Training network to advance integrated computational simulations in translational medicine, applied to intervertebral disc degeneration

Project Information

Disc4All

Grant agreement ID: 955735

DOI

10.3030/955735

Project closed

EC signature date 31 August 2020

Start date 1 November 2020

End date 31 May 2025

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 3 996 776,52

EU contribution

€ 3 996 776,52

Coordinated by

UNIVERSIDAD POMPEU FABRA
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (6)

Potential inputs for policy feedback
Annual Winter & Summer Schools and Advanced Training Event Public Reports

These deliverable will be updated in the following months: 12, 18, 24, 39, 48

Deployable platform backend design
Final conference Public Report
Design & capacity of the agnostic platform, with integrated cloud services & remote access

Design capacity of the agnostic platform with integrated cloud services remote access

Science-based & Transferable skills Public Report

Demonstrators, pilots, prototypes (2)

AB-FE Multiscale mechanistic modelling software
Phenotype-gene biomarker-comorbidities association tool

Open Research Data Pilot (2)

Primary data interoperability & secondary data
Data governance framework

Other (2)

ESRs Recruitment published
Supervisory Board of the network

Websites, patent fillings, videos etc. (2)

Project Website with Social Media & Annual Public Progress Reports

This deliverable will be updated in the following months: 1, 12, 24, 39, 48

Dissemination & Outreach Reports

This deliverable will be upadated in the following months: 24, 55

Publications

Peer reviewed articles (26)

A systematic review of intervertebral disc degeneration clinical trial protocols

Author(s): Francis Chemorion, Jerome Noailly, Marc-Antonio Bisotti
Published in: Open Research Europe, Issue 5, 2025, Page(s) 284, ISSN 2732-5121
Publisher: F1000 Research Ltd
DOI: 10.12688/openreseurope.21091.1

Immuno-Modulatory Effects of Intervertebral Disc Cells

Author(s): Bermudez-Lekerika P, Crump KB, Tseranidou S, Nüesch A, Kanelis E, Alminnawi A, Baumgartner L, Muñoz-Moya E, Compte R, Gualdi F, Alexopoulos LG, Geris L, Wuertz-Kozak K, Le Maitre CL, Noailly J, Gantenbein B
Published in: Frontiers in Cell and Developmental Biology, Issue 10, 2022, ISSN 2296-634X
Publisher: frontiers
DOI: 10.3389/fcell.2022.924692

TNF induces catabolism in human cartilaginous endplate cells in 3D agarose culture under dynamic compression

Author(s): Katherine B. Crump, Exarchos Kanelis, Maria Segarra-Queralt, Andreu Pascuet-Fontanet, Paola Bermudez-Lekerika, Ahmad Alminnawi, Liesbet Geris, Leonidas G. Alexopoulos, Jérôme Noailly, Benjamin Gantenbein
Published in: Scientific Reports, Issue 15, 2025, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-025-00538-w

Sulfated Hydrogels in Intervertebral Disc and Cartilage Research

Author(s): Lazarus E, Bermudez-Lekerika P, Farchione D, Schofield T, Howard S, Mambetkadyrov I, Lamoca M, Rivero IV, Gantenbein B, Lewis CL, Wuertz-Kozak K
Published in: Cells, 2021, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10123568

In-silico proteomic analysis of the role of IL-4 and IL-10 in IVD degeneration: Protein-protein interaction networks for candidate prioritisation

Author(s): Paola Bermudez-Lekerika, Francesco Gualdi, Christine L. Le Maitre, Janet Piñero, Baldomero Oliva, Benjamin Gantenbein
Published in: Computational and Structural Biotechnology Journal, Issue 27, 2025, Page(s) 1600-1613, ISSN 2001-0370
Publisher: Elsevier BV
DOI: 10.1016/j.csbj.2025.04.015

The interplay between biochemical mediators and mechanotransduction in chondrocytes: Unravelling the differential responses in primary knee osteoarthritis

