Oligonucleotides for Medical Applications

Informations projet

OLIGOMED

N° de convention de subvention: 956070

DOI

10.3030/956070

Projet clôturé

Date de signature de la CE 13 Août 2020

Date de début 1 Janvier 2021

Date de fin 31 Juillet 2026

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 4 138 062,98

Contribution de l’UE

€ 4 138 062,98

Coordonné par

UNIVERSITY OF SOUTHAMPTON
United Kingdom

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Other (4)

Research Data Management Plan established
"3 Student-led ""Meet the expert"" webinars"

Student-led network e-meeting.This deliverable will be updated as follows:In month 17 to reflect Student-led network e-meeting 2 (month 27).In month 28 to reflect Student-led network e-meeting 2 (month 37).

Supervisory and Scientific Advisory Board established

Document establishing the supervisory board and defining the way of working.The SB represents the strategic decision-making body (Chair: SOTON; Members: 1 representative of each beneficiary, 2 ESR representatives with annually rotating positions; partner organisations are invited to participate).The SAB advises on scientific and training related matters and its members are involved in the ESR Boards.

4 OLIGOMED Weeks (annual training events)

OLIGOMED Training Week 2021, Marseille, FRProject discussions: “Presentations by ESRs and feedback by SB and SAB”Summer School: “General nucleic acid chemistry; ON synthesis and analysis, including modifications and conjugates and introduction to peptides and peptide nucleic acids; Enzymes for synthesis of nucleotides and ONs; Introduction to and overview of Oligonucleotide TherapyVITAE workshop 2: “Effective and Collaborative Researcher”This deliverable will be updated as follows:In month 11 to reflect OLIGOMED Training week 2022 (month 21)In month 22 to reflect OLIGOMED Training week 2023 (month 32)In month 33 to reflect OLIGOMED Training week 2024 (month 41)

Websites, patent fillings, videos etc. (3)

OLIGOMED website established

The website will provide an introduction to the topic of ON and present the breadth of available DNA technologies and their medical applications in layman terms to make this site work also an educational tool The website will also serve additional communication purposes such as establishing transparency on project partners and funding informing about OLIGOMED activities and achievements as well as enabling interaction with interested parties such as registration for newsletter or training events and links to social media

"15 Recordings of ""PhD in 3 minutes"""

The ESRs will do a threeminute presentation with the aid of exactly one slide to describe their project This version during OLIGOMED week 2021 presents the project aims in its wider context and first advancements The presentations are aimed at the general public for awareness of OLIGOMED and promoting science through societal impactThis deliverable will be updated in month 22 to reflect the second recording with due date month 41The ESRs will do a threeminute presentation with the aid of exactly one slide to describe their project This version in OLIGOMED week 2023 presents the major results impact and outlook The presentations are aimed at the general public for awareness of OLIGOMED and promoting science through societal impact

OLIGOMED Video

A threeminute clip will be produced that presents the overarching aim of the project 12 illustrative example ESR projects and the relevance for the general public It will be made available on the website and on YouTube

Publications

Peer reviewed articles (23)

FALCON-qPCR: a new method for the quantification of oxidative lesions in mitochondrial DNA

Auteurs: Veronica Bazzani, Eve Harding, Szymon Balinski, Mara Equisoain Redin, Dario Alessi, Pierfrancesco Del Mestre, Walter Baratta, Daniela Cesselli, Antonio Paolo Beltrami, Michał Turek, Umberto Baccarani, Carlo Vascotto
Publié dans: Bioanalysis, Numéro 17, 2026, Page(s) 1671-1683, ISSN 1757-6180
Éditeur: Future Science
DOI: 10.1080/17576180.2025.2608757

Furan-based (photo)oxidation reactions and their application in nucleic acid and protein targeting

Auteurs: Jack, Barr; Gertjan, Colpaert; Enrico, Cadoni; Annemieke, Madder
Publié dans: Methods, Numéro 2, 2023, ISSN 1046-2023
Éditeur: Academic Press
DOI: 10.1016/j.ymeth.2023.08.011

