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CORDIS

Oligonucleotides for Medical Applications

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Research Data Management Plan established (opens in new window)
"3 Student-led ""Meet the expert"" webinars" (opens in new window)

Student-led network e-meeting.This deliverable will be updated as follows:In month 17 to reflect Student-led network e-meeting 2 (month 27).In month 28 to reflect Student-led network e-meeting 2 (month 37).

Supervisory and Scientific Advisory Board established (opens in new window)

Document establishing the supervisory board and defining the way of working.The SB represents the strategic decision-making body (Chair: SOTON; Members: 1 representative of each beneficiary, 2 ESR representatives with annually rotating positions; partner organisations are invited to participate).The SAB advises on scientific and training related matters and its members are involved in the ESR Boards.

4 OLIGOMED Weeks (annual training events) (opens in new window)

OLIGOMED Training Week 2021, Marseille, FRProject discussions: “Presentations by ESRs and feedback by SB and SAB”Summer School: “General nucleic acid chemistry; ON synthesis and analysis, including modifications and conjugates and introduction to peptides and peptide nucleic acids; Enzymes for synthesis of nucleotides and ONs; Introduction to and overview of Oligonucleotide TherapyVITAE workshop 2: “Effective and Collaborative Researcher”This deliverable will be updated as follows:In month 11 to reflect OLIGOMED Training week 2022 (month 21)In month 22 to reflect OLIGOMED Training week 2023 (month 32)In month 33 to reflect OLIGOMED Training week 2024 (month 41)

OLIGOMED website established (opens in new window)

The website will provide an introduction to the topic of ON and present the breadth of available DNA technologies and their medical applications in layman terms to make this site work also an educational tool The website will also serve additional communication purposes such as establishing transparency on project partners and funding informing about OLIGOMED activities and achievements as well as enabling interaction with interested parties such as registration for newsletter or training events and links to social media

"15 Recordings of ""PhD in 3 minutes""" (opens in new window)

The ESRs will do a threeminute presentation with the aid of exactly one slide to describe their project This version during OLIGOMED week 2021 presents the project aims in its wider context and first advancements The presentations are aimed at the general public for awareness of OLIGOMED and promoting science through societal impactThis deliverable will be updated in month 22 to reflect the second recording with due date month 41The ESRs will do a threeminute presentation with the aid of exactly one slide to describe their project This version in OLIGOMED week 2023 presents the major results impact and outlook The presentations are aimed at the general public for awareness of OLIGOMED and promoting science through societal impact

OLIGOMED Video (opens in new window)

A threeminute clip will be produced that presents the overarching aim of the project 12 illustrative example ESR projects and the relevance for the general public It will be made available on the website and on YouTube

Publications

Furan-based (photo)oxidation reactions and their application in nucleic acid and protein targeting (opens in new window)

Author(s): Jack, Barr; Gertjan, Colpaert; Enrico, Cadoni; Annemieke, Madder
Published in: Methods, Issue 2, 2023, ISSN 1046-2023
Publisher: Academic Press
DOI: 10.1016/j.ymeth.2023.08.011

A red light-triggered chemical tool for sequence-specific alkylation of G-quadruplex and I-motif DNA (opens in new window)

Author(s): Enrico Cadoni; Lessandro De Paepe; Gertjan Colpaert; Ruben Tack; Dries Waegeman; Alex Manicardi; Annemieke Madder
Published in: Nucleic Acids Research, 2023, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkad189

Therapeutic Oligonucleotides: An Outlook on Chemical Strategies to Improve Endosomal Trafficking (opens in new window)

Author(s): Priyanka Mangla; Quentin Vicentini; Annabelle Biscans
Published in: Cells, Issue 1, 2023, Page(s) 2253, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells12182253

Small Activating RNA Modulation of the G Protein‐Coupled Receptor for Cancer Treatment (opens in new window)

Author(s): Yunfang Xiong; Ran Ke; Qingyu Zhang; Wenjun Lan; Wanjun Yuan; Karol Nga Ieng Chan; Tom Roussel; Yifan Jiang; Jing Wu; Shuai Liu; Alice Sze Tsai Wong; Joong Sup Shim; Xuanjun Zhang; Ruiyu Xie; Nelson Dusetti; Juan Iovanna; Nagy Habib; Ling Peng; Leo Tsz On Lee
Published in: Advanced Science, 2022, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202200562

Bola‐Amphiphilic Glycodendrimers: New Carbohydrate‐Mimicking Scaffolds to Target Carbohydrate‐Binding Proteins (opens in new window)

Author(s): Wenzheng Zhang; Dinesh Dhumal; Xiaolei Zhu; Brigino Ralahy; Aleksandra Ellert‐Miklaszewska; Jing Wu; Erik Laurini; Yi‐Wen Yao; Chai‐Lin Kao; Juan L. Iovanna; Sabrina Pricl; Bozena Kaminska; Yi Xia; Ling Peng
Published in: Chemistry - A European Journal, 2022, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202201400

Beyond small molecules: targeting G-quadruplex structures with oligonucleotides and their analogues. (opens in new window)

Author(s): Enrico Cadoni; Lessandro De Paepe; Alex Manicardi; Annemieke Madder
Published in: Nucleic Acids Research, Issue Vol. 49, No. 12, 2021, Page(s) 6638–6659, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkab334

Is Drp1 a link between mitochondrial dysfunction and inflammation in Alzheimer’s disease? (opens in new window)

Author(s): Oualid Sbai; Veronica Bazzani; Shreya Tapaswi; Joshua McHale; Carlo Vascotto; Carlo Vascotto; Lorena Perrone
Published in: Frontiers in Molecular Neuroscience, Vol 16 (2023), Issue 1, 2023, ISSN 1662-5099
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnmol.2023.1166879

Mitochondrial DNA Repair in Neurodegenerative Diseases and Ageing (opens in new window)

Author(s): Veronica Bazzani; Mara Equisoain Redin; Joshua McHale; Lorena Perrone; Carlo Vascotto
Published in: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms231911391

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