Description du projet
Formation à l’administration de médicaments spécifiques au côlon (ciblage du côlon)
L’administration orale est peut-être la voie d’administration la plus pratique et la plus privilégiée, mais des problèmes liés à la solubilité, à l’absorption et au métabolisme nuisent à son efficacité. En outre, la performance des formulations qui délivrent des médicaments spécifiquement dans le gros intestin (appelées formulations ciblant le côlon) dépend également de la variabilité physiologique intra- et inter-individuelle (par exemple le pH de l’appareil digestif). Le projet COLOTAN, financé par l’UE, a pour objectif de résoudre ces problèmes d’administration de médicaments ainsi que le manque d’outils et de modèles qui résument les événements survenant dans le côlon et qui peuvent prédire la libération, l’absorption et la performance des médicaments spécifiques au côlon. Grâce à un programme de recherche et de formation interdisciplinaire qui comprend également des activités de développement de carrière, COLOTAN soutiendra la prochaine génération de scientifiques pharmaceutiques.
Objectif
The Colon Targeting Network (COLOTAN) is a European Training Network that will train 13 Early Stage Researchers (ESRs) in (bio)pharmaceutical sciences to improve targeting of oral drugs to the colon.
Oral administration of drugs is the preferred delivery route due to its non-invasiveness and convenience for the patient. However, issues related to solubility, absorption, and metabolism often cause oral drug candidate attrition. Oral formulations that release the drug in a pH- or time-dependent manner in the colon have been developed for local treatment of colonic diseases. However, currently available colon-targeting formulations suffer from an inconsistent performance and lack of efficiency due to intra- and interindividual (patho)physiological variability. Moreover, the available tools to predict drug absorption mainly focus on the upper gastrointestinal tract and fail to recapitulate events occurring in the colon, resulting in a lack of validated models to predict drug and formulation behaviour in the colon.
To meet these challenges, we must move beyond traditional, mainly monodisciplinary education and train a new generation of pharmaceutical scientists in diverse disciplines ranging from drug delivery to chemistry, cell biology, microbiology and gastroenterology.
In an ambitious intersectoral environment, COLOTAN will deliver this new generation via an advanced research and training programme with a total value of 180 ECTS comprising challenging Individual Research Projects, workshops with joint training in scientific and transferable skills, online training, individual training, dissemination, outreach and career development activities. At the end of the project, all ESRs will obtain a doctoral degree. This new generation of ESRs will become future leaders in academia and industry and will be at the forefront of developing a new generation of innovative colon targeting drugs.
Champ scientifique
Mots‑clés
Programme(s)
Régime de financement
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinateur
3000 Leuven
Belgique