Oligonucleotides for Medical Applications

Leistungen

Research Data Management Plan established
"3 Student-led ""Meet the expert"" webinars"

Student-led network e-meeting.This deliverable will be updated as follows:In month 17 to reflect Student-led network e-meeting 2 (month 27).In month 28 to reflect Student-led network e-meeting 2 (month 37).

Supervisory and Scientific Advisory Board established

Document establishing the supervisory board and defining the way of working.The SB represents the strategic decision-making body (Chair: SOTON; Members: 1 representative of each beneficiary, 2 ESR representatives with annually rotating positions; partner organisations are invited to participate).The SAB advises on scientific and training related matters and its members are involved in the ESR Boards.

4 OLIGOMED Weeks (annual training events)

OLIGOMED Training Week 2021, Marseille, FRProject discussions: “Presentations by ESRs and feedback by SB and SAB”Summer School: “General nucleic acid chemistry; ON synthesis and analysis, including modifications and conjugates and introduction to peptides and peptide nucleic acids; Enzymes for synthesis of nucleotides and ONs; Introduction to and overview of Oligonucleotide TherapyVITAE workshop 2: “Effective and Collaborative Researcher”This deliverable will be updated as follows:In month 11 to reflect OLIGOMED Training week 2022 (month 21)In month 22 to reflect OLIGOMED Training week 2023 (month 32)In month 33 to reflect OLIGOMED Training week 2024 (month 41)

OLIGOMED website established

The website will provide an introduction to the topic of ON and present the breadth of available DNA technologies and their medical applications in layman terms to make this site work also an educational tool The website will also serve additional communication purposes such as establishing transparency on project partners and funding informing about OLIGOMED activities and achievements as well as enabling interaction with interested parties such as registration for newsletter or training events and links to social media

"15 Recordings of ""PhD in 3 minutes"""

The ESRs will do a threeminute presentation with the aid of exactly one slide to describe their project This version during OLIGOMED week 2021 presents the project aims in its wider context and first advancements The presentations are aimed at the general public for awareness of OLIGOMED and promoting science through societal impactThis deliverable will be updated in month 22 to reflect the second recording with due date month 41The ESRs will do a threeminute presentation with the aid of exactly one slide to describe their project This version in OLIGOMED week 2023 presents the major results impact and outlook The presentations are aimed at the general public for awareness of OLIGOMED and promoting science through societal impact

OLIGOMED Video

A threeminute clip will be produced that presents the overarching aim of the project 12 illustrative example ESR projects and the relevance for the general public It will be made available on the website and on YouTube

Veröffentlichungen

FALCON-qPCR: a new method for the quantification of oxidative lesions in mitochondrial DNA

Autoren: Veronica Bazzani, Eve Harding, Szymon Balinski, Mara Equisoain Redin, Dario Alessi, Pierfrancesco Del Mestre, Walter Baratta, Daniela Cesselli, Antonio Paolo Beltrami, Michał Turek, Umberto Baccarani, Carlo Vascotto
Veröffentlicht in: Bioanalysis, Ausgabe 17, 2026, Seite(n) 1671-1683, ISSN 1757-6180
Herausgeber: Future Science
DOI: 10.1080/17576180.2025.2608757

Furan-based (photo)oxidation reactions and their application in nucleic acid and protein targeting

Autoren: Jack, Barr; Gertjan, Colpaert; Enrico, Cadoni; Annemieke, Madder
Veröffentlicht in: Methods, Ausgabe 2, 2023, ISSN 1046-2023
Herausgeber: Academic Press
DOI: 10.1016/j.ymeth.2023.08.011

Versatile introduction of multifunctional Michael-acceptor moieties on amino-oligonucleotides for bioconjugation purposes

Autoren: Jan H. Meffert, Mónica Lopes, Enrico Cadoni, Martin Bollmark, Ulf Tedebark, Annemieke Madder
Veröffentlicht in: Communications Chemistry, Ausgabe 9, 2026, ISSN 2399-3669
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1038/s42004-025-01882-8

