Drug Absorption in Geriatric Patients and Older People: a training network innovating drug development for the advanced age population

Información del proyecto

AGePOP

Identificador del acuerdo de subvención: 956146

DOI

10.3030/956146

Proyecto cerrado

Fecha de la firma de la CE 18 Agosto 2020

Fecha de inicio 1 Enero 2021

Fecha de finalización 31 Diciembre 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 2 790 443,16

Aportación de la UE

€ 2 790 443,16

Coordinado por

ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Greece

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (12)

Ranking of dosage form preferences in older people and geriatric patients
All developed PBPK models by ESR11 available on open-source software platform Github
Outreach Plan
Implementation of an absorption risk calculator for the development of medicines for older people and geriatric patients
Real life dosing conditions in older people and geriatric patients
Paracellular intestinal permeability characteristics in older people
Novel in vitro assay for swallowability testing
AGePOP symposium (final event)
Protein abundancy and activity of intestinal transporters and enzymes in older people and geriatric patients with Alzheimer's disease

Protein abundancy and activity of intestinal transporters and enzymes in older people and geriatric patients with Alzheimer’s disease

Gap analysis on oral drug absorption in older people and geriatric patients (ESRs 1-9)
Novel mobile test kit for individual gastric emptying measurement
Gap analysis on PBB/PBPK modelling in older people and geriatric patients (ESRs 10 and 11)

Other (4)

Research Webinars
Research image exhibit
11 PhD theses (drafts)
3 AGePOP Weeks

Open Research Data Pilot (1)

Data Management Plan

Websites, patent fillings, videos etc. (2)

AGePOP project website
White Paper

Publicaciones

Peer reviewed articles (18)

Determination of Gastric Water Emptying in Fasted and Fed State Conditions Using a Compression-Coated Tablet and Salivary Caffeine Kinetics

Autores: Theodora Tzakri, Lara Rehenbrock, Stefan Senekowitsch, Adrian Rump, Philipp Schick, Julius Krause, Marie-Luise Kromrey, Michael Grimm, Werner Weitschies
Publicado en: Pharmaceutics, Edición 15, 2023, Página(s) 2584, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15112584

Real-life dosing conditions in older adults and geriatric patients in Poland – An international questionnaire study to investigate the regional differences in drug intake behaviour in the older population

Autores: Dorota Sarwinska, Marta Miller, Jagoda Arendt, Michał Markiewicz, Katarzyna Michta, Michael Grimm, Łukasz Balwicki, Werner Weitschies
Publicado en: European Journal of Pharmaceutical Sciences, Edición 206, 2025, Página(s) 107001, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2024.107001

Decreased Kidney Function Explains Higher Vancomycin Exposure in Older Adults

Autores: Angela Elma Edwina, Erwin Dreesen, Matthias Gijsen, Helena Cornelia van den Hout, Stefanie Desmet, Johan Flamaing, Lorenz Van der Linden, Isabel Spriet, Jos Tournoy
Publicado en: Drugs & Aging, Edición 41, 2024, Página(s) 753-762, ISSN 1170-229X
Editor: Adis International Ltd.
DOI: 10.1007/s40266-024-01140-x

Impact of advanced age on the gastric emptying of water under fasted and fed state conditions

Autores: Theodora Tzakri, Stefan Senekowitsch, Toni Wildgrube, Dorota Sarwinska, Julius Krause, Philipp Schick, Michael Grimm, Stefan Engeli, Werner Weitschies
Publicado en: European Journal of Pharmaceutical Sciences, Edición 201, 2024, Página(s) 106853, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2024.106853

The effect of sparkling water on the systemic pharmacokinetics of paracetamol in older adults

Autores: Fritz Harder, Malissa Bresseleers, Joachim Brouwers, Tim Vanuytsel, Patrick Augustijns
Publicado en: International Journal of Pharmaceutics, Edición 662, 2024, Página(s) 124482, ISSN 0378-5173
Editor: Elsevier BV
DOI: 10.1016/j.ijpharm.2024.124482

Tracking the journey: Gastrointestinal transit and intraluminal pH dynamics in aging populations using wireless motility capsule

Autores: Angela Elma Edwina, Mirko Koziolek, Nele Steenackers, Tim Vanuytsel, Álvaro López Mármol, Christophe Matthys, Erwin Dreesen, Lorenz Van der Linden, Isabel Spriet, Jos Tournoy
Publicado en: International Journal of Pharmaceutics, Edición 669, 2025, Página(s) 125016, ISSN 0378-5173
Editor: Elsevier BV
DOI: 10.1016/j.ijpharm.2024.125016

Esophageal transit of solid oral dosage forms – impact of different surface materials characterized in vitro and in vivo by MRI in healthy volunteers

Autores: Henriette Hummler, Susanne Page, Cordula Stillhart, Phil Lorenz, Marie-Luise Kromrey, Werner Weitschies, Michael Grimm
Publicado en: European Journal of Pharmaceutical Sciences, Edición 203, 2024, Página(s) 106926, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2024.106926

