Project description
Training in colon specific drug delivery (colon targeting)
Oral administration may be the most convenient and preferred drug delivery route, but issues relating to solubility, absorption and metabolism hamper its effectiveness. Moreover, the performance of formulations that deliver drugs specifically to the large intestine (so called colon targeting formulations) also depends on intra- and inter-individual physiological variability (e.g. pH profile in the gastrointestinal tract). The EU-funded COLOTAN project aims to address such drug delivery challenges as well as the lack of tools and models that recapitulate events occurring in the colon which can predict colon specific drug release, absorption and performance. Through an interdisciplinary research and training programme that also includes career development activities, COLOTAN will support the next generation of pharmaceutical scientists.
Objective
The Colon Targeting Network (COLOTAN) is a European Training Network that will train 13 Early Stage Researchers (ESRs) in (bio)pharmaceutical sciences to improve targeting of oral drugs to the colon.
Oral administration of drugs is the preferred delivery route due to its non-invasiveness and convenience for the patient. However, issues related to solubility, absorption, and metabolism often cause oral drug candidate attrition. Oral formulations that release the drug in a pH- or time-dependent manner in the colon have been developed for local treatment of colonic diseases. However, currently available colon-targeting formulations suffer from an inconsistent performance and lack of efficiency due to intra- and interindividual (patho)physiological variability. Moreover, the available tools to predict drug absorption mainly focus on the upper gastrointestinal tract and fail to recapitulate events occurring in the colon, resulting in a lack of validated models to predict drug and formulation behaviour in the colon.
To meet these challenges, we must move beyond traditional, mainly monodisciplinary education and train a new generation of pharmaceutical scientists in diverse disciplines ranging from drug delivery to chemistry, cell biology, microbiology and gastroenterology.
In an ambitious intersectoral environment, COLOTAN will deliver this new generation via an advanced research and training programme with a total value of 180 ECTS comprising challenging Individual Research Projects, workshops with joint training in scientific and transferable skills, online training, individual training, dissemination, outreach and career development activities. At the end of the project, all ESRs will obtain a doctoral degree. This new generation of ESRs will become future leaders in academia and industry and will be at the forefront of developing a new generation of innovative colon targeting drugs.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology
- medical and health sciences clinical medicine gastroenterology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.1. - Fostering new skills by means of excellent initial training of researchers
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-ITN-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
3000 LEUVEN
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.