Descripción del proyecto
Plataforma de diagnóstico predictivo para las deficiencias motoras/cognitivas en los recién nacidos prematuros
El nacimiento prematuro aumenta el riesgo de un desarrollo neurológico alterado en la niñez y la adolescencia, y muchos niños que sobreviven afrontan una vida con discapacidad. El diagnóstico precoz de la lesión cerebral y la detección precoz de las deficiencias son necesarios para mejorar el bienestar de los niños, lo que mejora el seguimiento del desarrollo, la evaluación médica y la optimización de las opciones terapéuticas. El proyecto PARENT, financiado con fondos europeos, concibe un enfoque multidisciplinario para desarrollar plataformas de diagnóstico y predicción centradas en las deficiencias motoras/cognitivas del recién nacido, y programas de formación para investigadores noveles. El proyecto tiene como objetivo crear una infraestructura de «software» de bases de datos integradas, componentes de algoritmos validados y plataformas basadas en ellos. PARENT combina los esfuerzos de una red multidisciplinaria de diez grupos de investigación europeos líderes junto con socios de la industria, hospitales pediátricos y asociaciones de padres para capacitar a quince investigadores noveles.
Objetivo
Prematurity exponentially increases the risk for an altered neurodevelopmental outcomes in childhood and adolescence. Many survivors children, face a lifetime of disability. Despite the advances in neonatal care have greatly improved survival of preterm born infants even at extremely low gestational ages we are now at a period of steadiness where no further improvement in long-term neurodevelopmental outcome is seen. The impact of these sequelae affects not only at a personal and familiar level but also poses a significant burden on society. Early diagnostics of brain injury and/or brain dysmaturation as well as early detection of impairments are important strategies to improve the well-being of children and their families allowing for developmental monitoring and medical evaluation of the specific type of disorder that affects a child and optimize therapeutics options.
In this context, PARENT is a vision for a multidisciplinary approach to develop diagnostic and predictive platforms focused on newborn motor/cognitive impairments. PARENT will make a critical contribution towards an open neurodevelopmental disease diagnostic software infrastructure by interlinking disciplines from clinical data, neuroimaging collection and processing, biomarkers, data fusion, machine learning applied to clinical data, novel prediction algorithms.
To best leverage the data potential, PARENT envisions an easy-to-use software infrastructure which provides integrated databases, validated algorithms components and platforms built upon them. This vision can be included in the more general paradigm of evidence-based medicine, personalized medicine and patient center care, as well as decision support systems in clinical field.
PARENT combines the efforts of a multidisciplinary network of 10 leading European research groups, industry partners, pediatric hospitals and parents’ association to develop a technological infrastructure that will train 15 Early Stage Researchers.
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MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinador
10129 Torino
Italia