Drug Absorption in Geriatric Patients and Older People: a training network innovating drug development for the advanced age population

Informacje na temat projektu

AGePOP

Identyfikator umowy o grant: 956146

DOI

10.3030/956146

Projekt został zamknięty

Data podpisania przez KE 18 Sierpnia 2020

Data rozpoczęcia 1 Stycznia 2021

Data zakończenia 31 Grudnia 2024

Finansowanie w ramach

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Koszt całkowity

€ 2 790 443,16

Wkład UE

€ 2 790 443,16

Koordynowany przez

ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Greece

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Documents, reports (12)

Ranking of dosage form preferences in older people and geriatric patients
All developed PBPK models by ESR11 available on open-source software platform Github
Outreach Plan
Implementation of an absorption risk calculator for the development of medicines for older people and geriatric patients
Real life dosing conditions in older people and geriatric patients
Paracellular intestinal permeability characteristics in older people
Novel in vitro assay for swallowability testing
AGePOP symposium (final event)
Protein abundancy and activity of intestinal transporters and enzymes in older people and geriatric patients with Alzheimer's disease

Protein abundancy and activity of intestinal transporters and enzymes in older people and geriatric patients with Alzheimer’s disease

Gap analysis on oral drug absorption in older people and geriatric patients (ESRs 1-9)
Novel mobile test kit for individual gastric emptying measurement
Gap analysis on PBB/PBPK modelling in older people and geriatric patients (ESRs 10 and 11)

Other (4)

Research Webinars
Research image exhibit
11 PhD theses (drafts)
3 AGePOP Weeks

Open Research Data Pilot (1)

Data Management Plan

Websites, patent fillings, videos etc. (2)

AGePOP project website
White Paper

Publikacje

Peer reviewed articles (18)

Determination of Gastric Water Emptying in Fasted and Fed State Conditions Using a Compression-Coated Tablet and Salivary Caffeine Kinetics

Autorzy: Theodora Tzakri, Lara Rehenbrock, Stefan Senekowitsch, Adrian Rump, Philipp Schick, Julius Krause, Marie-Luise Kromrey, Michael Grimm, Werner Weitschies
Opublikowane w: Pharmaceutics, Numer 15, 2023, Strona(/y) 2584, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15112584

Real-life dosing conditions in older adults and geriatric patients in Poland – An international questionnaire study to investigate the regional differences in drug intake behaviour in the older population

Autorzy: Dorota Sarwinska, Marta Miller, Jagoda Arendt, Michał Markiewicz, Katarzyna Michta, Michael Grimm, Łukasz Balwicki, Werner Weitschies
Opublikowane w: European Journal of Pharmaceutical Sciences, Numer 206, 2025, Strona(/y) 107001, ISSN 0928-0987
Wydawca: Elsevier BV
DOI: 10.1016/j.ejps.2024.107001

Decreased Kidney Function Explains Higher Vancomycin Exposure in Older Adults

Autorzy: Angela Elma Edwina, Erwin Dreesen, Matthias Gijsen, Helena Cornelia van den Hout, Stefanie Desmet, Johan Flamaing, Lorenz Van der Linden, Isabel Spriet, Jos Tournoy
Opublikowane w: Drugs & Aging, Numer 41, 2024, Strona(/y) 753-762, ISSN 1170-229X
Wydawca: Adis International Ltd.
DOI: 10.1007/s40266-024-01140-x

Impact of advanced age on the gastric emptying of water under fasted and fed state conditions

Autorzy: Theodora Tzakri, Stefan Senekowitsch, Toni Wildgrube, Dorota Sarwinska, Julius Krause, Philipp Schick, Michael Grimm, Stefan Engeli, Werner Weitschies
Opublikowane w: European Journal of Pharmaceutical Sciences, Numer 201, 2024, Strona(/y) 106853, ISSN 0928-0987
Wydawca: Elsevier BV
DOI: 10.1016/j.ejps.2024.106853

The effect of sparkling water on the systemic pharmacokinetics of paracetamol in older adults

Autorzy: Fritz Harder, Malissa Bresseleers, Joachim Brouwers, Tim Vanuytsel, Patrick Augustijns
Opublikowane w: International Journal of Pharmaceutics, Numer 662, 2024, Strona(/y) 124482, ISSN 0378-5173
Wydawca: Elsevier BV
DOI: 10.1016/j.ijpharm.2024.124482

Tracking the journey: Gastrointestinal transit and intraluminal pH dynamics in aging populations using wireless motility capsule

Autorzy: Angela Elma Edwina, Mirko Koziolek, Nele Steenackers, Tim Vanuytsel, Álvaro López Mármol, Christophe Matthys, Erwin Dreesen, Lorenz Van der Linden, Isabel Spriet, Jos Tournoy
Opublikowane w: International Journal of Pharmaceutics, Numer 669, 2025, Strona(/y) 125016, ISSN 0378-5173
Wydawca: Elsevier BV
DOI: 10.1016/j.ijpharm.2024.125016

Esophageal transit of solid oral dosage forms – impact of different surface materials characterized in vitro and in vivo by MRI in healthy volunteers

Autorzy: Henriette Hummler, Susanne Page, Cordula Stillhart, Phil Lorenz, Marie-Luise Kromrey, Werner Weitschies, Michael Grimm
Opublikowane w: European Journal of Pharmaceutical Sciences, Numer 203, 2024, Strona(/y) 106926, ISSN 0928-0987
Wydawca: Elsevier BV
DOI: 10.1016/j.ejps.2024.106926

Impact of Tablet Size and Shape on the Swallowability in Older Adults

Autorzy: Henriette Hummler, Cordula Stillhart, Lisa Meilicke, Michael Grimm, Elischa Krause, Marwan Mannaa, Maik Gollasch, Werner Weitschies, Susanne Page
Opublikowane w: Pharmaceutics, Numer 15, 2024, Strona(/y) 1042, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15041042

