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Drug Absorption in Geriatric Patients and Older People: a training network innovating drug development for the advanced age population

Description du projet

Absorption orale des médicaments pour la population âgée

Paradoxalement, même si les personnes âgées (plus de 65 ans) sont le groupe le plus atteint de troubles chroniques, ils ne sont pas pris en compte dans le processus de développement de médicaments, qui n’emploie que des données issues d’adultes en bonne santé âgés de 18 à 55 ans. Pour répondre à cette contrainte, le projet AGePOP, financé par l’UE, étudiera les altérations physiologiques du système digestif associées au vieillissement et améliorera l’efficacité des médicaments oraux. Grâce à un programme de formation interdisciplinaire, le projet permettra à des chercheurs en début de carrière d’étudier les caractéristiques du système digestif des personnes âgées et des patients gériatriques, orientant ainsi le futur développement de médicaments adaptés à cette tranche d’âge.

Objectif

The advanced age population (>65y) makes up ~20% of the total population in Europe, is the main carrier of chronic diseases and the major end-user group of medications. Yet, despite an ageing society, these end-users are entirely disregarded in the drug development process, which considers only healthy adults aged 18-55. Effective absorption of oral drugs, which remain the preferred form of administration, relies on a sound knowledge of the physiological alterations associated with ageing and of the characteristics of the gastrointestinal (GI) tract in older subjects. Nonetheless, both the knowledge and the experts in this area are lacking. The AGePOP European Training Network (ETN) will boost Europe’s innovation capacity and leadership in oral drug development. Its multisectoral approach will train 11 Early Stage Researchers (ESRs) to become the future experts in drug development for the advanced age population, shedding a much needed light on the needs of our ageing society. With an open science philosophy and a multidisciplinary strategy, the ESRs will collect the first ever dataset of physiological characteristics of the GI tract of older people and geriatric patients, developing novel in vitro and in silico tools, e.g. a mobile test kit to evaluate gastric emptying kinetics and an absorption risk calculator to predict adverse effects from altered pharmacokinetics. Complementary training in transferable, business and wider horizon skills will equip the ESRs with an all-rounded skillset. AGePOP is a network of 6 Beneficiaries and 7 Partner Organisations from 5 European countries. Its 3 academic partners with research excellence in oral drug products synergise with renowned clinicians and researchers from 8 leading pharma companies and 1 SME specialised in ETN training. Building on long-standing collaborations, the consortium will provide 11 ESRs with a unique Europe-wide learning experience, preparing them to lead their future careers with confidence and success.

Coordinateur

ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Contribution nette de l'UE
€ 729 052,92
Adresse
6 CHRISTOU LADA STR
10561 Athina
Grèce

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Région
Αττική Aττική Κεντρικός Τομέας Αθηνών
Type d’activité
Higher or Secondary Education Establishments
Liens
Coût total
€ 729 052,92

Participants (5)