Versatile introduction of multifunctional Michael-acceptor moieties on amino-oligonucleotides for bioconjugation purposes

Auteurs: Jan H. Meffert, Mónica Lopes, Enrico Cadoni, Martin Bollmark, Ulf Tedebark, Annemieke Madder
Publié dans: Communications Chemistry, Numéro 9, 2026, ISSN 2399-3669
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/s42004-025-01882-8

Self-assembling supramolecular dendrimers for biomedical applications

Auteurs: Abdechakour Elkihel, Jing Wu, Ling Peng
Publié dans: Comptes Rendus. Chimie, Numéro 29, 2026, Page(s) 321-347, ISSN 1631-0748
Éditeur: Elsevier Masson
DOI: 10.5802/crchim.451

Characterization of a new mutation of mitochondrial ND6 gene in hepatocellular carcinoma and its effects on respiratory complex I

Auteurs: Veronica Bazzani, Deepali L Kundnani, Mara Equisoain Redin, Francesca Agostini, Kirti Chhatlani, Angelo Corso Faini, Jakub Poziemski, Umberto Baccarani, Pawel Siedlecki, Silvia Deaglio, Francesca Storici, Carlo Vascotto
Publié dans: Scientific Reports, Numéro 15, 2025, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-025-91746-x

Red-Light-Induced Cysteine Modifications Suitable for Protein Labeling

Auteurs: Tomasz Wdowik, Egor Fedorov, Tina-Thien Ho, Patrick Duriez, Eugen Stulz, Dorota Gryko
Publié dans: ACS Organic & Inorganic Au, Numéro 5, 2025, Page(s) 238-243, ISSN 2694-247X
Éditeur: American Chemical Society (ACS)
DOI: 10.1021/acsorginorgau.5c00025

Concerted Action of Targeted Nucleic Acid Therapeutics as Flexible, Precision and Personalized Cancer Treatment

Auteurs: Jing Wu, Jiaxuan Chen, Abdechakour Elkihel, Wenjun Lan, Nicolas Fraunhoffer, Dandan Zhu, Baoping Lian, Christina Galanakou, Zhancun Bian, Xi Liu, Odile Gayet, Loic Moubri, Julie Aglietti Roques, Vikash Reebye, Nagy Habib, Xiaoxuan Liu, Nelson Dusetti, Juan Lucio Iovanna, Ling Peng
Publié dans: Advanced Science, 2026, ISSN 2198-3844
Éditeur: Wiley
DOI: 10.1002/advs.76840

Synthesis and stability studies of bicyclo[6.1.0]nonyne scaffolds for automated solid-phase oligonucleotide synthesis

Auteurs: Kristina Karalė, Martin Bollmark, Antanas Karalius, Mónica Lopes, Oswaldo Pérez, Roger Strömberg, Ulf Tedebark
Publié dans: RSC Advances, Numéro 14, 2026, Page(s) 17406-17412, ISSN 2046-2069
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d3ra08732h

A red light-triggered chemical tool for sequence-specific alkylation of G-quadruplex and I-motif DNA

Auteurs: Enrico Cadoni; Lessandro De Paepe; Gertjan Colpaert; Ruben Tack; Dries Waegeman; Alex Manicardi; Annemieke Madder
Publié dans: Nucleic Acids Research, 2023, ISSN 0305-1048
Éditeur: Oxford University Press
DOI: 10.1093/nar/gkad189

Multimeric Conjugates Using Engineered Peptide Scaffolds for Efficient siRNA Delivery

Auteurs: Quentin Vicentini, Dennis Hekman, Deepak Bhatt, Rouven Stulz, Mahya Dezfouli, Peter Gennemark, Nicola Guzzi, Naoko Toki, Bojana Lazovic, Carolina Tängemo, Shalini Andersson, Samir EL Andaloussi, Anders Dahlén
Publié dans: Bioconjugate Chemistry, Numéro 36, 2025, Page(s) 1299-1310, ISSN 1043-1802
Éditeur: American Chemical Society
DOI: 10.1021/acs.bioconjchem.5c00156

