Drug Absorption in Geriatric Patients and Older People: a training network innovating drug development for the advanced age population

Project Information

AGePOP

Grant agreement ID: 956146

DOI

10.3030/956146

Project closed

EC signature date 18 August 2020

Start date 1 January 2021

End date 31 December 2024

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 2 790 443,16

EU contribution

€ 2 790 443,16

Coordinated by

ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Greece

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (12)

Ranking of dosage form preferences in older people and geriatric patients
All developed PBPK models by ESR11 available on open-source software platform Github
Outreach Plan
Implementation of an absorption risk calculator for the development of medicines for older people and geriatric patients
Real life dosing conditions in older people and geriatric patients
Paracellular intestinal permeability characteristics in older people
Novel in vitro assay for swallowability testing
AGePOP symposium (final event)
Protein abundancy and activity of intestinal transporters and enzymes in older people and geriatric patients with Alzheimer's disease

Protein abundancy and activity of intestinal transporters and enzymes in older people and geriatric patients with Alzheimer’s disease

Gap analysis on oral drug absorption in older people and geriatric patients (ESRs 1-9)
Novel mobile test kit for individual gastric emptying measurement
Gap analysis on PBB/PBPK modelling in older people and geriatric patients (ESRs 10 and 11)

Other (4)

Research Webinars
Research image exhibit
11 PhD theses (drafts)
3 AGePOP Weeks

Open Research Data Pilot (1)

Data Management Plan

Websites, patent fillings, videos etc. (2)

AGePOP project website
White Paper

Publications

Peer reviewed articles (18)

Determination of Gastric Water Emptying in Fasted and Fed State Conditions Using a Compression-Coated Tablet and Salivary Caffeine Kinetics

Author(s): Theodora Tzakri, Lara Rehenbrock, Stefan Senekowitsch, Adrian Rump, Philipp Schick, Julius Krause, Marie-Luise Kromrey, Michael Grimm, Werner Weitschies
Published in: Pharmaceutics, Issue 15, 2023, Page(s) 2584, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15112584

Real-life dosing conditions in older adults and geriatric patients in Poland – An international questionnaire study to investigate the regional differences in drug intake behaviour in the older population

Author(s): Dorota Sarwinska, Marta Miller, Jagoda Arendt, Michał Markiewicz, Katarzyna Michta, Michael Grimm, Łukasz Balwicki, Werner Weitschies
Published in: European Journal of Pharmaceutical Sciences, Issue 206, 2025, Page(s) 107001, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2024.107001

Decreased Kidney Function Explains Higher Vancomycin Exposure in Older Adults

Author(s): Angela Elma Edwina, Erwin Dreesen, Matthias Gijsen, Helena Cornelia van den Hout, Stefanie Desmet, Johan Flamaing, Lorenz Van der Linden, Isabel Spriet, Jos Tournoy
Published in: Drugs & Aging, Issue 41, 2024, Page(s) 753-762, ISSN 1170-229X
Publisher: Adis International Ltd.
DOI: 10.1007/s40266-024-01140-x

Impact of advanced age on the gastric emptying of water under fasted and fed state conditions

Author(s): Theodora Tzakri, Stefan Senekowitsch, Toni Wildgrube, Dorota Sarwinska, Julius Krause, Philipp Schick, Michael Grimm, Stefan Engeli, Werner Weitschies
Published in: European Journal of Pharmaceutical Sciences, Issue 201, 2024, Page(s) 106853, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2024.106853

The effect of sparkling water on the systemic pharmacokinetics of paracetamol in older adults

Author(s): Fritz Harder, Malissa Bresseleers, Joachim Brouwers, Tim Vanuytsel, Patrick Augustijns
Published in: International Journal of Pharmaceutics, Issue 662, 2024, Page(s) 124482, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2024.124482

Tracking the journey: Gastrointestinal transit and intraluminal pH dynamics in aging populations using wireless motility capsule

Author(s): Angela Elma Edwina, Mirko Koziolek, Nele Steenackers, Tim Vanuytsel, Álvaro López Mármol, Christophe Matthys, Erwin Dreesen, Lorenz Van der Linden, Isabel Spriet, Jos Tournoy
Published in: International Journal of Pharmaceutics, Issue 669, 2025, Page(s) 125016, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2024.125016

Esophageal transit of solid oral dosage forms – impact of different surface materials characterized in vitro and in vivo by MRI in healthy volunteers

Author(s): Henriette Hummler, Susanne Page, Cordula Stillhart, Phil Lorenz, Marie-Luise Kromrey, Werner Weitschies, Michael Grimm
Published in: European Journal of Pharmaceutical Sciences, Issue 203, 2024, Page(s) 106926, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2024.106926

Impact of Tablet Size and Shape on the Swallowability in Older Adults

Author(s): Henriette Hummler, Cordula Stillhart, Lisa Meilicke, Michael Grimm, Elischa Krause, Marwan Mannaa, Maik Gollasch, Werner Weitschies, Susanne Page
Published in: Pharmaceutics, Issue 15, 2024, Page(s) 1042, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15041042

Parameters to consider for successful medication use in older adults - An AGePOP review

Author(s): Henriette Hummler, Dorota Sarwinska, Werner Weitschies, Maik Gollasch, Susanne Page
Published in: European Journal of Pharmaceutical Sciences, Issue 187, 2024, Page(s) 106453, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2023.106453

The impact of advanced age on gastrointestinal characteristics that are relevant to oral drug absorption: An AGePOP review

Author(s): Cordula Stillhart, Adam Asteriadis, Ekaterina Bocharova, Gabriel Eksteen, Fritz Harder, Jonas Kusch, Theodora Tzakri, Patrick Augustijns, Christophe Matthys, Maria Vertzoni, Werner Weitschies, Christos Reppas
Published in: European Journal of Pharmaceutical Sciences, Issue 187, 2023, Page(s) 106452, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2023.106452

Investigation of real-life drug intake behaviour in older adults and geriatric patients in Northern Germany – A biopharmaceutical perspective

Author(s): Dorota Sarwinska, Michael Grimm, Julius Krause, Philipp Schick, Maik Gollasch, Marwan Mannaa, Christoph A. Ritter, Werner Weitschies
Published in: European Journal of Pharmaceutical Sciences, Issue 200, 2024, Page(s) 106814, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2024.106814

Influence of Solid Oral Dosage Form Characteristics on Swallowability, Visual Perception, and Handling in Older Adults

Author(s): Henriette Hummler, Susanne Page, Cordula Stillhart, Lisa Meilicke, Michael Grimm, Marwan Mannaa, Maik Gollasch, Werner Weitschies
Published in: Pharmaceutics, Issue 15, 2024, Page(s) 1315, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15041315

Insights into the Pharmacokinetics and Pharmacodynamics of Direct Oral Anticoagulants in Older Adults with Atrial Fibrillation: A Structured Narrative Review

Author(s): Angela Elma Edwina, Nada Dia, Erwin Dreesen, Thomas Vanassche, Peter Verhamme, Isabel Spriet, Lorenz Van der Linden, Jos Tournoy
Published in: Clinical Pharmacokinetics, Issue 62, 2023, Page(s) 351-373, ISSN 0312-5963
Publisher: Adis International Ltd.
DOI: 10.1007/s40262-023-01222-w

Physiologically based pharmacokinetic (PBPK) modelling of oral drug absorption in older adults – an AGePOP review

Author(s): Cleo Demeester, Donnia Robins, Angela Elma Edwina, Jos Tournoy, Patrick Augustijns, Ibrahim Ince, Andreas Lehmann, Maria Vertzoni, Jan Frederik Schlender
Published in: European Journal of Pharmaceutical Sciences, Issue 188, 2024, Page(s) 106496, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2023.106496

Agreement Between a Colorimetric Assay and Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry for Quantifying Paracetamol Plasma Concentrations

Author(s): Angela Elma Edwina, Erwin Dreesen, Julie Hias, Birgit C. P. Koch, Nele Van den Eede, Steven Pauwels, Karel Allegaert, Lorenz Van der Linden, Isabel Spriet, Jos Tournoy
Published in: The AAPS Journal, Issue 26, 2024, ISSN 1550-7416
Publisher: Springer New York
DOI: 10.1208/s12248-024-00890-1

A quantification of gastric and duodenal fluid volumes in older adults using MRI

Author(s): Cleo Demeester, Matthias Van der Veken, Joachim Brouwers, Ragna Vanslembrouck, André Dallmann, Thomas Wendl, Patrick Augustijns
Published in: International Journal of Pharmaceutics, Issue 666, 2024, Page(s) 124831, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2024.124831

Analyzing parametric influences driving age-associated changes in absorption using a PBPK-GSA approach

Author(s): Donnia Robins, Andreas Lehmann, Katharina Krollik, Maria Vertzoni
Published in: European Journal of Pharmaceutical Sciences, Issue 202, 2024, Page(s) 106881, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2024.106881

Selenium Deficiency After Bariatric Surgery Is More Than Surface Deep

Author(s): Gabriel Eksteen; Tim Vanuytsel; Christophe Matthys; Bart Van der Schueren; Nele Steenackers
Published in: Obesity Surgery, Issue 32, 2022, Page(s) 2473-2475, ISSN 1708-0428
Publisher: Springer
DOI: 10.1007/s11695-022-06084-y

Thesis and dissertations (2)

Patient-centric Drug Product Development for Older Adults: Influence of Solid Oral Dosage Form Characteristics on Patient Acceptability

Author(s): Henriette Hummler
Published in: 2024
Publisher: Universität Greifswald, epub

Investigation of gastric water empyting in older adults assessed by salivary caffeine kinetics and a novel tablet formulation

Author(s): Theodora Tzakri
Published in: 2024
Publisher: Universität Greifswald