Author(s): Maria Segarra-Queralt, Katherine Crump, Andreu Pascuet-Fontanet, Benjamin Gantenbein, Jérôme Noailly
Published in: Physics of Life Reviews, Issue 48, 2025, Page(s) 205-221, ISSN 1571-0645
Publisher: Elsevier BV
DOI: 10.1016/j.plrev.2024.02.003

Inhibition of the extracellular signal-regulated kinase pathway reduces the inflammatory component in nucleus pulposus cells

Author(s): Tekari A, Marazza A, Crump K, Bermudez-Lekerika P, Gantenbein B
Published in: J Orthop Res, 2022, ISSN 1554-527X
Publisher: Wiley
DOI: 10.1002/jor.25273

Nucleus pulposus cell network modelling in the intervertebral disc

Author(s): Sofia Tseranidou, Maria Segarra-Queralt, Francis Kiptengwer Chemorion, Christine Lyn Le Maitre, Janet Piñero, Jérôme Noailly
Published in: npj Systems Biology and Applications, Issue 11, 2025, ISSN 2056-7189
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41540-024-00479-6

Are current machine learning applications comparable to radiologist classification of degenerate and herniated discs and Modic change? A systematic review and meta-analysis

Author(s): Roger Compte, Isabelle Granville Smith, Amanda Isaac, Nathan Danckert, Terence McSweeney, Panagiotis Liantis, Frances M. K. Williams
Published in: European Spine Journal, Issue 32, 2023, Page(s) 3764-3787, ISSN 0940-6719
Publisher: Springer Verlag
DOI: 10.1007/s00586-023-07718-0

Modic change is associated with increased BMI but not autoimmune diseases in TwinsUK

Author(s): Francesco Gualdi, Isabelle Granville Smith, Roger Compte Boixader, Frances M. K. Williams
Published in: European Spine Journal, Issue 32, 2023, Page(s) 3379-3386, ISSN 0940-6719
Publisher: Springer Verlag
DOI: 10.1007/s00586-023-07870-7

A porohyperelastic scheme targeted at High-Performance Computing frameworks for the simulation of the intervertebral disc

Author(s): Dimitrios Lialios, Beatriz Eguzkitza, Guillaume Houzeaux, Eva Casoni, Laura Baumgartner, Jérôme Noailly, Estefano Muñoz-Moya, Benjamin Gantenbein, Mariano Vázquez
Published in: Computer Methods and Programs in Biomedicine, Issue 259, 2024, Page(s) 108493, ISSN 0169-2607
Publisher: Elsevier BV
DOI: 10.1016/j.cmpb.2024.108493

Unveiling interactions between intervertebral disc morphologies and mechanical behavior through personalized finite element modeling

Author(s): Estefano Muñoz-Moya, Morteza Rasouligandomani, Carlos Ruiz Wills, Francis Kiptengwer Chemorion, Gemma Piella, Jérôme Noailly
Published in: Frontiers in Bioengineering and Biotechnology, Issue 12, 2024, ISSN 2296-4185
Publisher: Frontiers Media SA
DOI: 10.3389/fbioe.2024.1384599

No evidence of association between either Modic change or disc degeneration and five circulating inflammatory proteins

Author(s): Roger Compte, Maxim B. Freidin, Isabelle Granville Smith, Christine L. Le Maitre, Dovile Vaitkute, Ayrun Nessa, Genevieve Lachance, Frances M. K. Williams
Published in: JOR SPINE, Issue 7, 2024, ISSN 2572-1143
Publisher: Wiley
DOI: 10.1002/jsp2.1323

Ex Vivo and In Vitro Proteomic Approach to Elucidate the Relevance of IL-4 and IL-10 in Intervertebral Disc Pathophysiology

Author(s): Bermudez-Lekerika P, Tseranidou S, Kanelis E, Nüesch A, Crump KB, Alexopoulos LG, Wuertz-Kozak K, Noailly J, Le Maitre CL, Gantenbein B
Published in: JOR Spine, Issue 8(1), 2025, Page(s) e70048, ISSN 2572-1143
Publisher: Wiley & sons
DOI: 10.1002/jsp2.70048