Therapeutic Oligonucleotides: An Outlook on Chemical Strategies to Improve Endosomal Trafficking

Auteurs: Priyanka Mangla; Quentin Vicentini; Annabelle Biscans
Publié dans: Cells, Numéro 1, 2023, Page(s) 2253, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells12182253

Small Activating RNA Modulation of the G Protein‐Coupled Receptor for Cancer Treatment

Auteurs: Yunfang Xiong; Ran Ke; Qingyu Zhang; Wenjun Lan; Wanjun Yuan; Karol Nga Ieng Chan; Tom Roussel; Yifan Jiang; Jing Wu; Shuai Liu; Alice Sze Tsai Wong; Joong Sup Shim; Xuanjun Zhang; Ruiyu Xie; Nelson Dusetti; Juan Iovanna; Nagy Habib; Ling Peng; Leo Tsz On Lee
Publié dans: Advanced Science, 2022, ISSN 2198-3844
Éditeur: Wiley
DOI: 10.1002/advs.202200562

Bola‐Amphiphilic Glycodendrimers: New Carbohydrate‐Mimicking Scaffolds to Target Carbohydrate‐Binding Proteins

Auteurs: Wenzheng Zhang; Dinesh Dhumal; Xiaolei Zhu; Brigino Ralahy; Aleksandra Ellert‐Miklaszewska; Jing Wu; Erik Laurini; Yi‐Wen Yao; Chai‐Lin Kao; Juan L. Iovanna; Sabrina Pricl; Bozena Kaminska; Yi Xia; Ling Peng
Publié dans: Chemistry - A European Journal, 2022, ISSN 0947-6539
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202201400

Precision chemical engineering of dendrimers for nucleic acid delivery

Auteurs: Qianqian Ni, Donald A. Tomalia, Jing Wu, Christina Galanakou, Ling Peng
Publié dans: Nature Reviews Chemistry, 2026, ISSN 2397-3358
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/s41570-026-00855-2

Cyclophilin D is a new non-canonical substrate of the mitochondrial intermembrane space assembly pathway

Auteurs: Mara Equisoain Redin, Veronica Bazzani, Eve Harding, Joshua McHale, Carlo Vascotto
Publié dans: Journal of Biological Chemistry, Numéro 301, 2026, Page(s) 110883, ISSN 0021-9258
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2025.110883

Self-assembling dendrimer nanodrug formulations for decreased hERG-related toxicity and enhanced therapeutic efficacy

Auteurs: Xi Liu, Dinesh Dhumal, Patricia Santofimia-Castaño, Juan Liu, Marion Casanova, Alicia Comino Garcia-Muñoz, Teodora-Adriana Perles-Barbacaru, Abdechakour Elkihel, Wenzheng Zhang, Tom Roussel, Christina Galanakou, Jing Wu, Eleni Zerva, Nelson Dusetti, Yi Xia, Xing-Jie Liang, Angèle Viola, Juan L. Iovanna, Ling Peng
Publié dans: Science Advances, Numéro 11, 2025, ISSN 2375-2548
Éditeur: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.adu9948

Quantitative analysis of oligonucleotide delivery into isolated mitochondria: a proof-of-concept method

Auteurs: Joshua McHale, Veronica Bazzani, Abdechakour Elkihel, Jing Wu, Ling Peng, Carlo Vascotto
Publié dans: BioTechniques, Numéro 78, 2026, Page(s) 1-11, ISSN 0736-6205
Éditeur: Eaton Publishing Co.
DOI: 10.1080/07366205.2026.2635461

Lipid and Carbohydrate Modifications Enhance Potency of Antisense Oligonucleotides Targeting Oncogenic KRAS

Auteurs: Faith Kivunga, Virginie Baylot, Julien Verget, Helene Pereira, Brune Vialet, Patricia Korczak, Jean Dessolin, Philippe Barthélémy
Publié dans: Bioconjugate Chemistry, Numéro 37, 2026, Page(s) 875-880, ISSN 1043-1802
Éditeur: American Chemical Society
DOI: 10.1021/acs.bioconjchem.5c00627

Beyond small molecules: targeting G-quadruplex structures with oligonucleotides and their analogues.

