Description du projet
Aperçu du rôle des modifications de l’ARNm
De nouvelles preuves indiquent qu’à l’instar de la chromatine, l’ARNm est porteur de certaines modifications covalentes. Bien que leur rôle soit encore à l’étude, il semble que ces modifications déterminent les niveaux, la traduisibilité et la compartimentation subcellulaire des ARNm cibles, avec de graves conséquences sur les processus cellulaires. Le projet ROPES, financé par l’UE, se concentrera sur l’épitranscriptomique en tant que lien manquant entre la variabilité génomique et le phénotype cellulaire. Les résultats aideront à définir les mécanismes de la maladie, à identifier de nouveaux biomarqueurs et à développer des thérapies innovantes. En formant des chercheurs en début de carrière, le projet ROPES entend établir un cadre européen susceptible d’accélérer les efforts de recherche et les applications industrielles dans le domaine prometteur de l’épitranscriptomique.
Objectif
Epitranscriptomics is the study of RNA modifications and their role in the regulation of gene expression. As happened for DNA, extensive covalent modification of RNA was found already in the 70s. Nevertheless, a spectacular expansion of epitranscriptomics occurred mostly in the past seven years, when an extensive layer of base decorations was discovered in mRNAs and shown to undergo cell modulation. These modifications produce programmable fluctuations in mRNA levels, translatability and subcellular compartmentalization, affecting primary cell programs such as cell differentiation and response to stress. We thus anticipate that RNA modifications will prove as important as chromatin dynamics in shaping cell phenotypes. This emerging field is hence crucial for both basic science and application to human disease. Epitranscriptomic would provide the missing link between genomic variability and cellular phenotypes, contributing to explaining the cause of specific diseases and developing novel therapies. Epitranscriptomic research is dominated by the US and China, with the EU lagging behind. We thus need to rapidly create a European framework to integrate and accelerate research efforts and industrial applications in this emerging field. To address this major European need, ROPES will train a group of Early Stage Researchers who will become the seed of the European epitranscriptome science of this decade. They will join a recently established network of academic research groups and biotech companies devoted to advancing our understanding of RNA modifications while promoting the development of new biomarkers and therapies. Focusing on RNA editing and m6A methylation, ROPES will investigate disease mechanisms and new therapies in the fields of cancer, stem cell diseases and innate immunity, while developing innovative epitranscriptomics methods. The ROPES European Training Network is the first European effort to tackle the epitranscriptome for the advancement of medicine.
Champ scientifique
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MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinateur
38122 Trento
Italie