Self-assembling supramolecular dendrimers for biomedical applications

Autoren: Abdechakour Elkihel, Jing Wu, Ling Peng
Veröffentlicht in: Comptes Rendus. Chimie, Ausgabe 29, 2026, Seite(n) 321-347, ISSN 1631-0748
Herausgeber: Elsevier Masson
DOI: 10.5802/crchim.451

Characterization of a new mutation of mitochondrial ND6 gene in hepatocellular carcinoma and its effects on respiratory complex I

Autoren: Veronica Bazzani, Deepali L Kundnani, Mara Equisoain Redin, Francesca Agostini, Kirti Chhatlani, Angelo Corso Faini, Jakub Poziemski, Umberto Baccarani, Pawel Siedlecki, Silvia Deaglio, Francesca Storici, Carlo Vascotto
Veröffentlicht in: Scientific Reports, Ausgabe 15, 2025, ISSN 2045-2322
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41598-025-91746-x

Red-Light-Induced Cysteine Modifications Suitable for Protein Labeling

Autoren: Tomasz Wdowik, Egor Fedorov, Tina-Thien Ho, Patrick Duriez, Eugen Stulz, Dorota Gryko
Veröffentlicht in: ACS Organic & Inorganic Au, Ausgabe 5, 2025, Seite(n) 238-243, ISSN 2694-247X
Herausgeber: American Chemical Society (ACS)
DOI: 10.1021/acsorginorgau.5c00025

Concerted Action of Targeted Nucleic Acid Therapeutics as Flexible, Precision and Personalized Cancer Treatment

Autoren: Jing Wu, Jiaxuan Chen, Abdechakour Elkihel, Wenjun Lan, Nicolas Fraunhoffer, Dandan Zhu, Baoping Lian, Christina Galanakou, Zhancun Bian, Xi Liu, Odile Gayet, Loic Moubri, Julie Aglietti Roques, Vikash Reebye, Nagy Habib, Xiaoxuan Liu, Nelson Dusetti, Juan Lucio Iovanna, Ling Peng
Veröffentlicht in: Advanced Science, 2026, ISSN 2198-3844
Herausgeber: Wiley
DOI: 10.1002/advs.76840

Synthesis and stability studies of bicyclo[6.1.0]nonyne scaffolds for automated solid-phase oligonucleotide synthesis

Autoren: Kristina Karalė, Martin Bollmark, Antanas Karalius, Mónica Lopes, Oswaldo Pérez, Roger Strömberg, Ulf Tedebark
Veröffentlicht in: RSC Advances, Ausgabe 14, 2026, Seite(n) 17406-17412, ISSN 2046-2069
Herausgeber: Royal Society of Chemistry
DOI: 10.1039/d3ra08732h

A red light-triggered chemical tool for sequence-specific alkylation of G-quadruplex and I-motif DNA

Autoren: Enrico Cadoni; Lessandro De Paepe; Gertjan Colpaert; Ruben Tack; Dries Waegeman; Alex Manicardi; Annemieke Madder
Veröffentlicht in: Nucleic Acids Research, 2023, ISSN 0305-1048
Herausgeber: Oxford University Press
DOI: 10.1093/nar/gkad189

Multimeric Conjugates Using Engineered Peptide Scaffolds for Efficient siRNA Delivery

Autoren: Quentin Vicentini, Dennis Hekman, Deepak Bhatt, Rouven Stulz, Mahya Dezfouli, Peter Gennemark, Nicola Guzzi, Naoko Toki, Bojana Lazovic, Carolina Tängemo, Shalini Andersson, Samir EL Andaloussi, Anders Dahlén
Veröffentlicht in: Bioconjugate Chemistry, Ausgabe 36, 2025, Seite(n) 1299-1310, ISSN 1043-1802
Herausgeber: American Chemical Society
DOI: 10.1021/acs.bioconjchem.5c00156

Therapeutic Oligonucleotides: An Outlook on Chemical Strategies to Improve Endosomal Trafficking