Auteurs: Enrico Cadoni; Lessandro De Paepe; Alex Manicardi; Annemieke Madder
Publié dans: Nucleic Acids Research, Numéro Vol. 49, No. 12, 2021, Page(s) 6638–6659, ISSN 0305-1048
Éditeur: Oxford University Press
DOI: 10.1093/nar/gkab334

Is Drp1 a link between mitochondrial dysfunction and inflammation in Alzheimer’s disease?

Auteurs: Oualid Sbai; Veronica Bazzani; Shreya Tapaswi; Joshua McHale; Carlo Vascotto; Carlo Vascotto; Lorena Perrone
Publié dans: Frontiers in Molecular Neuroscience, Vol 16 (2023), Numéro 1, 2023, ISSN 1662-5099
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fnmol.2023.1166879

Mitochondrial DNA Repair in Neurodegenerative Diseases and Ageing

Auteurs: Veronica Bazzani; Mara Equisoain Redin; Joshua McHale; Lorena Perrone; Carlo Vascotto
Publié dans: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms231911391

Dendrimer engineering to overcome delivery challenges of nucleic acids

Auteurs: Qianqian Ni, Jing Wu, Christina Galanakou, Cheng-Cai Zhang, Donald A. Tomalia, Ling Peng
Publié dans: Nature Reviews Bioengineering, Numéro 3, 2026, Page(s) 806-807, ISSN 2731-6092
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/s44222-025-00347-w

Vitamin B12 functionalized with hydroxy-pyrrol-2-one linkers

Auteurs: Mateusz Woźny, Monica Fresta, Jan Meffert, Annemieke Madder, Dorota Gryko
Publié dans: Journal of Porphyrins and Phthalocyanines, Numéro 29, 2025, Page(s) 46-51, ISSN 1088-4246
Éditeur: Society of Porphyrins and Phthalocyanines
DOI: 10.1142/s1088424624500676

Thesis and dissertations (4)

Targeting the IRES structure of mRNA for modulating gene translation

Auteurs: Ferriol Monjo, Albert
Publié dans: 2025
Éditeur: SOTON

Modular DNA nanopore (NP) for targeted cell killing

Auteurs: Ho, Tina-Thien
Publié dans: 2025
Éditeur: SOTON

Development of method for large scale manufacturing of ON constructs

Auteurs: Lopes, Monica Monteiro
Publié dans: 2026
Éditeur: SOTON, RISE

Towards the development of next-generation MergoTM — a nucleic acid-based delivery platform

Auteurs: Reyes Fraile, Laura
Publié dans: 2026
Éditeur: SOTON, Sixfold

Other (2)

Self-Assembled Nucleolipid G-Quadruplexes Act as Multitarget Decoys for Oncogene Suppression in Pancreatic Cancer

Auteurs: Faith Kivunga, Virginie Baylot, Tina Kauss, Brune Vialet, Jules Simonin Garcia, Patricia Korczak, Zahraa Othman, Gilmar Salgado, Philippe Barthélémy
Publié dans: 2026
Éditeur: openRxiv
DOI: 10.64898/2026.04.03.715535

PNA-Guided Modular Self-Assembly of Antibody-Oligonucleotide Constructs Enables Targeted Oligonucleotide Delivery

Auteurs: Tina-Thien Ho, Jan H. Meffert, Alexandros Kostakis, Mónica M. Lopes, Matthijs Pijnappel, Lara E. Buermann, Enrico Cadoni, Martin Bollmark, Ulf Tedebark, Sara Mangsbo, Annemieke Madder, Eugen Stulz
Publié dans: 2026
Éditeur: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv.15002633/v1