External Validation of SpineNet, an Open-Source Deep Learning Model for Grading Lumbar Disk Degeneration MRI Features, Using the Northern Finland Birth Cohort 1966

Author(s): Terence P. McSweeney, Aleksei Tiulpin, Simo Saarakkala, Jaakko Niinimäki, Rhydian Windsor, Amir Jamaludin, Timor Kadir, Jaro Karppinen, Juhani Määttä
Published in: Spine, Issue 48, 2025, Page(s) 484-491, ISSN 0362-2436
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/brs.0000000000004572

Exploring Mechanotransduction and Inflammation in Human Cartilaginous Endplate Cells in Blended Collagen–Agarose Hydrogels Under Cyclic Compression

Author(s): Katherine B. Crump, Chloé Chapallaz, Ahmad Alminnawi, Paola Bermudez-Lekerika, Liesbet Geris, Jérôme Noailly, Benjamin Gantenbein
Published in: Gels, Issue 11, 2025, Page(s) 736, ISSN 2310-2861
Publisher: MDPI AG
DOI: 10.3390/gels11090736

Predicting gene disease associations with knowledge graph embeddings for diseases with curtailed information

Author(s): Francesco Gualdi, Baldomero Oliva, Janet Piñero
Published in: NAR Genomics and Bioinformatics, Issue 6, 2024, ISSN 2631-9268
Publisher: Oxford University Press (OUP)
DOI: 10.1093/nargab/lqae049

Influence of disc height and strain-dependent solute diffusivity on metabolic transport in patient-personalized intervertebral disc models

Author(s): Zerihun G. Workineh, Estefano Muñoz-Moya, Carlos Ruiz Wills, Dimitrios Lialios, Jérôme Noailly
Published in: Frontiers in Bioengineering and Biotechnology, Issue 13, 2025, ISSN 2296-4185
Publisher: Frontiers Media SA
DOI: 10.3389/fbioe.2025.1651786

EGR2, IGF1 and IL6 Expression Are Elevated in the Intervertebral Disc of Patients Suffering from Diffuse Idiopathic Skeletal Hyperostosis (DISH) Compared to Degenerative or Trauma Discs

Author(s): Benjamin Gantenbein; Rahel Deborah May; Paola Bermudez-Lekerika; Katharina A. C. Oswald; Lorin Michael Benneker; Christoph E. Albers
Published in: Applied Sciences, Issue 2, 2021, Page(s) 4072, ISSN 2076-3417
Publisher: MDPI
DOI: 10.48350/156197

The Bone Morphogenetic Protein 2 Analogue L51P Enhances Spinal Fusion in Combination with BMP2 in an In Vivo Rat Tail Model

Author(s): Gantenbein B, Oswald KA, Erbach GF, Croft AS, Bermudez-Lekerika P, Strunz F, Bigdon SF, Albers CE
Published in: Acta Biomaterialia, 2024, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2024.01.039

Dataset of Finite Element Models of Normal and Deformed Thoracolumbar Spine

Author(s): Morteza Rasouligandomani, Alejandro del Arco, Francis Kiptengwer Chemorion, Marc-Antonio Bisotti, Fabio Galbusera, Jérôme Noailly, Miguel A. González Ballester
Published in: Scientific Data, Issue 11, 2024, ISSN 2052-4463
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41597-024-03351-8

Sulfated Hydrogels as Primary Intervertebral Disc Cell Culture Systems

Author(s): Paola Bermudez-Lekerika, Katherine B. Crump, Karin Wuertz-Kozak, Christine L. Le Maitre, Benjamin Gantenbein
Published in: Gels, Issue 10, 2025, Page(s) 330, ISSN 2310-2861
Publisher: MDPI AG
DOI: 10.3390/gels10050330

