Training network to advance integrated computational simulations in translational medicine, applied to intervertebral disc degeneration

Información del proyecto

Disc4All

Identificador del acuerdo de subvención: 955735

DOI

10.3030/955735

Proyecto cerrado

Fecha de la firma de la CE 31 Agosto 2020

Fecha de inicio 1 Noviembre 2020

Fecha de finalización 31 Mayo 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 3 996 776,52

Aportación de la UE

€ 3 996 776,52

Coordinado por

UNIVERSIDAD POMPEU FABRA
Spain

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Other (2)

ESRs Recruitment published
Supervisory Board of the network

Open Research Data Pilot (1)

Data governance framework

Documents, reports (1)

Design & capacity of the agnostic platform, with integrated cloud services & remote access

Design capacity of the agnostic platform with integrated cloud services remote access

Websites, patent fillings, videos etc. (1)

Project Website with Social Media & Annual Public Progress Reports

This deliverable will be updated in the following months: 1, 12, 24, 39, 48

Publicaciones

Peer reviewed articles (11)

Immuno-Modulatory Effects of Intervertebral Disc Cells

Autores: Bermudez-Lekerika P, Crump KB, Tseranidou S, Nüesch A, Kanelis E, Alminnawi A, Baumgartner L, Muñoz-Moya E, Compte R, Gualdi F, Alexopoulos LG, Geris L, Wuertz-Kozak K, Le Maitre CL, Noailly J, Gantenbein B
Publicado en: Frontiers in Cell and Developmental Biology, Edición 10, 2022, ISSN 2296-634X
Editor: frontiers
DOI: 10.3389/fcell.2022.924692

TNF induces catabolism in human cartilaginous endplate cells in 3D agarose culture under dynamic compression

Autores: Katherine B. Crump, Exarchos Kanelis, Maria Segarra-Queralt, Andreu Pascuet-Fontanet, Paola Bermudez-Lekerika, Ahmad Alminnawi, Liesbet Geris, Leonidas G. Alexopoulos, Jérôme Noailly, Benjamin Gantenbein
Publicado en: Scientific Reports, Edición 15, 2025, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-025-00538-w

Sulfated Hydrogels in Intervertebral Disc and Cartilage Research

Autores: Lazarus E, Bermudez-Lekerika P, Farchione D, Schofield T, Howard S, Mambetkadyrov I, Lamoca M, Rivero IV, Gantenbein B, Lewis CL, Wuertz-Kozak K
Publicado en: Cells, 2021, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells10123568

In-silico proteomic analysis of the role of IL-4 and IL-10 in IVD degeneration: Protein-protein interaction networks for candidate prioritisation

Autores: Paola Bermudez-Lekerika, Francesco Gualdi, Christine L. Le Maitre, Janet Piñero, Baldomero Oliva, Benjamin Gantenbein
Publicado en: Computational and Structural Biotechnology Journal, Edición 27, 2025, Página(s) 1600-1613, ISSN 2001-0370
Editor: Elsevier BV
DOI: 10.1016/j.csbj.2025.04.015

Inhibition of the extracellular signal-regulated kinase pathway reduces the inflammatory component in nucleus pulposus cells

Autores: Tekari A, Marazza A, Crump K, Bermudez-Lekerika P, Gantenbein B
Publicado en: J Orthop Res, 2022, ISSN 1554-527X
Editor: Wiley
DOI: 10.1002/jor.25273

Ex Vivo and In Vitro Proteomic Approach to Elucidate the Relevance of IL-4 and IL-10 in Intervertebral Disc Pathophysiology

Autores: Bermudez-Lekerika P, Tseranidou S, Kanelis E, Nüesch A, Crump KB, Alexopoulos LG, Wuertz-Kozak K, Noailly J, Le Maitre CL, Gantenbein B
Publicado en: JOR Spine, Edición 8(1), 2025, Página(s) e70048, ISSN 2572-1143
Editor: Wiley & sons
DOI: 10.1002/jsp2.70048

Exploring Mechanotransduction and Inflammation in Human Cartilaginous Endplate Cells in Blended Collagen–Agarose Hydrogels Under Cyclic Compression

Autores: Katherine B. Crump, Chloé Chapallaz, Ahmad Alminnawi, Paola Bermudez-Lekerika, Liesbet Geris, Jérôme Noailly, Benjamin Gantenbein
Publicado en: Gels, Edición 11, 2025, Página(s) 736, ISSN 2310-2861
Editor: MDPI AG
DOI: 10.3390/gels11090736

EGR2, IGF1 and IL6 Expression Are Elevated in the Intervertebral Disc of Patients Suffering from Diffuse Idiopathic Skeletal Hyperostosis (DISH) Compared to Degenerative or Trauma Discs

Autores: Benjamin Gantenbein; Rahel Deborah May; Paola Bermudez-Lekerika; Katharina A. C. Oswald; Lorin Michael Benneker; Christoph E. Albers
Publicado en: Applied Sciences, Edición 2, 2021, Página(s) 4072, ISSN 2076-3417
Editor: MDPI
DOI: 10.48350/156197

The Bone Morphogenetic Protein 2 Analogue L51P Enhances Spinal Fusion in Combination with BMP2 in an In Vivo Rat Tail Model

Autores: Gantenbein B, Oswald KA, Erbach GF, Croft AS, Bermudez-Lekerika P, Strunz F, Bigdon SF, Albers CE
Publicado en: Acta Biomaterialia, 2024, ISSN 1742-7061
Editor: Elsevier BV
DOI: 10.1016/j.actbio.2024.01.039

Cartilaginous endplates: A comprehensive review on a neglected structure in intervertebral disc research

Autores: Crump KB, Alminnawi A, Bermudez-Lekerika P, Compte R, Gualdi F, McSweeney T, Muñoz-Moya E, Nüesch A, Geris L, Dudli S, Karppinen J, Noailly J, Le Maitre C, Gantenbein B
Publicado en: JOR Spine, Edición [epub, 2023, Página(s) e1294, ISSN 2572-1143
Editor: Wiley
DOI: 10.1002/jsp2.1294

New Frontiers towards Regeneration of the Intervertebral Disc: On Progenitor Cells, Growth Factors and Biomaterials

Autores: Gantenbein, Benjamin
Publicado en: Regeneration of the Intervertebral Disc, Applied sciences special issue, Edición 5, 2021, ISSN 2076-3417
Editor: MDPI
DOI: 10.3390/app112411913

Conference proceedings (3)

Society of Back Pain Research Travel Fellowship 2021, price €2180

Autores: Terence McSweeney
Publicado en: 2022
Editor: Terence McSweeney

VPHI BEST POSTER AWARD 2022 WON BY MARIE SKLODOWSKA-CURIE PHD FELLOW SOFIA TSERANIDOU

Autores: Virtual Physiological Human Institute for Integrative Biomedical Research
Publicado en: 2022
Editor: Virtual Physiological Human Institute for Integrative Biomedical Research

Suomalainen Selkätutkimusseura Ry (Finnish Spine Society) early career researcher abstract prize 2022, €1000

Autores: Terence McSweeney
Publicado en: 2022
Editor: @TerMcS (Twitter)

Other (1)

Editorial: Immunological imbalance: What is its role in intervertebral disc degeneration?

Autores: Gantenbein B, Sun Z, Liu Z, Samartzis D
Publicado en: Frontiers in Cell and Developmental Biology, Edición 11, 2023, Página(s) 2, ISSN 2296-634X
Editor: frontiers
DOI: 10.3389/fcell.2023.1196377