Parameters to consider for successful medication use in older adults - An AGePOP review

Autorzy: Henriette Hummler, Dorota Sarwinska, Werner Weitschies, Maik Gollasch, Susanne Page
Opublikowane w: European Journal of Pharmaceutical Sciences, Numer 187, 2024, Strona(/y) 106453, ISSN 0928-0987
Wydawca: Elsevier BV
DOI: 10.1016/j.ejps.2023.106453

The impact of advanced age on gastrointestinal characteristics that are relevant to oral drug absorption: An AGePOP review

Autorzy: Cordula Stillhart, Adam Asteriadis, Ekaterina Bocharova, Gabriel Eksteen, Fritz Harder, Jonas Kusch, Theodora Tzakri, Patrick Augustijns, Christophe Matthys, Maria Vertzoni, Werner Weitschies, Christos Reppas
Opublikowane w: European Journal of Pharmaceutical Sciences, Numer 187, 2023, Strona(/y) 106452, ISSN 0928-0987
Wydawca: Elsevier BV
DOI: 10.1016/j.ejps.2023.106452

Investigation of real-life drug intake behaviour in older adults and geriatric patients in Northern Germany – A biopharmaceutical perspective

Autorzy: Dorota Sarwinska, Michael Grimm, Julius Krause, Philipp Schick, Maik Gollasch, Marwan Mannaa, Christoph A. Ritter, Werner Weitschies
Opublikowane w: European Journal of Pharmaceutical Sciences, Numer 200, 2024, Strona(/y) 106814, ISSN 0928-0987
Wydawca: Elsevier BV
DOI: 10.1016/j.ejps.2024.106814

Influence of Solid Oral Dosage Form Characteristics on Swallowability, Visual Perception, and Handling in Older Adults

Autorzy: Henriette Hummler, Susanne Page, Cordula Stillhart, Lisa Meilicke, Michael Grimm, Marwan Mannaa, Maik Gollasch, Werner Weitschies
Opublikowane w: Pharmaceutics, Numer 15, 2024, Strona(/y) 1315, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15041315

Insights into the Pharmacokinetics and Pharmacodynamics of Direct Oral Anticoagulants in Older Adults with Atrial Fibrillation: A Structured Narrative Review

Autorzy: Angela Elma Edwina, Nada Dia, Erwin Dreesen, Thomas Vanassche, Peter Verhamme, Isabel Spriet, Lorenz Van der Linden, Jos Tournoy
Opublikowane w: Clinical Pharmacokinetics, Numer 62, 2023, Strona(/y) 351-373, ISSN 0312-5963
Wydawca: Adis International Ltd.
DOI: 10.1007/s40262-023-01222-w

Physiologically based pharmacokinetic (PBPK) modelling of oral drug absorption in older adults – an AGePOP review

Autorzy: Cleo Demeester, Donnia Robins, Angela Elma Edwina, Jos Tournoy, Patrick Augustijns, Ibrahim Ince, Andreas Lehmann, Maria Vertzoni, Jan Frederik Schlender
Opublikowane w: European Journal of Pharmaceutical Sciences, Numer 188, 2024, Strona(/y) 106496, ISSN 0928-0987
Wydawca: Elsevier BV
DOI: 10.1016/j.ejps.2023.106496

Agreement Between a Colorimetric Assay and Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry for Quantifying Paracetamol Plasma Concentrations

Autorzy: Angela Elma Edwina, Erwin Dreesen, Julie Hias, Birgit C. P. Koch, Nele Van den Eede, Steven Pauwels, Karel Allegaert, Lorenz Van der Linden, Isabel Spriet, Jos Tournoy
Opublikowane w: The AAPS Journal, Numer 26, 2024, ISSN 1550-7416
Wydawca: Springer New York
DOI: 10.1208/s12248-024-00890-1

A quantification of gastric and duodenal fluid volumes in older adults using MRI

Autorzy: Cleo Demeester, Matthias Van der Veken, Joachim Brouwers, Ragna Vanslembrouck, André Dallmann, Thomas Wendl, Patrick Augustijns
Opublikowane w: International Journal of Pharmaceutics, Numer 666, 2024, Strona(/y) 124831, ISSN 0378-5173
Wydawca: Elsevier BV
DOI: 10.1016/j.ijpharm.2024.124831

Analyzing parametric influences driving age-associated changes in absorption using a PBPK-GSA approach

Autorzy: Donnia Robins, Andreas Lehmann, Katharina Krollik, Maria Vertzoni
Opublikowane w: European Journal of Pharmaceutical Sciences, Numer 202, 2024, Strona(/y) 106881, ISSN 0928-0987
Wydawca: Elsevier BV
DOI: 10.1016/j.ejps.2024.106881

Selenium Deficiency After Bariatric Surgery Is More Than Surface Deep

Autorzy: Gabriel Eksteen; Tim Vanuytsel; Christophe Matthys; Bart Van der Schueren; Nele Steenackers
Opublikowane w: Obesity Surgery, Numer 32, 2022, Strona(/y) 2473-2475, ISSN 1708-0428
Wydawca: Springer
DOI: 10.1007/s11695-022-06084-y

Thesis and dissertations (2)

Patient-centric Drug Product Development for Older Adults: Influence of Solid Oral Dosage Form Characteristics on Patient Acceptability

Autorzy: Henriette Hummler
Opublikowane w: 2024
Wydawca: Universität Greifswald, epub

Investigation of gastric water empyting in older adults assessed by salivary caffeine kinetics and a novel tablet formulation

Autorzy: Theodora Tzakri
Opublikowane w: 2024
Wydawca: Universität Greifswald