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C-C Bond Formation Using Top Performing Enzymes

Objective

Industrial Biotechnology is a Key Enabling Technology under Horizon 2020, expected to boost technological innovation and industrial leadership in the EU. It can improve chemical processes in compliance with the principles of Green Chemistry and effectively address social, environmental and economic needs. Assembling simple fragments to build larger, more complex products is an essential technology at the heart of industrial organic synthesis. With traditional chemical methods, C–C bond formation (“carboligation”) is difficult to control selectively, whereas enzymes can catalyze carboligation with excellent precision. Such addition reactions are ideally suited for industrial applications, being highly atom-efficient and producing no waste material. For unleashing the vast, hidden treasury of enzymatic carboligation, the CC-TOP consortium has identified and will address a number of critical needs, technology gaps, practical challenges and synthetic opportunities presenting a huge potential for innovation. The main goal of the CC-TOP ETN is to deliver tailored training and education to 15 top early-career researchers on cuttingedge carboligation enzyme technology and its translation into efficient Industrial Biotechnology applications, i.e. production of chiral fine chemicals and pharmaceuticals. The training will be implemented within an established network of worldleading European academic institutions and industrial partners, forming strong interdisciplinary relations through cosupervision and inter-sectoral secondments of the ESRs. The network´s aim for efficient translation of breakthrough technology into industrial applications is emphasized through the implementation of an industrial skills module involving all ESRs. CC-TOP combines leading-edge discovery technologies with state-of-the-art protein engineering and structural biology methods to specifically optimize process-validated carboligases for scalable applications in Industrial Biotechnology.

Field of science

  • /natural sciences/biological sciences/molecular biology/structural biology
  • /engineering and technology/industrial biotechnology
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/enzymes

Call for proposal

H2020-MSCA-ITN-2020
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

TECHNISCHE UNIVERSITAT DARMSTADT
Address
Karolinenplatz 5
64289 Darmstadt
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 505 576,80

Participants (11)

SVEUCILISTE U ZAGREBU FAKULTET KEMIJSKOG INZENJERSTVA I TEHNOLOGIJE
Croatia
EU contribution
€ 237 367,08
Address
Marulicev Trg 19
10000 Zagreb
Activity type
Higher or Secondary Education Establishments
PROZOMIX LIMITED
United Kingdom
EU contribution
€ 303 172,56
Address
Station Court 3
NE49 9HN Haltwhistle
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSIDAD AUTONOMA DE MADRID
Spain
EU contribution
€ 250 904,88
Address
Calle Einstein 3 Ciudad Univ Cantoblanco Rectorado
28049 Madrid
Activity type
Higher or Secondary Education Establishments
ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Germany
EU contribution
€ 252 788,40
Address
Fahnenbergplatz
79098 Freiburg
Activity type
Higher or Secondary Education Establishments
UNIVERSITY COLLEGE LONDON
United Kingdom
EU contribution
€ 303 172,56
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
GEORG-AUGUST-UNIVERSITAT GOTTINGEN STIFTUNG OFFENTLICHEN RECHTS
Germany
EU contribution
€ 505 576,80
Address
Wilhelmsplatz 1
37073 Gottingen
Activity type
Higher or Secondary Education Establishments
UNIVERSITE CLERMONT AUVERGNE
France
EU contribution
€ 274 802,04
Address
49 Boulevard Francois Mitterrand
63000 Clermont-ferrand
Activity type
Higher or Secondary Education Establishments
JOHNSON MATTHEY PLC
United Kingdom
EU contribution
€ 303 172,56
Address
Farringdon Street 25 5Th Floor
EC4A 4AB London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BASF SE
Germany
EU contribution
€ 252 788,40
Address
Carl Bosch Strasse 38
67063 Ludwigshafen Am Rhein
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
RIJKSUNIVERSITEIT GRONINGEN
Netherlands
EU contribution
€ 531 239,76
Address
Broerstraat 5
9712CP Groningen
Activity type
Higher or Secondary Education Establishments
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 250 904,88
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations