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ROles of ePitranscriptomic in diseasES

Objective

Epitranscriptomics is the study of RNA modifications and their role in the regulation of gene expression. As happened for DNA, extensive covalent modification of RNA was found already in the 70s. Nevertheless, a spectacular expansion of epitranscriptomics occurred mostly in the past seven years, when an extensive layer of base decorations was discovered in mRNAs and shown to undergo cell modulation. These modifications produce programmable fluctuations in mRNA levels, translatability and subcellular compartmentalization, affecting primary cell programs such as cell differentiation and response to stress. We thus anticipate that RNA modifications will prove as important as chromatin dynamics in shaping cell phenotypes. This emerging field is hence crucial for both basic science and application to human disease. Epitranscriptomic would provide the missing link between genomic variability and cellular phenotypes, contributing to explaining the cause of specific diseases and developing novel therapies. Epitranscriptomic research is dominated by the US and China, with the EU lagging behind. We thus need to rapidly create a European framework to integrate and accelerate research efforts and industrial applications in this emerging field. To address this major European need, ROPES will train a group of Early Stage Researchers who will become the seed of the European epitranscriptome science of this decade. They will join a recently established network of academic research groups and biotech companies devoted to advancing our understanding of RNA modifications while promoting the development of new biomarkers and therapies. Focusing on RNA editing and m6A methylation, ROPES will investigate disease mechanisms and new therapies in the fields of cancer, stem cell diseases and innate immunity, while developing innovative epitranscriptomics methods. The ROPES European Training Network is the first European effort to tackle the epitranscriptome for the advancement of medicine.

Field of science

  • /natural sciences/biological sciences/genetics and heredity/rna
  • /medical and health sciences/medical biotechnology/cells technologies/stem cells

Call for proposal

H2020-MSCA-ITN-2020
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

UNIVERSITA DEGLI STUDI DI TRENTO
Address
Via Calepina 14
38122 Trento
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 522 999,36

Participants (10)

MEDIZINISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 264 207,24
Address
Spitalgasse 23
1090 Wien
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE LAUSANNE
Switzerland
EU contribution
€ 281 276,64
Address
Quartier Unil-centre Bâtiment Unicentre
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY
Poland
EU contribution
€ 227 478,60
Address
Ks. Trojdena 4
02-109 Warsaw
Activity type
Research Organisations
UMEA UNIVERSITET
Sweden
EU contribution
€ 281 982,96
Address
Universitetomradet
901 87 Umea
Activity type
Higher or Secondary Education Establishments
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany
EU contribution
€ 252 788,40
Address
Im Neuenheimer Feld 280
69120 Heidelberg
Activity type
Research Organisations
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 261 499,68
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
FUNDACIO CENTRE DE REGULACIO GENOMICA
Spain
EU contribution
€ 250 904,88
Address
Carrer Doctor Aiguader 88
08003 Barcelona
Activity type
Research Organisations
Masarykova univerzita
Czechia
EU contribution
€ 234 871,56
Address
Zerotinovo Namesti 9
60177 Brno Stred
Activity type
Higher or Secondary Education Establishments
IMMAGINA BIOTECHNOLOGY SRL
Italy
EU contribution
€ 261 499,68
Address
Via Alla Cascata 56/C
38123 Trento
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITE LIBRE DE BRUXELLES
Belgium
EU contribution
€ 256 320
Address
Avenue Franklin Roosevelt 50
1050 Bruxelles
Activity type
Higher or Secondary Education Establishments