Developmental Biology, Edición 10, 2022, ISSN 2296-634X
Editor: frontiers
DOI: 10.3389/fcell.2022.924692

TNF induces catabolism in human cartilaginous endplate cells in 3D agarose culture under dynamic compression

Autores: Katherine B. Crump, Exarchos Kanelis, Maria Segarra-Queralt, Andreu Pascuet-Fontanet, Paola Bermudez-Lekerika, Ahmad Alminnawi, Liesbet Geris, Leonidas G. Alexopoulos, Jérôme Noailly, Benjamin Gantenbein
Publicado en: Scientific Reports, Edición 15, 2025, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-025-00538-w

Sulfated Hydrogels in Intervertebral Disc and Cartilage Research

Autores: Lazarus E, Bermudez-Lekerika P, Farchione D, Schofield T, Howard S, Mambetkadyrov I, Lamoca M, Rivero IV, Gantenbein B, Lewis CL, Wuertz-Kozak K
Publicado en: Cells, 2021, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells10123568

In-silico proteomic analysis of the role of IL-4 and IL-10 in IVD degeneration: Protein-protein interaction networks for candidate prioritisation

Autores: Paola Bermudez-Lekerika, Francesco Gualdi, Christine L. Le Maitre, Janet Piñero, Baldomero Oliva, Benjamin Gantenbein
Publicado en: Computational and Structural Biotechnology Journal, Edición 27, 2025, Página(s) 1600-1613, ISSN 2001-0370
Editor: Elsevier BV
DOI: 10.1016/j.csbj.2025.04.015

The interplay between biochemical mediators and mechanotransduction in chondrocytes: Unravelling the differential responses in primary knee osteoarthritis

Autores: Maria Segarra-Queralt, Katherine Crump, Andreu Pascuet-Fontanet, Benjamin Gantenbein, Jérôme Noailly
Publicado en: Physics of Life Reviews, Edición 48, 2025, Página(s) 205-221, ISSN 1571-0645
Editor: Elsevier BV
DOI: 10.1016/j.plrev.2024.02.003

Inhibition of the extracellular signal-regulated kinase pathway reduces the inflammatory component in nucleus pulposus cells

Autores: Tekari A, Marazza A, Crump K, Bermudez-Lekerika P, Gantenbein B
Publicado en: J Orthop Res, 2022, ISSN 1554-527X
Editor: Wiley
DOI: 10.1002/jor.25273

Nucleus pulposus cell network modelling in the intervertebral disc

Autores: Sofia Tseranidou, Maria Segarra-Queralt, Francis Kiptengwer Chemorion, Christine Lyn Le Maitre, Janet Piñero, Jérôme Noailly
Publicado en: npj Systems Biology and Applications, Edición 11, 2025, ISSN 2056-7189
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41540-024-00479-6

Are current machine learning applications comparable to radiologist classification of degenerate and herniated discs and Modic change? A systematic review and meta-analysis

Autores: Roger Compte, Isabelle Granville Smith, Amanda Isaac, Nathan Danckert, Terence McSweeney, Panagiotis Liantis, Frances M. K. Williams
Publicado en: European Spine Journal, Edición 32, 2023, Página(s) 3764-3787, ISSN 0940-6719
Editor: Springer Verlag
DOI: 10.1007/s00586-023-07718-0

Modic change is associated with increased BMI but not autoimmune diseases in TwinsUK

Autores: Francesco Gualdi, Isabelle Granville Smith, Roger Compte Boixader, Frances M. K. Williams
Publicado en: European Spine Journal, Edición 32, 2023, Página(s) 3379-3386, ISSN 0940-6719
Editor: Springer Verlag
DOI: 10.1007/s00586-023-07870-7

A porohyperelastic scheme targeted at High-Performance Computing frameworks for the simulation of the intervertebral disc

Autores: Dimitrios Lialios, Beatriz Eguzkitza, Guillaume Houzeaux, Eva Casoni, Laura Baumgartner, Jérôme Noailly, Estefano Muñoz-Moya, Benjamin Gantenbein, Mariano Vázquez
Publicado en: Computer Methods and Programs in Biomedicine, Edición 259, 2024, Página(s) 108493, ISSN 0169-2607
Editor: Elsevier BV
DOI: 10.1016/j.cmpb.2024.108493

Unveiling interactions between intervertebral disc morphologies and mechanical behavior through personalized finite element modeling

