Descripción del proyecto
Absorción de fármacos por vía oral para la población de edad avanzada
Aunque la población de mayor edad (mayores de sesenta y cinco años) es el grupo que más trastornos crónicos padece, paradójicamente no se les tiene en cuenta en el proceso de desarrollo de fármacos, en el que solo se emplean datos de adultos sanos de entre dieciocho y cincuenta y cinco años. Para hacer frente a esta limitación, en el proyecto financiado con fondos europeos AGePOP se investigarán las alteraciones fisiológicas del tubo gastrointestinal asociadas con el envejecimiento y mejorará la eficacia de los medicamentos orales. Mediante un programa de formación interdisciplinaria, el proyecto ayudará a investigadores noveles a estudiar las características del tubo gastrointestinal de personas de edad avanzada y pacientes geriátricos, lo que orientará el futuro desarrollo de fármacos adecuados para este grupo de edad.
Objetivo
The advanced age population (>65y) makes up ~20% of the total population in Europe, is the main carrier of chronic diseases and the major end-user group of medications. Yet, despite an ageing society, these end-users are entirely disregarded in the drug development process, which considers only healthy adults aged 18-55. Effective absorption of oral drugs, which remain the preferred form of administration, relies on a sound knowledge of the physiological alterations associated with ageing and of the characteristics of the gastrointestinal (GI) tract in older subjects. Nonetheless, both the knowledge and the experts in this area are lacking. The AGePOP European Training Network (ETN) will boost Europe’s innovation capacity and leadership in oral drug development. Its multisectoral approach will train 11 Early Stage Researchers (ESRs) to become the future experts in drug development for the advanced age population, shedding a much needed light on the needs of our ageing society. With an open science philosophy and a multidisciplinary strategy, the ESRs will collect the first ever dataset of physiological characteristics of the GI tract of older people and geriatric patients, developing novel in vitro and in silico tools, e.g. a mobile test kit to evaluate gastric emptying kinetics and an absorption risk calculator to predict adverse effects from altered pharmacokinetics. Complementary training in transferable, business and wider horizon skills will equip the ESRs with an all-rounded skillset. AGePOP is a network of 6 Beneficiaries and 7 Partner Organisations from 5 European countries. Its 3 academic partners with research excellence in oral drug products synergise with renowned clinicians and researchers from 8 leading pharma companies and 1 SME specialised in ETN training. Building on long-standing collaborations, the consortium will provide 11 ESRs with a unique Europe-wide learning experience, preparing them to lead their future careers with confidence and success.
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MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinador
10561 Athina
Grecia