Autoren: Priyanka Mangla; Quentin Vicentini; Annabelle Biscans
Veröffentlicht in: Cells, Ausgabe 1, 2023, Seite(n) 2253, ISSN 2073-4409
Herausgeber: MDPI
DOI: 10.3390/cells12182253

Small Activating RNA Modulation of the G Protein‐Coupled Receptor for Cancer Treatment

Autoren: Yunfang Xiong; Ran Ke; Qingyu Zhang; Wenjun Lan; Wanjun Yuan; Karol Nga Ieng Chan; Tom Roussel; Yifan Jiang; Jing Wu; Shuai Liu; Alice Sze Tsai Wong; Joong Sup Shim; Xuanjun Zhang; Ruiyu Xie; Nelson Dusetti; Juan Iovanna; Nagy Habib; Ling Peng; Leo Tsz On Lee
Veröffentlicht in: Advanced Science, 2022, ISSN 2198-3844
Herausgeber: Wiley
DOI: 10.1002/advs.202200562

Bola‐Amphiphilic Glycodendrimers: New Carbohydrate‐Mimicking Scaffolds to Target Carbohydrate‐Binding Proteins

Autoren: Wenzheng Zhang; Dinesh Dhumal; Xiaolei Zhu; Brigino Ralahy; Aleksandra Ellert‐Miklaszewska; Jing Wu; Erik Laurini; Yi‐Wen Yao; Chai‐Lin Kao; Juan L. Iovanna; Sabrina Pricl; Bozena Kaminska; Yi Xia; Ling Peng
Veröffentlicht in: Chemistry - A European Journal, 2022, ISSN 0947-6539
Herausgeber: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202201400

Precision chemical engineering of dendrimers for nucleic acid delivery

Autoren: Qianqian Ni, Donald A. Tomalia, Jing Wu, Christina Galanakou, Ling Peng
Veröffentlicht in: Nature Reviews Chemistry, 2026, ISSN 2397-3358
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1038/s41570-026-00855-2

Cyclophilin D is a new non-canonical substrate of the mitochondrial intermembrane space assembly pathway

Autoren: Mara Equisoain Redin, Veronica Bazzani, Eve Harding, Joshua McHale, Carlo Vascotto
Veröffentlicht in: Journal of Biological Chemistry, Ausgabe 301, 2026, Seite(n) 110883, ISSN 0021-9258
Herausgeber: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2025.110883

Self-assembling dendrimer nanodrug formulations for decreased hERG-related toxicity and enhanced therapeutic efficacy

Autoren: Xi Liu, Dinesh Dhumal, Patricia Santofimia-Castaño, Juan Liu, Marion Casanova, Alicia Comino Garcia-Muñoz, Teodora-Adriana Perles-Barbacaru, Abdechakour Elkihel, Wenzheng Zhang, Tom Roussel, Christina Galanakou, Jing Wu, Eleni Zerva, Nelson Dusetti, Yi Xia, Xing-Jie Liang, Angèle Viola, Juan L. Iovanna, Ling Peng
Veröffentlicht in: Science Advances, Ausgabe 11, 2025, ISSN 2375-2548
Herausgeber: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.adu9948

Quantitative analysis of oligonucleotide delivery into isolated mitochondria: a proof-of-concept method

Autoren: Joshua McHale, Veronica Bazzani, Abdechakour Elkihel, Jing Wu, Ling Peng, Carlo Vascotto
Veröffentlicht in: BioTechniques, Ausgabe 78, 2026, Seite(n) 1-11, ISSN 0736-6205
Herausgeber: Eaton Publishing Co.
DOI: 10.1080/07366205.2026.2635461

Lipid and Carbohydrate Modifications Enhance Potency of Antisense Oligonucleotides Targeting Oncogenic KRAS

Autoren: Faith Kivunga, Virginie Baylot, Julien Verget, Helene Pereira, Brune Vialet, Patricia Korczak, Jean Dessolin, Philippe Barthélémy
Veröffentlicht in: Bioconjugate Chemistry, Ausgabe 37, 2026, Seite(n) 875-880, ISSN 1043-1802
Herausgeber: American Chemical Society
DOI: 10.1021/acs.bioconjchem.5c00627

Beyond small molecules: targeting G-quadruplex structures with oligonucleotides and their analogues.