Autores: Estefano Muñoz-Moya, Morteza Rasouligandomani, Carlos Ruiz Wills, Francis Kiptengwer Chemorion, Gemma Piella, Jérôme Noailly
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 12, 2024, ISSN 2296-4185
Editor: Frontiers Media SA
DOI: 10.3389/fbioe.2024.1384599

No evidence of association between either Modic change or disc degeneration and five circulating inflammatory proteins

Autores: Roger Compte, Maxim B. Freidin, Isabelle Granville Smith, Christine L. Le Maitre, Dovile Vaitkute, Ayrun Nessa, Genevieve Lachance, Frances M. K. Williams
Publicado en: JOR SPINE, Edición 7, 2024, ISSN 2572-1143
Editor: Wiley
DOI: 10.1002/jsp2.1323

Ex Vivo and In Vitro Proteomic Approach to Elucidate the Relevance of IL-4 and IL-10 in Intervertebral Disc Pathophysiology

Autores: Bermudez-Lekerika P, Tseranidou S, Kanelis E, Nüesch A, Crump KB, Alexopoulos LG, Wuertz-Kozak K, Noailly J, Le Maitre CL, Gantenbein B
Publicado en: JOR Spine, Edición 8(1), 2025, Página(s) e70048, ISSN 2572-1143
Editor: Wiley & sons
DOI: 10.1002/jsp2.70048

External Validation of SpineNet, an Open-Source Deep Learning Model for Grading Lumbar Disk Degeneration MRI Features, Using the Northern Finland Birth Cohort 1966

Autores: Terence P. McSweeney, Aleksei Tiulpin, Simo Saarakkala, Jaakko Niinimäki, Rhydian Windsor, Amir Jamaludin, Timor Kadir, Jaro Karppinen, Juhani Määttä
Publicado en: Spine, Edición 48, 2025, Página(s) 484-491, ISSN 0362-2436
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/brs.0000000000004572

Exploring Mechanotransduction and Inflammation in Human Cartilaginous Endplate Cells in Blended Collagen–Agarose Hydrogels Under Cyclic Compression

Autores: Katherine B. Crump, Chloé Chapallaz, Ahmad Alminnawi, Paola Bermudez-Lekerika, Liesbet Geris, Jérôme Noailly, Benjamin Gantenbein
Publicado en: Gels, Edición 11, 2025, Página(s) 736, ISSN 2310-2861
Editor: MDPI AG
DOI: 10.3390/gels11090736

Predicting gene disease associations with knowledge graph embeddings for diseases with curtailed information

Autores: Francesco Gualdi, Baldomero Oliva, Janet Piñero
Publicado en: NAR Genomics and Bioinformatics, Edición 6, 2024, ISSN 2631-9268
Editor: Oxford University Press (OUP)
DOI: 10.1093/nargab/lqae049

Influence of disc height and strain-dependent solute diffusivity on metabolic transport in patient-personalized intervertebral disc models

Autores: Zerihun G. Workineh, Estefano Muñoz-Moya, Carlos Ruiz Wills, Dimitrios Lialios, Jérôme Noailly
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 13, 2025, ISSN 2296-4185
Editor: Frontiers Media SA
DOI: 10.3389/fbioe.2025.1651786

EGR2, IGF1 and IL6 Expression Are Elevated in the Intervertebral Disc of Patients Suffering from Diffuse Idiopathic Skeletal Hyperostosis (DISH) Compared to Degenerative or Trauma Discs

Autores: Benjamin Gantenbein; Rahel Deborah May; Paola Bermudez-Lekerika; Katharina A. C. Oswald; Lorin Michael Benneker; Christoph E. Albers
Publicado en: Applied Sciences, Edición 2, 2021, Página(s) 4072, ISSN 2076-3417
Editor: MDPI
DOI: 10.48350/156197

The Bone Morphogenetic Protein 2 Analogue L51P Enhances Spinal Fusion in Combination with BMP2 in an In Vivo Rat Tail Model

Autores: Gantenbein B, Oswald KA, Erbach GF, Croft AS, Bermudez-Lekerika P, Strunz F, Bigdon SF, Albers CE
Publicado en: Acta Biomaterialia, 2024, ISSN 1742-7061
Editor: Elsevier BV
DOI: 10.1016/j.actbio.2024.01.039

Dataset of Finite Element Models of Normal and Deformed Thoracolumbar Spine

Autores: Morteza Rasouligandomani, Alejandro del Arco, Francis Kiptengwer Chemorion, Marc-Antonio Bisotti, Fabio Galbusera, Jérôme Noailly, Miguel A. González Ballester
Publicado en: Scientific Data, Edición 11, 2024, ISSN 2052-4463
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41597-024-03351-8

