Descrizione del progetto
Una piattaforma diagnostica predittiva per i deficit motori/cognitivi nei neonati prematuri
Le nascite premature aumentano il rischio di un neurosviluppo alterato nell’infanzia e nell’adolescenza, e molti bambini sopravvissuti devono fare i conti con una disabilità a vita. Per migliorare il benessere di questi bambini sono necessari una diagnosi precoce delle lesioni cerebrali e un precoce rilevamento di tali deficit, potenziando il monitoraggio evolutivo, la valutazione clinica e l’ottimizzazione delle opzioni terapeutiche. Il progetto PARENT, finanziato dall’UE, prevede un approccio multidisciplinare per sviluppare piattaforme diagnostiche predittive incentrate sui deficit motori/cognitivi dei neonati, e programmi di formazione per ricercatori in fase iniziale di carriera. Il progetto si propone di creare un’infrastruttura software di banche dati integrate, componenti di algoritmi convalidati e piattaforme basate su questi ultimi. PARENT riunisce gli sforzi di una rete multidisciplinare di 10 importanti gruppi di ricerca europei e di partner industriali, ospedali pediatrici e associazioni di genitori per formare 15 ricercatori in fase iniziale di carriera.
Obiettivo
Prematurity exponentially increases the risk for an altered neurodevelopmental outcomes in childhood and adolescence. Many survivors children, face a lifetime of disability. Despite the advances in neonatal care have greatly improved survival of preterm born infants even at extremely low gestational ages we are now at a period of steadiness where no further improvement in long-term neurodevelopmental outcome is seen. The impact of these sequelae affects not only at a personal and familiar level but also poses a significant burden on society. Early diagnostics of brain injury and/or brain dysmaturation as well as early detection of impairments are important strategies to improve the well-being of children and their families allowing for developmental monitoring and medical evaluation of the specific type of disorder that affects a child and optimize therapeutics options.
In this context, PARENT is a vision for a multidisciplinary approach to develop diagnostic and predictive platforms focused on newborn motor/cognitive impairments. PARENT will make a critical contribution towards an open neurodevelopmental disease diagnostic software infrastructure by interlinking disciplines from clinical data, neuroimaging collection and processing, biomarkers, data fusion, machine learning applied to clinical data, novel prediction algorithms.
To best leverage the data potential, PARENT envisions an easy-to-use software infrastructure which provides integrated databases, validated algorithms components and platforms built upon them. This vision can be included in the more general paradigm of evidence-based medicine, personalized medicine and patient center care, as well as decision support systems in clinical field.
PARENT combines the efforts of a multidisciplinary network of 10 leading European research groups, industry partners, pediatric hospitals and parents’ association to develop a technological infrastructure that will train 15 Early Stage Researchers.
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MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinatore
10129 Torino
Italia