A multidisciplinary training network for the bioinspired development of glycomimetics tuning the Siglec-Sialoglycan axis

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Site-Selective Functionalized PD-1 Mutant for a Modular Immunological Activity against Cancer Cells

Autori: Silvia Fallarini, Linda Cerofolini, Maria Salobehaj, Domenico Rizzo, Giulia Roxana Gheorghita, Giulia Licciardi, Daniela Eloisa Capialbi, Valerio Zullo, Andrea Sodini, Cristina Nativi*, and Marco Fragai*
Pubblicato in: Biomacromolecules, Numero 24, 2023, Pagina/e 5428–5437, ISSN 1526-4602
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.3c00893

Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b

Autori: Maria Pia Lenza, Leire Egia-Mendikute, Asier Antoñana-Vildosola, Cátia O. Soares, Helena Coelho, Francisco Corzana, Alexandre Bosch, Prodhi Manisha, Jon Imanol Quintana, Iker Oyenarte, Luca Unione, María Jesús Moure, Mikel Azkargorta, Unai Atxabal, Klaudia Sobczak, Felix Elortza, James D. Sutherland, Rosa Barrio, Filipa Marcelo, Jesús Jiménez-Barbero, Asis Palazon & June Ereño-Orbea
Pubblicato in: Nature Communications, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-39119-8

Combining Solid‐State NMR with Structural and Biophysical Techniques to Design Challenging Protein‐Drug Conjugates

Autori: Linda Cerofolini; Kristian Vasa; Elisa Bianconi; Maria Salobehaj; Giulia Cappelli; Alice Bonciani; Giulia Licciardi; Anna Pérez‐Ràfols; Luis Padilla‐Cortés; Sabrina Antonacci; Domenico Rizzo; Enrico Ravera; Caterina Viglianisi; Vito Calderone; Giacomo Parigi; Claudio Luchinat; Antonio Macchiarulo; Stefano Menichetti; Marco Fragai
Pubblicato in: Angewandte Chemie - International Edition, 2023, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202303202

UV light-induced spatial loss of sialic acid capping using a photoactivatable sialyltransferase inhibitor

Autori: Sam J. Moons; Daniël L.A.H. Hornikx; Mikkel K. M. Aasted; Johan F.A. Pijnenborg; Matteo Calzari; Paul B. White; Yoshiki Narimatsu; Henrik Clausen; Hans H. Wandall; Thomas J. Boltje; Christian Büll
Pubblicato in: RCS Chemical Biology, Numero 4, 2023, ISSN 2633-0679
Editore: Royal Society of Chemistry
DOI: 10.1039/d3cb00006k

The sialic acid-Siglec immune checkpoint: an opportunity to enhance immune responses and therapy effectiveness in melanoma

Autori: Magali Coccimiglio, Fabrizio Chiodo, Yvette van Kooyk
Pubblicato in: British Journal of Dermatology, 2024, ISSN 1365-2133
Editore: Oxford Academic
DOI: 10.1093/bjd/ljad517

Molecular Insights into O-Linked Sialoglycans Recognition by the Siglec-Like SLBR-N (SLBRUB10712) of Streptococcus gordonii

Autori: Cristina Di Carluccio, Linda Cerofolini, Miguel Moreira, Frédéric Rosu, Luis Padilla-Cortés, Giulia Roxana Gheorghita, Zhuojia Xu, Abhishek Santra, Hai Yu, Shinji Yokoyama, Taylor E. Gray, Chris D. St. Laurent, Yoshiyuki Manabe, Xi Chen, Koichi Fukase, Matthew S. Macauley, Antonio Molinaro, Tiehai Li, Barbara A. Bensing, Roberta Marchetti*, Valérie Gabelica, Marco Fragai, and Alba Silipo*
Pubblicato in: ACS Cent. Sci., 2024, Pagina/e 447–459, ISSN 2374-7951
Editore: ACS Publications
DOI: 10.1021/acscentsci.3c01598

Engineering the sialome of mammalian cells with sialic acid mimetics

Autori: Daniël L A H Hornikx , Eline A Visser , Venetia Psomiadou , Christian Büll , Thomas J Boltje
Pubblicato in: STAR Protocols, 2023, ISSN 2666-1667
Editore: Elsevier Inc
DOI: 10.1016/j.xpro.2023.102330

Sialic acids in infection and their potential use in detection and protection against pathogens

Autori: Simone Dedola, Sanaz Ahmadipour,a Peterson de Andrade, Alexander N. Baker, Andrew N. Boshra, Simona Chessa, Matthew I. Gibson, Pedro J. Hernando, Irina M. Ivanova,b Jessica E. Lloyd,María J. Marín, O Alexandra J. Munro-Clark, Giulia Pergolizzi, Sarah-Jane Richards, Iakovia Ttofi, Ben A. Wagstaffa and Robert A. Field
Pubblicato in: RSC Chemical Biology, 2023, ISSN 2633-0679
Editore: Royal Society of Chemistry
DOI: 10.1039/d3cb00155e

Solid-state NMR – a complementary technique for protein framework characterization

Autori: Cerofolini, Linda; Ramberg, Kiefer O.; Padilla, Luis C.; Antonik, Paweł; Ravera, Enrico; Luchinat, Claudio; Fragai, Marco; Crowley, Peter
Pubblicato in: Chemical Communications, Numero 59, 2023, Pagina/e 776-779, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/d2cc05725e

A photoaffinity glycan-labeling approach to investigate immunoglobulin glycan-binding partners

Autori: Miles D Holborough-Kerkvliet; Greta Mucignato; Sam J Moons; Venetia Psomiadou; Rohit S R Konada; Nichole J Pedowitz; Matthew R Pratt; Theresa Kissel; Carolien A M Koeleman; Rayman T N Tjokrodirijo; Petrus A van Veelen; Thomas Huizinga; Karin A J van Schie; Manfred Wuhrer; Jennifer J Kohler; Kimberly M Bonger; Thomas J Boltje; Reinaldus E M Toes
Pubblicato in: Glycobiology, Numero 9, 2023, Pagina/e 732–744, ISSN 1460-2423
Editore: Oxford University Press
DOI: 10.1093/glycob/cwad055

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