Impact of Tablet Size and Shape on the Swallowability in Older Adults

Autores: Henriette Hummler, Cordula Stillhart, Lisa Meilicke, Michael Grimm, Elischa Krause, Marwan Mannaa, Maik Gollasch, Werner Weitschies, Susanne Page
Publicado en: Pharmaceutics, Edición 15, 2024, Página(s) 1042, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15041042

Parameters to consider for successful medication use in older adults - An AGePOP review

Autores: Henriette Hummler, Dorota Sarwinska, Werner Weitschies, Maik Gollasch, Susanne Page
Publicado en: European Journal of Pharmaceutical Sciences, Edición 187, 2024, Página(s) 106453, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2023.106453

The impact of advanced age on gastrointestinal characteristics that are relevant to oral drug absorption: An AGePOP review

Autores: Cordula Stillhart, Adam Asteriadis, Ekaterina Bocharova, Gabriel Eksteen, Fritz Harder, Jonas Kusch, Theodora Tzakri, Patrick Augustijns, Christophe Matthys, Maria Vertzoni, Werner Weitschies, Christos Reppas
Publicado en: European Journal of Pharmaceutical Sciences, Edición 187, 2023, Página(s) 106452, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2023.106452

Investigation of real-life drug intake behaviour in older adults and geriatric patients in Northern Germany – A biopharmaceutical perspective

Autores: Dorota Sarwinska, Michael Grimm, Julius Krause, Philipp Schick, Maik Gollasch, Marwan Mannaa, Christoph A. Ritter, Werner Weitschies
Publicado en: European Journal of Pharmaceutical Sciences, Edición 200, 2024, Página(s) 106814, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2024.106814

Influence of Solid Oral Dosage Form Characteristics on Swallowability, Visual Perception, and Handling in Older Adults

Autores: Henriette Hummler, Susanne Page, Cordula Stillhart, Lisa Meilicke, Michael Grimm, Marwan Mannaa, Maik Gollasch, Werner Weitschies
Publicado en: Pharmaceutics, Edición 15, 2024, Página(s) 1315, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15041315

Insights into the Pharmacokinetics and Pharmacodynamics of Direct Oral Anticoagulants in Older Adults with Atrial Fibrillation: A Structured Narrative Review

Autores: Angela Elma Edwina, Nada Dia, Erwin Dreesen, Thomas Vanassche, Peter Verhamme, Isabel Spriet, Lorenz Van der Linden, Jos Tournoy
Publicado en: Clinical Pharmacokinetics, Edición 62, 2023, Página(s) 351-373, ISSN 0312-5963
Editor: Adis International Ltd.
DOI: 10.1007/s40262-023-01222-w

Physiologically based pharmacokinetic (PBPK) modelling of oral drug absorption in older adults – an AGePOP review

Autores: Cleo Demeester, Donnia Robins, Angela Elma Edwina, Jos Tournoy, Patrick Augustijns, Ibrahim Ince, Andreas Lehmann, Maria Vertzoni, Jan Frederik Schlender
Publicado en: European Journal of Pharmaceutical Sciences, Edición 188, 2024, Página(s) 106496, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2023.106496

Agreement Between a Colorimetric Assay and Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry for Quantifying Paracetamol Plasma Concentrations

Autores: Angela Elma Edwina, Erwin Dreesen, Julie Hias, Birgit C. P. Koch, Nele Van den Eede, Steven Pauwels, Karel Allegaert, Lorenz Van der Linden, Isabel Spriet, Jos Tournoy
Publicado en: The AAPS Journal, Edición 26, 2024, ISSN 1550-7416
Editor: Springer New York
DOI: 10.1208/s12248-024-00890-1

A quantification of gastric and duodenal fluid volumes in older adults using MRI

Autores: Cleo Demeester, Matthias Van der Veken, Joachim Brouwers, Ragna Vanslembrouck, André Dallmann, Thomas Wendl, Patrick Augustijns
Publicado en: International Journal of Pharmaceutics, Edición 666, 2024, Página(s) 124831, ISSN 0378-5173
Editor: Elsevier BV
DOI: 10.1016/j.ijpharm.2024.124831

Analyzing parametric influences driving age-associated changes in absorption using a PBPK-GSA approach

Autores: Donnia Robins, Andreas Lehmann, Katharina Krollik, Maria Vertzoni
Publicado en: European Journal of Pharmaceutical Sciences, Edición 202, 2024, Página(s) 106881, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2024.106881

Selenium Deficiency After Bariatric Surgery Is More Than Surface Deep

Autores: Gabriel Eksteen; Tim Vanuytsel; Christophe Matthys; Bart Van der Schueren; Nele Steenackers
Publicado en: Obesity Surgery, Edición 32, 2022, Página(s) 2473-2475, ISSN 1708-0428
Editor: Springer
DOI: 10.1007/s11695-022-06084-y

Thesis and dissertations (2)

Patient-centric Drug Product Development for Older Adults: Influence of Solid Oral Dosage Form Characteristics on Patient Acceptability

Autores: Henriette Hummler
Publicado en: 2024
Editor: Universität Greifswald, epub

Investigation of gastric water empyting in older adults assessed by salivary caffeine kinetics and a novel tablet formulation

Autores: Theodora Tzakri
Publicado en: 2024
Editor: Universität Greifswald