Sulfated Hydrogels as Primary Intervertebral Disc Cell Culture Systems

Autores: Paola Bermudez-Lekerika, Katherine B. Crump, Karin Wuertz-Kozak, Christine L. Le Maitre, Benjamin Gantenbein
Publicado en: Gels, Edición 10, 2025, Página(s) 330, ISSN 2310-2861
Editor: MDPI AG
DOI: 10.3390/gels10050330

Semiautomatic Assessment of Facet Tropism From Lumbar Spine MRI Using Deep Learning

Autores: Narasimharao Kowlagi, Antti Kemppainen, Egor Panfilov, Terence McSweeney, Simo Saarakkala, Mika Nevalainen, Jaakko Niinimäki, Jaro Karppinen, Aleksei Tiulpin
Publicado en: Spine, Edición 49, 2025, Página(s) 630-639, ISSN 0362-2436
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/brs.0000000000004909

Cartilaginous endplates: A comprehensive review on a neglected structure in intervertebral disc research

Autores: Crump KB, Alminnawi A, Bermudez-Lekerika P, Compte R, Gualdi F, McSweeney T, Muñoz-Moya E, Nüesch A, Geris L, Dudli S, Karppinen J, Noailly J, Le Maitre C, Gantenbein B
Publicado en: JOR Spine, Edición [epub, 2023, Página(s) e1294, ISSN 2572-1143
Editor: Wiley
DOI: 10.1002/jsp2.1294

New Frontiers towards Regeneration of the Intervertebral Disc: On Progenitor Cells, Growth Factors and Biomaterials

Autores: Gantenbein, Benjamin
Publicado en: Regeneration of the Intervertebral Disc, Applied sciences special issue, Edición 5, 2021, ISSN 2076-3417
Editor: MDPI
DOI: 10.3390/app112411913

Application and Validation of Semiautomatic Quantification of Immunohistochemically Stained Sections for Low Cellular Tissue <scp>Such as Intervertebral Disc</scp> Using <scp>QuPath</scp>

Autores: Andrea Nüesch, Maria Paola Ferri, Christine L. Le Maitre
Publicado en: JOR SPINE, Edición 8, 2025, ISSN 2572-1143
Editor: Wiley
DOI: 10.1002/jsp2.70054

Conference proceedings (3)

Society of Back Pain Research Travel Fellowship 2021, price €2180

Autores: Terence McSweeney
Publicado en: 2022
Editor: Terence McSweeney

VPHI BEST POSTER AWARD 2022 WON BY MARIE SKLODOWSKA-CURIE PHD FELLOW SOFIA TSERANIDOU

Autores: Virtual Physiological Human Institute for Integrative Biomedical Research
Publicado en: 2022
Editor: Virtual Physiological Human Institute for Integrative Biomedical Research

Suomalainen Selkätutkimusseura Ry (Finnish Spine Society) early career researcher abstract prize 2022, €1000

Autores: Terence McSweeney
Publicado en: 2022
Editor: @TerMcS (Twitter)

Non-peer reviewed articles (1)

SPIRIT-based prediction of clinical trial completion in intervertebral disc degeneration

Autores: Francis Chemorion, Jerome Noailly, Marc-Antonio Bisotti
Publicado en: Open Research Europe, Edición 5, 2025, Página(s) 285, ISSN 2732-5121
Editor: F1000 Research Ltd
DOI: 10.12688/openreseurope.21092.1

Other (1)

Editorial: Immunological imbalance: What is its role in intervertebral disc degeneration?

Autores: Gantenbein B, Sun Z, Liu Z, Samartzis D
Publicado en: Frontiers in Cell and Developmental Biology, Edición 11, 2023, Página(s) 2, ISSN 2296-634X
Editor: frontiers
DOI: 10.3389/fcell.2023.1196377

Book chapters (1)

Pixel2Mechanics: Automated Biomechanical Simulations of High-Resolution Intervertebral Discs from Anisotropic MRIs

Autores: Sai Natarajan, Estefano Muñoz-Moya, Carlos Ruiz Wills, Gemma Piella, Jérôme Noailly, Ludovic Humbert, Miguel A. González Ballester
Publicado en: Lecture Notes in Computer Science, Medical Image Computing and Computer Assisted Intervention – MICCAI 2024, 2024, Página(s) 572-582
Editor: Springer Nature Switzerland
DOI: 10.1007/978-3-031-72104-5_55