Semiautomatic Assessment of Facet Tropism From Lumbar Spine MRI Using Deep Learning

Author(s): Narasimharao Kowlagi, Antti Kemppainen, Egor Panfilov, Terence McSweeney, Simo Saarakkala, Mika Nevalainen, Jaakko Niinimäki, Jaro Karppinen, Aleksei Tiulpin
Published in: Spine, Issue 49, 2025, Page(s) 630-639, ISSN 0362-2436
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/brs.0000000000004909

Cartilaginous endplates: A comprehensive review on a neglected structure in intervertebral disc research

Author(s): Crump KB, Alminnawi A, Bermudez-Lekerika P, Compte R, Gualdi F, McSweeney T, Muñoz-Moya E, Nüesch A, Geris L, Dudli S, Karppinen J, Noailly J, Le Maitre C, Gantenbein B
Published in: JOR Spine, Issue [epub, 2023, Page(s) e1294, ISSN 2572-1143
Publisher: Wiley
DOI: 10.1002/jsp2.1294

New Frontiers towards Regeneration of the Intervertebral Disc: On Progenitor Cells, Growth Factors and Biomaterials

Author(s): Gantenbein, Benjamin
Published in: Regeneration of the Intervertebral Disc, Applied sciences special issue, Issue 5, 2021, ISSN 2076-3417
Publisher: MDPI
DOI: 10.3390/app112411913

Application and Validation of Semiautomatic Quantification of Immunohistochemically Stained Sections for Low Cellular Tissue <scp>Such as Intervertebral Disc</scp> Using <scp>QuPath</scp>

Author(s): Andrea Nüesch, Maria Paola Ferri, Christine L. Le Maitre
Published in: JOR SPINE, Issue 8, 2025, ISSN 2572-1143
Publisher: Wiley
DOI: 10.1002/jsp2.70054

Conference proceedings (3)

Society of Back Pain Research Travel Fellowship 2021, price €2180

Author(s): Terence McSweeney
Published in: 2022
Publisher: Terence McSweeney

VPHI BEST POSTER AWARD 2022 WON BY MARIE SKLODOWSKA-CURIE PHD FELLOW SOFIA TSERANIDOU

Author(s): Virtual Physiological Human Institute for Integrative Biomedical Research
Published in: 2022
Publisher: Virtual Physiological Human Institute for Integrative Biomedical Research

Suomalainen Selkätutkimusseura Ry (Finnish Spine Society) early career researcher abstract prize 2022, €1000

Author(s): Terence McSweeney
Published in: 2022
Publisher: @TerMcS (Twitter)

Non-peer reviewed articles (1)

SPIRIT-based prediction of clinical trial completion in intervertebral disc degeneration

Author(s): Francis Chemorion, Jerome Noailly, Marc-Antonio Bisotti
Published in: Open Research Europe, Issue 5, 2025, Page(s) 285, ISSN 2732-5121
Publisher: F1000 Research Ltd
DOI: 10.12688/openreseurope.21092.1

Other (1)

Editorial: Immunological imbalance: What is its role in intervertebral disc degeneration?

Author(s): Gantenbein B, Sun Z, Liu Z, Samartzis D
Published in: Frontiers in Cell and Developmental Biology, Issue 11, 2023, Page(s) 2, ISSN 2296-634X
Publisher: frontiers
DOI: 10.3389/fcell.2023.1196377

Book chapters (1)

Pixel2Mechanics: Automated Biomechanical Simulations of High-Resolution Intervertebral Discs from Anisotropic MRIs

Author(s): Sai Natarajan, Estefano Muñoz-Moya, Carlos Ruiz Wills, Gemma Piella, Jérôme Noailly, Ludovic Humbert, Miguel A. González Ballester
Published in: Lecture Notes in Computer Science, Medical Image Computing and Computer Assisted Intervention – MICCAI 2024, 2024, Page(s) 572-582
Publisher: Springer Nature Switzerland
DOI: 10.1007/978-3-031-72104-5_55