Autoren: Enrico Cadoni; Lessandro De Paepe; Alex Manicardi; Annemieke Madder
Veröffentlicht in: Nucleic Acids Research, Ausgabe Vol. 49, No. 12, 2021, Seite(n) 6638–6659, ISSN 0305-1048
Herausgeber: Oxford University Press
DOI: 10.1093/nar/gkab334

Is Drp1 a link between mitochondrial dysfunction and inflammation in Alzheimer’s disease?

Autoren: Oualid Sbai; Veronica Bazzani; Shreya Tapaswi; Joshua McHale; Carlo Vascotto; Carlo Vascotto; Lorena Perrone
Veröffentlicht in: Frontiers in Molecular Neuroscience, Vol 16 (2023), Ausgabe 1, 2023, ISSN 1662-5099
Herausgeber: Frontiers Research Foundation
DOI: 10.3389/fnmol.2023.1166879

Mitochondrial DNA Repair in Neurodegenerative Diseases and Ageing

Autoren: Veronica Bazzani; Mara Equisoain Redin; Joshua McHale; Lorena Perrone; Carlo Vascotto
Veröffentlicht in: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms231911391

Dendrimer engineering to overcome delivery challenges of nucleic acids

Autoren: Qianqian Ni, Jing Wu, Christina Galanakou, Cheng-Cai Zhang, Donald A. Tomalia, Ling Peng
Veröffentlicht in: Nature Reviews Bioengineering, Ausgabe 3, 2026, Seite(n) 806-807, ISSN 2731-6092
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1038/s44222-025-00347-w

Vitamin B12 functionalized with hydroxy-pyrrol-2-one linkers

Autoren: Mateusz Woźny, Monica Fresta, Jan Meffert, Annemieke Madder, Dorota Gryko
Veröffentlicht in: Journal of Porphyrins and Phthalocyanines, Ausgabe 29, 2025, Seite(n) 46-51, ISSN 1088-4246
Herausgeber: Society of Porphyrins and Phthalocyanines
DOI: 10.1142/s1088424624500676

Targeting the IRES structure of mRNA for modulating gene translation

Autoren: Ferriol Monjo, Albert
Veröffentlicht in: 2025
Herausgeber: SOTON

Modular DNA nanopore (NP) for targeted cell killing

Autoren: Ho, Tina-Thien
Veröffentlicht in: 2025
Herausgeber: SOTON

Development of method for large scale manufacturing of ON constructs

Autoren: Lopes, Monica Monteiro
Veröffentlicht in: 2026
Herausgeber: SOTON, RISE

Towards the development of next-generation MergoTM — a nucleic acid-based delivery platform

Autoren: Reyes Fraile, Laura
Veröffentlicht in: 2026
Herausgeber: SOTON, Sixfold

Self-Assembled Nucleolipid G-Quadruplexes Act as Multitarget Decoys for Oncogene Suppression in Pancreatic Cancer

Autoren: Faith Kivunga, Virginie Baylot, Tina Kauss, Brune Vialet, Jules Simonin Garcia, Patricia Korczak, Zahraa Othman, Gilmar Salgado, Philippe Barthélémy
Veröffentlicht in: 2026
Herausgeber: openRxiv
DOI: 10.64898/2026.04.03.715535

PNA-Guided Modular Self-Assembly of Antibody-Oligonucleotide Constructs Enables Targeted Oligonucleotide Delivery

Autoren: Tina-Thien Ho, Jan H. Meffert, Alexandros Kostakis, Mónica M. Lopes, Matthijs Pijnappel, Lara E. Buermann, Enrico Cadoni, Martin Bollmark, Ulf Tedebark, Sara Mangsbo, Annemieke Madder, Eugen Stulz
Veröffentlicht in: 2026
Herausgeber: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv.15002633/v1

Projektergebnisse

Leistungen

Veröffentlichungen

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